Abstract: The invention relates to recombinant antibodies which bind to prostate-specific stem cell antigen (PSCA). The antibody of the invention comprises complementarity-determining regions (CDR) having the following amino acid sequences: CDR of the variable region of the light chain: CDR1 SEQ ID No. 1, CDR2 SEQ ID No. 2, CDR3 SEQ ID No. 3, and CDR of the variable region of the heavy chain: CDR1 SEQ ID No. 4, CDR2 SEQ ID No. 5, CDR3 SEQ ID No. 6. The invention also embraces the use of the antibodies of the invention as medicinal products, especially for the treatment of tumour diseases, or as a diagnostic agent. The antibodies are suitable for use in the areas of medicine, pharmacy and biomedical research.

Abstract: A microstructured composite component is provided including structures for carrying out fluid processes. A device is provided for producing microstructured composite components. A method provided includes a first step during which a first film is arranged above a second film between first and second mold parts. The first and/or second mold parts have microstructured cavities to be filled. In a second step, the first and second mold parts are heated in at least one region in which they contact one of the films. An excess pressure is then produced between the first film and the second film to force the first and/or second films into the cavities. In a further step, the first and second mold parts are pressed together by a pressing force. Once the first mold part, the second mold part, the first film and the second film are cooled, they form a microstrutured composite component.

Abstract: The invention relates to an apparatus for picking up particles from the surface of a water system, in particular oil, algae or dirt particles, comprising a particle separation space, which is connected to an inflow opening through which water that contains particles can enter the particle separation space, a particle-collecting space into which particles that have been separated from the water that contains particles reach from the particle separation space via a separation mechanism and an adjustment mechanism, which is configured to regulate a filling level of the water that contains particles in the particle separation space. In addition, the invention relates to a method for picking up particles, in particular oil, algae or dirt particles, from the surface of a water system.

Abstract: An exemplary embodiment of the invention relates to a method for classifying a video sequence (VS), characterized by the steps of analyzing the video sequence using a plurality of genre-specific detector modules (M1-M5), each genre-specific detector module providing a probability value (P1-P5) indicating the probability that the video sequence belongs to the genre assigned to the genre-specific detector module; and analyzing the probability values of the plurality of genre-specific detector modules using a combiner (CM) which analyzes said probability values and generates a classification signal (SC) classifying the video sequence as belonging to a specific genre (g).

Abstract: A shaft power plant for energy conversion of a discharge between a headwater and a tailwater, comprising a vertical shaft, the top of which forms an inflow plane which is parallel to the bed and extends below the headwater water level, wherein the shaft is open toward the top and is closed by a base at its bottom end, a unit composed of a turbine and an electrical machine, wherein the unit is arranged entirely under water in the shaft and wherein the turbine is arranged for water to pass through horizontally, and an outflow, which is connected to the turbine, represents a closed flow channel and leads through a through-passage in the shaft to the tailwater, wherein a horizontal first cross-sectional area of the shaft is much larger than a vertical second cross-sectional area taken up by the turbine runner.

Abstract: A compound, or a pharmaceutically acceptable salt or ester thereof, comprises the structure: [(P1-S1j)p-L-(S2q-P2)r]t wherein: P1 and P2, which may be the same or different, are cyclic oligopeptide moieties, at least one of P1 and P2 having the motif B-Arg or B-(Me)Arg within the cyclic moiety, wherein B is a basic amino acid, a derivative thereof, or phenylalanine or a derivative thereof; S1 and S2 are spacer groups, which may be the same or different; L is a linker moiety containing at least two functional groups for attachment of the cyclic oligopeptides or spacer groups; n and q are independently 0 or 1; p and r are independently integers of 1 or more; and t is an integer of 1 or more, provided that, when t, p or r is greater than 1, the cyclic oligopeptide moiety, spacer group and/or the value of j or q may be the same or different between the multiple (P1-S1j) moieties or multiple (S2q-P2) moieties.

Abstract: Provided herein are compounds or conjugates useful for diagnostic imaging and/or therapeutic purposes. Each compound or conjugate comprises a ligand for the chemokine receptor CXCR4 and a detectable label. The ligand has a binding affinity for the CXCR4 receptor, measured as IC50 in the presence of 125I-CPCR4, of 250 nM or lower, and the ligand comprises a cyclic oligopeptide moiety having the motif B-Arg or B-(Me)Arg within the cyclic moiety, wherein B is a basic amino acid, a derivative thereof, or phenylalanine, provided that the motif is B-Arg when B is a N?-methyl derivative of a basic amino acid.

Abstract: The present invention is directed to a cross-reactive antibody that specifically inhibits or blocks mammalian Toll-like receptor 2 (TLR2)-mediated immune cell activation. The invention is further directed to an isolated nucleic acid or vector coding for the variable regions of the heavy and/or light chain of such an antibody. Also provided is a pharmaceutical composition comprising such an antibody, or a nucleic acid or vector encoding it. Further provided are methods of use of such compositions in the prevention and/or treatment of inflammatory processes or any other process induced by bacterial infection, trauma, or chronic inflammation, or for the prevention and/or treatment of bacteriaemia or sepsis.

Abstract: The invention relates to a method and a device (1, 100) for determining the sex of fertilized, nonincubated bird eggs (13, 130), where an egg (13, 130) has a solid egg shell (14), an egg yolk (2) which is surrounded by the egg shell and further egg integuments and a blastodisc (3) associated with the egg yolk (2), and where a probe (4, 40) for measuring a spectrum is introduced through a hole (17) of the egg shell (14) towards the blastodisc (3) with blastodisc cells (23), with the following steps: —positioning of the probe (4, 40) in the region of the blastodisc (3), —spectroscopic in-ovo characterization of the blastodisc cells (23), and —identification of the sex by an automatic classification of spectra.

Abstract: A method and a device for processing light-polymerizable material for the assembly of a mold, utilizing a lithography-based generative manufacturing technique wherein a layer of a light-polymerizable material, the material being located in at least one trough (4) having a particularly light-transmissive, horizontal bottom (6), is polymerized by illumination on at least one horizontal platform (12), the platform having a prespecified geometry and projecting into a trough (4), in an illumination field, wherein the platform (12) is displaced vertically to form a subsequent layer, light-polymerizable material is then added to the most recently formed layer, and repetition of the foregoing steps leads to the layered construction of the mold in the desired form, which arises from the succession of layer geometries.

Abstract: A compound, or a pharmaceutically acceptable salt or ester thereof, comprises the structure: [(P1-S1j)p-L-(S2q-P2)r]t wherein: P1 and P2, which may be the same or different, are cyclic oligopeptide moieties, at least one of P1 and P2 having the motif B-Arg or B-(Me) Arg within the cyclic moiety, wherein B is a basic amino acid, a derivative thereof, or phenylalanine or a derivative thereof; S1 and S2 are spacer groups, which may be the same or different; L is a linker moiety containing at least two functional groups for attachment of the cyclic oligopeptides or spacer groups; n and q are independently 0 or 1; p and r are independently integers of 1 or more; and t is an integer of 1 or more, provided that, when t, p or r is greater than 1, the cyclic oligopeptide moiety, spacer group and/or the value of j or q may be the same or different between the multiple (P1-S1j) moieties or multiple (S2q-P2) moieties.

Abstract: The invention relates to a device (1) for irradiating tissue (G) with light pulses (L), comprising a housing (2), at least one light source (3) for emitting the light pulses (L) with a wavelength (?) of from 600 nm to 660 run, a modulator (4) and a power stage (6) for generating the light pulses (L), and with an activating element (5). For creating a device (1) which is as small, as cost-efficient and as effective as possible, by which as good a therapy success as possible is achieved in various applications, the modulator (4) is designed for generating the light pulses (L) with a pulse frequency (f) of from 1 to 10 Hz, and the power stage (6) is designed for emitting the light pulses (L) with an energy which causes breaking up of the photosensitizer in the photodynamic therapy and evokes a frequency doubling or a two-photon absorption (TPA) in the tissue (G) when treating inflammations without a sensitizer.

Abstract: The present invention is directed to an isolated miR-206 target site, comprising or consisting of a nucleic acid sequence with a sequence identity of at least 80% compared to wild type miR-206 target site with SEQ ID No. 1, characterized in that the nucleic acid sequence comprises at least one nucleotide substitution at a position from nucleotide 2 to 8 and/or at least one nucleotide substitution at a position from nucleotide 12 to 16 of SEQ D No. 1, wherein the nucleotide positions of SEQ ID No. 1 are numbered from the 3?- to the 5?-end; as well as to an expression cassette, vector and pharmaceutical composition comprising at least one isolated miR-206 target site of the invention.

Abstract: Increased in vivo and/or in vitro stability is imparted to a biologically active protein by fusing to an amino acid sequence consisting of at least about 100 amino acid residues, which are Alanine, Serine and Proline, which form a random coil conformation. Specific examples are described. Also described are related nucleic acids, vectors and cells encoding such amino acids; compositions of biologically active proteins fused to a random coil domain, and methods of making and using the compounds and compositions of the invention.

Abstract: The invention relates to a method for the production of a photon pair source, which generates entangled photon pairs, having at least one quantum dot, wherein in the method the operational behaviour of the photon pair source is determined by adjusting the fine structure splitting of the excitonic energy level of the at least one quantum dot. It is provided according to the invention for the fine structure splitting of the excitonic energy level to be adjusted by depositing the at least one quantum dot on a {111} crystal surface of a semiconductor substrate.

Abstract: The invention relates to a heat storage system using sand as a solid heat storage medium, characterized in that it comprises the following components: a storage tank (1) for cold sand; a storage tank (2) for hot sand; a fluidized bed heat exchanger (3) arranged therebetween, which is separated from the storage tanks (1, 2) by weirs (4, 5) and divided into a plurality of chambers (7) by weirs (6), wherein the weirs (4, 5, 6) are arranged as a combination of overflow and underflow weirs; wherein means (8) for transferring heat from a heat source to the sand fluidized therein as well as means (9) for transferring heat from the sand fluidized therein to a heat transport medium are provided in the chambers (7) of the heat exchanger (3); and at least one blower (14) positioned underneath the heat exchanger (3) for fluidizing the sand.

Abstract: The invention relates to a gasification reactor (1) and associated method for the entrained-flow gasification of solid fuels under pressure. The reactor essentially consists of a pressure vessel (4) that can be cooled and an inner jacket (7) that is equipped with a heat shield. At least one crude gas outflow (8) is located at the upper end of the cylindrical pressure vessel and at least one bottoms withdrawal outlet (30) is located at the lower end, the pressure vessel having at least enough space for a moving bed (13), an entrained flow (11) that circulates internally above the surface of the moving bed and a buffer zone (3) situated above said entrained bed.

Abstract: The present invention relates to a headlight for a motor vehicle having a light source, which is arranged in a reflector, for emission of light beams in a light outlet direction, having a masking apparatus (1) which has a mask (2) which can be moved to a first position in order to mask out at least a portion of the light beams, and which can be moved to a second position in which the mask (2) is moved at least partially out of the light beams, wherein the movement of the mask (2) can be produced by an actuator unit (3) which has at least one magnet coil (4) and a magnet yoke (5) in order to form a magnetic flux circuit. According to the invention, a hinged armature (6) is provided, is held in an articulated manner on at least a part of the magnet yoke (5) and is in the form of part of the mask (2), such that the hinged armature (6) carries out a folding movement, and produces the movement of the mask (2), when current is passed through the magnet coil (4).

Abstract: The invention relates to lactocepins and/or a functionally active fragment thereof for use in the prophylaxis and/or the treatment of a disease and to one or more lactocepin(s) and/or one or more functionally active fragment(s) thereof for use in the prophylaxis and/or treatment of IP-10-mediated inflammatory diseases.

Abstract: The invention relates to a method of enhancing the seed yield and promoting the growth of monocotyledonous or dicotyledonous plants by overexpression of TMT (tonoplast monosaccharide transporter) protein in osogenic or transgenic plant cells. The invention further concerns a transgenic plant having the property of an enhanced seed yield and increased growth as compared with the wild type, comprising a nucleotide sequence which codes for a TMT (tonoplast monosaccharide transporter) protein, as well as a regulatory nucleotide sequence, operably linked therewith, for the control of an increased gene expression of the TMT protein in the plant cells of the transgenic plant. It further relates to the use of the transgenic plant for the cultivation or production of cultivated plants or useful plants, or biomass, oils or proteins produced therefrom.