Patents Assigned to Sigma-Tau HealthScience S.p.A.
  • Patent number: 7303765
    Abstract: L-carnitine which has a particle size such that it substantially passes through a 100 USBS mesh sieve exhibits an increased bioavailability, a decreased hygroscopicity, and may be conveniently formulated with oil-based materials.
    Type: Grant
    Filed: January 25, 2005
    Date of Patent: December 4, 2007
    Assignee: Sigma-Tau HealthScience S.p.A.
    Inventor: Ken Hassan
  • Publication number: 20050124558
    Abstract: L-carnitine which has a particle size such that it substantially passes through a 100 USBS mesh sieve exhibits an increased bioavailability, a decreased hygroscopicity, and may be conveniently formulated with oil-based materials.
    Type: Application
    Filed: January 25, 2005
    Publication date: June 9, 2005
    Applicant: Sigma-Tau HealthScience S.p.A.
    Inventor: Ken Hassen
  • Publication number: 20040057994
    Abstract: A composition is disclosed which is suitable for the prevention and treatment of kidney dysfunctions and diseases and which can therefore take the form of a food supplement or of an actual medicinal drug comprising a combination of acetyl L-carnitine and propionyl L-carnitine or their pharmacologically acceptable salts.
    Type: Application
    Filed: September 23, 2003
    Publication date: March 25, 2004
    Applicant: Sigma-Tau HealthScience S.p.A.
    Inventor: Claudio Cavazza
  • Patent number: 6653349
    Abstract: A composition is disclosed which is suitable for the prevention and treatment of kidney dysfunctions and diseases and which can therefore take the form of a food supplement or of an actual medicinal drug, comprising a combination of acetyl L-carnitine and propionyl L-carnitine or their pharmacologically acceptable salts.
    Type: Grant
    Filed: January 3, 2002
    Date of Patent: November 25, 2003
    Assignee: Sigma-Tau HealthScience S.p.A.
    Inventor: Claudio Cavazza
  • Publication number: 20030206895
    Abstract: A composition is disclosed which comprises as characterizing active ingredients propionyl L-carnitine and a flavonoid, typically quercetin or its 3-rutinoside, rutin, for the prevention and/or therapeutic treatment of various alterations and pathological states induced by free radicals and by thrombotic or atherosclerotic abnormalities, that may take the form of a dietary supplement, dietetic support or of an actual medicine.
    Type: Application
    Filed: June 4, 2003
    Publication date: November 6, 2003
    Applicant: Sigma-Tau HealthScience S.p.A.
    Inventor: Claudio Cavazza
  • Patent number: 6641849
    Abstract: A composition is disclosed suitable for the prevention and/or treatment of circulatory disorders at both peripheral and cerebral level, and which can therefore take the form of a dietary supplement, a dietetic support or of an actual medicine, comprising as characterizing active ingredients: (a) a carnitine selected from the group consisting of acetyl L-carnitine and propionyl L-carnitine or a pharmacologically acceptable salt thereof or mixtures thereof; and (b) an extract of Ginkgo biloba or one or more of the ginkgolides isolated from Ginkgo biloba or mixtures thereof.
    Type: Grant
    Filed: May 7, 2002
    Date of Patent: November 4, 2003
    Assignee: Sigma-Tau HealthScience S.p.A.
    Inventor: Claudio Cavazza
  • Patent number: 6602512
    Abstract: A composition is disclosed suitable for the prevention and/or treatment of muscular energetic deficiencies and states of asthenia for enhancing sport performances and for the treatment of states of heart fatigue, that may take the form of a dietary supplement, dietetic support or of an actual medicine, which comprises as characterizing active ingredients a combination of L-carnitine and/or at least one alkanoyl L-carnitine and creatinol-phosphate.
    Type: Grant
    Filed: January 3, 2002
    Date of Patent: August 5, 2003
    Assignee: Sigma-Tau HealthScience S.p.A.
    Inventor: Claudio Cavazza
  • Publication number: 20030129177
    Abstract: A dietary supplement is disclosed which supplies the skeletal muscle with energy and protects the cardiovascular tract, the characterising components of which comprise propionyl L-carnitine, coenzyme Q10, nicotinamide, riboflavin and pantothenic acid.
    Type: Application
    Filed: January 14, 2003
    Publication date: July 10, 2003
    Applicant: Sigma-Tau HealthScience S.p.A.
    Inventor: Franco Gaetani
  • Patent number: 6565876
    Abstract: A composition is disclosed suitable for the prevention and/or treatment of cardiovascular and neurocerebral disorders, tissue anoxic forms, muscular energy deficits, inflammatory-type abnormalities, alterations of blood coagulation such as thrombosis, and tissue proliferation forms, that may take the form of a dietary supplement, dietetic support or of an actual medicine, which comprises as characterizing active ingredients: (a) propionyl L-carnitine or a pharmacologically acceptable salt thereof; and (b) an inositol phosphate, particularly the inositol hexaphosphate (IP6).
    Type: Grant
    Filed: December 21, 2000
    Date of Patent: May 20, 2003
    Assignee: Sigma-Tau HealthScience S.p.A.
    Inventor: Claudio Cavazza
  • Patent number: 6552070
    Abstract: A health food/dietary supplement is disclosed, endowed with a protective action on liver function against exogenous and endogenous hepatoxic agents, the characterizing components of which are isovaleryl L-carnitine and/or propionyl L-carnitine and an extract of Silybum marianum (milk thistle) standardized to a least 70 percent by weight of silymarin.
    Type: Grant
    Filed: March 4, 2002
    Date of Patent: April 22, 2003
    Assignee: Sigma-Tau HealthScience S.p.A.
    Inventor: Pietro Pola
  • Patent number: 6515020
    Abstract: A pharmaceutical product which comprises admixed or separately packaged (A) L-Carnitine or an alkanoyl L-canitine and (B) a trihydroxy- or tetrahydroxystilbene such as resveratrol is useful for the prevention and treatment of pathological neuronal or cerebral disorders.
    Type: Grant
    Filed: March 30, 2001
    Date of Patent: February 4, 2003
    Assignee: Sigma-Tau HealthScience S.p.A.
    Inventor: Claudio Cavazza
  • Patent number: 6511685
    Abstract: A process is described for manufacturing dietary supplements (food integrators) by means of a natural fermentation, including the following steps: a) preparation of a “mix” at a 18° Centigrade temperature, containing one or more types of pasteurized milk from animal origin; b) introduction in such a “basic material” of a 1.5-4.5% in weight of polysaccharide “grains” mainly formed “friendly bacteria”; c) maintenance of the previous substance at a 18-25° Centigrade temperature for a first period of 6-12 hours then adding a quantity of 1-3 % in weight of a second pool of polysaccharide “grains”, mainly formed by yeasts; d) maintenance of the substance at 18-25 ° C. during a second period of 6-12 hours, by adding again 2.5-65% in weight of “grains” mainly formed by yeasts, then adding some minerals (calcium, magnesium, etc.) in proportion 0.2-1.
    Type: Grant
    Filed: December 13, 2000
    Date of Patent: January 28, 2003
    Assignee: Sigma-Tau Healthscience S.p.A.
    Inventor: Joseph A. Weissmahr
  • Publication number: 20030008921
    Abstract: A therapeutical method is disclosed for treating idiopathic asthenozoospermia which comprises orally or parenterally administering to a patient in need thereof a combination preparation comprising in admixture L-carnitine and acetyl L-carnitine or the pharmacologically acceptable salts thereof, in substantially equimolar amouts.
    Type: Application
    Filed: July 16, 2002
    Publication date: January 9, 2003
    Applicant: Sigma-Tau HealthScience S.p.A.
    Inventor: Claudio Cavazza
  • Publication number: 20020111383
    Abstract: L-carnitine which has a particle size such that it substantially passes through a 100 USBS mesh sieve exhibits an increased bioavailability, a decreased hygroscopicity, and may be conveniently formulated with oil-based materials.
    Type: Application
    Filed: February 14, 2002
    Publication date: August 15, 2002
    Applicant: Sigma-Tau HealthScience S.p.A.
    Inventor: Ken Hassen
  • Patent number: 6417233
    Abstract: Compositions containing as active ingredients a lipid-soluble benzoquinone, e.g. Coenzyme Q10 and at least one omega-3 polyunsaturated fatty acid selected from eicosapentaenoic acid (EPA), docosahexaenoic acid (DHA) and linolenic acid (LNA), for the prevention and/or treatment of mitochondriopathies.
    Type: Grant
    Filed: May 23, 2001
    Date of Patent: July 9, 2002
    Assignee: Sigma-Tau HealthScience S.p.A.
    Inventors: Grazia Sears, Janos Feher
  • Publication number: 20020058632
    Abstract: A therapeutical method is disclosed for treating idiopathic asthenozoospermia which comprises orally or parenterally administering to a patient in need thereof a combination preparation comprising in admixture L-carnitine and acetyl L-carnitine or the pharmacologically acceptable salts thereof, in substantially equimolar amouts.
    Type: Application
    Filed: December 6, 2001
    Publication date: May 16, 2002
    Applicant: Sigma-Tau HealthScience S.p.A.
    Inventor: Claudio Cavazza
  • Patent number: 6365622
    Abstract: A composition containing the active ingredients acetyl L-carnitine and &agr;-lipoic acid for the prevention and/or therapeutic treatment of various alterations and pathological states induced by free radicals, that may be in the form of a dietary supplement, dietetic support or of an actual medicine.
    Type: Grant
    Filed: March 12, 2001
    Date of Patent: April 2, 2002
    Assignee: Sigma-Tau HealthScience S.p.A.
    Inventor: Claudio Cavazza
  • Patent number: 6346282
    Abstract: This invention relates to a composition of acetyl-L-carnitine in combination with hypericin and/or Hypericum extract (Hypericum perforatum L. (St. John's Wort)) in synergistically effective amounts. The composition is effective at treating a nervous alteration due to an anxiety state, irritability, or depression.
    Type: Grant
    Filed: December 26, 2000
    Date of Patent: February 12, 2002
    Assignee: Sigma-Tau Healthscience S.p.A.
    Inventor: Claudio Cavazza
  • Patent number: 6335021
    Abstract: The use of acetyl L-carnitine and its pharmacologically acceptable salts is disclosed for producing a composition suitable for controlling mood disorders mainly in young individuals who are not affected by permanent pathological CNS disturbances.
    Type: Grant
    Filed: December 20, 1999
    Date of Patent: January 1, 2002
    Assignee: Sigma-Tau HealthScience S.p.A.
    Inventor: Claudio Cavazza
  • Patent number: 6335038
    Abstract: A composition that may take the form of a dietary supplement or of a medicament is disclosed which comprises as active ingredients propionyl L-carnitine and the isoflavone genistein for the therapeutic treatment of osteoporosis and menopause syndrome.
    Type: Grant
    Filed: December 22, 2000
    Date of Patent: January 1, 2002
    Assignee: Sigma-Tau Healthscience S.p.A.
    Inventor: Claudio Cavazza