Abstract: A method of treating amyloid diseases by administering a compound of Formula I:
wherein:
R7-R13 are independently —H or —OH; and
A is H, —OH, or a moiety of Formula II:
wherein:
R1 is hydrogen, lower alkanoyl of up to 6 carbon atoms or aroyl selected from benzoyl and naphthoyl;
R2 is hydrogen, lower alkyl of up to 6 carbon atoms or arylalkyl selected from benzyl, phenylethyl and phenylpropyl;
R3 is hydrogen or lower alkyl of up to 6 carbon atoms;
R4 is hydrogen or lower alkyl of up to 6 carbon atoms, or when X is oxygen, R4 together with R5 can represent —CH2—O—;
X is a valency bond, —CH2, oxygen or sulfur;
Ar is selected from phenyl, naphthyl, indanyl and tetrahydronaphthyl;
R5 and R6 are individually selected from hydrogen, fluorine, chlorine, bromine, hydroxyl, lower alkyl of up to 6 carbon atoms, a —CONH2— group, lower alkoxy of up to 6 carbon atoms, benzyloxy, lower alkylthio of up to 6 carbon atoms,
Abstract: This invention relates to a process for preparing epoxy esters, and intermediates prepared by this process, in particular, to a process which produces non-racemic epoxy esters which are of use as intermediates in the preparation of pharmaceutical compounds.
Type:
Grant
Filed:
June 14, 1989
Date of Patent:
May 5, 1992
Assignee:
Smithkline Beckman Corp.
Inventors:
Joseph R. Flisak, Paul G. Gassman, Ivan Lantos, Wilford L. Mendelson