Patents Assigned to TDELTAS LIMITED
  • Patent number: 10821062
    Abstract: A method of protecting animal tissue particularly skin, from damage caused by radiation exposure, by contacting the tissue with a ketone ester, a method of protecting skin, reducing the deterioration of skin or maintaining or improving the properties of skin by applying topically to the skin a ketone body comprising (R)-3-hydroxybutyrate moieties is disclosed. A ketone body comprising (R)-3-hydroxybutyrate moieties, especially enantiomerically enriched R-1,3-hydroxybutyl-(R)-3-hydroxybutyrate, for such uses is also provided.
    Type: Grant
    Filed: September 16, 2013
    Date of Patent: November 3, 2020
    Assignees: TDELTAS LIMITED, GOVERNMENT OF THE USA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICE
    Inventors: Kieran Clarke, Richard Lewis Veech
  • Patent number: 10660958
    Abstract: An organoleptically acceptable composition containing a ketone body or a ketone body precursor including a hydroxybutyrate ester and a flavouring is provided and gives improved palatability and user adherence to the intended dose regime. The flavouring may be a bitter flavouring and the composition may further contain an adsorbent for the ketone such that on ingestion, the bitterness of the composition may be masked. The composition may be in the form of a solid, gel or liquid and provides increased blood ketone levels and may be used in therapy or in treating muscle impairment or fatigue.
    Type: Grant
    Filed: February 22, 2011
    Date of Patent: May 26, 2020
    Assignee: TDELTAS LIMITED
    Inventor: Kieran Clarke
  • Patent number: 10478415
    Abstract: Described herein is the surprising discovery that ketone bodies protect cell and tissues from ionizing radiation. Based on this finding, methods of protecting animal tissue and cells from damage caused by radiation exposure are disclosed which include, contacting the tissue with a therapeutically effective amount of an agent including at least one ketone ester, thereby protecting the tissue from radiation damage. Ketone esters can be used to minimize, reduce and/or prevent tissue damage following intentional and accidental radiation exposure, as well as increasing the therapeutic efficacy of radiation therapies by protecting non-target tissue from incidental radiation damage.
    Type: Grant
    Filed: January 11, 2017
    Date of Patent: November 19, 2019
    Assignees: TDELTAS LIMITED, THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES
    Inventors: Richard Lewis Veech, Kieran Clarke
  • Publication number: 20150164855
    Abstract: Ketone bodies and ketone body esters maintain or improve muscle power output upon oral administration. Certain esters of hydroxybutyrate monomers are organoleptically acceptable and have high levels of uptake from the gut to the blood thereby allowing a rapid increase of blood concentration of hydroxybutyrate and beneficial physiological response including improved power output during exercise. Compositions containing the ketone bodies or ketone body esters are also described.
    Type: Application
    Filed: April 5, 2013
    Publication date: June 18, 2015
    Applicant: TDELTAS LIMITED
    Inventors: Kieran Clarke, Peter Cox
  • Publication number: 20150065571
    Abstract: Use of a ketone body and a ketone body ester for preserving glycogen and/or protein, thereby reducing muscle breakdown and improving endurance during exercise and promoting muscle recovery following exercise. Also for retarding muscle wasting in aging and disease. (R)-3-hydroxybutyl (R)-3-hydroxybutyrate for use in reducing muscle glycogen and protein breakdown during exercise or decreasing muscle wasting in aging and disease. Certain esters of hydroxybutyrate monomers, particularly a monoester of D-?-hydroxybutyrate with R-1,3-butanediol or with glycerol to reduce muscle breakdown and aid muscle recovery after exercise or retard muscle wasting. Compositions containing the ketone bodies or ketone body esters are also described.
    Type: Application
    Filed: August 7, 2014
    Publication date: March 5, 2015
    Applicant: TDELTAS LIMITED
    Inventors: Kieran Clarke, Peter Cox
  • Publication number: 20130102663
    Abstract: An organoleptically acceptable composition containing a ketone body or a ketone body precursor including a hydroxybutyrate ester and a flavouring is provided and gives improved palatability and user adherence to the intended dose regime. The flavouring may be a bitter flavouring and the composition may further contain an adsorbent for the ketone such that on ingestion, the bitterness of the composition may be masked. The composition may be in the form of a solid, gel or liquid and provides increased blood ketone levels and may be used in therapy or in treating muscle impairment or fatigue.
    Type: Application
    Filed: February 22, 2011
    Publication date: April 25, 2013
    Applicant: TDELTAS LIMITED
    Inventor: Kieran Clarke