Patents Assigned to Sonus Pharmaceuticals, Inc.
  • Patent number: 7786164
    Abstract: Lipophilic di(anticancer drug) compounds, compositions that include the compounds, and methods for treating a cell proliferative disease using the compounds.
    Type: Grant
    Filed: December 19, 2006
    Date of Patent: August 31, 2010
    Assignee: Sonus Pharmaceuticals, Inc.
    Inventors: Yuehua Zhang, Lynn C. Gold
  • Patent number: 7786134
    Abstract: Lipophilic anticancer drug compounds, compositions that include the compounds, and methods for treating a cell proliferative disease using the compounds.
    Type: Grant
    Filed: December 15, 2006
    Date of Patent: August 31, 2010
    Assignee: Sonus Pharmaceuticals, Inc.
    Inventors: Yuehua Zhang, Lynn C. Gold
  • Publication number: 20080045559
    Abstract: Tocopherol-modified therapeutic drug compounds; emulsion, microemulsion, and micelle formulations that include the compounds; methods for making the compounds and formulations; methods for administering the compounds and formulations; and methods for treating conditions using the compounds and formulations.
    Type: Application
    Filed: August 22, 2007
    Publication date: February 21, 2008
    Applicant: SONUS PHARMACEUTICALS, INC.
    Inventors: Yuehua Zhang, Lynn Gold
  • Patent number: 7268245
    Abstract: Multinuclear platinum compounds, compositions that include the platinum compounds, methods for making the platinum compounds, and methods for treating cellular proliferative diseases by administering the platinum compounds.
    Type: Grant
    Filed: October 18, 2006
    Date of Patent: September 11, 2007
    Assignee: Sonus Pharmaceuticals, Inc.
    Inventors: Manjari Lal, Lynn C. Gold
  • Publication number: 20070207196
    Abstract: Tocopherol-modified therapeutic drug compounds; emulsion, microemulsion, and micelle formulations that include the compounds; methods for making the compounds and formulations; methods for administering the compounds and formulations; and methods for treating conditions using the compounds and formulations.
    Type: Application
    Filed: March 22, 2007
    Publication date: September 6, 2007
    Applicant: SONUS PHARMACEUTICALS, INC.
    Inventor: Yuehua Zhang
  • Publication number: 20070142331
    Abstract: Lipophilic anticancer drug compounds, compositions that include the compounds, and methods for treating a cell proliferative disease using the compounds.
    Type: Application
    Filed: December 15, 2006
    Publication date: June 21, 2007
    Applicant: SONUS PHARMACEUTICALS, INC.
    Inventors: Yuehua Zhang, Lynn Gold
  • Publication number: 20070141093
    Abstract: Lipophilic di(anticancer drug) compounds, compositions that include the compounds, and methods for treating a cell proliferative disease using the compounds.
    Type: Application
    Filed: December 19, 2006
    Publication date: June 21, 2007
    Applicant: Sonus Pharmaceuticals, Inc.
    Inventors: Yuehua Zhang, Lynn Gold
  • Patent number: 7232919
    Abstract: Platinum compounds, pharmaceutically acceptable salts, and prodrugs thereof. Compositions that include the platinum compounds, either alone or in combination with at least one additional therapeutic agent, with a pharmaceutically acceptable carrier. Methods for using the platinum compounds, either alone or in combination with at least one additional therapeutic agent, in the prophylaxis or treatment of proliferative diseases.
    Type: Grant
    Filed: December 19, 2005
    Date of Patent: June 19, 2007
    Assignee: Sonus Pharmaceuticals, Inc.
    Inventor: Manjari Lal
  • Publication number: 20070129431
    Abstract: Multinuclear platinum compounds, compositions that include the platinum compounds, methods for making the platinum compounds, and methods for treating cellular proliferative diseases by administering the platinum compounds.
    Type: Application
    Filed: October 18, 2006
    Publication date: June 7, 2007
    Applicant: SONUS PHARMACEUTICALS, INC.
    Inventors: Manjari Lal, Lynn Gold
  • Patent number: 7223770
    Abstract: Tocopherol-modified therapeutic drug compounds; emulsion, microemulsion, and micelle formulations that include the compounds; methods for making the compounds and formulations; methods for administering the compounds and formulations; and methods for treating conditions using the compounds and formulations.
    Type: Grant
    Filed: October 29, 2004
    Date of Patent: May 29, 2007
    Assignee: Sonus Pharmaceuticals, Inc.
    Inventors: Yuehua Zhang, Lynn C. Gold
  • Publication number: 20060252840
    Abstract: Fluorinated compounds and emulsions including the compounds. The compositions are useful as oxygen carriers and surfactants. In one embodiment, the fluorinated compound is pH sensitive. In one embodiment, the fluorinated compound is a vitamin E derivative. In one embodiment, the fluorinated compound is a vitamin K derivative.
    Type: Application
    Filed: June 12, 2006
    Publication date: November 9, 2006
    Applicant: Sonus Pharmaceuticals, Inc.
    Inventors: Yuehua Zhang, Manjari Lal, Andrew Leo, Nagesh Palepu
  • Patent number: 7129368
    Abstract: Platinum carboxylate anticancer compounds, pharmaceutical compositions that include the platinum carboxylate compounds, and methods for treating cellular proliferative diseases by administering the platinum carboxylate compounds.
    Type: Grant
    Filed: March 14, 2005
    Date of Patent: October 31, 2006
    Assignee: Sonus Pharmaceuticals, Inc.
    Inventor: Manjari Lal
  • Publication number: 20060229359
    Abstract: Tocopherol-modified therapeutic drug compounds; emulsion, microemulsion, and micelle formulations that include the compounds; methods for making the compounds and formulations; methods for administering the compounds and formulations; and methods for treating conditions using the compounds and formulations.
    Type: Application
    Filed: June 8, 2006
    Publication date: October 12, 2006
    Applicant: Sonus Pharmaceuticals, Inc.
    Inventors: Yuehua Zhang, Lynn Gold
  • Patent number: 7091374
    Abstract: Fluorinated compounds and emulsions including the compounds. The compositions are useful as oxygen carriers and surfactants. In one embodiment, the fluorinated compound is pH sensitive. In one embodiment, the fluorinated compound is a vitamin E derivative. In one embodiment, the fluorinated compound is a vitamin K derivative.
    Type: Grant
    Filed: April 23, 2004
    Date of Patent: August 15, 2006
    Assignee: Sonus Pharmaceuticals, Inc.
    Inventors: Yuehua Zhang, Manjari Lal, Andrew Leo, Nagesh Palepu
  • Patent number: 7038071
    Abstract: Platinum compounds, pharmaceutically acceptable salts, and prodrugs thereof. Compositions that include the platinum compounds, either alone or in combination with at least one additional therapeutic agent, with a pharmaceutically acceptable carrier. Methods for using the platinum compounds, either alone or in combination with at least one additional therapeutic agent, in the prophylaxis or treatment of proliferative diseases.
    Type: Grant
    Filed: July 16, 2003
    Date of Patent: May 2, 2006
    Assignee: Sonus Pharmaceuticals, Inc.
    Inventor: Manjari Lal
  • Patent number: 7030155
    Abstract: A method of making an emulsion of tocopherol incorporating a co-solvent and, stabilized by biocompatible surfactants, as a vehicle or carrier for therapeutic drugs, which is substantially ethanol free and which can be administered to animals or humans by various routes, is disclosed. Also included in the emulsion is PEGylated vitamin E. PEGylated ?-tocopherol includes polyethylene glycol subunits attached by a succinic acid diester at the ring hydroxyl of vitamin E and serves as a primary surfactant, stabilizer and a secondary solvent in emulsions of ?-tocopherol.
    Type: Grant
    Filed: May 17, 2002
    Date of Patent: April 18, 2006
    Assignee: Sonus Pharmaceuticals, Inc.
    Inventors: Karel J. Lambert, Panayiotis P. Constantinides, Alexander K. Tustian, Steven C. Quay
  • Patent number: 6982282
    Abstract: An emulsion of ?-tocopherol, stabilized by biocompatible surfactants, as a vehicle or carrier for therapeutic drugs, which is substantially ethanol free and which can be administered to animals or humans via various routes is disclosed. Also included in the emulsion is PEGylated vitamin E. PEGylated ?-tocopherol includes polyethylene glycol subunits attached by a succinic acid diester at the ring hydroxyl of vitamin E and serves as a primary surfactant, stabilizer and a secondary solvent in emulsions of ?-tocopherol.
    Type: Grant
    Filed: May 17, 2002
    Date of Patent: January 3, 2006
    Assignee: Sonus Pharmaceuticals, Inc.
    Inventors: Karel J. Lambert, Panayiotis P. Constantinides, Steven C. Quay
  • Patent number: 6864386
    Abstract: Fluorinated compounds and emulsions including the compounds. The compositions are useful as oxygen carriers and surfactants. In one embodiment, the fluorinated compound is pH sensitive. In one embodiment, the fluorinated compound is a vitamin E derivative. In one embodiment, the fluorinated compound is a vitamin K derivative.
    Type: Grant
    Filed: November 20, 2002
    Date of Patent: March 8, 2005
    Assignee: Sonus Pharmaceuticals, Inc.
    Inventors: Yuehua Zhang, Manjari Lal, Andrew Leo, Nagesh Palepu
  • Patent number: 6858227
    Abstract: Vitamin E conjugates, methods for their preparation, and compositions that include the conjugates. The vitamin E conjugates include a tocopherol moiety covalently coupled through a linker moiety to either a pyroglutamate moiety, a pyrrolidinone moiety, or a gentisic acid moiety.
    Type: Grant
    Filed: November 20, 2002
    Date of Patent: February 22, 2005
    Assignee: Sonus Pharmaceuticals, Inc.
    Inventors: Manjari Lal, Yuehua Zhang, Nagesh Palepu
  • Publication number: 20040202712
    Abstract: An emulsion of &agr;-tocopherol, stabilized by biocompatible surfactants, as a vehicle or carrier for therapeutic drugs, which is substantially ethanol free and which can be administered to animals or humans various routes is disclosed. Also included in the emulsion is PEGylated vitamin E PEGylated &agr;-tocopherol includes polyethylene glycol subunits attached by a succinic acid diester at the ring hydroxyl of vitamin E and serves as a primary surfactant, stabilizer and a secondary solvent in emulsions of &agr;-tocopherol.
    Type: Application
    Filed: April 28, 2004
    Publication date: October 14, 2004
    Applicant: Sonus Pharmaceuticals, Inc.
    Inventors: Karel J. Lambert, Panayiotis P. Constantinides, Steven C. Quay