Abstract: A vascular closure device includes an anchor, a suture carrying portion, and at least three needles. The anchor is positionable through a vessel puncture in a vessel wall and operable between expanded and retracted positions. The suture carrying portion is positioned distal of the anchor and configured to carry at least one suture. The needles are operable between an advanced position extending through the vessel wall adjacent to the vessel puncture to connect to the at least one suture, and a retracted position in which the needles position the at least one suture through the vessel wall. The needles and sutures are configurable to close large bore openings in the vessel wall.

Abstract: A vascular closure system includes a suture carrying portion, a plurality of needles, and an internal sealing member. The suture carrying portion is insertable through a vessel puncture of a vessel and carries first and second suture ends of at least a first suture member. The plurality of needles are extendable through a wall of the vessel adjacent to the vessel puncture and are configured to connect to the first and second suture ends. Withdrawal of the plurality of needles draws the first and second suture ends through the vessel wall. The internal sealing member is configured to advance along the first suture member through the vessel puncture and into the vessel. Applying a withdrawal force to the first and second suture ends draws the internal sealing member against an internal surface of the vessel wall to at least partially seal closed the vessel puncture.

Abstract: A tissue puncture assembly includes an ultrasound probe, a tissue puncture device, and an adjustment device. The ultrasound probe includes a probe end arranged to contact a tissue surface, the ultrasound probe being operable to determine a depth of a body cavity positioned below the tissue surface. The tissue puncture device is configured to penetrate the tissue surface to gain access to the body cavity. The adjustment device is mounted to the ultrasound probe and operable to adjust an orientation of the tissue puncture device relative to the ultrasound probe.

Abstract: A tissue puncture closure assembly including a wire assembly and first and second devices. The wire assembly includes a first wire member and a second wire member that each include a distal end portion and a proximal end portion. At least portions of the second wire member are arranged side-by-side with the first wire member. The distal end portion of the first wire member is connected to the distal end portion of the second wire member, and a proximal end portion of the first wire member is disconnected from the proximal end portion of the second wire member. The first device is operable to advance over the first wire member. The second device is operable to advance over the second wire member.

Abstract: A bioadhesive delivery catheter includes a manifold, a dual lumen tube, and a mixing member. The manifold includes a delivery device passage and an injection port. The tube is insertable into the delivery device passage and includes first and second lumens positioned side-by-side. The first lumen extends proximal of the second lumen within the delivery device passage, and the second lumen is in flow communication with the injection port. The mixing member is positioned between a proximal inlet of the injection port and the second lumen and is configured to help mix a bioadhesive material that is delivered through the injection port into the second lumen.

Abstract: A bioadhesive delivery catheter includes a manifold, a dual lumen tube, and a mixing member. The manifold includes a delivery device passage and an injection port. The tube is insertable into the delivery device passage and includes first and second lumens positioned side-by-side. The first lumen extends proximal of the second lumen within the delivery device passage, and the second lumen is in flow communication with the injection port. The mixing member is positioned between a proximal inlet of the injection port and the second lumen and is configured to help mix a bioadhesive material that is delivered through the injection port into the second lumen.

Abstract: A vascular closure system includes a suture and an anchor assembly. The anchor assembly includes a first anchor portion having a plurality of petal members automatically expandable from a retracted position for delivery through a vessel puncture in a vessel, and an expanded position when deployed within the vessel. The anchor assembly also includes a second anchor portion connected to the suture and positioned distal of the first anchor portion within the vessel. Withdrawing the suture pulls the second anchor portion against the first anchor portion to contact the first anchor portion against an inner surface of the vessel adjacent to the vessel puncture. The vascular closure system may also include an automatic compaction assembly that automatically compacts a sealing member against the anchor assembly to seal closed the vessel puncture upon withdrawal of the vascular closure system.

Abstract: A vascular closure device includes an anchor, a suture carrying portion, and at least three needles. The anchor is positionable through a vessel puncture in a vessel wall and operable between expanded and retracted positions. The suture carrying portion is positioned distal of the anchor and configured to carry at least one suture. The needles are operable between an advanced position extending through the vessel wall adjacent to the vessel puncture to connect to the at least one suture, and a retracted position in which the needles position the at least one suture through the vessel wall. The needles and sutures are configurable to close large bore openings in the vessel wall.

Abstract: A vascular closure device includes an anchor, a suture carrying portion, and a plurality of needles. The anchor is positionable through a vessel puncture in a vessel wall and operable between expanded and contracted positions. The suture carrying portion is positioned distal of the anchor and configured to carry at least one suture. The plurality of needles are operable between an advanced position extending through the vessel wall adjacent to the vessel puncture to connect to the at least one suture, and a retracted position in which the plurality of needles position the at least one suture through the vessel wall. At least one of the plurality of needles extends through an aperture in the anchor when in the advanced position.

Abstract: A vascular closure assembly is configured to seal a vascular puncture in a vessel. The vascular closure assembly includes a balloon location device and a sealant delivery device. The balloon location device includes an inflation tube and an inflatable balloon positioned at a distal end of the inflation tube and operable, when inflated, between a first position blocking blood flow through the vessel and a second position sealing the puncture from within the vessel. The sealant delivery device includes a sealant delivery tube having a first lumen sized to advance over the inflation tube to the puncture, and a second lumen configured to deliver a volume of sealant to the puncture. The first lumen may include a rapid exchange feature.

Abstract: A vascular closure device includes a catheter, a balloon, an introducer, and a guidewire lumen. The catheter includes an inflation lumen. The balloon is positioned at a distal end portion of the catheter. The introducer is positioned distal of the balloon. The guidewire lumen extends along at least a portion of the introducer and terminates at a rapid exchange port positioned distal of the balloon. The guidewire lumen is receptive of a guidewire to guide the catheter through a vessel puncture in a vessel to position the balloon within the vessel.

Abstract: A closure device operable to seal a vessel puncture and including a delivery member and a sealant material applicator. The delivery member is insertable through a tissue tract to the vessel puncture. The sealant material applicator is configured to supply a volume of sealant material to the delivery member and includes a housing, a plunger assembly, and at least one container. The housing includes at least first and second chambers, wherein the first chamber carries a first sealant component and the second chamber carries a second sealant component. The container is insertable into the first or second chamber and carries a third sealant component of the sealant material. The sealant material applicator creates flow communication between the container and at least one of the first and second chambers to mix the third sealant component with the first and second sealant components.

Abstract: A vascular closure device includes a vessel locating device, a sealant delivery device, a detachable sealing tip, and a suture. The vessel locating device includes an expandable portion configured to extend through and temporarily seal a vessel puncture from within a vessel. The sealant delivery device is configured to deliver a first volume of flowable sealant to the vessel puncture along an exterior of the vessel. The detachable sealing tip is carried at a distal end of the vessel locating device. The suture is connected to and extends proximally from the detachable sealing tip. The detachable sealing tip is configured for release within the first volume of flowable sealant upon withdrawal of the vessel locating device through the first volume of flowable sealant. The suture is anchored at a location proximal of the detachable sealing tip.

Abstract: A vascular closure device, having an insertion sheath and a vascular closure implant positioned at least partially in the insertion sheath. The vascular closure implant may have an anchor element, the anchor element including an expandable material, a first puncture contact portion, a bend portion connected to the first puncture contact portion, the bend portion including a bend, and a second puncture contact portion connected to the bend portion. The vascular closure implant may also include a plug element coupled to the bend portion of the anchor element. The anchor element may be formed of an expandable material having the same or a different expansion rate than a material forming the plug element. The vascular closure device may additionally include a locator tube having a vessel locator positioned at least partially in the locator tube. The vessel locator may also have an elongated member that includes a superelastic material.

Abstract: A sealant delivery device includes a delivery tube, a bioadhesive container, and an adapter. The delivery tube includes proximal and distal ends. The bioadhesive container holds a sealant activator and a sealant precursor separated from each other. The adapter is interposed between the delivery tube and the bioadhesive container. The adapter includes a first channel member that couples a first lumen of the delivery tube to the sealant activator, and a second channel member that couples the first lumen to the sealant precursor. The adapter provides separation of the sealant activator and the sealant precursor until a position distal of the bioadhesive container.

Abstract: Apparatuses and methods are disclosed that may be used to bond materials using thermoset and thermoplastic polymer materials arranged with a thermoplastic strike layer on a surface of the material. Apparatuses and methods are also disclosed for manufacturing and configuring catheters and other tubular devices with a bonding surface or layer. These apparatuses and devices may have a strike layer of thermoplastic polymer material that melts or softens upon application of heat and bonds to other polymer materials upon cooling, thus avoiding the use of externally-applied adhesives in the construction of a bond between two surfaces, such as between an inner surface of a tubular catheter and an outer surface of a tubular catheter tip.

Abstract: A suture cutting device including a housing, a cutting member, a suture recess, and an actuator. The cutting member is positioned in the housing. The suture recess is formed in the housing and configured to releasably connect the housing to the suture. The actuator is accessible outside of the housing and operable to move the cutting member laterally relative to the suture within the housing from a first position out of contact with the suture to a second position cutting the suture.

Abstract: A vascular closure device includes a handle, a carrier tube, a sealing tip, a sealing tip connection member, and an actuator. The carrier tube extends from the handle. The sealing tip is positioned at a distal end of the carrier tube. The sealing tip connection member extends from the sealing tip to the handle. The actuator is mounted to the handle and operable to move the sealing tip connection member to release the sealing tip from the carrier tube.

Abstract: Various embodiments of a device are shown and disclosed for closing a vascular access puncture site following percutaneous diagnostic or therapeutic interventional procedures. The vascular closure device is configured to safely and accurately deploy a sealing material that undergoes a phase change when deployed inside the tissue tract. The sealing material may be a solid at room temperature and a liquid or gel at body temperature. Also, the sealing material may change from a liquid or gel to a cubic phase when it comes into contact with bodily fluids.

Abstract: A tissue puncture locator device that includes an expandable member, a deformable membrane, and an actuator. The expandable member is movable between an unexpanded position and an expanded position. The deformable membrane extends around at least a portion of the expandable member. The membrane has a stress relief portion. The actuator is operable to move the expandable member between the unexpanded and expanded positions.