Patents Assigned to Taipei Medical University
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Patent number: 11504406Abstract: A probiotic combination for inhibition of vancomycin-resistant enterococci includes Bacillus coagulans, Lactobacillus rhamnosus CG, Lactobacillus reuteri, and Lactobacillus acidophilus. The probiotic combination can inhibit growth, host cell attachment, or virulence of vancomycin-resistant enterococci, and also can inhibit virulence gene expression of vancomycin-resistant enterococci. The virulence gene includes at least one of asa1, acm, ebpA, ebpB, ebpC, efaA, sagA, esp, sgrA, and scm genes.Type: GrantFiled: March 13, 2020Date of Patent: November 22, 2022Assignees: DELTA ELECTRONICS, INC., TAIPEI MEDICAL UNIVERSITYInventors: Shiuh-Bin Fang, Kun-Nan Tsai, Wei-Sheng Sun, Yu-Hsuan Ho, Yuarn-Jang Lee
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Patent number: 11505523Abstract: Provided herein, inter alia, are compound and methods of treating cancer by inhibiting HDAC8.Type: GrantFiled: May 7, 2019Date of Patent: November 22, 2022Assignees: CITY OF HOPE, TAIPEI MEDICAL UNIVERSITY, ACADEMIA SINICAInventors: Ya-Huei Kuo, Wei-Jan Huang, Chung-I Chang
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Patent number: 11485776Abstract: The invention provides anti-CaENO1 antibodies and humanized antibodies as effective diagnostic agent or therapeutic treatment against infections caused by Candida spp. (preferably Candida. albicans, Candida tropicalis), fluconazole resistance Candida spp., Streptococcus, or Staphylococcus.Type: GrantFiled: July 23, 2020Date of Patent: November 1, 2022Assignee: TAIPEI MEDICAL UNIVERSITYInventors: Sy-Jye Leu, Yi-Yuan Yang, Yu-Ching Lee, Ching-Hua Su, Ko-Jiunn Liu, Hsiu-Jung Lo, Yun-Liang Yang
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Patent number: 11479528Abstract: This disclosure is related to aromatic compounds of formula (I), and methods of their use in treating medical conditions associated with Heat Shock Protein-90 (HSP90), e.g., cancer. Compounds of formula (I) have the following structure: Also disclosed are pharmaceutical compositions comprising compounds of formula (I).Type: GrantFiled: March 20, 2018Date of Patent: October 25, 2022Assignee: TAIPEI MEDICAL UNIVERSITYInventors: Jing-ping Liou, Che-ming Teng, Shiow-lin Pan
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Patent number: 11427935Abstract: A passive intermittent rotating assembly can automatically adjust a part of a cleaning material when the cleaning material cleans a spinning jet each time and that can stably operate in a high-voltage environment. The passive intermittent rotating assembly includes a plurality of first abutment members and second abutment members being arranged respectively at an inner side and outer side of the main wheel along the circumferential direction, and being separated from each other to form gaps for a push portion of a push member to pass through. Each of the first abutment members includes a first inner-side abutment portion and a first outer-side abutment portion provided for abutting against the push portion. Each of the second abutment members includes a second inner-side abutment portion and a second outer-side abutment portion provided for abutting against the push portion.Type: GrantFiled: March 12, 2021Date of Patent: August 30, 2022Assignee: TAIPEI MEDICAL UNIVERSITYInventor: How Tseng
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Patent number: 11426346Abstract: A lutein-containing ophthalmic composition, wherein the ophthalmic composition is mainly consisting of a natural anti-inflammatory substance, a substance with increasing liquid viscosity, and an artificial tear. The substance with increasing liquid viscosity could apply the ophthalmic composition to elongate the retention time on the ocular surface, thereby increasing the retention time of anti-inflammatory substance on the ocular surface for treating dry eye syndrome and inhibiting ocular surface inflammation.Type: GrantFiled: October 13, 2019Date of Patent: August 30, 2022Assignee: TAIPEI MEDICAL UNIVERSITYInventors: Ching-Li Tseng, I-Chan Lin, Yi-Zhou Chen, Yu-Lun Chuang, Cheng-Han Tsai, Zhi-Yu Chen
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Patent number: 11427544Abstract: Disclosed is hydroxamic acid compounds of Formula (I) set forth herein. Also disclosed are a pharmaceutical composition containing such a compound and a method of using the compound for treating a condition associated with histone deacetylase 6.Type: GrantFiled: May 16, 2017Date of Patent: August 30, 2022Assignees: TAIPEI MEDICAL UNIVERSITY, NATIONAL TAIWAN UNIVERSITYInventors: Che-Ming Teng, Jing-Ping Liou, Shiow-Lin Pan, Chia-Ron Yang
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Publication number: 20220251043Abstract: Disclosed herein are hydroxamic acid compounds. Also disclosed is a method of using the hydroxamic acid compounds for treating a condition associated with histone deacetylase 6.Type: ApplicationFiled: July 22, 2020Publication date: August 11, 2022Applicant: Taipei Medical UniversityInventors: Shiow-Lin PAN, Chia-Ron YANG, Han-Li HUANG, Huang-Ju TU, Jing-Ping LIOU
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Publication number: 20220192594Abstract: A device includes an angiography module, a phototherapy module, a carrier including an optical filter and accommodating the angiography module and the phototherapy module, and a control unit controlling operation of the angiography module and the phototherapy module. The angiography module includes infrared LEDs emitting infrared light through the optical filter to irradiate a limb of a subject, and an infrared sensor sensing a part of the infrared light reflected off the limb to generate a result, based on which the control unit generates an angiogram. The phototherapy module emits infrared light through the optical filter to irradiate the limb for phototherapy.Type: ApplicationFiled: April 15, 2021Publication date: June 23, 2022Applicant: Taipei Medical UniversityInventor: Jian-Chiun Liou
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Patent number: 11365200Abstract: The invention relates to compounds for treating and/or preventing obesity and obesity-related disorders. Particularly, the invention provides chromanone derivatives used as ATF3 inducer and for treating and/or preventing obesity and obesity-related disorders such as heart disease, hypertension, hyperlipidemia and diabetes.Type: GrantFiled: March 22, 2018Date of Patent: June 21, 2022Assignees: TAIPEI MEDICAL UNIVERSITY, NATIONAL RESEARCH INSTITUTE OF CHINESE MEDICINE, MINISTRY OF HEALTH AND WELFARE, ACADEMIA SINICA, BUDDHIST TZU CHI MEDICAL FOUNDATIONInventors: Heng Lin, Ming-jaw Don, Ching-feng Cheng, Jing-jy Cheng, Wen-shan Li, Hui-chen Ku, Hsiao-fen Li, Hsi-hsien Chen, W J Huang
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Patent number: 11351400Abstract: A biological object image-capturing and treatment system includes a micro detection and treatment device. The micro detection and treatment device includes a plurality of signal transmitting and receiving elements arranged as an array, wherein adjacent at least two signal transmitting and receiving elements transmit signals or receive signals during different periods. When performing an image-capturing procedure, at least one signal transmitting and receiving element transmits a first power signal and, when performing a treatment procedure, at least one signal transmitting and receiving element transmits a second power signal, wherein a power of the first power signal is different from a power of the second power signal.Type: GrantFiled: June 16, 2020Date of Patent: June 7, 2022Assignee: TAIPEI MEDICAL UNIVERSITYInventor: Jian-Chiun Liou
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Patent number: 11320427Abstract: The invention provides a tandemly repeated protein comprising at least two repeats of an amino acid sequence of an antibody binding protein or a fragment thereof and a cell having the repeats expressed on the membrane thereof, which can be used in immunoassay to improve detection sensitivity and detection limit.Type: GrantFiled: July 13, 2017Date of Patent: May 3, 2022Assignee: TAIPEI MEDICAL UNIVERSITYInventors: Kuo-Hsiang Chuang, Yi-Jou Chen, Michael Chen
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Publication number: 20220122246Abstract: The present disclosure provides an operating method of a dopamine transporter check system, and the operation method includes steps as follows. A scan image of a subject's brain is obtained from a scan machine, and the scan image is a three-dimensional image. The scan image is aligned to a standard brain space to obtain a standardized scan image. Intensity normalization is performed on the standardized scan image. The standardized scan image after the intensity normalization is converted into a two-dimensional image. A plurality of image data are got from at least one region of interest in the two-dimensional image, and the at least one region of interest includes a left caudate, a left putamen, a right caudate and a right putamen. A dopamine neuron loss degree measurement and evaluation model based on the image data is established through a transfer learning.Type: ApplicationFiled: December 9, 2020Publication date: April 21, 2022Applicant: Taipei Medical University (TMU)Inventors: Syu-Jyun Peng, Hsin-Yung Chen, Ya-Ju Tsai
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Patent number: 11278523Abstract: The invention relates to the use of Indoline derivatives, and their effective dose in the prevention and/or treatment of fibrosis diseases. The compound can effectively prevent and/or treat a fibrosis disease without cytotoxicity or genotoxicity.Type: GrantFiled: October 27, 2015Date of Patent: March 22, 2022Assignee: Taipei Medical UniversityInventors: Chien Huang Lin, Jing-Ping Liou, Shiow-Lin Pan, Che-Ming Teng
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Patent number: 11282197Abstract: The present disclosure provides an operating method of a system for analyzing brain tissue based on computerized tomographic imaging, and the operation method includes steps as follows. A computed tomography image of a subject is aligned to a predetermined standard brain space image, to obtain a first normalized test computed tomography image. A voxel contrast of the first normalized test computed tomography image is enhanced to obtain an enhanced first normalized test computed tomography image. The enhanced first normalized test computed tomography image is aligned to an average computed tomographic image of a control group to obtain a second normalized test computed tomography image. An analysis based on the second normalized test computed tomography image and a plurality of computerized tomographic images of the control group is performed to obtain a t-score map.Type: GrantFiled: July 14, 2020Date of Patent: March 22, 2022Assignees: National Central University, Taipei Medical University (TMU)Inventors: Syu-Jyun Peng, Yu-Wei Chen, Jing-Yu Yang, Jang-Zern Tsai, Kuo-Wei Wang, Yeh-Lin Kuo
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Patent number: 11246499Abstract: A far-infrared emitters with physiological signal detection and method of operating the same is disclosed. A far-infrared beam module is switched on and generates far-infrared beam irradiating to a human body when a control unit starting up a microwave detecting module detecting physiological signal of the human body. The control unit is switched off when the time that the far-infrared beam irradiating on the human body reach a presetting period of time, thereby achieving the purpose of energy conservation.Type: GrantFiled: November 12, 2019Date of Patent: February 15, 2022Assignees: NATIONAL TAIWAN UNIVERSITY OF SCIENCE AND TECHNOLOGY, TAIPEI MEDICAL UNIVERSITYInventors: San-Liang Lee, Chao-Hsiung Tseng, Ling-Hsiu Hung, Yung-Ho Hsu, Cheng-Hsien Chen
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Patent number: 11238591Abstract: A medical image processing system includes a memory and a processor coupled to each other. The processor accesses and executes instructions which memory stores to perform the following: obtaining a plurality of brain MR images corresponding to a subject, wherein the brain MR images corresponds to a subject brain space; accessing a DBS targets atlas corresponding to a specific stimulation area; transforming the DBS targets atlas from a MNI brain space to the subject brain space based on a DARTEL algorithm; marking at least one coordinate having a largest Voxel value in the brain MR images based on the transformed DBS targets atlas; and storing the brain MR images being targeted with the at least one coordinate into a predetermined format corresponding to a guiding device so that the guiding device displays the brain MR images being targeted with the at least one coordinate for guidance in DBS procedure.Type: GrantFiled: July 15, 2020Date of Patent: February 1, 2022Assignees: Taipei Medical University (TMU), Kaohsiung Chang Gung Memorial HospitalInventors: Syu-Jyun Peng, Fu-Yuan Shih
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Patent number: 11229375Abstract: The invention relates to a method for determining ischemic status. The method comprises acquiring magnetic resonance diffusion tensor matrices and obtaining a relative decrease of diffusion magnitude due to the ischemic status from the magnetic resonance diffusion tensor matrices. The invention also relates to a method for assessing stroke onset time. The method comprises acquiring magnetic resonance diffusion tensor matrices and obtaining a relative decrease of pure anisotropy due to stroke from the magnetic resonance diffusion tensor matrices.Type: GrantFiled: July 28, 2017Date of Patent: January 25, 2022Assignee: Taipei Medical UniversityInventors: Cheng-Yu Chen, Hsiao-Wen Chung, Duen-Pang Kuo, Chia-Feng Lu, Yu-Chieh Jill Kao
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Patent number: 11220734Abstract: A magnesium-based bulk metallic glass composite includes a magnesium-based bulk metallic glass composite comprising a magnesium-based material and a TiZr alloy.Type: GrantFiled: May 15, 2019Date of Patent: January 11, 2022Assignees: NATIONAL CENTRAL UNIVERSITY, TAIPEI MEDICAL UNIVERSITYInventors: Chih-Hwa Chen, Shian-Ching Jang, Hsiang-Ho Chen, Lau-Yuen Woo, Erh-Yuan Chuang
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Patent number: 11185386Abstract: A smart marking system for a surgical video and a method thereof are disclosed. The image recognition is performed for each surgical video to generate object information corresponding to each surgical video. The object information is used as feature data of the surgical video corresponding thereto. After a video to be analyzed is loaded, eigenvalue analysis and statistics are performed according to the video to be analyzed and all the feature data to calculate a similarity rate between the video to be analyzed and each surgical video. A surgical name corresponding to the surgical video with the highest similarity rate is selected to mark as a surgical name corresponding to the video to be analyzed. The video to be analyzed and the surgical name corresponding thereto are stored in a database as the surgical video. Thus, the efficiency of marking the surgical videos is improved.Type: GrantFiled: August 22, 2019Date of Patent: November 30, 2021Assignee: Taipei Medical UniversityInventors: Wei Min Liu, Yu Chieh Lee, Yi Ta Shen