Abstract: The present disclosure relates to novel compounds of formulas (1) through (19) and to a method for treating humans infected with a virus including various respiratory viruses such as members of the Paramyxoviridae family (respiratory syncytial virus (RSV), human metapneumovirus (HMPV), human parainfluenza virus (HPIV), measles virus, and mumps virus) with a compound of formulas (1) through (19). The present disclosure also relates to a cytopathic effect (CPE)-based assay that will assess virus-induced CPE for screening of compounds for treating viral diseases or inhibiting a virus.
Type:
Application
Filed:
February 8, 2011
Publication date:
April 4, 2013
Applicant:
Sourthern Research Institute Office of Commercialization and Intellectual Prop.
Inventors:
Bill Severson, Dong Hong Chung, Colleen B. Jonsson, Ellie Lucile White, Lynn Rasmussen, Clinton Boykin Maddox, Subramaniam Ananthan, Ashish K. Pathak, Joseph A. Maddry