Patents Assigned to Smithkline Beckman Corp.
  • Patent number: 6358990
    Abstract: A method of treating amyloid diseases by administering a compound of Formula I: wherein: R7-R13 are independently —H or —OH; and A is H, —OH, or a moiety of Formula II:  wherein: R1 is hydrogen, lower alkanoyl of up to 6 carbon atoms or aroyl selected from benzoyl and naphthoyl; R2 is hydrogen, lower alkyl of up to 6 carbon atoms or arylalkyl selected from benzyl, phenylethyl and phenylpropyl; R3 is hydrogen or lower alkyl of up to 6 carbon atoms; R4 is hydrogen or lower alkyl of up to 6 carbon atoms, or when X is oxygen, R4 together with R5 can represent —CH2—O—; X is a valency bond, —CH2, oxygen or sulfur; Ar is selected from phenyl, naphthyl, indanyl and tetrahydronaphthyl; R5 and R6 are individually selected from hydrogen, fluorine, chlorine, bromine, hydroxyl, lower alkyl of up to 6 carbon atoms, a —CONH2— group, lower alkoxy of up to 6 carbon atoms, benzyloxy, lower alkylthio of up to 6 carbon atoms,
    Type: Grant
    Filed: April 13, 2000
    Date of Patent: March 19, 2002
    Assignees: Boehringer Mannheim Pharmaceuticals Corp., SmithKline Beckman Corp. Limited Partnership No. 1
    Inventors: David Robert Howlett, Davina Elizabeth Mitchell
  • Patent number: 5110959
    Abstract: This invention relates to a process for preparing epoxy esters, and intermediates prepared by this process, in particular, to a process which produces non-racemic epoxy esters which are of use as intermediates in the preparation of pharmaceutical compounds.
    Type: Grant
    Filed: June 14, 1989
    Date of Patent: May 5, 1992
    Assignee: Smithkline Beckman Corp.
    Inventors: Joseph R. Flisak, Paul G. Gassman, Ivan Lantos, Wilford L. Mendelson