Patents Assigned to St. Marianna University School of Medicine
  • Patent number: 10660551
    Abstract: A concentration measurement apparatus measures a temporal relative change amount (?cHb, ?O2Hb) of either or both of total hemoglobin concentration and oxygenated hemoglobin concentration in the head that vary due to repetition of chest compression, and includes a light incidence section making measurement light incident on the head, a light detection section detecting the measurement light propagated through the interior of the head and generating a detection signal in accordance with the intensity of the measurement light, and a CPU determining, based on the detection signal, the relative change amount (?cHb, ?O2Hb) and performing a filtering process of removing frequency components less than a predetermined frequency from frequency components contained in the relative change amount (?cHb, ?O2Hb).
    Type: Grant
    Filed: September 29, 2017
    Date of Patent: May 26, 2020
    Assignees: ST. MARIANNA UNIVERSITY SCHOOL OF MEDICINE, HAMAMATSU PHOTONICS K.K.
    Inventors: Yasuaki Koyama, Takeo Ozaki, Susumu Suzuki
  • Patent number: 10561141
    Abstract: A collected living tissue cryopreserving tool is composed of a tissue piece holder and a resin-made accommodating bag. The tissue piece holder is composed of a plate-shaped body part including a thermally conductive plate-shaped lower member and a plate-shaped upper member and a covering sheet held by the plate-shaped body part. The tissue piece holder has a tissue piece placing part formed of a cut-out part provided on the plate-shaped upper member and a part, of an upper surface of the thermally conductive plate-shaped lower member, which is disposed at the cut-out part. The covering sheet is capable of covering the tissue piece placing part.
    Type: Grant
    Filed: June 1, 2017
    Date of Patent: February 18, 2020
    Assignees: KITAZATO CORPORATION, ST. MARIANNA UNIVERSITY SCHOOL OF MEDICINE
    Inventors: Nao Suzuki, Yodo Sugishita, Futoshi Inoue
  • Publication number: 20200010553
    Abstract: An object of the present invention is to provide a novel therapeutic or preventive agent for human T cell leukemia virus type-1 associated myelopathy (HAM) containing an anti-human CC-chemokine receptor 4 (CCR4) antibody or an antibody fragment thereof as an active ingredient, and characterized by the administration and dosage of the antibody or the antibody fragment thereof. The present invention relates to a therapeutic or preventative agent for HAM characterized in that an anti-human CCR4 antibody or an antibody fragment thereof is contained as an active ingredient and the antibody or the antibody fragment thereof is administered at a low dose.
    Type: Application
    Filed: March 2, 2018
    Publication date: January 9, 2020
    Applicants: St. Marianna University School of Medicine, KYOWA KIRIN CO., LTD.
    Inventor: Yoshihisa YAMANO
  • Publication number: 20190343816
    Abstract: The present invention provides a pharmaceutical composition containing an inhibitor selected from the group consisting of an EZH1 inhibitor, an EZH2 inhibitor and an EZH1/2 dual inhibitor as an active ingredient, for use in treating HTLV-1-associated myelopathy. The present invention provides a pharmaceutical composition for use in treating HTLV-1-associated myelopathy, containing a 1,3-benzodioxole derivative or a pharmaceutically acceptable salt thereof.
    Type: Application
    Filed: January 18, 2018
    Publication date: November 14, 2019
    Applicants: DAIICHI SANKYO COMPANY, LIMITED, ST. MARIANNA UNIVERSITY SCHOOL OF MEDICINE
    Inventors: Yoshihisa YAMANO, Natsumi UEDA, Kazushi ARAKI
  • Publication number: 20190336169
    Abstract: An instrument for fixedly transplanting a living body embryo into a uterus has an instrument, for transplanting the living body embryo into the uterus, which is to be inserted into a uterus and a magnetic embryo accommodation container holding instrument (transferred embryo fixing instrument) to be attached to the living body. The instrument for transplanting the living body embryo into the uterus has an embryo accommodation container having an embryo accommodation part having an embryo insertion portion communicating with outside and a magnetic material and a shaft-shaped container transfer tool for separably holding the embryo accommodation container at its distal end portion. The magnetic container holding instrument has an attaching part to be attached to an epidermis of the living body and a magnet capable of attracting the magnetic material of the embryo accommodation container thereto.
    Type: Application
    Filed: July 15, 2019
    Publication date: November 7, 2019
    Applicants: THE UNIVERSITY OF TOKYO, ST. MARIANNA UNIVERSITY SCHOOL OF MEDICINE, KITAZATO CORPORATION
    Inventors: Masashi IKEUCHI, Kazuhiro KAWAMURA, Futoshi INOUE
  • Patent number: 10322185
    Abstract: The present invention can provide a controlled drug release carrier formed by using a silk fibroin porous material, which has high drug controlled release rate, controllability of the drug controlled release speed, high strength, easy handleability, skin care properties from high biocompatibility, high water retentivity, and capability of efficiently retaining a drug.
    Type: Grant
    Filed: April 24, 2013
    Date of Patent: June 18, 2019
    Assignees: HITACHI CHEMICAL COMPANY, LTD., ST. MARIANNA UNIVERSITY, SCHOOL OF MEDICINE, NATIONAL INSTITUTE OF AGROBIOLOGICAL SCIENCES
    Inventors: Kazutoshi Kobayashi, Kunihiro Suto, Naosuke Sumi, Hajime Inoue, Yasushi Tamada
  • Patent number: 10294302
    Abstract: The object of the present invention is to provide a new therapeutic method and a new therapeutic agent that are different from known therapeutic medicines for human T cell leukemia virus type-1 (also known as human T lymphotropic virus type-1) associated myelopathy (HAM) patients and asymptomatic HTLV-1 carriers. The present invention relates to a therapeutic method and a therapeutic agent for human T cell leukemia virus type-1 (HTLV-1) associated myelopathy (HAM) patients and asymptomatic HTLV-1 carriers (ACs), which is characterized by reducing HTLV-1 virus-infected cells using an anti-human CC-chemokine receptor 4 (CCR4) antibody.
    Type: Grant
    Filed: March 31, 2017
    Date of Patent: May 21, 2019
    Assignees: ST. MARIANNA UNIVERSITY SCHOOL OF MEDICINE, KYOWA HAKKO KIRIN CO., LTD
    Inventor: Yoshihisa Yamano
  • Patent number: 9808189
    Abstract: A concentration measurement apparatus measures a temporal relative change amount (?cHb, ?O2Hb) of either or both of total hemoglobin concentration and oxygenated hemoglobin concentration in the head that vary due to repetition of chest compression, and includes a light incidence section making measurement light incident on the head, a light detection section detecting the measurement light propagated through the interior of the head and generating a detection signal in accordance with the intensity of the measurement light, and a CPU determining, based on the detection signal, the relative change amount (?cHb, ?O2Hb) and performing a filtering process of removing frequency components less than a predetermined frequency from frequency components contained in the relative change amount (?cHb, ?O2Hb).
    Type: Grant
    Filed: April 6, 2012
    Date of Patent: November 7, 2017
    Assignees: St. Marianna University School of Medicine, HAMAMATSU PHOTONICS K.K.
    Inventors: Yasuaki Koyama, Takeo Ozaki, Susumu Suzuki
  • Publication number: 20170265457
    Abstract: A collected living tissue cryopreserving tool is composed of a tissue piece holder and a resin-made accommodating bag. The tissue piece holder is composed of a plate-shaped body part including a thermally conductive plate-shaped lower member and a plate-shaped upper member and a covering sheet held by the plate-shaped body part. The tissue piece holder has a tissue piece placing part formed of a cut-out part provided on the plate-shaped upper member and a part, of an upper surface of the thermally conductive plate-shaped lower member, which is disposed at the cut-out part. The covering sheet is capable of covering the tissue piece placing part.
    Type: Application
    Filed: June 1, 2017
    Publication date: September 21, 2017
    Applicants: Kitazato BioPharma Co., Ltd., St. Marianna University School of Medicine
    Inventors: Nao SUZUKI, Yodo SUGISHITA, Futoshi INOUE
  • Publication number: 20170204189
    Abstract: The object of the present invention is to provide a new therapeutic method and a new therapeutic agent that are different from known therapeutic medicines for human T cell leukemia virus type-1 (also known as human T lymphotropic virus type-1) associated myelopathy (HAM) patients and asymptomatic HTLV-1 carriers. The present invention relates to a therapeutic method and a therapeutic agent for human T cell leukemia virus type-1 (HTLV-1) associated myelopathy (HAM) patients and asymptomatic HTLV-1 carriers (ACs), which is characterized by reducing HTLV-1 virus-infected cells using an anti-human CC-chemokine receptor 4 (CCR4) antibody.
    Type: Application
    Filed: March 31, 2017
    Publication date: July 20, 2017
    Applicants: St. Marianna University School of Medicine, KYOWA HAKKO KIRIN CO., LTD
    Inventor: Yoshihisa YAMANO
  • Publication number: 20170164606
    Abstract: A collected living tissue cryopreserving appliance is composed of a collected tissue accommodating container, a heat-sealable accommodating bag for accommodating the collected tissue accommodating container therein, and a container holding member for holding the collected tissue accommodating container accommodated inside the accommodating bag. The collected tissue accommodating container is composed of a bottomed cylindrical container body and a lid member mountable on the container body in an airtight state. The lid member has a tissue piece placing member and a sealing member, formed on an inner surface of a lid body part, for sealing an open portion of the transparent container body.
    Type: Application
    Filed: February 27, 2017
    Publication date: June 15, 2017
    Applicants: Kitazato BioPharma Co., Ltd., St. Marianna University School of Medicine
    Inventors: Nao SUZUKI, Futoshi INOUE
  • Patent number: 9642910
    Abstract: The object of the present invention is to provide a new therapeutic method and a new therapeutic agent that are different from known therapeutic medicines for human T cell leukemia virus type-1 (also known as human T lymphotropic virus type-1) associated myelopathy (HAM) patients and asymptomatic HTLV-1 carriers. The present invention relates to a therapeutic method and a therapeutic agent for human T cell leukemia virus type-1 (HTLV-1) associated myelopathy (HAM) patients and asymptomatic HTLV-1 carriers (ACs), which is characterized by reducing HTLV-1 virus-infected cells using an anti-human CC-chemokine receptor 4 (CCR4) antibody.
    Type: Grant
    Filed: July 8, 2013
    Date of Patent: May 9, 2017
    Assignees: St. Marianna University School of Medicine, KYOWA HAKKO KIRIN CO., LTD
    Inventor: Yoshihisa Yamano
  • Publication number: 20150094262
    Abstract: The present invention can provide a controlled drug release carrier formed by using a silk fibroin porous material, which has high drug controlled release rate, controllability of the drug controlled release speed, high strength, easy handleability, skin care properties from high biocompatibility, high water retentivity, and capability of efficiently retaining a drug.
    Type: Application
    Filed: April 24, 2013
    Publication date: April 2, 2015
    Applicants: Hitachi Chemical Company, Ltd., St. Marianna University, School of Medicine, National Institute of Agrobiological Sciences
    Inventors: Kazutoshi Kobayashi, Kunihiro Suto, Naosuke Sumi, Hajime Inoue, Yasushi Tamada
  • Publication number: 20140058233
    Abstract: A concentration measurement apparatus measures a temporal relative change amount (?cHb, ?O2Hb) of either or both of total hemoglobin concentration and oxygenated hemoglobin concentration in the head that vary due to repetition of chest compression, and includes a light incidence section making measurement light incident on the head, a light detection section detecting the measurement light propagated through the interior of the head and generating a detection signal in accordance with the intensity of the measurement light, and a CPU determining, based on the detection signal, the relative change amount (?cHb, ?O2Hb) and performing a filtering process of removing frequency components less than a predetermined frequency from frequency components contained in the relative change amount (?cHb, ?O2Hb).
    Type: Application
    Filed: April 6, 2012
    Publication date: February 27, 2014
    Applicants: HAMAMATSU PHOTONICS K.K., ST. MARIANNA UNIVERSITY SCHOOL OF MEDICINE
    Inventors: Yasuaki Koyama, Takeo Ozaki, Susumu Suzuki
  • Publication number: 20140037654
    Abstract: The object of the present invention is to provide a new therapeutic method and a new therapeutic agent that are different from known therapeutic medicines for human T cell leukemia virus type-1 associated myelopathy (HAM) patients and asymptomatic HTLV-1 carriers. The present invention relates to a therapeutic method and a therapeutic agent for human T cell leukemia virus type-1 (HTLV-1) associated myelopathy (HAM) patients and asymptomatic HTLV-1 carriers (ACs), which is characterized by reducing HTLV-1 virus-infected cells using an anti-human CC-chemokine receptor 4 (CCR4) antibody.
    Type: Application
    Filed: July 8, 2013
    Publication date: February 6, 2014
    Applicants: KYOWA HAKKO KIRIN CO., LTD, St. Marianna University School of Medicine
    Inventor: Yoshihisa YAMANO
  • Publication number: 20130310687
    Abstract: A blood vessel embolization method includes inserting a balloon catheter into a blood vessel of a human or an animal having a lesion site and disposing a balloon of the balloon catheter at a portion located at a proximal side of the blood vessel and in a neighborhood of the lesion site thereof; shutting off a blood flow in the blood vessel by expanding the balloon; discharging a glucose solution from a distal end of the balloon catheter in a state in which the blood flow in the blood vessel is shut off; discharging a cyanoacrylate-based embolization substance-containing liquid from the distal end of the balloon catheter after the glucose solution injection step; hardening an embolization substance by maintaining a blood flow shut-off state of the blood vessel after the embolization substance injection step; and removing the balloon catheter from the blood vessel after the embolization substance-hardening step.
    Type: Application
    Filed: May 21, 2012
    Publication date: November 21, 2013
    Applicants: TERUMO CLINICAL SUPPLY CO., LTD., ST. MARIANNA UNIVERSITY SCHOOL OF MEDICINE
    Inventors: Kenji TAKIZAWA, Yukihiko Murata
  • Patent number: 8440893
    Abstract: When C60 was added to synovial fibroblasts, infiltrating lymphocytes, and macrophages, and the inflammatory cytokine production level was measured, the inflammatory cytokine production level was significantly suppressed in all cells. Furthermore, when C60 was added to osteoclast precursor cells and cultured in the presence of osteoclast differentiation-inducing factors, a certain concentration or more of C60 suppressed their differentiation into osteoclasts. Observation of the effect of C60 addition on bone resorption showed that C60 suppressed bone resorption by osteoclasts. In addition, the use of arthritis model animals confirmed in vivo that C60 suppressed inflammatory symptoms, as well as bone resorption and bone destruction by osteoclasts. C60 is effective for treating arthritic diseases such as rheumatoid arthritis through its effects of suppressing osteoclast differentiation, bone resorption, and inflammatory cytokines.
    Type: Grant
    Filed: October 18, 2007
    Date of Patent: May 14, 2013
    Assignees: St. Marianna University School of Medicine, Mitsubishi Corporaion
    Inventor: Kazuo Yudoh
  • Patent number: 8395037
    Abstract: Fullerene inhibited the decrease in cell proliferation ability of chondrocytes which is observed when cultured chondrocytes are treated with a cartilage degenerating factor (IL-1? or H2O2). Fullerene inhibited production of cartilage matrix-degrading enzymes (matrix metalloprotease (MMP)-1, 3 and 13) which is induced in cultured chondrocytes by cartilage degenerating factors. Fullerene restored the decrease in cartilage matrix (proteoglycan) synthesizing ability which is observed in treating cultured chondrocytes with cartilage degenerating factors. In an analysis using an osteoarthritis rabbit model, the progress of cartilage degeneration was reduced by administering fullerene. Moreover, the dynamic friction coefficient was decreased by adding fullerene to synovial fluid.
    Type: Grant
    Filed: March 23, 2006
    Date of Patent: March 12, 2013
    Assignees: Mitsubishi Corporation, St. Marianna University School of Medicine
    Inventor: Kazuo Yudoh
  • Publication number: 20120330320
    Abstract: An outer needle of a bone cement injection puncture needle has first side holes near the tip, and second side holes near the base. When an inner needle is removed from the outer needle and an inner tube is inserted into the outer needle in place thereof, a reduced-pressure passage is formed between the outer needle and the inner tube. When bone cement is injected into a bone, gas and liquid in the bone pass through the reduced-pressure passage and are discharged from the body, thereby preventing increased pressure in the bone. As a result, the bone cement can be prevented from leaking to outside of the bone.
    Type: Application
    Filed: March 7, 2011
    Publication date: December 27, 2012
    Applicants: Terumo Kabushiki Kaisha, St Marianna University School of Medicine
    Inventors: Kenji Takizawa, Koichi Hayakawa
  • Publication number: 20110202065
    Abstract: A bone cement injection needle comprises: a hollow outer needle; an outer needle hub affixed to the base end part of the outer needle; an inner needle that can be slidably inserted into the hollow part of the outer needle; and an inner needle hub affixed to the base end part of the inner needle. The outer needle comprises a first side hole located near the tip; a second side hole located near the base end part; and a depressurization passage which connects the first side hole and the second side hole.
    Type: Application
    Filed: October 16, 2009
    Publication date: August 18, 2011
    Applicants: St. Marianna University School of Medicine, Terumo Kabushiki Kaisha
    Inventors: Kenji Takizawa, Koichi Hayakawa, Takuya Uno, Makoto Saruhashi