Patents Assigned to SmithKline Corporation
  • Patent number: 7247748
    Abstract: Disclosed is a compound having the formula (I) pharmaceutically acceptable salts or solvates thereof and pharmaceutical compositions containing the same, wherein the structural variables are as defined herein.
    Type: Grant
    Filed: March 26, 2003
    Date of Patent: July 24, 2007
    Assignee: SmithKline Corporation
    Inventors: Scott K. Thompson, James S. Frazee, Lara S. Kallander, Chun Ma, Joseph P. Marino, Michael J. Neeb, Ning Wang
  • Patent number: 6331631
    Abstract: A process for the preparation of 1-butyl-4-piperidinylmethylamine using toluene as a solvent is disclosed.
    Type: Grant
    Filed: August 22, 2000
    Date of Patent: December 18, 2001
    Assignee: SmithKline Corporation p.l.c.
    Inventors: Michael Fedouloff, David William Guest, Gillian Elizabeth Smith
  • Patent number: 4353902
    Abstract: Supplemented livestock feedstuffs and methods of feeding using as active ingredient a chemical compound having histamine H.sub.2 antagonist activity improve the utilization of food by meat producing animals. A specific compound of use as the active ingredient is metiamide.
    Type: Grant
    Filed: September 22, 1980
    Date of Patent: October 12, 1982
    Assignee: SmithKline Corporation
    Inventors: Richard D. Hedde, Roger C. Parish
  • Patent number: 4352754
    Abstract: 3-Furylmethyl- and thienylmethyl-6-halo-7,8-dihydroxy-1-phenyl-2,3,4,5-tetrahydro-1H-3-benzaz epines have potent dopaminergic activity. As such they have utility an antihypertensive and anti-Parkinsonism agents.
    Type: Grant
    Filed: June 12, 1980
    Date of Patent: October 5, 1982
    Assignee: SmithKline Corporation
    Inventor: Joseph Weinstock
  • Patent number: 4352809
    Abstract: Method of producing alpha.sub.2 antagonism by administering thiadiazolo- and oxadiazolotetrahydroisoquinoline compounds.
    Type: Grant
    Filed: September 4, 1981
    Date of Patent: October 5, 1982
    Assignee: Smithkline Corporation
    Inventors: William E. Bondinell, Robert M. DeMarinis, Jacob P. Hieble, Robert G. Pendleton
  • Patent number: 4350685
    Abstract: Imidodisulfamide derivatives useful in the treatment of allergic conditions are prepared by reaction of an appropriately substituted phenylcycloalkylamine and bis(chlorosulfonyl)imide in the presence of a non-nucleophilic organic base. Pharmaceutical compositions and methods of inhibiting the symptoms of an allergic response are also disclosed.
    Type: Grant
    Filed: February 6, 1981
    Date of Patent: September 21, 1982
    Assignee: SmithKline Corporation
    Inventors: Faida E. Ali, John G. Gleason
  • Patent number: 4350698
    Abstract: Imidosulfamide derivatives useful in the treatment of allergic conditions are prepared by reaction of an appropriately substituted tetrahydroisoquinoline and chlorosulfonylisocyanate in the presence of a non-nucleophilic organic base. Pharmaceutical compositions and methods of inhibiting the symptoms of an allergic response are also disclosed.
    Type: Grant
    Filed: September 25, 1981
    Date of Patent: September 21, 1982
    Assignee: SmithKline Corporation
    Inventors: John G. Gleason, David T. Hill
  • Patent number: 4342686
    Abstract: The preparation and use as intermediates is described for 7,8-dihydroxy-1-phenyl-2,3,4,5-tetrahydro-1H-3-benzazepines whose structures are characterized by having either an aralkyl or lower alkanoyl group at position 2 or an .alpha.-hydroxyalkyl or .alpha.-chloroalkyl group at position 6.
    Type: Grant
    Filed: November 13, 1980
    Date of Patent: August 3, 1982
    Assignee: SmithKline Corporation
    Inventors: Charles K. Brush, Joseph Weinstock
  • Patent number: 4341786
    Abstract: Octahydrobenzo[f]quinoline compounds having 7- and 10-substituents are centrally acting alpha.sub.1 agonists.
    Type: Grant
    Filed: March 2, 1981
    Date of Patent: July 27, 1982
    Assignee: SmithKline Corporation
    Inventors: Robert M. DeMarinis, Dinubhai H. Shah
  • Patent number: 4340601
    Abstract: A new series of compounds having renal vasodilating activity described. The compounds are 2-allyl-8-halo-4-(p-hydroxyphenyl)-1,2,3,4-tetrahydroisoquinolines.
    Type: Grant
    Filed: July 8, 1980
    Date of Patent: July 20, 1982
    Assignee: SmithKline Corporation
    Inventor: L. Martin Brenner
  • Patent number: 4340600
    Abstract: 4-Phenyl-1,2,3,4-tetrahydroisoquinolines whose structures have two hydroxy groups substituted at the 3,4-position on the 4-phenyl ring have been found to have renal vasodilating activity upon internal administration. The active ingredients are prepared by cyclizing N-(2-substituted benzyl)-1-(3,4-dimethoxyphenyl)-aminoethanol using either a Lewis acid or an acid cyclizing agent followed by demethylation at the 3,4-dimethoxyphenyl moiety.
    Type: Grant
    Filed: May 22, 1980
    Date of Patent: July 20, 1982
    Assignee: SmithKline Corporation
    Inventors: L. Martin Brenner, Joe R. Wardell, Jr.
  • Patent number: 4340733
    Abstract: A process for preparing 3-chloro-6-(2-hydroxyphenyl)pyridazines by the reaction of 6-(2-hydroxyphenyl)-3(2H)-pyridazinones with phosphorus oxychloride and a disubstituted formamide. The chloropyridazine compounds are useful intermediates for preparing compounds which have .beta.-adrenergic blocking and vasodilator activity and are useful as antihypertensive agents.
    Type: Grant
    Filed: September 2, 1980
    Date of Patent: July 20, 1982
    Assignee: SmithKline Corporation
    Inventor: Bing L. Lam
  • Patent number: 4336254
    Abstract: 2,4-Amino, guanidinopyrimidines have diuretic activity. A representative species of these compounds is 2-guanidino-4-amino-6-chloroguanidine which is prepared by the stepwise replacement of first the 2-halo of a 2,4,6-trihalopyrimidine by guanidino and then the 4-halo by ammonia.
    Type: Grant
    Filed: March 24, 1981
    Date of Patent: June 22, 1982
    Assignee: SmithKline Corporation
    Inventor: David L. Ladd
  • Patent number: 4336255
    Abstract: Pharmaceutical compositions having as active diuretic ingredients certain 4-guanidinopyridines are described. Representative diuretic compounds are 5-amino-6-chloro-4-guanidinopyrimidine and 6-amino-5-nitro-4-guanidinopyrimidine.
    Type: Grant
    Filed: March 24, 1981
    Date of Patent: June 22, 1982
    Assignee: SmithKline Corporation
    Inventor: David L. Ladd
  • Patent number: 4327023
    Abstract: A group of new chemical compounds are described which are intermediates for preparing 7,8-amino, hydroxy-1-phenyl-2,3,4,5-tetrahydro-1H-3-benzazepines. The intermediates are distinguished in structure by a benzyloxy substituent at either the 7 or 8-position.
    Type: Grant
    Filed: August 7, 1980
    Date of Patent: April 27, 1982
    Assignee: SmithKline Corporation
    Inventors: Kenneth G. Holden, Carl Kaiser, Joseph Weinstock
  • Patent number: 4321399
    Abstract: Thiophenecarbonyl chloride is produced in good yields by the direct acylation of thiophene in the presence of aluminum chloride with control of temperature and concentration.
    Type: Grant
    Filed: June 21, 1978
    Date of Patent: March 23, 1982
    Assignee: SmithKline Corporation
    Inventors: Stella S. Jones, Christine B. Ogston, Robert L. Webb
  • Patent number: 4321254
    Abstract: Imidodisulfamide derivatives useful in the treatment of allergic conditions are prepared by reaction of an appropriately substituted tetrahydroisoquinoline and bis(chlorosulfonyl)imide in the presence of a tertiary amine. Pharmaceutical compositions and methods of inhibiting the symptoms of an allergic response are also disclosed.
    Type: Grant
    Filed: September 26, 1980
    Date of Patent: March 23, 1982
    Assignee: SmithKline Corporation
    Inventor: Fadia E. Ali
  • Patent number: 4321195
    Abstract: Certain 6-halo-7,8-dimethoxy-1-(methoxyphenyl)-2,3,4,5-tetrahydro-1H-3-benzazepine s and N-[2-(2-halo-3,4-dimethoxyphenyl)ethyl]-2-hydroxy-2-(methoxyphenyl)ethylam ines are intermediates for preparing 6-halo-7,8-dihydroxy-1-(hydroxyphenyl)-2,3,4,5-tetrahydro-1H-3-benzazepine s which are peripheral dopaminergic agents.
    Type: Grant
    Filed: May 23, 1979
    Date of Patent: March 23, 1982
    Assignee: SmithKline Corporation
    Inventor: Joseph Weinstock
  • Patent number: 4321393
    Abstract: A method of preparing 2-cyanamidobenzimidazoles or 2-cyanamidobenzoxazoles comprising reacting N-cyanodiphenoxyiminocarbonate with an o-amino or o-hydroxy aniline.
    Type: Grant
    Filed: January 14, 1981
    Date of Patent: March 23, 1982
    Assignee: SmithKline Corporation
    Inventors: Clifford S. Labaw, Robert L. Webb
  • Patent number: 4320148
    Abstract: 2-Aminotetralin compounds having 5- and 8- substituents are centrally acting alpha.sub.1 agonists.
    Type: Grant
    Filed: November 24, 1980
    Date of Patent: March 16, 1982
    Assignee: SmithKline Corporation
    Inventor: Robert M. DeMarinis