Patents Assigned to SmithKline Corporation
  • N,N'-Bis[substituted-1,2,3,4 tetrahydroisoquinolyl]disulfonylimides and antiallergic compositions and method of use
    Patent number: 4317826
    Abstract: Imidodisulfamide derivatives useful in the treatment of allergic conditions are prepared by reaction of an appropriately substituted tetrahydroisoquinoline and bis (chlorosulfonyl)imide in the presence of a tertiary amine. Pharmaceutical compositions and methods of inhibiting the symptoms of an allergic response are also disclosed.
    Type: Grant
    Filed: May 27, 1980
    Date of Patent: March 2, 1982
    Assignee: SmithKline Corporation
    Inventor: John G. Gleason
  • Polynitroxin antibiotics produced by Nocardiopsis mutabilis Shearer sp. nov. ATCC 31520
    Patent number: 4317812
    Abstract: A novel antibiotic, polynitroxin, is produced by the cultivation of a fermentation broth containing Nocardiopsis mutabilis Shearer sp. nov. ATCC 31520 in an aqueous nutrient medium under submerged aerobic conditions.
    Type: Grant
    Filed: January 15, 1981
    Date of Patent: March 2, 1982
    Assignee: SmithKline Corporation
    Inventor: Tikam C. Jain
  • N,N'-Bis[substituted-1,2,3,4-tetrahydroisoquinolinolyl]disulfonylimides and antiallergic compositions and method of use
    Patent number: 4315935
    Abstract: Imidodisulfamide derivatives useful in the treatment of allergic conditions are prepared by reaction of an appropriately substituted tetrahydroisoquinoline and bis(chlorosulfonyl)imide in the presence of a tertiary amine.
    Type: Grant
    Filed: June 13, 1980
    Date of Patent: February 16, 1982
    Assignee: SmithKline Corporation
    Inventor: Fadia E. Ali
  • 4-Aminoalkyl-7-hydroxy-2(3H)-indolones
    Patent number: 4314944
    Abstract: A new group of 2(3H)-indolones whose structures are characterized by having an aminoalkyl substituent at position 4 and a hydroxy group at position 7 of the indolone nucleus have beneficial activity on the cardiovascular system. A typical species of the group is 4-di-n-propylaminoethyl-7-hydroxy-2(3H)-indolone and its acid addition salts.
    Type: Grant
    Filed: August 22, 1980
    Date of Patent: February 9, 1982
    Assignee: SmithKline Corporation
    Inventors: William F. Huffman, James W. Wilson
  • 7-[2-Alkoxyimino-2-(amino-thiazole)acetami do]-3-[1-(sulfaminoalkly)tetrazolthiomethyl]cephalosporins
    Patent number: 4308267
    Abstract: Novel cephalosporins with improved antibacterial and pharmacokinetic properties are disclosed. These compounds have a 2-alkoxyimino-2-(2-amino-4-thiazolyl)-acetamido group at position 7 and a sulfaminoalkyltetrazolythio group at position 3.
    Type: Grant
    Filed: July 3, 1980
    Date of Patent: December 29, 1981
    Assignee: SmithKline Corporation
    Inventors: David A. Berges, George L. Dunn
  • Method for preparing lower alkyl .beta.-(S-benzylmercapto)-.beta.,.beta.-pentamethylenepropionates
    Patent number: 4299969
    Abstract: Lower alkyl .beta.-(S-benzylmercapto)-.beta.,.beta.-pentamethylenepropionates are prepared in improved yields by reacting lower alkyl cyclohexylideneacetates with benzylmercaptan in the presence of an alkali metal mercaptide.
    Type: Grant
    Filed: August 8, 1980
    Date of Patent: November 10, 1981
    Assignee: SmithKline Corporation
    Inventors: William F. Huffman, Nelson C. Yim
  • Anthracycline antibiotics produced by Streptosporangium fragilis Shearer sp. nov. ATCC 31519
    Patent number: 4293546
    Abstract: A novel anthracycline antibiotic complex, fragilomycin complex, is produced by the cultivation of a fermentation broth containing Streptosporangium fragilis Shearer sp. nov. ATCC 31519 microorganisms in an aqueous nutrient medium under submerged aerobic conditions. The fragilomycin complex and its major bioactive component, fragilomycin A, exhibit antibiotic activity.
    Type: Grant
    Filed: July 24, 1980
    Date of Patent: October 6, 1981
    Assignee: SmithKline Corporation
    Inventors: Claude H. Nash, III, Marcia C. Shearer, Kenneth M. Snader, Joseph R. Valenta, David Cooper
  • Antiallergic imidodisulfamides
    Patent number: 4292305
    Abstract: Imidodisulfamide derivatives useful in the treatment of allergic conditions are prepared by reaction of an appropriately substituted primary amine and bis(chlorosulfonyl) imide in the presence of a tertiary amine.
    Type: Grant
    Filed: February 13, 1980
    Date of Patent: September 29, 1981
    Assignee: SmithKline Corporation
    Inventors: Fadia E. Ali, Robert D. Krell, Kenneth M. Snader
  • 7,8-Dihydroxy-1-(sulfamylphenyl)-2,3,4,5-tetrahydro-1H-3-benzazepine derivatives
    Patent number: 4285938
    Abstract: New 7,8-dihydroxy-1-(sulfamylphenyl)-2,3,4,5-tetrahydro-1H-3-benzazepines having pharmaceutical activity together with new intermediates and methods of synthesis for preparing them. The lead compound is 6-chloro-7,8-dihydroxy-1-(p-sulfamylphenyl)-2,3,4,5-tetrahydro-1H-3-benzaz epine which has very potent renal dopaminergic activity.
    Type: Grant
    Filed: October 11, 1979
    Date of Patent: August 25, 1981
    Assignee: SmithKline Corporation
    Inventor: Francis R. Pfeiffer
  • N-Phenyl-N'-cyano-O-phenylisoureas
    Patent number: 4285878
    Abstract: N-Phenyl-N'-cyano-O-phenylisoureas are prepared from N-cyanodiphenoxyimidocarbonate and an optionally substituted o-phenylenediamine or o-aminophenol. The isoureas are new chemical intermediates especially useful for preparing 2-cyanamido and 2-carbomethoxyaminobenzimidazole and benzoxazole compounds having anthelmintic activity.
    Type: Grant
    Filed: January 31, 1980
    Date of Patent: August 25, 1981
    Assignee: SmithKline Corporation
    Inventors: Clifford S. Labaw, Robert L. Webb
  • 7-Acyl-3-(substituted tetrazolyl thiomethyl)cephalosporins
    Patent number: 4286089
    Abstract: The compounds of this invention are cephalosporins having various acyl substituents at the 7-position and a substituted tetrazolyl thiomethyl group at the 3-position of the cephem nucleus and intermediates for the preparation thereof. The 7-acylated compounds have antibacterial activity.
    Type: Grant
    Filed: December 27, 1974
    Date of Patent: August 25, 1981
    Assignee: SmithKline Corporation
    Inventor: David A. Berges
  • 7,8-Amino, hydroxy-1-phenyl-2,3,4,5-tetrahydro-1H-3-benzazepines
    Patent number: 4284556
    Abstract: A group of 1-phenyl-2,3,4,5-tetrahydro-1H-3-benzazepines whose structures have amino, hydroxy substituents at the 7,8-positions of the benzazepine nucleus is disclosed. Novel intermediates and routes of synthesis used for preparing them are also described. The end products have pharmacodynamic activity.
    Type: Grant
    Filed: January 31, 1980
    Date of Patent: August 18, 1981
    Assignee: SmithKline Corporation
    Inventors: Kenneth G. Holden, Carl Kaiser, Joseph Weinstock
  • Renal vasodilating 3,4-dihydroxyphenyltetrahydrothienopyridines
    Patent number: 4282227
    Abstract: 3,4-Dihydroxyphenyltetrahydrothieno[2,3-c] or [3,2-c] pyridines are prepared by cyclization of a N-thienylmethyl-2-(3',4'-dimethoxyphenyl)-ethanolamine. These compounds have renal vasodilating activity. A species is 4-(3,4-dihydroxyphenyl)-1,2,3,4-tetrahydrothieno[2,3-c]pyridine and its pharmaceutically acceptable acid addition salts or esters.
    Type: Grant
    Filed: May 22, 1980
    Date of Patent: August 4, 1981
    Assignee: SmithKline Corporation
    Inventor: L. Martin Brenner
  • 7-Alpha-oxyiminoacylcephalosporins
    Patent number: 4278670
    Abstract: New semisynthetic cephalosporins having antibacterial activity are described. The structures of the new compounds are characterized by having an .alpha.-oxyimino group in the 7-acetamidomoiety plus a carboxyalkyltetrazolylthiomethyl group at position 3.
    Type: Grant
    Filed: July 12, 1976
    Date of Patent: July 14, 1981
    Assignee: SmithKline Corporation
    Inventor: George L. Dunn
  • 3,3'-Bis-methylene-1,3-benzo-thiazine compounds
    Patent number: 4272531
    Abstract: 3,3'-Bis-Methylene-1,3-benzothiazine compounds are inhibitors of phenylethanolamine N-methyl-transferase.
    Type: Grant
    Filed: June 26, 1980
    Date of Patent: June 9, 1981
    Assignee: SmithKline Corporation
    Inventor: Robert M. DeMarinis
  • Intermediates for preparing hydroxyphenylpyridazinones
    Patent number: 4272440
    Abstract: 5-(5'-Halo-2'-methoxyphenyl)-3,4-dihalo-2(5H)-furanones are prepared by a Friedel-Crafts reaction using a p-haloanisole and a mucohalic acid in the presence of aluminum chloride. They are used as chemical intermediates for preparing hydroxyphenylpyridazinones.
    Type: Grant
    Filed: February 2, 1979
    Date of Patent: June 9, 1981
    Assignee: SmithKline Corporation
    Inventors: Angelina J. Duggan, Robert L. Webb
  • 6-Lower alkyl-7,8-dihydroxy-1-phenyl-2,3,4,5-tetrahydro-1H-3-benzazepines
    Patent number: 4265889
    Abstract: A series of 6-lower alkyl-7,8-dihydroxyl-1-phenyl-2,3,4,5-tetrahydro-1H-3-benzazepines having dopaminergic activity together with intermediates and processes for their preparation are disclosed.
    Type: Grant
    Filed: December 22, 1978
    Date of Patent: May 5, 1981
    Assignee: SmithKline Corporation
    Inventors: Charles K. Brush, Joseph Weinstock
  • 6-Phenyl thio- and 6-cyclohexyl thio-2,3,4,5-tetrahydro-1H-3-benzazepines
    Patent number: 4265890
    Abstract: Mercapto substituted-2,3,4,5-tetrahydro-1H-3-benzazepines having dopamine receptor blocking activity are prepared from o-quinones or via standard preparative procedures.
    Type: Grant
    Filed: May 17, 1979
    Date of Patent: May 5, 1981
    Assignee: SmithKline Corporation
    Inventors: Kenneth G. Holden, Carl Kaiser
  • 5,6-Phenyl-2,3-dihydroimidazo [2,1-b] thiazoles
    Patent number: 4263311
    Abstract: The compounds are 5,6-phenyl-2,3-dihydroimidazo[2,1-b]thiazoles which have antiarthritic activity. A preferred compound is 5,6-bis(p-anisyl)-2,3-dihydroimidazo[2,1-b]thiazole.
    Type: Grant
    Filed: August 18, 1977
    Date of Patent: April 21, 1981
    Assignee: SmithKline Corporation
    Inventor: Paul E. Bender
  • Inhibiting phenylethanolamine N-methyltransferase with thiadiazolo and oxadiazolotetrahydroisoquinolines
    Patent number: 4258049
    Abstract: Thiadiazolo- and oxadiazolotetrahydroisoquinoline compounds are inhibitors of phenylethanolamine N-methyltransferase.
    Type: Grant
    Filed: March 17, 1980
    Date of Patent: March 24, 1981
    Assignee: SmithKline Corporation
    Inventors: William E. Bondinell, Gerald R. Girard