Patents Assigned to Societe de Conseils de Recherches et
  • Patent number: 8348881
    Abstract: The invention concerns a device for injecting a solid medicine (10) comprising a body (2) inside which moves along a general forward moving axis (X-X) a bevelled (34) needle (4) wherein is introduced the medicine (10), said injection device (1) further comprising retaining means for preventing the medicine from falling (10) prior to being injected. The invention is characterized in that the medicine (10) is retained through an elastic deformation imparted to the needle (4) by the retaining means or by an elastic deformation of the retaining means themselves, or still by the combined flexibility of those two means.
    Type: Grant
    Filed: November 15, 2005
    Date of Patent: January 8, 2013
    Assignee: Société de Conseils de Recherches et d'Applications Scientifiques (S.C.R.A.S) SAS
    Inventors: Christophe Aubert, Roland Cherif-Cheikh, Thierry Rimlinger, Fabrice Bonacci, Serge Barneaud
  • Patent number: 7897578
    Abstract: The present invention relates to peptides with anti-proliferative activity, of sequence SEQ ID No. 1, SEQ ID No. 2 or SEQ ID No. 3.
    Type: Grant
    Filed: June 11, 2007
    Date of Patent: March 1, 2011
    Assignee: Societe de Conseils de Recherches et d'Applications Scientifiques (S.C.R.A.S.)
    Inventors: Eric Ferrandis, José-Antonio Camara Y Ferrer, Jean-Grégoire Marin
  • Patent number: 7815928
    Abstract: A method for implanting or inserting a solid or semisolid formulation containing at least one active principle uses a device comprising one part set inside the body of the patient and which conditions the solid or semisolid form, brings these conditioning action to the deposit site, injects or inserts in this deposit site, and withdraws after injection or insertion, with one part remaining outside and activating the functions of the device. The invention also concerns a sustained-release solid formulation for parenteral administration comprising a homogeneous mixture of an active principle in non-dispersed state and of a biologically compatible and biodegradable excipient, in which the amount of active principle is at least 50% by weight.
    Type: Grant
    Filed: August 17, 2007
    Date of Patent: October 19, 2010
    Assignee: Societe de Conseils de Recherches et d'Applications Scientifiques SCRAS
    Inventor: Roland Cherif Cheikh
  • Publication number: 20100144714
    Abstract: The present invention relates to new derivatives of imidazo, pyrimido and diazepine-pyrimidine-dione of the general formula (I) in which R1, R2, L1, L2, Y, Z and A are various and varying groups. These products exhibit a good affinity for certain sub-types of cannabinoid receptors, in particular the CB2 receptors. They are particularly useful for treating pathological conditions and diseases in which one or more cannabinoid receptors are involved. The invention also relates to pharmaceutical compositions containing said products, and to the use thereof for preparing a drug.
    Type: Application
    Filed: December 17, 2007
    Publication date: June 10, 2010
    Applicant: SOCIETE DE CONSEILS DE RECHERCHES ET D'APPLICATIONS SCIENTIFIQUES (S.C.R.A.S.)
    Inventors: Lydie Poitout, Valérie Brault
  • Patent number: 7713244
    Abstract: A syringe for parenteral injection of a semi-solid formulation. The syringe includes a hollow element forming a reservoir for the semi-solid product to be injected between a plunger and a needle hub urged in contact with the reservoir end. The plunger comes into direct contact with the hub when the dose contained in the reservoir-forming element has been injected. The element forming a reservoir and the needle are maintained mutually interlocked at the hub through a mount or case receiving the element forming a reservoir.
    Type: Grant
    Filed: September 17, 1999
    Date of Patent: May 11, 2010
    Assignee: Societe de Conseils de Recherches et d'Applications Scientifiques SCRAS
    Inventors: Roland Cherif Cheikh, Christophe Aubert
  • Patent number: 7705155
    Abstract: The present application relates to a new process for the asymmetric production of 3-(pyridin-4-yl)-3-hydroxy-pentanoic acid derivatives, which are useful intermediates in the manufacture of compounds that are known to show antiproliferative activity.
    Type: Grant
    Filed: March 21, 2007
    Date of Patent: April 27, 2010
    Assignee: Societe de Conseils de Recherches et D'Applications Scientifiques
    Inventors: Christian Diolez, Eric Manginot, Rene Peters, Alain Rolland, Marc Veyrat
  • Patent number: 7696197
    Abstract: The invention concerns the use of a phenothiazine derivative of formula (I), wherein: R represents the hydrogen atom, an alkyl radical, arylalkyl, or —C(O)R?, for preparing a medicine for preventing and/or treating hearing loss.
    Type: Grant
    Filed: March 25, 2005
    Date of Patent: April 13, 2010
    Assignee: Societe de Conseils de Recherches et d'Applications Scientifiques
    Inventors: Bernadette Pignol, Jean-Luc Puel, Serge Auvin, Pierre-Entienne Chabrier de Lassauniere, Jing Wang
  • Publication number: 20100036120
    Abstract: The invention concerns a novel method for synthesis of 1,4-morpholine-2,5-diones of formula (I), wherein: R, R1, R2, R3 and R4 independently represent various radicals, by oxidizing the ketone function of a cyclic compound of formula (II).
    Type: Application
    Filed: January 24, 2007
    Publication date: February 11, 2010
    Applicant: Societe de Conseils de Recherches et D'Applications Scientifiques (S.C.R.A.S.)
    Inventors: Didier Bourissou, Blaca Martin-Vaca, Sylvie Moebs-Sanchez, Coralie Ivens, Roland Cherif-cheikh, Anne-Paula De Sousa Delgado
  • Patent number: 7655438
    Abstract: A process for preparing recombinant heterocarpine with the complete sequence of heterocarpine (SEQ. ID. NO. 10), expression vectors comprising a polynucleotide encoding for heterocarpine, host cells transformed or transfected by said expression vectors as well as a process for obtaining heterocarpine by means of said transformed or transfected host cells are described where in the recombinant heterocarpine obtained is used to treat cancer.
    Type: Grant
    Filed: December 9, 2003
    Date of Patent: February 2, 2010
    Assignee: Societe de Conseils de Recherches et d'Application Scientifiques (S.C.R.A.S.)
    Inventor: Eric Ferrandis
  • Patent number: 7632811
    Abstract: The present invention is directed to peptide analogues of fragment of parathyroid hormone (PTH) or parathyroid hormone-related protein (PTHrP), a method of using said analogues alone or in combination with a bisphosphonate or calcitonin to treat osteoporosis and pharmaceutical compositions comprising said analogues alone or in combination with a bisphosphonate or calcitonin.
    Type: Grant
    Filed: March 30, 2005
    Date of Patent: December 15, 2009
    Assignee: Societe de Conseils de Recherches et D'Applications Scientifiques, SAS
    Inventor: Zheng Xin Dong
  • Publication number: 20090275624
    Abstract: A subject of the present invention is novel compounds comprising 2 or 3 benzothiazole-4,7-dione- or benzooxazole-4,7-dione-type units, which inhibit the cdc25 phosphatases, in particular cdc25-C phosphatase. These compounds can in particular be used in the treatment of cancer.
    Type: Application
    Filed: December 16, 2005
    Publication date: November 5, 2009
    Applicant: Societe de Conseils de Recherches et D'Applications Scientifiques (S.C.R.A.S.)
    Inventors: Marie-Odile Galcera-Contour, Dennis Bigg, Grégoire Prevost, Alban Sidhu
  • Publication number: 20090270401
    Abstract: The invention relates to the use of (1R)-1-[({(2R)-2-amino-3-[(8S)-8-(cyclohexylmethyl)-2-phenyl-5,6-dihydroimidazo[1,2-a]pyrazine-7(8H)-yl]-3-oxopropyl}dithio)methyl]-2-[(8S)-8-(cyclohexylmethyl)-2-phenyl-5,6-dihydroimidazo[1,2-a]pyrazine-7(8H)-yl]-2-oxoethylamine or an pharmaceutically acceptable salt thereof for preparing a drug for preventing or treating pain.
    Type: Application
    Filed: December 16, 2005
    Publication date: October 29, 2009
    Applicant: Societe de Conseils de Recherches et D'Applications Sceintifiques (S.C.R.A.S.)
    Inventors: Michel Auguet, Christine Favre, Gregoire Prevost
  • Publication number: 20090270372
    Abstract: A subject of the present Application is novel derivatives of benzimidazole and imidazopyridine which have a good affinity for certain sub-types of melanocortin receptors, in particular the MC4 receptors. They are particularly useful for treating pathological conditions and diseases in which one or more melanocortin receptors are involved. The invention also relates to pharmaceutical compositions containing said products.
    Type: Application
    Filed: January 21, 2009
    Publication date: October 29, 2009
    Applicant: Societe de Conseils de Recherches et
    Inventors: Lydie POITOUT, Valerie Brault, Carole Sackur, Roubert Pierre, Pascale Plas
  • Publication number: 20090270400
    Abstract: The invention relates to a product comprising (1R)-1-[(({2R)-2-amino-3-[(8S)-8-(cyclohexylmethyl) -2-phenyl-5,6-dihydroimidazo [1,2-a]pyrazin-7(8H)-yl]-3-oxopropyl}dithio)methyl]-2-[(8S)-8-(cyclohexylmethyl) -2-phenyl-5,6-dihydrolmidazo[1,2-a]pyrazin-7(8H)-yl]-2-oxoethylamine in association with an analgesic agent selected from morphine, the similar or a morphine derivative, sodium channel inhibitors, non-steroidal antiflammatory agents (AINS), glutamatergic system inhibitors, tricycle antidepressants and gabaergic derivatives for simultaneous therapeutic use which is separated or out over the time for pain treatment or prevention.
    Type: Application
    Filed: December 16, 2005
    Publication date: October 29, 2009
    Applicant: Societe de Conseils de Recherches et D'Applications Scientifiques (S.C.R.A.S.)
    Inventors: Michel Auguet, Christine Favre, Gregoire Prevost, Pierre-Etienne Chabrier De Lassauniere
  • Patent number: 7579435
    Abstract: Disclosed is a series of somatostatin-dopamine chimeric analogs which retain both somatostatin and dopamine activity in vivo. An example is: 6-n-propyl-8?-ergolinglmethylthioacetyl-D-Phe-c-(Cys-Tyr-D-Trp-Lys-Abu-Cys)-Thr-NH2.
    Type: Grant
    Filed: June 7, 2002
    Date of Patent: August 25, 2009
    Assignee: Societe de Conseils de Recherches et d'Applications Scientifiques, S.A.S.
    Inventors: Michael D. Culler, Zheng Xin Dong, Sun H. Kim, Jacques-Pierre Moreau
  • Publication number: 20090209466
    Abstract: The present invention relates to peptides with anti-proliferative activity, of sequence SEQ ID No. 1, SEQ ID No. 2 or SEQ ID No. 3.
    Type: Application
    Filed: June 11, 2007
    Publication date: August 20, 2009
    Applicant: Societe de Conseils de Recherches et D'Applications Scientifiques (S.C.R.A.S.)
    Inventors: Eric Ferrandis, José-Antonio Camara Y Ferrer, Jean-Grégoire Marin
  • Publication number: 20090209903
    Abstract: The invention relates to a device which is used to inject an implant (6) into tissues (50). The inventive device is characterized in that it comprises : a main hollow body (2; 2?) having a hollow needle (4; 4?) fixed thereto, into which the implant (6) is introduced; a secondary body (26; 26?) which is disposed coaxially inside the main body (2; 2?) and which surrounds the needle (4; 4?); and a plunger rod (36; 36?) which can slide coaxially inside the hollow needle (4; 4?).
    Type: Application
    Filed: November 15, 2005
    Publication date: August 20, 2009
    Applicant: Société de Conseils de Recherches et d'Application Scientifiques (S.C.R.A.S.) SAS
    Inventors: Roland Cherif-Cheikh, Christophe Aubert, Thierry Rimlinger, Fabrice Bonacci, Serge Barneaud
  • Patent number: 7572883
    Abstract: Disclosed is a series of somatostatin-dopamine chimeric analogs which retain both somatostatin and dopamine activity in vivo.
    Type: Grant
    Filed: May 15, 2006
    Date of Patent: August 11, 2009
    Assignee: Societe de Conseils de Recherches et d'Applications Scientifiques, S.A.S.
    Inventors: Michael D. Culler, Zheng Xin Dong, Sun H. Kim, Jacques-Pierre Moreau
  • Patent number: 7566734
    Abstract: The present invention is directed to imidazolyl derivatives of formula (I) where the substituents are defined in the specification, which are useful as agonists or antagonists of somatostatin receptors.
    Type: Grant
    Filed: July 31, 2001
    Date of Patent: July 28, 2009
    Assignee: Societe de Conseils de Recherches et d'Applications Scientifiques, S.A.S.
    Inventors: Christophe Alain Thurieau, Lydie Francine Poitout, Marie-Odile Galcera, Thomas D. Gordon, Barry A. Morgan, Christophe Philippe Moinet, Dennis C. H. Bigg
  • Publication number: 20090186930
    Abstract: The invention concerns novel imidazole derivatives of general formula (I), wherein Z? and Z represent different variable groups. Said products have an antitumoral activity. The invention also concerns pharmaceutical compositions containing said products and their use for preparing antitumoral medicine.
    Type: Application
    Filed: April 26, 2007
    Publication date: July 23, 2009
    Applicant: Societe de Conseils de Recherches et D' Applications Scientifiques (S.C.R.A.S.)
    Inventors: Anne-Marie Liberatore, Dennis Bigg, Dominique Pons, Grégoire Prevost