Patents Assigned to Surmodics, Inc.
  • Publication number: 20150165035
    Abstract: The present invention relates to a pharmaceutical composition for intravascular delivery of a therapeutic agent, such as paclitaxel, rapamycin, or an analog thereof. The composition includes the therapeutic agent and a biocompatible solvent, such as glycofurol. The composition can aid tissue penetration by the therapeutic agent. A catheter assembly that protects the pharmaceutical composition from the surroundings can be used for its intravascular delivery.
    Type: Application
    Filed: February 4, 2015
    Publication date: June 18, 2015
    Applicant: Surmodics, Inc.
    Inventor: Ralph A. Chappa
  • Patent number: 8999377
    Abstract: Biocompatible foams having excellent physical and chemical properties are described. The biocompatible foams can be formed in situ or applied as a pre-formed foam for the treatment of tissue. The invention provides biocompatible degradable foams formed with a poly-?(1?4)glucopyranose macromer. The invention also provides biostable foams formed with a poly(alkylene oxide) macromer.
    Type: Grant
    Filed: September 19, 2008
    Date of Patent: April 7, 2015
    Assignee: Surmodics, Inc.
    Inventors: Emily R. Rolfes, Pamela J. Reed
  • Patent number: 8974808
    Abstract: Described herein are implantable composites, kits comprising the composites, implant devices comprising the composites, and methods of making and using same, including point of use methods.
    Type: Grant
    Filed: December 21, 2009
    Date of Patent: March 10, 2015
    Assignee: SurModics, Inc.
    Inventors: Arthur J. Tipton, Kevin W. Burton
  • Patent number: 8968782
    Abstract: The present invention relates to relates to combination degradable and non-degradable matrices and related methods. In an embodiment, the invention includes an active agent delivery matrix including a degradable polymer network, a non-degradable polymer network, the non-degradable polymer network interspersed within the degradable polymer network, and an active agent. In an embodiment, the invention includes an active agent elution control matrix including a degradable polymer; and a non-degradable polymer interspersed with the degradable polymer. In an embodiment, the invention includes a method of making an active agent delivery matrix including mixing a degradable polymer with a first solvent to form a degradable polymer solution; mixing a non-degradable polymer with a second solvent to form a non-degradable polymer solution; and simultaneously depositing the degradable polymer solution and the non-degradable polymer solution onto a substrate.
    Type: Grant
    Filed: June 28, 2007
    Date of Patent: March 3, 2015
    Assignee: SurModics, Inc.
    Inventors: Ralph A. Chappa, Robert W. Hergenrother, Paula Bushendorf, Joram Slager
  • Patent number: 8961457
    Abstract: A catheter assembly includes an expandable and collapsible structure having an outer surface. The expandable and collapsible structure is adapted to expand between a contracted state and a dilated state. A guard is bonded to the outer surface of the expandable and collapsible structure. The guard and the expandable and collapsible structure cooperatively define a plurality of reservoirs. A coating disposed in the reservoirs. The coating includes a bioactive agent. The coating protrudes from the reservoirs when the expandable and collapsible structure is expanded to the dilated state.
    Type: Grant
    Filed: September 29, 2011
    Date of Patent: February 24, 2015
    Assignee: Surmodics, Inc.
    Inventor: Ralph A. Chappa
  • Patent number: 8956682
    Abstract: The invention is directed to medical device coatings, such as coated guidewires and catheters, containing a visualization moiety providing color to the coating in ambient or applied light. The coating allows for visual or machine inspection of coating properties such as uniformity of coverage. In some embodiments the coatings include the visualization moiety and an activated UV photogroup, which is used to provide covalent bonding in the coating. The visualization moiety can be in particulate form and entrained in the coating, or can be covalently bonded to the hydrophilic polymer backbone. In other embodiments the visualization moiety includes a stilbene chemical group. Exemplary coatings include a hydrophilic vinyl pyrrolidone polymer, which can provide lubricity to the device surface, along with the colored properties.
    Type: Grant
    Filed: April 2, 2013
    Date of Patent: February 17, 2015
    Assignee: Surmodics, Inc.
    Inventors: Nathan A. Lockwood, Bruce M. Jelle, Aleksey V. Kurdyumov
  • Patent number: 8951545
    Abstract: The present invention provides insertable medical devices having elastic surfaces associated with bioactive agent-containing microparticulates and a coating material. Upon expansion of the elastic surfaces the microparticulates can be released to a subject.
    Type: Grant
    Filed: March 27, 2009
    Date of Patent: February 10, 2015
    Assignee: Surmodics, Inc.
    Inventors: James Howard Arps, Andrew G. Bach
  • Patent number: 8936811
    Abstract: Embodiments of the invention include particles with nucleic acid complexes, medical devices including the same and related methods. In an embodiment, the invention can include a method of making a medical device. The method can include contacting nucleic acids with cationic carrier agents to form nucleic acid complexes, adsorbing the nucleic acid complexes to porous particles to form nucleic acid complex containing particles, mixing the nucleic acid complex containing particles with a polymer solution to form a coating mixture, and applying the coating mixture to a substrate. In an embodiment, the method can include contacting nucleic acids with cationic carrier agents to form nucleic acid complexes, combining the nucleic acid complexes with a material to form nucleic acid complex containing particles in situ, mixing the nucleic acid complex particles with a polymer solution to form a coating mixture, and applying the coating mixture to a substrate.
    Type: Grant
    Filed: May 7, 2009
    Date of Patent: January 20, 2015
    Assignee: SurModics, Inc.
    Inventors: Joram Slager, Joseph Schmidt McGonigle
  • Patent number: 8932694
    Abstract: The invention provides fluorinated polymeric articles formed a composition including a fluoropolymer. The fluoropolymer is formed using a fluorinated monomer that provides the fluoropolymer with most or all of the fluorine atoms not directly covalently attached to an atom of the fluoropolymer backbone. The fluoropolymer can also include a non-fluorinated hydrophilic monomer in a weight amount greater than the fluorinated monomer. The fluoropolymer composition also includes an ultraviolet light (UV)-reactive group capable of covalent bonding to promotes formation of the fluorinated polymeric article. The fluorinated polymeric article can be in the form of a durable lubricious coating on the surface of an implantable medical device. Coatings of the invention exhibit excellent wet/dry lubricity, durability, and controlled swelling.
    Type: Grant
    Filed: June 29, 2011
    Date of Patent: January 13, 2015
    Assignee: Surmodics, Inc.
    Inventor: Emily R. Rolfes Meyering
  • Patent number: 8932616
    Abstract: Hydrophobic ?(1?4)glucopyranose polymers with enhanced degradation properties are described. Between the ?(1?4)glucopyranose polymeric portion and the hydrophobic portion exists a linker portion having a silyl ether chemistry that facilitates degradation of the polymer. Biodegradable matrices can be formed from these polymers, and the matrices can be used for the preparation of implantable and injectable medical devices wherein the matrix is capable of degrading in vivo at an increased rate. Matrices including and capable of releasing a bioactive agent in vivo are also described.
    Type: Grant
    Filed: September 30, 2010
    Date of Patent: January 13, 2015
    Assignee: Surmodics, Inc.
    Inventor: Aleksey V. Kurdyumov
  • Patent number: 8927226
    Abstract: The invention provides compositions, kits, and methods for performing colorimetric analysis. A substrate is reacted to generate a chromogenic reaction product, and a reaction stop reagent that is a sulfonic acid is added to stop and stabilize the reaction product. The absorbance properties of the chromogenic reaction product can be maintained over significantly longer periods of time of that of conventional reagents and methods. The sulfonic acid can be used in assays such as ELISAs in order to provide a more accurate and safer detection of analytes in a biological sample.
    Type: Grant
    Filed: April 30, 2014
    Date of Patent: January 6, 2015
    Assignee: SurModics, Inc.
    Inventors: Gary Opperman, Wendy Nelson
  • Patent number: 8927000
    Abstract: The present invention relates compositions for delivering therapeutic agents from a medical device including an expandable and collapsible structure and methods employing them. A lipid coating including one or more fatty acids increases the amount of therapeutic agent released from the device at the delivery site. The therapeutic agent can be in a matrix including a hydrophilic polymer or an amphiphilic polymer. Release and adhesion coatings can also facilitate delivery of therapeutic agent.
    Type: Grant
    Filed: June 30, 2011
    Date of Patent: January 6, 2015
    Assignee: SurModics, Inc.
    Inventors: Ralph A. Chappa, Emily R. Rolfes Meyering
  • Patent number: 8901092
    Abstract: Embodiments of the invention include functionalized polysaccharides and compositions and structures including the same. In an embodiment, the invention includes an active agent delivery composition including a polysaccharide functionalized with a coupling group, wherein the polysaccharide lacks charged groups at a pH of between 6 and 8; and a complex comprising a nucleic acid and a transfection agent. In an embodiment, the invention includes an active agent delivery structure including a matrix comprising a polysaccharide covalently cross-linked through the residue of a coupling group on the polysaccharide, the polysaccharide lacking charged groups at a pH of between 6 and 8; and a nucleic acid delivery complex disposed within the active agent delivery structure. In an embodiment, the invention includes a material for medical applications including glycogen functionalized with coupling groups at a degree of substitution of between about 0.01 and 0.5. Other embodiments are also included herein.
    Type: Grant
    Filed: December 22, 2011
    Date of Patent: December 2, 2014
    Assignee: SurModics, Inc.
    Inventor: Joram Slager
  • Patent number: 8889760
    Abstract: Described herein is a degradable linking agent of formula Photo1-LG-Photo2, wherein Photo1 and Photo2 independently represent at least one photoreactive group and LG represents a linking group comprising one or more silicon atoms or one or more phosphorous atoms. The degradable linking agent includes a covalent linkage between at least one photoreactive group and the linking group, wherein the covalent linkage between at least one photoreactive group and the linking group is interrupted by at least one heteroatom. A method for coating a support surface with the degradable linking agent, coated support surfaces and medical devices are also described.
    Type: Grant
    Filed: March 29, 2011
    Date of Patent: November 18, 2014
    Assignee: SurModics, Inc.
    Inventors: Aleksey V. Kurdyumov, Dale G. Swan
  • Publication number: 20140336571
    Abstract: Disclosed herein is a delivery composition for administering a hydrophobic active agent. In one embodiment, a delivery composition for local administration of a hydrophobic active agent to a tissue or organ of a patient is disclosed. In one embodiment, the delivery composition includes a cationic delivery agent, a therapeutically effective amount of a hydrophobic active agent and a pharmaceutically acceptable aqueous carrier. In one embodiment, the cationic delivery agent includes polyethyleneimine (PEI). In an embodiment, the invention includes a drug delivery device including a substrate; and coated therapeutic agent particles disposed on the substrate, the coated therapeutic agent particles comprising a particulate hydrophobic therapeutic agent; and a vinyl amine polymer. Methods of making the delivery composition, as well as kits and methods of use are also included herein.
    Type: Application
    Filed: May 16, 2014
    Publication date: November 13, 2014
    Applicant: SurModics, Inc.
    Inventors: Joram Slager, Dale G. Swan, Darin DuMez, Joseph Ventura, Shannon Wadman, Joseph Schmidt McGonigle, Robert W. Hergenrother
  • Patent number: 8883208
    Abstract: Embodiments of the invention include devices and methods for the release of nucleic acid complexes. In an embodiment the invention includes a nucleic acid delivery particle. The delivery particle can include a polymeric matrix including a polyethyleneglycol containing copolymer and a nucleic acid complex disposed within the polymeric matrix. The nucleic acid complex can include a nucleic acid and a carrier agent. In an embodiment the invention includes a medical device including a first polymeric matrix comprising a first polymer and a plurality of nucleic acid delivery particles disposed within the first polymeric matrix. The medical device can be configured to release the nucleic acid complex when the medical device is implanted within a subject. Other embodiments are included herein.
    Type: Grant
    Filed: April 8, 2010
    Date of Patent: November 11, 2014
    Assignee: SurModics, Inc.
    Inventors: Joseph Schmidt McGonigle, Joram Slager
  • Publication number: 20140328998
    Abstract: Embodiments of the invention include apparatus and methods for coating drug eluting medical devices. In an embodiment, the invention includes a coating apparatus including a coating application unit comprising a movement restriction structure; a fluid applicator; and an air nozzle. The apparatus can further include a rotation mechanism and an axial motion mechanism, the axial motion mechanism configured to cause movement of at least one of the coating application unit and the rotation mechanism with respect to one another. Other embodiments are also included herein.
    Type: Application
    Filed: May 7, 2014
    Publication date: November 6, 2014
    Applicant: SurModics, Inc.
    Inventors: Ralph A. Chappa, Andrew G. Bach, Mark MacGregor
  • Patent number: 8871819
    Abstract: Embodiments of the invention include glycerol esters and use of the same for active agent delivery systems and methods. In an embodiment, the invention includes an active agent eluting device including a glycerol ester, an active agent dispersed within the glycerol ester, the active agent eluting device configured to elute the active agent from the glycerol ester in response to degradation of the glycerol ester. In an embodiment, the invention includes a composition including a glycerol ester; an active agent dispersed within the glycerol ester; the active agent eluting device configured to elute the active agent from the glycerol ester in response to degradation of the glycerol ester. Other embodiments are also included herein.
    Type: Grant
    Filed: May 10, 2011
    Date of Patent: October 28, 2014
    Assignee: SurModics, Inc.
    Inventors: Emily R. R. Meyering, Stephen J. Chudzik
  • Publication number: 20140234874
    Abstract: The invention provides compositions, kits, and methods for performing colorimetric analysis. A substrate is reacted to generate a chromogenic reaction product, and a reaction stop reagent that is a sulfonic acid is added to stop and stabilize the reaction product. The absorbance properties of the chromogenic reaction product can be maintained over significantly longer periods of time of that of conventional reagents and methods. The sulfonic acid can be used in assays such as ELISAs in order to provide a more accurate and safer detection of analytes in a biological sample.
    Type: Application
    Filed: April 30, 2014
    Publication date: August 21, 2014
    Applicant: SurModics, Inc.
    Inventors: Gary Opperman, Wendy Nelson
  • Patent number: 8802121
    Abstract: Silane-functionalized hydrophobic ?(1?4)glucopyranose polymers and polymeric matrices are described. Biodegradable matrices can be formed from hydrophobic ?(1?4)glucopyranose polymers with reactive pendent silyl ether groups. Reaction of the silyl ether groups provides improved matrix formation through bonding to a device surface of a device, polymer-polymer crosslinking, or both. Biodegradable matrices can be used for the preparation of implantable and injectable medical devices, including those that release a bioactive agent.
    Type: Grant
    Filed: June 2, 2010
    Date of Patent: August 12, 2014
    Assignee: Surmodics, Inc.
    Inventors: Aleksey V. Kurdyumov, Nathan A. Lockwood, Joram Slager, Dale G. Swan, Robert Hergenrother