Patents Assigned to SRI International
  • Publication number: 20240043229
    Abstract: Repulsive force created by actuated permanent magnets is used to levitate and transport heavy loads. A bed of permanent magnets is selectively actuated to levitate an array of magnets positioned above the bed, such that the magnets in the levitated array are opposed to the actuated magnets, and of the same magnetic pole, thereby creating a repulsive force. The actuated magnets are vertically offset from magnets in the bed of permanent magnets that have not been raised, thereby imparting maximum levitation forces to the magnets in the levitated array. These systems can levitate and transport objects over level or sloped surfaces, in a straight path or along curves and corners. A bed of magnets can be attached to the floor, or to a set of moving decks that rearrange themselves in a desired path. Our systems can simulate walking or running, similar to a treadmill or virtual gaming platform.
    Type: Application
    Filed: December 16, 2021
    Publication date: February 8, 2024
    Applicants: SRI International, US Positronix Inc.
    Inventors: John M. Baker, Remigio Perales, Clifford J. P. Gilman
  • Patent number: 11885822
    Abstract: Embodiments in accordance with the present disclosure are directed to apparatuses used for reaction screening and optimization purposes. An example apparatus includes a plurality of reaction vessels, a dispensing subsystem, at least one reactor module, an analysis subsystem, an automation subsystem, and control circuitry. The dispensing subsystem delivers reagents to the plurality of reaction vessels for a plurality of reaction mixtures having varied reaction conditions. The at least one reactor module drives a plurality of reactions within the plurality of reaction vessels. The analysis subsystem analyzes compositions contained in the plurality of reaction vessels. The automation subsystem selectively moves the plurality of reaction vessels from a location proximal to the dispensing subsystem to the at least one reactor module based on experimental design parameters. And, the control circuitry identifies optimum reaction conditions for a target end product based on the analysis.
    Type: Grant
    Filed: June 29, 2018
    Date of Patent: January 30, 2024
    Assignee: SRI International
    Inventors: Nathan Collins, Jeremiah Malerich, Jason D. White, Kevin Luebke, Kristina Rucker, Brian McCoy
  • Publication number: 20240024495
    Abstract: Disclosed herein, are compositions comprising one or more a molecular guidance system (MGS) peptides and a cytotoxic agent. Also described herein, are methods of administering the compositions to patients with cancer.
    Type: Application
    Filed: July 14, 2023
    Publication date: January 25, 2024
    Applicant: SRI International
    Inventors: Kathlynn C. Brown, Curtis Allred, Michael McGuire
  • Publication number: 20240016456
    Abstract: Embodiments are directed to a non-transitory computer-readable storage medium comprising instructions that when executed cause processor circuitry to generate a longitudinal dataset of a set of features from tracked physical measurements of a user received from sensor circuitry, apply at least one machine learning model to the longitudinal dataset of the set of features to identify a pattern within the set of features indicative of a probability of the user being in a state of menopause, predict a current state of menopause for the user based on the identified pattern, and communicate a data message indicative of the current state of menopause for the user. In some embodiments, the set of features are compressed to pseudo-features and input to a first ML model using a second ML model.
    Type: Application
    Filed: November 3, 2021
    Publication date: January 18, 2024
    Applicant: SRI International
    Inventors: Massimiliano de Zambotti, Fiona Baker, Andreas Tsiartas
  • Publication number: 20230398215
    Abstract: An example genetically engineered natural killer (NK) cell comprises an exogenous polynucleotide sequence that includes a receptor element, an actuator element, and an effector element. The receptor element encodes a chimeric antigen receptor (CAR) comprising an extracellular antigen binding domain operably linked to a transmembrane domain, and an intracellular signaling domain, wherein the extracellular antigen binding domain recognizes a surface antigen of a target cell. The actuator element encodes a transcription factor binding site that upregulates synthesis of an effector protein. The effector element encodes the effector protein operably linked to a signal peptide, wherein, in response to the antigen binding domain of the CAR binding to the antigen of the target cell, the engineered NK cell is configured to activate and, to synthesize and secrete the effector protein.
    Type: Application
    Filed: October 28, 2021
    Publication date: December 14, 2023
    Applicant: SRI International
    Inventor: Parijat Bhatnagar
  • Publication number: 20230393140
    Abstract: An example binding assay includes a plurality of sub-regions, a plurality of synthetic compounds on beads, wherein each of the plurality of sub-regions includes one of the plurality of synthetic compounds, a biological target labeled with a first detectable label in each of the plurality sub-regions, and a biological counter target labeled with a second detectable label in each of the plurality of sub-regions. The biological counter target is configured to bind to the biological target when the biological target is in a first orientation. And, wherein a first subset of the plurality of synthetic compounds bind to the biological target and effect interactions between the biological target and the biological counter target.
    Type: Application
    Filed: October 15, 2021
    Publication date: December 7, 2023
    Applicant: SRI International
    Inventors: Peter Madrid, Nathan Collins, Michal Avital-Shmilovici, Xiaohe Liu, Thomas Shaler
  • Patent number: 11835711
    Abstract: An example apparatus includes a pointing structure, a magnetic-contrast bearing, and drive circuitry. The magnetic-contrast bearing is coupled to the pointing structure, and includes a magnetic array and a substrate that is arranged with the magnetic array. The drive circuitry generates a magnetic field that interacts with the magnetic array and causes control of a pointing position of the pointing structure.
    Type: Grant
    Filed: April 21, 2020
    Date of Patent: December 5, 2023
    Assignee: SRI International
    Inventors: Ronald Pelrine, Nicole Heidel, Jesse Wodin, Annjoe Wong-Foy
  • Patent number: 11831862
    Abstract: A computing system includes an interface, a memory, and processing circuitry. The interface is configured to receive, from a production system, a first test stream and a second test stream. The memory is in communication with the interface and is configured to store at least a portion of the first test stream and at least a portion of the second test stream. The processing circuitry is in communication with the memory and is configured to: detect first embedded information in the first test stream representative of a first timestamp and second embedded information in the second test stream representative of a second timestamp; determine, based on the first timestamp and the second timestamp, an offset between the first test stream and the second test stream; output the offset.
    Type: Grant
    Filed: December 16, 2022
    Date of Patent: November 28, 2023
    Assignee: SRI INTERNATIONAL
    Inventors: Robert Norman Hurst, Jr., Arkady Kopansky, Jonathan Parlett
  • Patent number: 11822609
    Abstract: Systems and methods for forecasting the prominence of various attributes in a future subject matter area are disclosed. An attribute is determined based on inputs received by a computing system. A set of indicators is determined based on the attribute and features extracted from an existing document set. The prominence of the attribute in the existing document set is determined. A prominence estimate of the attribute in a future document set is determined.
    Type: Grant
    Filed: January 15, 2016
    Date of Patent: November 21, 2023
    Assignee: SRI INTERNATIONAL
    Inventors: John J Byrnes, Clint Frederickson, Kyle J McIntyre, Tulay Muezzinoglu, Edmond D Chow, William T Deans
  • Patent number: 11823658
    Abstract: The disclosed technologies include methods for generating a calibration model using data that is selected to match the conditions of a particular trial that involves an automated comparison of data samples, such as a comparison-based trial performed by an audio-based recognition, identification, or detection system. The disclosed technologies also include improved methods for selecting candidate data used to build the calibration model. The disclosed technologies further include methods for evaluating the performance of the calibration model and for rejecting a trial when not enough matched candidate data is available to build the calibration model. The disclosed technologies additionally include the use of regularization and automated data generation techniques to further improve the robustness of the calibration model.
    Type: Grant
    Filed: September 5, 2018
    Date of Patent: November 21, 2023
    Assignee: SRI INTERNATIONAL
    Inventors: Mitchell Leigh McLaren, Aaron Lawson
  • Patent number: 11804301
    Abstract: Embodiments in accordance with the present disclosure are directed to systems and methods for managing hot flashes and/or menopause symptoms. An example system includes sensor circuitry and logic circuitry. The sensor circuitry obtains a physical measurement associated with a user and communicates the physical measurement. The logic circuitry generates a predictive model that indicates a probability of the user having a hot flash at a date and time based on a plurality of input parameters, revises the probability based on the physical measurement using the predictive model, and communicates data indicative of an action in response to the revised probability being outside a threshold, such as providing cooling relief.
    Type: Grant
    Filed: July 3, 2019
    Date of Patent: October 31, 2023
    Assignee: SRI International
    Inventors: Massimiliano de Zambotti, Fiona C. Baker, Mohamad Forouzanfar, Bhaskar Ramamurthy, Laurie Menoud
  • Patent number: 11796514
    Abstract: Embodiments in accordance with the present disclosure are directed to methods and apparatuses used for extracting heavy rare gas. An example method includes passing inlet air through an airflow path of an apparatus, removing carbon dioxide and gaseous water from the inlet air, and cooling the inlet air to a threshold temperature while passing along the airflow path. The method further includes passing the cooled inlet air through an adsorption chamber of the apparatus to adsorb heavy rare gas from the cooled inlet air while the cooled inlet air is in a gaseous state, and extracting the heavy rare gas from the adsorption chamber.
    Type: Grant
    Filed: January 24, 2019
    Date of Patent: October 24, 2023
    Assignee: SRI International
    Inventors: Marc D. Hornbostel, Anoop Nagar, Elisabeth Perea
  • Publication number: 20230329631
    Abstract: Example embodiments are directed systems including processing circuitry and memory circuitry to store a predictive data model indicative of different patterns and probabilities of a user transitioning from an awake state to a sleep state. The processing circuitry is to detect, using data indicative of a current psychophysiological state of the user, a pattern among the different patterns of the predictive data model that is indicative of a probability of the user transitioning from the awake state to the sleep state at a date and time, based on the detected pattern, select an intervention action predicted to increase the probability of the user transitioning to the sleep state at the date and time, and communicate a message indicative of the intervention action to the user.
    Type: Application
    Filed: June 29, 2021
    Publication date: October 19, 2023
    Applicant: SRI International
    Inventors: Massimiliano de Zambotti, Fiona Baker, Devin Prouty, Ian Colrain, Bhaskar Ramamurthy, Glen W. McLaughlin
  • Patent number: 11790213
    Abstract: Techniques are disclosed for identifying multimodal subevents within an event having spatially-related and temporally-related features. In one example, a system receives a Spatio-Temporal Graph (STG) comprising (1) a plurality of nodes, each node having a feature descriptor that describes a feature present in the event, (2) a plurality of spatial edges, each spatial edge describing a spatial relationship between two of the plurality of nodes, and (3) a plurality of temporal edges, each temporal edge describing a temporal relationship between two of the plurality of nodes. Furthermore, the STG comprises at least one of: (1) variable-length descriptors for the feature descriptors or (2) temporal edges that span multiple time steps for the event. A machine learning system processes the STG to identify the multimodal subevents for the event. In some examples, the machine learning system comprises stacked Spatio-Temporal Graph Convolutional Networks (STGCNs), each comprising a plurality of STGCN layers.
    Type: Grant
    Filed: June 12, 2019
    Date of Patent: October 17, 2023
    Assignee: SRI INTERNATIONAL
    Inventors: Yi Yao, Ajay Divakaran, Pallabi Ghosh
  • Patent number: 11775390
    Abstract: A multiparty computing system includes at least a first compute node and a second compute node, each of the first compute node and the second compute node each configured to execute a multiparty computation. The first compute node is configured to perform first operations of the multiparty computation over a share of first secret data and a share of second secret data; detect a checkpoint event; and, in response to detection of the checkpoint event, save a state of the multiparty computation on the first compute node to a checkpoint storage. In response to detection of a resume event, the first compute node executes a resume protocol with the second compute node, where the resume protocol includes exchanging messages with the second compute node, and determining, based on the messages, an operation in the multiparty computation to be the starting point to resume the multiparty computation.
    Type: Grant
    Filed: October 20, 2021
    Date of Patent: October 3, 2023
    Assignee: SRI International
    Inventors: Karim Eldefrawy, Benjamin Terner
  • Patent number: 11763107
    Abstract: Small, low-cost satellite systems, like CubeSats or other microsatellites, can exhibit reduced reliability relative to higher-cost satellite systems. This can result in difficulty identifying, communicating with, and tracking such satellite systems when they fail. Provided herein are reliable, low-cost, low-energy, turn-key systems for identification and tracking of small satellites that can be readily added to a microsatellite with minimal integration costs and while occupying a minimal amount of volume, mass, and external area of the host satellite. These systems are electrically isolated from the satellite bus, being powered by internal batteries or other separate energy sources and providing reliable identification and tracking even when the other systems of the satellite have failed.
    Type: Grant
    Filed: June 24, 2021
    Date of Patent: September 19, 2023
    Assignee: SRI International
    Inventors: Samson Phan, Leon Tao, William Hoskins, Scott Gulkin, Bryan Klofas, Todd Koumrian, Michael Cousins
  • Publication number: 20230286552
    Abstract: We use permanent magnets to levitate and transport heavy loads. A bed of permanent magnets is selectively actuated to levitate an array of magnets positioned above the bed, such that the magnets in the levitated array are opposed to the actuated magnets, and of the same magnetic pole, thereby creating a repulsive force. The actuated magnets are offset from magnets in the bed of permanent magnets that have not been actuated, thereby imparting maximum levitation forces to the magnets in the levitated array. Our systems use magnetic repulsive force for levitating and transporting goods across a warehouse, simulating walking or running such as on a treadmill or in a virtual gaming platform, and for transporting people such as on a moving sidewalk. Our systems are electrical machines for holding or levitating devices using magnetic levitation, and also use permanent magnets to transmit power wirelessly.
    Type: Application
    Filed: August 11, 2021
    Publication date: September 14, 2023
    Applicants: US Positronix Inc., SRI International
    Inventors: John M. Baker, Remigio Perales, Clifford J. P. Gilman
  • Patent number: 11752339
    Abstract: Systems and methods of generating and applying a synthetic neuromodulatory signal are described. A subject may be put under a particular condition that causes an effect in the subject. While the subject is under the condition, a recording of neurogram signals derived from the condition can be made from the subject. For example, neuronal signals traveling on the vagus nerve of the subject may be monitored and recorded. The neurogram may then be used to create a synthetic neuromodulatory signal that can be administered to a user. When the synthetic neuromodulatory signal is administered to the user, the user may experience the same effect as the subject that had been placed in the condition, even though the user was never put under the same condition.
    Type: Grant
    Filed: May 30, 2017
    Date of Patent: September 12, 2023
    Assignee: SRI International
    Inventors: Christopher Connolly, Patrick Lincoln, Maneesh Yadav, John Cornwell, Bhaskar Ramamurthy
  • Publication number: 20230277106
    Abstract: Embodiments in accordance with the present disclosure are directed to systems, devices, and methods involving hot flash (HF) multi-sensor circuits. An example system includes a plurality of sensor circuits and processor circuitry. The sensor circuits obtain a plurality of sensor signals associated with the user. The processor circuitry extracts features from the plurality of sensor signals obtained by the plurality of sensor circuits, aligns the extracted features to a common time point, identifies a HF event for the user using a predictive data model indicative of probability of the HF event occurring for the user at a date and time and based on the aligned extracted features, and communicates a message indicative of the HF event to the user.
    Type: Application
    Filed: August 6, 2021
    Publication date: September 7, 2023
    Applicant: SRI International
    Inventors: Massimiliano de Zambotti, Fiona Baker, David Smith, Andreas Tsiartas
  • Patent number: 11741247
    Abstract: A method, apparatus and system for providing controlled access to data in a distributed computing environment include storing received data to be accessed via the distributed computing environment in at least one storage device, generating at least one integrity data structure identifying at least a storage location of at least a respective portion of the stored data, storing the generated at least one integrity data structure in a block of a blockchain, encrypting the at least one integrity data structure in the block of the blockchain, and selectively providing at least a portion of at least one decryption key for decrypting the encrypted at least one integrity data structure to enable access to the respective portion of the stored data for which the at least one integrity data structure is generated. Additionally, the stored data can be encrypted and a decryption key can be provided for decrypting the stored data.
    Type: Grant
    Filed: December 20, 2018
    Date of Patent: August 29, 2023
    Assignee: SRI International
    Inventors: Gabriela Ciocarlie, Karim Eldefrawy, Tancrede Lepoint