Abstract: The objective of the present invention is to provide a collagen material that possesses physical properties to an extent that allows suturing while still maintaining the biochemical properties inherently possessed by collagen, and retains its shape for a certain amount of time even after application to the body; its production process; and, a medical material on which it is based, examples of which include a artificial tube for nerve, artificial tube for spinal cord, artificial esophagus, artificial trachea, artificial blood vessel, artificial valve or alternative medical membranes such as artificial endocranium, artificial ligaments, artificial tendons, surgical sutures, surgical prostheses, surgical reinforcement, wound protecting materials, artificial skin and artificial cornea, characterized by filling or having inside a substance having biocompatibility that can be degraded and absorbed in the body into a matrix of a non-woven fabric-like multi-element structure of collagen fibers having ultra-fine fiber

Abstract: An artificial tube for a nerve is disclosed that has a controlled rate of decomposition in the body such that the tube remains in the body until the nerve regenerates, which induces axons regenerated from severed nerve stumps to extend in the proper direction without pressing on the regenerated nerve following nerve regeneration and causes rapid restoration of blood flow by promoting infiltration of blood capillaries from the body to promote regeneration of the nerve, and which comprises a tube (10) or (20) having a coating layer (13) or (23) that is composed of gelatin or collagen on at least the outer surface of tube (11) or (21) that is composed of a material that is biodegradable and absorbable in vivo, wherein a pre-thermal dehydration crosslinking treated collagen fiber bundle (referring to a bundle fibers (31) composed of collagen) is inserted in its lumen along the axis of the tube (10) or (20), and wherein the fibers composed of collagen are coated with laminin.

Abstract: The present invention has an object to provide an artificial trachea that is able to be used safely in the clinical application, and especially an artificial trachea for the intrathoracic trachea, and the artificial trachea comprises a polypropylene mesh tube for the base material, around the outer periphery of which a polypropylene filamentous stent is wound in a spiral shape, an amorphous collagen thin layer formed on the surface of the base material, and a fine fibrous collagen layer (20) formed on the inner and outer surface of the amorphous collagen thin layer, to which thermal dehydration crosslinking is performed.

Abstract: The present invention relates to a collagen material comprising a laminate in which a collagen ultra-fine fibrous non-woven fabric-like multi-layer structure is sandwiched between non-fibrous collagen layers, a thread-like material containing said collagen material, their production processes, and a medical material containing said collagen material, and particularly a medical alternative membrane comprised of said medical material.

Abstract: The present invention relates to a collagen gel, its production process, a medical material in which it is used or a kit for its production, wherein said collagen gel is obtained by crosslinking collagen with polyanion and carbodiimide.

Abstract: The present invention relates to a collagen material comprising a laminate in which a collagen ultra-fine fibrous non-woven fabric-like multi-layer structure is sandwiched between non-fibrous collagen layers, a thread-like material containing said collagen material, their production processes, and a medical material containing said collagen material, and particularly a medical alternative membrane comprised of said medical material.

Abstract: The object of the present invention is to provide an artificial tooth and its production method that is not required to be joined directly to the mandibula or the maxilla, and an artificial tooth and its production method that allows both homoplastic and heteroplastic transplantation. The artificial tooth of the present invention has a layer in which extracted collagen is filled into the root canal of a homoplastic or heteroplastic permanent tooth from which cellular components of periodontal ligament, nerve and blood vessel have been removed, and an extracted collagen membrane on the surface of the root having on top of it a periodontal ligament from which said cellular components have been removed.

Abstract: Disclosed is an artificial esophagus suitable for human use that includes a fine fibrous collagen layer and a tubular outer surface. The invention generally provides a degradable artificial structure that helps maintain an existing esophagus or form a new esophagus. The invention has many important uses including improving esophageal reconstruction techniques.

Abstract: The present invention provides an artificial blood vessel provided with collagen layer composed of ultra-fine fibers on at least the outside of a tube composed of a supporting framework material, and a method for producing the same. The present invention offers advantages such that its materials are easily acquired, it causes very little rejection after being transplanted into the body, it allows sutures to be maintained for a long time after transplant, and all or a portion is absorbed and degraded in the body after a predetermined period of time.

Abstract: The present invention offers an artificial tube for nerve which can remain in the body until the nerve regenerates while does not remain as a foreign body in the body following nerve regeneration, and which induces axons regenerated from severed nerve stumps, can promote infiltration of blood capillaries from the body and regeneration of nerve tissue. The present invention comprises a tube 10 or 20 having coating layers 12, 13 or 22, 23 composed of gelatin or collagen on the inner and outer surfaces of a tube 11 or 21 composed of a material being biodegradable and absorbable in vivo, and a collagen body 30 or 40 having cavities 32, 33 or 41 which pass through said tube so as to be substantially parallel to the axis of said tube; wherein, said cavities are filled with a matrix gel.