Patents Assigned to Stowers Institute for Medical Research
  • Publication number: 20210374388
    Abstract: This disclosure relates to the use of “pseudo-images” to perform image recognition, e.g., to perform facial image recognition. In an embodiment, the pseudo-image is obtained by starting with a real world image and, after optional preprocessing, subjecting the image to a non-linear transformation that converts the image into a pseudo-image. While real world objects (or, more generally, real world patterns) may be perceivable in the starting image, they cannot be perceived in the pseudo-image. Image recognition takes place by comparing the pseudo-image with a library of known pseudo-images, i.e., image recognition takes place in pseudo-image space without a return to real world space. In this way, robust image recognition is achieved even for imperfect real world images, such as, real world images that have been degraded by noise, poor illumination, uneven lighting, and/or occlusion, e.g., the presence of glasses, scarves, or the like in the case of facial images.
    Type: Application
    Filed: August 7, 2021
    Publication date: December 2, 2021
    Applicant: Stowers Institute for Medical Research
    Inventors: Congrong (Ron) Yu, Rishabh Raj, Dar Wilbur Dahlen
  • Patent number: 11173173
    Abstract: The disclosure provides methods of treating cancer by selectively inhibiting p-S552-?-catenin, p-T217-?-catenin, p-T332-?-catenin, and/or p-S675-?-catenin production and/or activity. Such methods also and/or limit cancer-initiating cells.
    Type: Grant
    Filed: July 28, 2016
    Date of Patent: November 16, 2021
    Assignees: UNIVERSITY OF CONNECTICUT, UNIVERSITY OF KANSAS, STOWERS INSTITUTE FOR MEDICAL RESEARCH
    Inventors: Rajeswari Kasi, Linheng Li, Xiuling Lu, John M. Perry, Gurusingham Sitta Sittampalam, Anuradha Roy, Xi C. He
  • Patent number: 11157721
    Abstract: This disclosure relates to the use of “pseudo-images” to perform image recognition, e.g., to perform facial image recognition. In an embodiment, the pseudo-image is obtained by starting with a real world image and, after optional preprocessing, subjecting the image to a non-linear transformation that converts the image into a pseudo-image. While real world objects (or, more generally, real world patterns) may be perceivable in the starting image, they cannot be perceived in the pseudo-image. Image recognition takes place by comparing the pseudo-image with a library of known pseudo-images, i.e., image recognition takes place in pseudo-image space without a return to real world space. In this way, robust image recognition is achieved even for imperfect real world images, such as, real world images that have been degraded by noise, poor illumination, uneven lighting, and/or occlusion, e.g., the presence of glasses, scarves, or the like in the case of facial images.
    Type: Grant
    Filed: June 26, 2019
    Date of Patent: October 26, 2021
    Assignee: Stowers Institute for Medical Research
    Inventors: Congrong (Ron) Yu, Rishabh Raj, Dar Wilbur Dahlen
  • Patent number: 11120253
    Abstract: This disclosure relates to the use of “pseudo-images” to perform image recognition, e.g., to perform facial image recognition. In an embodiment, the pseudo-image is obtained by starting with a real world image and, after optional preprocessing, subjecting the image to a non-linear transformation that converts the image into a pseudo-image. While real world objects (or, more generally, real world patterns) may be perceivable in the starting image, they cannot be perceived in the pseudo-image. Image recognition takes place by comparing the pseudo-image with a library of known pseudo-images, i.e., image recognition takes place in pseudo-image space without a return to real world space. In this way, robust image recognition is achieved even for imperfect real world images, such as, real world images that have been degraded by noise, poor illumination, uneven lighting, and/or occlusion, e.g., the presence of glasses, scarves, or the like in the case of facial images.
    Type: Grant
    Filed: June 26, 2019
    Date of Patent: September 14, 2021
    Assignee: Stowers Institute for Medical Research
    Inventors: Congrong (Ron) Yu, Rishabh Raj, Dar Wilbur Dahlen
  • Patent number: 10787643
    Abstract: The present invention relates to methods and kits for expanding a stem cell population. More particularly, the invention relates, inter alia, to methods, kits, and compositions for expanding a stem cell population, particularly a hematopoietic stem cell population.
    Type: Grant
    Filed: February 27, 2015
    Date of Patent: September 29, 2020
    Assignee: STOWERS INSTITUTE FOR MEDICAL RESEARCH
    Inventors: John M. Perry, Linheng Li, Justin C. Grindley
  • Publication number: 20200005023
    Abstract: This disclosure relates to the use of “pseudo-images” to perform image recognition, e.g., to perform facial image recognition. In an embodiment, the pseudo-image is obtained by starting with a real world image and, after optional preprocessing, subjecting the image to a non-linear transformation that converts the image into a pseudo-image. While real world objects (or, more generally, real world patterns) may be perceivable in the starting image, they cannot be perceived in the pseudo-image. Image recognition takes place by comparing the pseudo-image with a library of known pseudo-images, i.e., image recognition takes place in pseudo-image space without a return to real world space. In this way, robust image recognition is achieved even for imperfect real world images, such as, real world images that have been degraded by noise, poor illumination, uneven lighting, and/or occlusion, e.g., the presence of glasses, scarves, or the like in the case of facial images.
    Type: Application
    Filed: June 26, 2019
    Publication date: January 2, 2020
    Applicant: Stowers Institute for Medical Research
    Inventors: Congrong (Ron) Yu, Rishabh Raj, Dar Wilbur Dahlen
  • Patent number: 10287628
    Abstract: The present invention provides, inter alia, methods and kits for identifying where a polypeptide of interest binds in a genome. The methods include a) carrying out a chromatin immunoprecipitation coupled to exonuclease digestion (ChIP-exo) process with an antibody against the polypeptide of interest; (b) extracting a polynucleotide fragment to which the polypeptide of interest binds; (c) carrying out a library preparation protocol adapted from an individual nucleotide resolution UV cross-linking and immunoprecipitation (iCLIP) process on the ChIP-exo processed polynucleotide fragment; and (d) sequencing the resulting polynucleotides. The kits include: (a) reagents sufficient to carry out ChIP-exo; (b) reagents sufficient to carry out the library preparation protocol adapted from the iCLIP process; and (c) instructions for use.
    Type: Grant
    Filed: December 18, 2015
    Date of Patent: May 14, 2019
    Assignee: Stowers Institute for Medical Research
    Inventors: Julia Zeitlinger, Qiye He, Jeffrey Johnston
  • Patent number: 9938341
    Abstract: The present invention is directed to isolated polypeptides and antibodies suitable for producing therapeutic preparations, methods, and kits relating to bone deposition. One objective of the present invention is to provide compositions that improve bone deposition. Yet another objective of the present invention is to provide methods and compositions to be utilized in diagnosing bone dysregulation. The therapeutic compositions and methods of the present invention are related to the regulation of Wise, Sost, and closely related sequences. In particular, the nucleic acid sequences and polypeptides include Wise and Sost as well as a family of molecules that express a cysteine knot polypeptide.
    Type: Grant
    Filed: April 22, 2016
    Date of Patent: April 10, 2018
    Assignee: Stowers Institute for Medical Research
    Inventors: Robb Krumlauf, Debra Ellies
  • Patent number: 9932393
    Abstract: The present invention relates to methods and compositions for the prevention and treatment of renal damage. The invention provides protein-based renal therapeutic agents for administration to subjects in order to prevent or treat renal degeneration or damage.
    Type: Grant
    Filed: December 9, 2014
    Date of Patent: April 3, 2018
    Assignee: Stowers Institute for Medical Research
    Inventors: Robb Krumlauf, Debra Ellies
  • Patent number: 9896659
    Abstract: Methods and kits for expanding a stem cell population, particularly a hematopoietic stem cell population, in the presence of a DNA methyltransferase modulator and a Wnt pathway modulator are disclosed.
    Type: Grant
    Filed: October 17, 2012
    Date of Patent: February 20, 2018
    Assignee: STOWERS INSTITUTE FOR MEDICAL RESEARCH
    Inventors: John M Perry, Linheng Li, Aparna Venkatraman, Xi He
  • Patent number: 9771559
    Abstract: The present invention relates to methods for expanding a stem cell population. More particularly, the invention relates, inter alia, to methods and compositions for expanding a stem cell population, particularly a hematopoietic stem cell population.
    Type: Grant
    Filed: May 20, 2013
    Date of Patent: September 26, 2017
    Assignee: Stowers Institute for Medical Research
    Inventors: John M. Perry, Linheng Li, Justin C. Grindley
  • Patent number: 9334315
    Abstract: The present invention relates to a purified molecules, including antibodies, that bind specifically to murine ?-catenin phosphorylated at amino acid position Serine552 and to orthologs thereof, such as mammalian orthologs, including human orthologs. Methods of making and using such purified molecules are also provided. Kits containing such purified molecules are further provided.
    Type: Grant
    Filed: December 15, 2011
    Date of Patent: May 10, 2016
    Assignees: Stowers Institute for Medical Research, Institute For Systems Biology
    Inventors: Xi He, Tong Yin, Qiang Tian, Weiguo Tao, Leroy Hood, Linheng Li
  • Patent number: 9102750
    Abstract: The present invention provides compositions, combinations, methods, sequences and kits for use of novel fluorescent proteins derived from the genus Branchiostoma. Specifically, polynucleotide and polypeptide sequences encoding fluorescent proteins isolated from Branchiostoma floridae, including harmonized sequences, which permit enhanced expression of the encoded polypeptides in mammalian cells in vivo are provided.
    Type: Grant
    Filed: February 4, 2014
    Date of Patent: August 11, 2015
    Assignee: Stowers Institute for Medical Research
    Inventors: Arcady Mushegian, Congrong Yu, Joel Schwartz, Limei Ma
  • Patent number: 9018440
    Abstract: The present invention relates to compositions and methods useful for detecting and/or measuring, e.g., intracellular signaling in vivo. More particularly, compositions and methods are provided, which include transgenic animals, that are useful in mapping and examining, e.g., calcium fluctuations in vivo between and within populations of cells in real time. Methods for screening for candidate compounds that effect, e.g., intracellular calcium signaling are also provided.
    Type: Grant
    Filed: October 24, 2007
    Date of Patent: April 28, 2015
    Assignee: Stowers Institute for Medical Research
    Inventors: Congrong (Ron) Yu, Limei Ma
  • Publication number: 20140220629
    Abstract: The present invention provides compositions, combinations, methods, sequences and kits for use of novel fluorescent proteins derived from the genus Branchiostoma. Specifically, polynucleotide and polypeptide sequences encoding fluorescent proteins isolated from Branchiostoma floridae, including harmonized sequences, which permit enhanced expression of the encoded polypeptides in mammalian cells in vivo are provided.
    Type: Application
    Filed: February 4, 2014
    Publication date: August 7, 2014
    Applicant: STOWERS INSTITUTE FOR MEDICAL RESEARCH
    Inventors: Arcady MUSHEGIAN, Congrong (Ron) YU, Joel SCHWARTZ, Limei MA
  • Publication number: 20140127751
    Abstract: The present invention relates to nucleic acid sequences and amino acid sequences which influence bone deposition, the Wnt pathway, ocular development, tooth development, and may bind to LRP. The nucleic acid sequence and polypeptides include Wise and Sost as well as a family of molecules which express a cysteine knot polypeptide. Additionally, the present invention relates to various molecular tools derived from the nucleic acids and polypeptides including vectors, transfected host cells, monochronal antibodies, Fab fragments, and methods for impacting the pathways.
    Type: Application
    Filed: December 19, 2013
    Publication date: May 8, 2014
    Applicant: Stowers Institute for Medical Research
    Inventors: Robb KRUMLAUF, Debra ELLIES
  • Publication number: 20140127169
    Abstract: The invention relates to a method for reprogramming target cells to multipotent progenitor cells capable of differentiating into muscular, skeletal or dermal cell lines. In particular, the invention relates to an ex vivo method for preparing induced presomitic mesoderm (iPSM) cells, said method comprising the steps of: a) providing target cells to be reprogrammed, and, b) culturing said target cells under appropriate conditions for reprogramming said target cells into iPSM cells, wherein said appropriate conditions comprises increasing expression of at least one T-Box transcription factor in said target cells. The invention further relates to the use of said iPSM cells, for example, for regenerating skeletal, muscle, dermal and cartilage tissues.
    Type: Application
    Filed: January 24, 2012
    Publication date: May 8, 2014
    Applicants: UNIVERSITE DE STRASBOURG, STOWERS INSTITUTE FOR MEDICAL RESEARCH, ASSOCIATION FRANCAISE CONTRE LES MYOPATHIES
    Inventors: Olivier Pourquie, Matthias Wahl, Jerome Chal
  • Patent number: 8680235
    Abstract: The present invention provides compositions, combinations, methods, sequences and kits for use of novel fluorescent proteins derived from the genus Branchiostoma. Specifically, polynucleotide and polypeptide sequences encoding fluorescent proteins isolated from Branchiostoma floridae, including harmonized sequences, which permit enhanced expression of the encoded polypeptides in mammalian cells in vivo are provided.
    Type: Grant
    Filed: September 24, 2007
    Date of Patent: March 25, 2014
    Assignee: Stowers Institute For Medical Research
    Inventors: Arcady Mushegian, Congrong (Ron) Yu, Joel Schwartz, Limei Ma, Malcolm Cook
  • Publication number: 20140066602
    Abstract: The present invention is directed to isolated polypeptides and antibodies suitable for producing therapeutic preparations, methods, and kits relating to bone deposition. One objective of the present invention is to provide compositions that improve bone deposition. Yet another objective of the present invention is to provide methods and compositions to be utilized in diagnosing bone dysregulation. The therapeutic compositions and methods of the present invention are related to the regulation of Wise, Sost, and closely related sequences. In particular, the nucleic acid sequences and polypeptides include Wise and Sost as well as a family of molecules that express a cysteine knot polypeptide.
    Type: Application
    Filed: August 28, 2013
    Publication date: March 6, 2014
    Applicant: Stowers Institute for Medical Research
    Inventors: Robb KRUMLAUF, Debra ELLIES
  • Patent number: 8546545
    Abstract: The present invention is directed to isolated polypeptides and antibodies suitable for producing therapeutic preparations, methods, and kits relating to bone deposition. One objective of the present invention is to provide compositions that improve bone deposition. Yet another objective of the present invention is to provide methods and compositions to be utilized in diagnosing bone dysregulation. The therapeutic compositions and methods of the present invention are related to the regulation of Wise, Sost, and closely related sequences. In particular, the nucleic acid sequences and polypeptides include Wise and Sost as well as a family of molecules that express a cysteine knot polypeptide.
    Type: Grant
    Filed: March 22, 2012
    Date of Patent: October 1, 2013
    Assignee: Stowers Institute for Medical Research
    Inventors: Robb Krumlauf, Debra Ellies