Patents Assigned to Siemens Healthcare Diagnostics Inc.
  • Publication number: 20200169699
    Abstract: A depth-sensitive system for monitoring for and detecting a predefined condition at a specific location within a visually monitored portion of an area. Plural depth-sensitive cameras are oriented with respect to the area whereby each camera has a field of view within the area that at least partially overlaps with the field of view of another of the plural cameras. The combined field of view encompasses all portions of interest of the area. A system for providing a notification of the visual detection of a predefined condition at a particular location or set of locations within an area of interest is provided, as is a system for generating a visual representation of human activity at one or more specific locations within an area of interest.
    Type: Application
    Filed: August 8, 2018
    Publication date: May 28, 2020
    Applicant: Siemens Healthcare Diagnostics Inc.
    Inventor: Michael Heydlauf
  • Publication number: 20200166405
    Abstract: An apparatus for characterizing a specimen and/or specimen container. The characterization apparatus includes an imaging location configured to receive a specimen container containing a specimen, a light source configured to provide lighting of the imaging location, and a hyperspectral image capture device. The hyperspectral image capture device is configured to generate and capture a spectrally-resolved image of a small portion of the specimen container and specimen at a spectral image capture device. The spectrally-resolved image data received at the spectral image capture device is processed by a computer to determine at least one of: segmentation of at least one of the specimen and/or specimen container, and determination of a presence or absence of an interferent, such as hemolysis, icterus, or lipemia. Methods of imaging a specimen and/or specimen container, and specimen testing apparatus including a characterization apparatus are described, as are other aspects.
    Type: Application
    Filed: July 16, 2018
    Publication date: May 28, 2020
    Applicant: Siemens Healthcare Diagnostics Inc.
    Inventors: Patrick Wissmann, Benjamin S. Pollack
  • Publication number: 20200166531
    Abstract: A quality check module for characterizing a specimen and/or a specimen container including stray light compensation. The quality check module includes an imaging location within the quality check module configured to receive a specimen container containing a specimen, one or more image capture devices configured to capture images of the imaging location from one or more viewpoints, and one or more light sources configured to provide back lighting for the one or more image capture devices, and one or more stray light patches located in an area receiving stray light from the one or more light sources enabling stray light affecting the images to be compensated for and to provide a stray light compensated image.
    Type: Application
    Filed: July 16, 2018
    Publication date: May 28, 2020
    Applicant: Siemens Healthcare Diagnostics Inc.
    Inventors: Patrick Wissmann, Benjamin S. Pollack
  • Publication number: 20200158745
    Abstract: A method of characterizing a serum and plasma portion of a specimen in regions occluded by one or more labels. The characterization may be used for Hemolysis, Icterus, and/or Lipemia, or Normal detection. The method captures one or more images of a labeled specimen container including a serum or plasma portion, processes the one or more images to provide segmentation data and identification of a label-containing region, and classifying the label-containing region with a convolutional neural network (CNN) to provide a pixel-by-pixel (or patch-by-patch) characterization of the label thickness count, which may be used to adjust intensities of regions of a serum or plasma portion having label occlusion. Optionally, the CNN can characterize the label-containing region as one of multiple pre-defined label configurations. Quality check modules and specimen testing apparatus adapted to carry out the method are described, as are other aspects.
    Type: Application
    Filed: April 13, 2017
    Publication date: May 21, 2020
    Applicant: Siemens Healthcare Diagnostics Inc.
    Inventors: Jiang Tian, Stefan Kluckner, Shanhui Sun, Yao-Jen Chang, Terrence Chen, Benjamin S. Pollack
  • Patent number: 10656169
    Abstract: A method of reducing carryover of liquids, such as reagent and/or samples, in analytical or immunoassay testing. The method includes providing an incubation member including a plurality of reaction vessels thereon, pre-assigning certain ones of the reaction vessels in the incubation member for only first test types or certain reagent types for all test lots; and pre-assigning other ones of a second subset of reaction vessels in the incubation member for only second test types for all test lots. By ensuring no mixing of potentially interfering test types or reagent types from test lot to test lot, sample and/or reagent carryover is mitigated. Testing apparatus adapted to carry out the methods are provided, as are other aspects.
    Type: Grant
    Filed: May 26, 2015
    Date of Patent: May 19, 2020
    Assignee: Siemens Healthcare Diagnostics Inc.
    Inventors: Jianfang Wang, Mark Sprenkle, Colin Ingersoll, Stephen Frye
  • Publication number: 20200151878
    Abstract: A method of characterizing a serum and plasma portion of a specimen in regions occluded by one or more labels. The characterization method may be used to provide input to an HILN (H, I, and/or L, or N) detection method. The characterization method includes capturing one or more images of a labeled specimen container including a serum or plasma portion from multiple viewpoints, processing the one or more images to provide segmentation data including identification of a label-containing region, determining a closest label match of the label-containing region to a reference label configuration selected from a reference label configuration database, and generating a combined representation based on the segmentation information and the closest label match. Using the combined representation allows for compensation of the light blocking effects of the label-containing region. Quality check modules and testing apparatus and adapted to carry out the method are described, as are other aspects.
    Type: Application
    Filed: April 10, 2018
    Publication date: May 14, 2020
    Applicant: Siemens Healthcare Diagnostics Inc.
    Inventors: Stefan Kluckner, Patrick Wissmann, Yao-Jen Chang, Terrence Chen, Benjamin S. Pollack
  • Publication number: 20200151498
    Abstract: A method of characterizing a serum and plasma portion of a specimen in regions occluded by one or more labels. The characterization may be used for determining Hemolysis (H), Icterus (I), and/or Lipemia (L), or Normal (N) of a serum or plasma portion of a specimen. The method includes capturing one or more images of a labeled specimen container including a serum or plasma portion, processing the one or more images with a convolutional neural network to provide a determination of Hemolysis (H), Icterus (I), and/or Lipemia (L), or Normal (N). In further embodiments, the convolutional neural network can provide N-Class segmentation information. Quality check modules and testing apparatus adapted to carry out the method are described, as are other aspects.
    Type: Application
    Filed: April 10, 2018
    Publication date: May 14, 2020
    Applicant: Siemens Healthcare Diagnostics Inc.
    Inventors: Shanhui SUN, Stefan KLUCKNER, Yao-Jen CHANG, Terrence CHEN, Benjamin S. POLLACK
  • Publication number: 20200140917
    Abstract: Composition(s), device(s), kit(s), and method(s) for an improved analyte detection sensor(s) comprising at least one scavenger protein and method(s) of preserving the functioning and functional life of the improved analyte detection sensor(s).
    Type: Application
    Filed: July 30, 2018
    Publication date: May 7, 2020
    Applicant: Siemens Healthcare Diagnostics Inc.
    Inventors: Janine Cox, Christopher Lawrence, Murli Narayan, David Ledden
  • Patent number: 10643747
    Abstract: A method of providing dynamic analysis for troubleshooting in vitro diagnostics instrument issues includes receiving, at a second computing device in communication with a plurality of instruments, identification of an issue associated with a portion of an instrument of the plurality of instruments, the identification received from a first computing device in communication with the instrument. A central computing device accesses data from one or more databases and determines an ordering of one or more corrective actions for resolving the issue by applying the data to a probabilistic model based on at least one of: patterns from the plurality of instruments; and operator input. The central computing device provides the one or more corrective actions in the determined order to the first computing device to be displayed via a user interface at the instrument.
    Type: Grant
    Filed: May 19, 2015
    Date of Patent: May 5, 2020
    Assignee: Siemens Healthcare Diagnostics Inc.
    Inventors: Arnold Rudorfer, Steve Magowan, Markus Schmitt
  • Publication number: 20200132707
    Abstract: A wash system for use in an in vitro diagnostic immunoanalyzer utilizes a bridge having a linear track to move cuvettes from one incubation ring portion to another incubation ring portion. Washing stations along the linear track provide a magnetic field and fluid washing of cuvette contents independent of the size and motion of one or more incubation rings.
    Type: Application
    Filed: June 22, 2018
    Publication date: April 30, 2020
    Applicant: Siemens Healthcare Diagnostics Inc.
    Inventors: Ayman Ismail, Eric Gerolstein, Brian Bolger
  • Patent number: 10627417
    Abstract: An anti-evaporation tube for use with an in vitro diagnostics automation system is provided. The anti-evaporation tube includes an anti-evaporation tube body configured to be automatically inserted in a container and to limit evaporation of one or more fluids in the container and an alignment portion disposed on the anti-evaporation tube body. The alignment portion is configured to automatically align the anti-evaporation tube body within the container and cause the anti-evaporation tube body to remain aligned within the container. The alignment portion includes one or more openings disposed on an upper area of the anti-evaporation tube body. The one or more openings are configured to provide ventilation.
    Type: Grant
    Filed: October 30, 2014
    Date of Patent: April 21, 2020
    Assignee: Siemens Healthcare Diagnostics Inc.
    Inventors: Joseph Brennan, James Kegelman, William Hudson
  • Publication number: 20200114364
    Abstract: An embodiment is a sample rack system. The sample rack system comprises a rack having a base, a top opposite the base along a vertical direction, a receptacle that extends from the top toward the base along the vertical direction, and a receiver element proximate the top. The receptacle is sized to receive a sample collection unit. The system also includes a retention clip for holding the sample collection unit in the receptacle. The retention clip includes an engagement head for attachment to the receiver element of the rack. The engagement head defines an outer surface. The retention clip also includes a curved tail that extends from the engagement head and contacts the sample collection unit when the sample collection unit is placed in the receptacle. The outer surface of the retention clip does not project outwardly from the rack when the retention clip is attached to the rack.
    Type: Application
    Filed: May 8, 2018
    Publication date: April 16, 2020
    Applicant: Siemens Healthcare Diagnostics Inc.
    Inventors: Andrew Dunbar, Michael Chen, William Perry, Steven Geehan, Gyula Hojer, Norbert Laszka
  • Patent number: 10614287
    Abstract: A cell visualization system includes a digital holographic microscopy (DHM) device, a training device, and a virtual staining device. The DHM device produces DHM images of cells and the virtual staining device colorizes the DHM images based on an algorithm generated by the training device using generative adversarial networks and unpaired training data. A computer-implemented method for producing a virtually stained DHM image includes acquiring an image conversion algorithm which was trained using the generative adversarial networks, receiving a DHM image with depictions of one or more cells and virtually staining the DHM image by processing the DHM image using the image conversion algorithm. The virtually stained DHM image includes digital colorization of the one or more cells to imitate the appearance of a corresponding actually stained cell.
    Type: Grant
    Filed: April 24, 2018
    Date of Patent: April 7, 2020
    Assignee: Siemens Healthcare Diagnostics Inc.
    Inventors: Noha Youssry El-Zehiry, Saikiran Rapaka, Ali Kamen
  • Patent number: 10613106
    Abstract: Disclosed is a reaction vessel handling apparatus adapted for use in a biological fluid testing apparatus. The reaction vessel handling apparatus includes an incubation member and wash member that are overlapping. A transfer device transfers reaction vessels between the incubation member and wash member at the overlapping portions. Incubation and wash members may be rings. Testing apparatus (e.g., immunoassay apparatus or clinical analyzer apparatus) including the reaction vessel handling apparatus and methods of operating the apparatus are provided, as are other aspects.
    Type: Grant
    Filed: April 15, 2015
    Date of Patent: April 7, 2020
    Assignee: Siemens Healthcare Diagnostics Inc.
    Inventors: Beri Cohen, Nicolae Dumitrescu
  • Patent number: 10605762
    Abstract: A magnesium sensing membrane is disclosed for use in a potentiometric ion selective electrode that exhibits improved stability upon exposure to surfactant-containing reagents. Kits containing same are disclosed, along with methods of production and use of the magnesium sensing membrane.
    Type: Grant
    Filed: March 11, 2019
    Date of Patent: March 31, 2020
    Assignee: Siemens Healthcare Diagnostics Inc.
    Inventors: Wei Zhang, Kevin Horan
  • Publication number: 20200096469
    Abstract: A system includes a sample analyzer having a sensor assembly. The sensor assembly includes a first microsensor having a first outer sheath, a first membrane core within the first outer sheath, and a first conductive element at least partially encased by and in contact with the first membrane core. The first conductive element detects a first electrical response signal when the first membrane core is in contact with the fluid. The sensor assembly may include a second microsensor that is adjacent to the first microsensor. The second microsensor has a second outer sheath, a second membrane core within the outer sheath, and a second conductive element at least partially encased by and in direct contact with the second membrane core. The second conductive element detects the second electrical response signal when the second membrane core is in contact with the fluid.
    Type: Application
    Filed: December 13, 2017
    Publication date: March 26, 2020
    Applicant: Siemens Healthcare Diagnostics Inc.
    Inventor: Jennifer Samproni
  • Publication number: 20200080994
    Abstract: Analyzers and methods for making and using analyzers are described such as a method in which multiple absorption readings of a liquid assay are obtained by a photodetector using multiple light sources having at least three separate and independent wavelength ranges and with each of the absorption readings taken at a separate instant of time. Using at least one processor and calibration information of the liquid assay, an amount of at least two analytes within the liquid assay using the multiple absorption readings is determined.
    Type: Application
    Filed: December 12, 2017
    Publication date: March 12, 2020
    Applicant: Siemens Healthcare Diagnostics Inc.
    Inventor: Jacques Brunelle
  • Publication number: 20200072861
    Abstract: A sample receiving assembly capable of receiving a fluid sample from sample containers having different sizes and shapes includes an arm, an arm holder, a sample probe, and a support member, the support member having a bore therethrough and a plurality of linear grooves. The arm is disposed within the arm holder and the sample probe is disposed within the arm. The arm holder includes a hollow pivot pin insertable through the bore in the support member. The sample probe has a first portion extendable through a distal end of the arm, and a second portion extending axially through the hollow pivot pin. The plurality of linear grooves in the support member are sized and positioned to receive a guide pin on the arm and guide retraction of the arm into the arm holder from an extended position to a retracted position.
    Type: Application
    Filed: December 12, 2017
    Publication date: March 5, 2020
    Applicant: Siemens Healthcare Diagnostics Inc.
    Inventor: Kenneth P. Galano
  • Publication number: 20200072755
    Abstract: Methods of detecting compromise of at least one analyte reagent upon reaction with a test sample are disclosed. Also disclosed are reflectance spectroscopic diagnostic instruments that perform the method, and systems that contain same.
    Type: Application
    Filed: December 12, 2017
    Publication date: March 5, 2020
    Applicant: Siemens Healthcare Diagnostics Inc.
    Inventors: Lloyd Schulman, Christopher Zimmerle, Julie Chaney
  • Patent number: 10576473
    Abstract: An assembly for mitigating spillage of patient sample in a patient sample tube having an open top includes a patient sample in the tube and a layer of inert material floating on the sample fluid, such that the material restricts splashing movement of the sample's surface. The material can include a foam, a gel, or a disk. The disk can be approximately the diameter of the sample tube with a center opening configured to accept a pipette to provide access to the patient sample.
    Type: Grant
    Filed: August 25, 2016
    Date of Patent: March 3, 2020
    Assignee: Siemens Healthcare Diagnostics Inc.
    Inventors: Keld Sorensen, Baris Yagci, Robert Hempton