Patents Assigned to Temasek Life Sciences Laboratory Limited
  • Patent number: 11856926
    Abstract: The present invention generally relates to an aquatic farming system (200) comprising one or more stacked levels of an array of one or more aquatic farming modules (100). Each aquatic farming module (100) comprises an intermodal container (102) comprising a pair of opposing side walls (104) and a pair of opposing end entrances (106), and a housing structure (110) disposed in the intermodal container (102) and extending between the side walls (104) thereof. The aquatic farming module (100) further comprises a set of access doors (130) disposed at one or both end entrances (106) of the intermodal container (100), the access doors (130) actuatable planarly for selectively opening/closing the respective end entrances (106). Selective opening/closing of the end entrances (106) of the intermodal containers (102) in each stacked level facilitates user accessibility to the housing structures (110) in said stacked level for farming aquatic organisms.
    Type: Grant
    Filed: January 24, 2023
    Date of Patent: January 2, 2024
    Assignee: Temasek Life Sciences Laboratory Limited
    Inventor: Chin Heng Goh
  • Publication number: 20230365915
    Abstract: A culture for the fermentative production of Massoia lactone comprising an Aureobasidium melanogenum species in a culture medium, wherein the Aureobasidium melanogenum species expresses no functional Aureobasidin A synthase gene mRNA when cultured, the culture medium including KH2PO4, Na2HPO4, (NH4)2SO4, MgSO4·7H2O and CaCl2·2H2O; at least two trace elements selected from the group consisting of Fe2+, Cu2+, Zn2+ and MoO42?; urea; and a carbon source selected from the group consisting of glucose, mannose, xylose and mixtures thereof, wherein the culture medium has a pH from 5.5 to 6.5.
    Type: Application
    Filed: March 20, 2023
    Publication date: November 16, 2023
    Applicant: TEMASEK LIFE SCIENCES LABORATORY LIMITED
    Inventors: Lianghui JI, Si Te NGOH
  • Publication number: 20230298167
    Abstract: The present invention relates to the provision of an automated system and a computer-implemented method for detecting a disease such as nasopharyngeal cancer (NPC) based upon the use of either a Fuzzy Inference (FI) system or a deep learning-fuzzy inference (DeLFI) hybrid model to analyse immunofluorescence assay (IFA) images. For NPC detection, the system and method of the invention would distinguish between Epstein Barr Virus (EBV) Early Antigen (EA) positive and negative cells, and identify cellular patterns which are indicative of NPC. The DeLFI hybrid model requires less human evaluation and thereby has the potential to improve the scalability and accuracy of NPC detection.
    Type: Application
    Filed: June 7, 2021
    Publication date: September 21, 2023
    Applicants: TEMASEK LIFE SCIENCES LABORATORY LIMITED, PATHNOVA LABORATORIES PTE LTD
    Inventors: Sudipta SAMANTA, Muthukaruppan SWAMINATHAN, Jianing HU, Chan Soh HA, Shen-Yi Lan CHEONG
  • Publication number: 20230243750
    Abstract: The present invention relates to the use of a Raman spectral signature for detection of plant metabolites, specifically carotenoids, in tissue of a plant leaf. Carotenoids are used as a biomarker for an early, real-time diagnosis of shade avoidance syndrome (SAS) in growing plants in a non-invasive or non-destructive way in order to detect the adverse effect of the SAS upon their health, and ultimately their yield. The early, real-time diagnosis of SAS provides a window period within which further adverse effects of SAS may be slowed or prevented without negatively affecting the yield of growing plants or leafy vegetables.
    Type: Application
    Filed: May 20, 2021
    Publication date: August 3, 2023
    Applicants: TEMASEK LIFE SCIENCES LABORATORY LIMITED, MASSACHUSETTS INSTITUTE OF TECHNOLOGY
    Inventors: In-Cheol JANG, Benny Jian Rong SNG, Gajendra Pratap SINGH, Rajeev J. RAM
  • Publication number: 20230225298
    Abstract: The present invention generally relates to an aquatic farming system (200) comprising one or more stacked levels of an array of one or more aquatic farming modules (100). Each aquatic farming module (100) comprises an intermodal container (102) comprising a pair of opposing side walls (104) and a pair of opposing end entrances (106), and a housing structure (110) disposed in the intermodal container (102) and extending between the side walls (104) thereof. The aquatic farming module (100) further comprises a set of access doors (130) disposed at one or both end entrances (106) of the intermodal container (100), the access doors (130) actuatable planarly for selectively opening/closing the respective end entrances (106). Selective opening/closing of the end entrances (106) of the intermodal containers (102) in each stacked level facilitates user accessibility to the housing structures (110) in said stacked level for farming aquatic organisms.
    Type: Application
    Filed: January 24, 2023
    Publication date: July 20, 2023
    Applicant: Temasek Life Sciences Laboratory Limited
    Inventor: Chin Heng Goh
  • Publication number: 20230184684
    Abstract: The present invention relates to the use of a Raman spectral signature of nitrate, as a biomarker for an early, real-time diagnosis of nitrogen status in growing plants in a non-invasive or non-destructive way in order to detect nitrogen deficiency before the onset of any visible symptoms. The early, real-time diagnosis of nitrogen deficiency in plants makes it possible to correct nitrogen deficiency for the avoidance of negative effects on the yield and biomass of growing plants or leafy vegetables.
    Type: Application
    Filed: May 20, 2021
    Publication date: June 15, 2023
    Applicants: TEMASEK LIFE SCIENCES LABORATORY LIMITED, MASSACHUSETTS INSTITUTE OF TECHNOLOGY
    Inventors: Bong Soo PARK, Rajeev J. RAM, Chung Hao HUANG, Gajendra Pratap SINGH, Nam-Hai CHUA
  • Patent number: 11667946
    Abstract: The present invention relates to the field of diagnostics and more particularly to the detection of beta-hemolytic pathogens. More specifically, the present invention relates to the rapid and accurate detection of beta-hemolytic pathogens using sterically-stabilized liposomes.
    Type: Grant
    Filed: October 22, 2020
    Date of Patent: June 6, 2023
    Assignee: Temasek Life Sciences Laboratory Limited
    Inventors: Rongji Sum, Muthukaruppan Swaminathan, Ian Cheong
  • Patent number: 11639492
    Abstract: The present invention relates to the field of fermentation biotechnology, more particularly to methods for the fermentative production of massoia lactone by Aureobasidium species.
    Type: Grant
    Filed: December 12, 2019
    Date of Patent: May 2, 2023
    Assignee: Temasek Life Sciences Laboratory Limited
    Inventors: Lianghui Ji, Si Te Ngoh
  • Patent number: 11589561
    Abstract: The present invention generally relates to an aquatic farming system (200) comprising one or more stacked levels of an array of one or more aquatic farming modules (100). Each aquatic farming module (100) comprises an intermodal container (102) comprising a pair of opposing side walls (104) and a pair of opposing end entrances (106), and a housing structure (110) disposed in the intermodal container (102) and extending between the side walls (104) thereof. The aquatic farming module (100) further comprises a set of access doors (130) disposed at one or both end entrances (106) of the intermodal container (100), the access doors (130) actuatable planarly for selectively opening/closing the respective end entrances (106). Selective opening/closing of the end entrances (106) of the intermodal containers (102) in each stacked level facilitates user accessibility to the housing structures (110) in said stacked level for farming aquatic organisms.
    Type: Grant
    Filed: June 3, 2019
    Date of Patent: February 28, 2023
    Assignee: Temasek Life Sciences Laboratory Limited
    Inventor: Chin Heng Goh
  • Patent number: 11331272
    Abstract: Hyperstable liposome comprising an anti-mitotic agent, one or more anions and one or more cations entrapped in the inner milieu, wherein the entrapped anti-mitotic drug is released at a slow rate that is less than 0.6% in 12 hours or less than 5% in 8 hours when the liposomes are suspended in 600 mM sucrose. These liposomes are useful in the treatment of cancer. In particular, HEPC:Chol:DSPE-PEG2000 (50:45:5) liposomes comprising BI 2536 and citrate:phosphate in a ratio of 1:3.
    Type: Grant
    Filed: January 17, 2018
    Date of Patent: May 17, 2022
    Assignee: Temasek Life Sciences Laboratory Limited
    Inventors: Chang Zhi Adrian Ng, Shen-Yi Ian Cheong
  • Publication number: 20220098601
    Abstract: The present invention relates to a method for Agrobacterium-mediated transformation and regeneration of Stevia plants. In particular, the method involves co-culturing leaf explants with Agrobacterium in a medium comprising acetosyringone and 2,4-dichlorophenoxyacetic acid in the dark, callus induction and shoot regeneration in a medium comprising 6-benzylaminopurine, 3-indoleacetic acid, a selective agent and an Agrobacterium eradicant in the dark, and root regeneration in a medium comprising 3-in-doleacetic acid in a light/dark cycle. The present invention also relates to the overexpression of SrDXS I and SrKAH in transgenic plants, resulting in the enhancement of steviol glycosides in the transgenic plants. The present invention further relates to the overexpression SrUGT76G I in transgenic plants, resulting in higher Rebaudioside A (Reb A) to stevioside ratios in the transgenic plants.
    Type: Application
    Filed: January 17, 2019
    Publication date: March 31, 2022
    Applicant: TEMASEK LIFE SCIENCES LABORATORY LIMITED
    Inventors: In-Cheol JANG, Jun-shi ZHENG, Mi Jung KIM
  • Patent number: 11254943
    Abstract: The present invention relates to the field of molecular biology and more particularly to promoters useful for metabolic engineering in yeast or fungi for the production of biobased chemicals with broad applications. Intron-containing promoters with strong activity during oil-accumulation stages are particularly useful for genetic engineering in yeast and fungi, particularly Rhodosporidium or Rhodotorula genera. Such promoter are capable of driving strong expression of RNA or proteins in species of the Rhodosporidium or Rhodotorula genera.
    Type: Grant
    Filed: February 2, 2017
    Date of Patent: February 22, 2022
    Assignee: Temasek Life Sciences Laboratory Limited
    Inventors: Lianghui Ji, Yanbin Liu, Chong Mei John Koh, Sihui Amy Yap
  • Publication number: 20210227800
    Abstract: The present invention generally relates to an aquatic farming system (200) comprising one or more stacked levels of an array of one or more aquatic farming modules (100). Each aquatic farming module (100) comprises an intermodal container (102) comprising a pair of opposing side walls (104) and a pair of opposing end entrances (106), and a housing structure (110) disposed in the intermodal container (102) and extending between the side walls (104) thereof. The aquatic farming module (100) further comprises a set of access doors (130) disposed at one or both end entrances (106) of the intermodal container (100), the access doors (130) actuatable planarly for selectively opening/closing the respective end entrances (106). Selective opening/closing of the end entrances (106) of the intermodal containers (102) in each stacked level facilitates user accessibility to the housing structures (110) in said stacked level for farming aquatic organisms.
    Type: Application
    Filed: June 3, 2019
    Publication date: July 29, 2021
    Applicant: Temasek Life Sciences Laboratory Limited
    Inventor: Chin Heng Goh
  • Patent number: 11034981
    Abstract: The present invention relates to the field of fungal production fatty alcohols. More specifically, the present invention relates to genetically modified host cells, nucleic acid constructs and culture medium for the production of fatty alcohols in Rhodosporidium.
    Type: Grant
    Filed: January 29, 2018
    Date of Patent: June 15, 2021
    Assignee: TEMASEK LIFE SCIENCES LABORATORY LIMITED
    Inventors: Lianghui Ji, Yanbin Liu, Chong Mei John Koh, Sihui Amy Yap, Si Te Ngoh
  • Publication number: 20210123066
    Abstract: The present invention relates to a method for Agrobacterium-mediated transformation and regeneration of Stevia plants. In particular, the method involves co-culturing leaf explants with Agrobacterium in a medium comprising acetosyringone and 2,4-dichlorophenoxyacetic acid in the dark, callus induction and shoot regeneration in a medium comprising 6-benzylaminopurine, 3-indoleacetic acid, a selective agent and an Agrobacterium eradicant in the dark, and root regeneration in a medium comprising 3-indoleacetic acid in a light/dark cycle. The present invention also relates to the overexpression of SrDXS1 and SrKAH in transgenic plants, resulting in the enhancement of steviol glycosides in the transgenic plants. The present invention further relates to the overexpression SrUGT76G1 in transgenic plants, resulting in higher Rebaudioside A (Reb A) to stevioside ratios in the transgenic plants.
    Type: Application
    Filed: January 17, 2019
    Publication date: April 29, 2021
    Applicant: TEMASEK LIFE SCIENCES LABORATORY LIMITED
    Inventors: In-Cheol JANG, Jun-shi ZHENG, Mi Jung KIM
  • Publication number: 20210108246
    Abstract: The present invention relates to the field of diagnostics and more particularly to the detection of beta-hemolytic pathogens. More specifically, the present invention relates to the rapid and accurate detection of beta-hemolytic pathogens using sterically-stabilized liposomes.
    Type: Application
    Filed: October 22, 2020
    Publication date: April 15, 2021
    Applicant: TEMASEK LIFE SCIENCES LABORATORY LIMITED
    Inventors: Rongji SUM, Muthukaruppan SWAMINATHAN, Ian CHEONG
  • Publication number: 20200377898
    Abstract: The present invention relates to the field of molecular biology and more particularly to promoters useful for metabolic engineering in yeast or fungi for the production of biobased chemicals with broad applications. Intron-containing promoters with strong activity during oil-accumulation stages are particularly useful for genetic engineering in yeast and fungi, particularly Rhodosporidium or Rhodotorula genera. Such promoter are capable of driving strong expression of RNA or proteins in species of the Rhodosporidium or Rhodotorula genera.
    Type: Application
    Filed: February 2, 2017
    Publication date: December 3, 2020
    Applicant: TEMASEK LIFE SCIENCES LABORATORY LIMITED
    Inventors: Lianghui JI, Yanbin LIU, Chong Mei John KOH, Sihui Amy YAP
  • Publication number: 20200157488
    Abstract: The present invention relates to the field of fermentation biotechnology, more particularly to methods for the fermentative production of massoia lactone by Aureobasidium species.
    Type: Application
    Filed: December 12, 2019
    Publication date: May 21, 2020
    Applicant: TEMASEK LIFE SCIENCES LABORATORY LIMITED
    Inventors: Lianghui JI, Si Te NGOH
  • Patent number: 10570402
    Abstract: The present invention relates to the field of the production of transgenic plants through Agrobacterium-mediated transformation of cells of somatic embryogenic calli or embryogenic suspension cultures and regeneration of the transformed cells into fruit-setting plants. In particular, the present invention relates to the production of transgenic plants in the Euphorbiaceae family. The present invention further relates to media compositions, selection methods and engineered Agrobacterium tumefaciens strains that improve Agrobacterium-mediated transformation efficiency.
    Type: Grant
    Filed: November 14, 2018
    Date of Patent: February 25, 2020
    Assignee: Temasek Life Sciences Laboratory Limited
    Inventors: Lin Cai, Longhua Sun, Lin Fu, Lianghui Ji
  • Publication number: 20190360003
    Abstract: The present invention relates to the field of fungal production fatty alcohols. More specifically, the present invention relates to genetically modified host cells, nucleic acid constructs and culture medium for the production of fatty alcohols in Rhodosporidium.
    Type: Application
    Filed: January 29, 2018
    Publication date: November 28, 2019
    Applicant: TEMASEK LIFE SCIENCES LABORATORY LIMITED
    Inventors: Lianghui JI, Yanbin LIU, Chong Mei John KOH, Sihui Amy YAP, Si Te NGOH