Abstract: Disclosed is a compound having the formula (I) pharmaceutically acceptable salts or solvates thereof and pharmaceutical compositions containing the same, wherein the structural variables are as defined herein.
March 26, 2003
Date of Patent:
July 24, 2007
Scott K. Thompson, James S. Frazee, Lara S. Kallander, Chun Ma, Joseph P. Marino, Michael J. Neeb, Ning Wang
Abstract: Supplemented livestock feedstuffs and methods of feeding using as active ingredient a chemical compound having histamine H.sub.2 antagonist activity improve the utilization of food by meat producing animals. A specific compound of use as the active ingredient is metiamide.
Abstract: 3-Furylmethyl- and thienylmethyl-6-halo-7,8-dihydroxy-1-phenyl-2,3,4,5-tetrahydro-1H-3-benzaz epines have potent dopaminergic activity. As such they have utility an antihypertensive and anti-Parkinsonism agents.
Abstract: Imidodisulfamide derivatives useful in the treatment of allergic conditions are prepared by reaction of an appropriately substituted phenylcycloalkylamine and bis(chlorosulfonyl)imide in the presence of a non-nucleophilic organic base. Pharmaceutical compositions and methods of inhibiting the symptoms of an allergic response are also disclosed.
Abstract: Imidosulfamide derivatives useful in the treatment of allergic conditions are prepared by reaction of an appropriately substituted tetrahydroisoquinoline and chlorosulfonylisocyanate in the presence of a non-nucleophilic organic base. Pharmaceutical compositions and methods of inhibiting the symptoms of an allergic response are also disclosed.
Abstract: The preparation and use as intermediates is described for 7,8-dihydroxy-1-phenyl-2,3,4,5-tetrahydro-1H-3-benzazepines whose structures are characterized by having either an aralkyl or lower alkanoyl group at position 2 or an .alpha.-hydroxyalkyl or .alpha.-chloroalkyl group at position 6.
Abstract: 4-Phenyl-1,2,3,4-tetrahydroisoquinolines whose structures have two hydroxy groups substituted at the 3,4-position on the 4-phenyl ring have been found to have renal vasodilating activity upon internal administration. The active ingredients are prepared by cyclizing N-(2-substituted benzyl)-1-(3,4-dimethoxyphenyl)-aminoethanol using either a Lewis acid or an acid cyclizing agent followed by demethylation at the 3,4-dimethoxyphenyl moiety.
Abstract: A process for preparing 3-chloro-6-(2-hydroxyphenyl)pyridazines by the reaction of 6-(2-hydroxyphenyl)-3(2H)-pyridazinones with phosphorus oxychloride and a disubstituted formamide. The chloropyridazine compounds are useful intermediates for preparing compounds which have .beta.-adrenergic blocking and vasodilator activity and are useful as antihypertensive agents.
Abstract: 2,4-Amino, guanidinopyrimidines have diuretic activity. A representative species of these compounds is 2-guanidino-4-amino-6-chloroguanidine which is prepared by the stepwise replacement of first the 2-halo of a 2,4,6-trihalopyrimidine by guanidino and then the 4-halo by ammonia.
Abstract: Pharmaceutical compositions having as active diuretic ingredients certain 4-guanidinopyridines are described. Representative diuretic compounds are 5-amino-6-chloro-4-guanidinopyrimidine and 6-amino-5-nitro-4-guanidinopyrimidine.
Abstract: A group of new chemical compounds are described which are intermediates for preparing 7,8-amino, hydroxy-1-phenyl-2,3,4,5-tetrahydro-1H-3-benzazepines. The intermediates are distinguished in structure by a benzyloxy substituent at either the 7 or 8-position.
August 7, 1980
Date of Patent:
April 27, 1982
Kenneth G. Holden, Carl Kaiser, Joseph Weinstock
Abstract: Imidodisulfamide derivatives useful in the treatment of allergic conditions are prepared by reaction of an appropriately substituted tetrahydroisoquinoline and bis(chlorosulfonyl)imide in the presence of a tertiary amine. Pharmaceutical compositions and methods of inhibiting the symptoms of an allergic response are also disclosed.
Abstract: Certain 6-halo-7,8-dimethoxy-1-(methoxyphenyl)-2,3,4,5-tetrahydro-1H-3-benzazepine s and N-[2-(2-halo-3,4-dimethoxyphenyl)ethyl]-2-hydroxy-2-(methoxyphenyl)ethylam ines are intermediates for preparing 6-halo-7,8-dihydroxy-1-(hydroxyphenyl)-2,3,4,5-tetrahydro-1H-3-benzazepine s which are peripheral dopaminergic agents.