Patents Assigned to STICHTING RADBOUD UNIVERSITAIR MEDISCH CENTRUM
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Publication number: 20240424114Abstract: Immunomodulatory nanofilaments are provided which present immune factors, especially cytokines, to immune cells, particularly T cells, so as to modulate the immune response of said cells. Methods of using such nanofilaments are also provided.Type: ApplicationFiled: September 5, 2024Publication date: December 26, 2024Applicant: STICHTING RADBOUD UNIVERSITAIR MEDISCH CENTRUMInventors: Carl Figdor, Roel Hammink, Loek Eggermont
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Patent number: 12139711Abstract: The present invention relates to the fields of medicine and immunology. In particular, it relates to novel antisense oligonucleotides that may be used in the treatment, prevention and/or delay of Leber congenital amaurosis.Type: GrantFiled: February 23, 2022Date of Patent: November 12, 2024Assignee: Stichting Radboud universitair medisch centrumInventors: Robert Wilhelmus Johanna Collin, Franciscus Peter Maria Cremers, Antonia Ingrid Den Hollander
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Patent number: 12102688Abstract: Immunomodulatory nanofilaments are provided which present immune factors, especially cytokines, to immune cells, particularly T cells, so as to modulate the immune response of said cells. Methods of using such nanofilaments are also provided.Type: GrantFiled: February 6, 2019Date of Patent: October 1, 2024Assignee: STICHTING RADBOUD UNIVERSITAIR MEDISCH CENTRUMInventors: Carl Figdor, Roel Hammink, Loek Eggermont
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Patent number: 12086979Abstract: An apparatus including processing circuitry configured to: acquire a plurality of sets of medical imaging data of a region of a subject, each set of data corresponding to a respective different measurement period; apply a filter to the plurality of medical imaging data sets to produce a plurality of filtered medical imaging data sets corresponding to the different measurement periods, wherein the applying of the filter is such that, for each of the medical imaging data sets, the filtering uses at least some information from the other medical imaging data sets acquired at the different time periods and wherein the applying of the filter comprises applying at least one constraint or condition and the constraint or condition comprises preserving at least one measure of intensity for each medical imaging data set.Type: GrantFiled: December 21, 2020Date of Patent: September 10, 2024Assignees: Stichting Radboud universitair medisch centrum, CANON MEDICAL SYSTEMS CORPORATIONInventors: Mathias Prokop, Brian Mohr, Paul Thomson, Ewan Hemingway
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Publication number: 20240287521Abstract: The invention relates to the fields of medicine and immunology. In particular, it relates to novel antisense oligonucleotides that may be used in the treatment, prevention and/or delay of an RIPOR2 associated condition.Type: ApplicationFiled: June 24, 2022Publication date: August 29, 2024Applicant: Stichting Radboud universitair medisch centrumInventors: Hendrikus Antonius Rudolfus Van Wyk, Johanna Maria Josephina Kremer, Erik De Vrieze, Suzanne De Bruijn
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Publication number: 20240229164Abstract: The present invention relates to the field of medicine and molecular diagnostics. In particular, it relates to a molecular profiling assay for a complex microbiome.Type: ApplicationFiled: May 31, 2022Publication date: July 11, 2024Applicant: STICHTING RADBOUD UNIVERSITAIR MEDISCH CENTRUMInventors: Wilhelmus Petrus Johannes Leenders, Wilhelmus Johannes Gerardus Melchers, Martijn Adriaan Huijnen
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Publication number: 20240041443Abstract: The invention relates to the field of medicine. More specifically, the invention relates to an expandable plug for closing a defect in an organ or tissue without the need for sutures, wherein the plug has shape memory. The invention further relates to medical use of such plug.Type: ApplicationFiled: December 30, 2021Publication date: February 8, 2024Applicant: Stichting Radboud universitair medisch centrumInventors: Wilhelmina Francisca Daamen, Rob Thomas Christiaan Meuwese, Antonius H. M. S. M. van Kuppevelt
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Publication number: 20230273208Abstract: The use of soluble triggering receptor expressed on myeloid cells-1 (sTREM-1) as a marker in a method for identifying a subject suffering from a disease caused by a coronavirus such as COVID-19 at risk of having or developing a severe form and/or a complication or at risk of death, in a method for assessing the severity of a disease caused by a coronavirus such as COVID-19, and in a method for monitoring a subject suffering from a disease caused by a coronavirus such as COVID-19.Type: ApplicationFiled: June 7, 2021Publication date: August 31, 2023Applicants: INOTREM, CENTRE HOSPITALIER REGIONAL UNIVERSITAIRE DE NANCY, UNIVERSITE DE LORRAINE, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE, STICHTING RADBOUD UNIVERSITAIR MEDISCH CENTRUMInventors: Jean-Jacques GARAUD, Marc DERIVE, Margarita SALCEDO-MAGGUILLI, Lucie JOLLY, Sébastien GIBOT, David MOULIN, Mihai NETEA, Aline DE NOOIJER
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Publication number: 20230233361Abstract: Vaginal device (1) for pelvic organ prolapse treatment, having an elongated base element (2), an inflatable element (3) attached to a distal end part (2a) of the elongated base element (2), and a support element (4) attached to a proximal end part (2b) of the elongated base element (3). The support element (4) has at least two support members (5), which extend away from the proximal end (2b) of the elongated base element (2). The at least two support elements (5) are arranged to support lower parts of prolapsed compartments, and the support element (4) comprises an adjustable connector for fixing the position of the support element (4) along the proximal end part (2b) of the elongated base element (3).Type: ApplicationFiled: May 5, 2021Publication date: July 27, 2023Applicant: Stichting Radboud universitair medisch centrumInventors: Kim Josephina Bernadette Notten, Mirjam Weemhoff
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Publication number: 20230159702Abstract: The present invention is directed to nanofilaments for polymer brushes, to polymer brushes comprising the nanofilaments and methods of making the same. In particular, the invention provides water soluble nanofilaments which may be grafted to a surface and which may be functionalised with (bio)molecules.Type: ApplicationFiled: February 27, 2020Publication date: May 25, 2023Applicant: STICHTING RADBOUD UNIVERSITAIR MEDISCH CENTRUMInventors: Dion VOERMAN, Roelof HAMMINK, Martijn VERDOES, Carl Gustav FIGDOR
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Patent number: 11639364Abstract: The present invention relates to a new class of sialyltransferase inhibitors. The class features a carbamate or similar moiety on the amine of a neuraminic acid derivative. Such inhibitors are suitable for use as a medicament, for example for treating, preventing, or delaying bacterial infection, viral infection, cancer, a disorder of sialic acid metabolism, or an autoimmune disease.Type: GrantFiled: January 29, 2019Date of Patent: May 2, 2023Assignees: STICHTING RADBOUD UNIVERSITEIT, STICHTING RADBOUD UNIVERSITAIR MEDISCH CENTRUMInventors: Thomas Jan Boltje, Torben Heise, Johan Franciscus Adrianus Pijnenborg, Christian Büll, Gosse Jan Adema
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Publication number: 20220401570Abstract: Immunomodulatory nanofilaments are provided which present immune factors, especially cytokines, to immune cells, particularly T cells, so as to modulate the immune response of said cells. Methods of using such nanofilaments are also provided.Type: ApplicationFiled: February 6, 2019Publication date: December 22, 2022Applicant: Stichting Radboud Universitair Medisch CentrumInventors: Carl FIGDOR, Roel HAMMINK, Loek EGGERMONT
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Publication number: 20220389432Abstract: The invention relates to the fields of medicine and immunology. In particular, it relates to novel antisense oligonucleotides that may be used in the treatment, prevention and/or delay of an COCH associated condition.Type: ApplicationFiled: October 29, 2020Publication date: December 8, 2022Applicant: Stichting Radboud universitair medisch centrumInventors: Erwin van Wyk, Erik de Vrieze
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Publication number: 20220333078Abstract: The present invention relates to the field of medicine, specifically the field of treatment of cancer. More specifically, the invention relates to a method for the ex vivo production of a population of highly functional NK cells from CD34-positive cells, to a population of highly functional NK cells obtained and to the use of such population of highly functional NK cells for adoptive cell therapy.Type: ApplicationFiled: December 9, 2021Publication date: October 20, 2022Applicant: Stichting Radboud universitair medisch centrumInventor: Harmen Dolstra
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Publication number: 20220290154Abstract: The present invention relates to the field of medicine. In particular, it relates to novel antisense oligonucleotides that may be used in the treatment, prevention and/or delay of Stargardt disease.Type: ApplicationFiled: August 7, 2020Publication date: September 15, 2022Applicants: Stichting Radboud universitair medisch centrum, UCL Business LtdInventors: Robert Wilhelmus Johanna Collin, Alejandro Garanto Iglesias, Franciscus Peter Maria Cremers, Michael Edward Cheetham
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Publication number: 20220233555Abstract: The present invention relates to a new administration regime for glycylcyclines. Inhalation of these antibiotics was found to potently treat infection by Mycobacterium microbes such as Mycobacterium abscessus.Type: ApplicationFiled: May 25, 2020Publication date: July 28, 2022Applicant: Stichting Radboud universitair medisch centrumInventor: Jakobus van Ingen
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Publication number: 20220161017Abstract: A device (2) for providing circulatory assistance is provided and comprises a balloon (4) comprising a membrane defining a cavity having an internal volume (Vc), wherein the balloon comprises a proximal portion (4a) comprising a proximal end and a distal portion (4b) comprising a distal end. The device (2) further comprises a first catheter, affixed to the distal end of the balloon (4) at a first fixation point (P1) and a second catheter (8), affixed to the proximal end of the balloon at a second fixation point (P2). The second catheter (8) is configured for axial movement with respect to the first catheter or guide wire (6) between a first position in which the first and second fixation points (P1, P2) are spaced apart from each other in the longitudinal direction by a first distance (Dx), which is variable to bring about inversion of the balloon.Type: ApplicationFiled: February 28, 2020Publication date: May 26, 2022Applicant: Stichting Radboud universitair medisch centrumInventor: Daniël Immanuel Michaël van Dort
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Patent number: 11286352Abstract: A process for the preparation of beads including a biocompatible hydrophobic polymer, a perfluorocarbon, polyvinylalcohol and optionally a metal compound, including the steps of: adding the perfluorocarbon and optionally the metal compound to a solution of the biocompatible hydrophobic polymer in a polar solvent to provide a first liquid mixture, adding the first liquid mixture to an aqueous solution of a biocompatible surfactant including polyvinylalcohol under sonication to obtain a second liquid mixture, a) maintaining the sonication of the second liquid mixture while cooling, b) evaporating the polar solvent from the second liquid mixture to obtain a suspension of beads including the biocompatible hydrophobic polymer, the perfluorocarbon and optionally the metal compound, c) separating the beads from the suspension and preparing a water suspension of the beads and d) freeze-drying the water suspension to obtain the beads, wherein the addition of the first liquid mixture to the biocompatible surfactant inType: GrantFiled: March 13, 2017Date of Patent: March 29, 2022Assignee: STICHTING RADBOUD UNIVERSITAIR MEDISCH CENTRUMInventors: Mangala Srinivas, Olga Koshkina, Carl Gustav Figdor, Ingrid Jolanda Monique De Vries
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Patent number: 11279933Abstract: The present invention relates to the fields of medicine and immunology. In particular, it relates to novel antisense oligonucleotides that may be used in the treatment, prevention and/or delay of Leber congenital amaurosis.Type: GrantFiled: April 7, 2020Date of Patent: March 22, 2022Assignee: Stichting Radboud universitair medisch centrumInventors: Robert Wilhelmus Johanna Collin, Franciscus Peter Maria Cremers, Antonia Ingrid Den Hollander
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Publication number: 20220031189Abstract: A breath sampler for collecting a breath sample from a patient is disclosed. The breath sampler has a non-rebreather part including a sample inlet, a one-way outlet valve downstream of the sample inlet, and an air inlet. The one-way outlet valve and the sample inlet define a first portion of an internal breath flow pathway therebetween. The air inlet is arranged to be closed by a one-way inlet valve arranged to allow air to enter the non-rebreather part. The breath sampler also has a sample delivery part in fluid communication with the non-rebreather part at an upstream end via the one-way outlet valve. The sample delivery part defines a second portion of the internal breath flow pathway, and has an air diverter, a sample outlet, a return inlet and a sample collection chamber connector.Type: ApplicationFiled: September 13, 2019Publication date: February 3, 2022Applicant: Stichting Radboud universitair medisch centrumInventors: Marinus Isaäk de Jonge, Cornelis Hubertus van den Kieboom