Abstract: An infection resistant mat having individual segments containing foam padding and a contiguous cover of impervious material. The cover is constructed by radio frequency (RF) sealing of the seams which eliminates portals of entry of infectious organisms, vermin or fluid. Air channels within the cover communicate between the segments to allow air pressure equalization among the several segments during use. The contiguous cover creates hinges between the segments that allow the mat to be folded for storage. The mat also can be constructed with only one padded section.