Patents Assigned to Temasek Life Sciences Laboratory Limited
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Patent number: 11856926Abstract: The present invention generally relates to an aquatic farming system (200) comprising one or more stacked levels of an array of one or more aquatic farming modules (100). Each aquatic farming module (100) comprises an intermodal container (102) comprising a pair of opposing side walls (104) and a pair of opposing end entrances (106), and a housing structure (110) disposed in the intermodal container (102) and extending between the side walls (104) thereof. The aquatic farming module (100) further comprises a set of access doors (130) disposed at one or both end entrances (106) of the intermodal container (100), the access doors (130) actuatable planarly for selectively opening/closing the respective end entrances (106). Selective opening/closing of the end entrances (106) of the intermodal containers (102) in each stacked level facilitates user accessibility to the housing structures (110) in said stacked level for farming aquatic organisms.Type: GrantFiled: January 24, 2023Date of Patent: January 2, 2024Assignee: Temasek Life Sciences Laboratory LimitedInventor: Chin Heng Goh
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Publication number: 20230365915Abstract: A culture for the fermentative production of Massoia lactone comprising an Aureobasidium melanogenum species in a culture medium, wherein the Aureobasidium melanogenum species expresses no functional Aureobasidin A synthase gene mRNA when cultured, the culture medium including KH2PO4, Na2HPO4, (NH4)2SO4, MgSO4·7H2O and CaCl2·2H2O; at least two trace elements selected from the group consisting of Fe2+, Cu2+, Zn2+ and MoO42?; urea; and a carbon source selected from the group consisting of glucose, mannose, xylose and mixtures thereof, wherein the culture medium has a pH from 5.5 to 6.5.Type: ApplicationFiled: March 20, 2023Publication date: November 16, 2023Applicant: TEMASEK LIFE SCIENCES LABORATORY LIMITEDInventors: Lianghui JI, Si Te NGOH
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Publication number: 20230298167Abstract: The present invention relates to the provision of an automated system and a computer-implemented method for detecting a disease such as nasopharyngeal cancer (NPC) based upon the use of either a Fuzzy Inference (FI) system or a deep learning-fuzzy inference (DeLFI) hybrid model to analyse immunofluorescence assay (IFA) images. For NPC detection, the system and method of the invention would distinguish between Epstein Barr Virus (EBV) Early Antigen (EA) positive and negative cells, and identify cellular patterns which are indicative of NPC. The DeLFI hybrid model requires less human evaluation and thereby has the potential to improve the scalability and accuracy of NPC detection.Type: ApplicationFiled: June 7, 2021Publication date: September 21, 2023Applicants: TEMASEK LIFE SCIENCES LABORATORY LIMITED, PATHNOVA LABORATORIES PTE LTDInventors: Sudipta SAMANTA, Muthukaruppan SWAMINATHAN, Jianing HU, Chan Soh HA, Shen-Yi Lan CHEONG
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Publication number: 20230243750Abstract: The present invention relates to the use of a Raman spectral signature for detection of plant metabolites, specifically carotenoids, in tissue of a plant leaf. Carotenoids are used as a biomarker for an early, real-time diagnosis of shade avoidance syndrome (SAS) in growing plants in a non-invasive or non-destructive way in order to detect the adverse effect of the SAS upon their health, and ultimately their yield. The early, real-time diagnosis of SAS provides a window period within which further adverse effects of SAS may be slowed or prevented without negatively affecting the yield of growing plants or leafy vegetables.Type: ApplicationFiled: May 20, 2021Publication date: August 3, 2023Applicants: TEMASEK LIFE SCIENCES LABORATORY LIMITED, MASSACHUSETTS INSTITUTE OF TECHNOLOGYInventors: In-Cheol JANG, Benny Jian Rong SNG, Gajendra Pratap SINGH, Rajeev J. RAM
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Publication number: 20230225298Abstract: The present invention generally relates to an aquatic farming system (200) comprising one or more stacked levels of an array of one or more aquatic farming modules (100). Each aquatic farming module (100) comprises an intermodal container (102) comprising a pair of opposing side walls (104) and a pair of opposing end entrances (106), and a housing structure (110) disposed in the intermodal container (102) and extending between the side walls (104) thereof. The aquatic farming module (100) further comprises a set of access doors (130) disposed at one or both end entrances (106) of the intermodal container (100), the access doors (130) actuatable planarly for selectively opening/closing the respective end entrances (106). Selective opening/closing of the end entrances (106) of the intermodal containers (102) in each stacked level facilitates user accessibility to the housing structures (110) in said stacked level for farming aquatic organisms.Type: ApplicationFiled: January 24, 2023Publication date: July 20, 2023Applicant: Temasek Life Sciences Laboratory LimitedInventor: Chin Heng Goh
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Publication number: 20230184684Abstract: The present invention relates to the use of a Raman spectral signature of nitrate, as a biomarker for an early, real-time diagnosis of nitrogen status in growing plants in a non-invasive or non-destructive way in order to detect nitrogen deficiency before the onset of any visible symptoms. The early, real-time diagnosis of nitrogen deficiency in plants makes it possible to correct nitrogen deficiency for the avoidance of negative effects on the yield and biomass of growing plants or leafy vegetables.Type: ApplicationFiled: May 20, 2021Publication date: June 15, 2023Applicants: TEMASEK LIFE SCIENCES LABORATORY LIMITED, MASSACHUSETTS INSTITUTE OF TECHNOLOGYInventors: Bong Soo PARK, Rajeev J. RAM, Chung Hao HUANG, Gajendra Pratap SINGH, Nam-Hai CHUA
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Patent number: 11667946Abstract: The present invention relates to the field of diagnostics and more particularly to the detection of beta-hemolytic pathogens. More specifically, the present invention relates to the rapid and accurate detection of beta-hemolytic pathogens using sterically-stabilized liposomes.Type: GrantFiled: October 22, 2020Date of Patent: June 6, 2023Assignee: Temasek Life Sciences Laboratory LimitedInventors: Rongji Sum, Muthukaruppan Swaminathan, Ian Cheong
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Patent number: 11639492Abstract: The present invention relates to the field of fermentation biotechnology, more particularly to methods for the fermentative production of massoia lactone by Aureobasidium species.Type: GrantFiled: December 12, 2019Date of Patent: May 2, 2023Assignee: Temasek Life Sciences Laboratory LimitedInventors: Lianghui Ji, Si Te Ngoh
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Patent number: 11589561Abstract: The present invention generally relates to an aquatic farming system (200) comprising one or more stacked levels of an array of one or more aquatic farming modules (100). Each aquatic farming module (100) comprises an intermodal container (102) comprising a pair of opposing side walls (104) and a pair of opposing end entrances (106), and a housing structure (110) disposed in the intermodal container (102) and extending between the side walls (104) thereof. The aquatic farming module (100) further comprises a set of access doors (130) disposed at one or both end entrances (106) of the intermodal container (100), the access doors (130) actuatable planarly for selectively opening/closing the respective end entrances (106). Selective opening/closing of the end entrances (106) of the intermodal containers (102) in each stacked level facilitates user accessibility to the housing structures (110) in said stacked level for farming aquatic organisms.Type: GrantFiled: June 3, 2019Date of Patent: February 28, 2023Assignee: Temasek Life Sciences Laboratory LimitedInventor: Chin Heng Goh
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Patent number: 11331272Abstract: Hyperstable liposome comprising an anti-mitotic agent, one or more anions and one or more cations entrapped in the inner milieu, wherein the entrapped anti-mitotic drug is released at a slow rate that is less than 0.6% in 12 hours or less than 5% in 8 hours when the liposomes are suspended in 600 mM sucrose. These liposomes are useful in the treatment of cancer. In particular, HEPC:Chol:DSPE-PEG2000 (50:45:5) liposomes comprising BI 2536 and citrate:phosphate in a ratio of 1:3.Type: GrantFiled: January 17, 2018Date of Patent: May 17, 2022Assignee: Temasek Life Sciences Laboratory LimitedInventors: Chang Zhi Adrian Ng, Shen-Yi Ian Cheong
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Publication number: 20220098601Abstract: The present invention relates to a method for Agrobacterium-mediated transformation and regeneration of Stevia plants. In particular, the method involves co-culturing leaf explants with Agrobacterium in a medium comprising acetosyringone and 2,4-dichlorophenoxyacetic acid in the dark, callus induction and shoot regeneration in a medium comprising 6-benzylaminopurine, 3-indoleacetic acid, a selective agent and an Agrobacterium eradicant in the dark, and root regeneration in a medium comprising 3-in-doleacetic acid in a light/dark cycle. The present invention also relates to the overexpression of SrDXS I and SrKAH in transgenic plants, resulting in the enhancement of steviol glycosides in the transgenic plants. The present invention further relates to the overexpression SrUGT76G I in transgenic plants, resulting in higher Rebaudioside A (Reb A) to stevioside ratios in the transgenic plants.Type: ApplicationFiled: January 17, 2019Publication date: March 31, 2022Applicant: TEMASEK LIFE SCIENCES LABORATORY LIMITEDInventors: In-Cheol JANG, Jun-shi ZHENG, Mi Jung KIM
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Patent number: 11254943Abstract: The present invention relates to the field of molecular biology and more particularly to promoters useful for metabolic engineering in yeast or fungi for the production of biobased chemicals with broad applications. Intron-containing promoters with strong activity during oil-accumulation stages are particularly useful for genetic engineering in yeast and fungi, particularly Rhodosporidium or Rhodotorula genera. Such promoter are capable of driving strong expression of RNA or proteins in species of the Rhodosporidium or Rhodotorula genera.Type: GrantFiled: February 2, 2017Date of Patent: February 22, 2022Assignee: Temasek Life Sciences Laboratory LimitedInventors: Lianghui Ji, Yanbin Liu, Chong Mei John Koh, Sihui Amy Yap
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Publication number: 20210227800Abstract: The present invention generally relates to an aquatic farming system (200) comprising one or more stacked levels of an array of one or more aquatic farming modules (100). Each aquatic farming module (100) comprises an intermodal container (102) comprising a pair of opposing side walls (104) and a pair of opposing end entrances (106), and a housing structure (110) disposed in the intermodal container (102) and extending between the side walls (104) thereof. The aquatic farming module (100) further comprises a set of access doors (130) disposed at one or both end entrances (106) of the intermodal container (100), the access doors (130) actuatable planarly for selectively opening/closing the respective end entrances (106). Selective opening/closing of the end entrances (106) of the intermodal containers (102) in each stacked level facilitates user accessibility to the housing structures (110) in said stacked level for farming aquatic organisms.Type: ApplicationFiled: June 3, 2019Publication date: July 29, 2021Applicant: Temasek Life Sciences Laboratory LimitedInventor: Chin Heng Goh
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Patent number: 11034981Abstract: The present invention relates to the field of fungal production fatty alcohols. More specifically, the present invention relates to genetically modified host cells, nucleic acid constructs and culture medium for the production of fatty alcohols in Rhodosporidium.Type: GrantFiled: January 29, 2018Date of Patent: June 15, 2021Assignee: TEMASEK LIFE SCIENCES LABORATORY LIMITEDInventors: Lianghui Ji, Yanbin Liu, Chong Mei John Koh, Sihui Amy Yap, Si Te Ngoh
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Publication number: 20210123066Abstract: The present invention relates to a method for Agrobacterium-mediated transformation and regeneration of Stevia plants. In particular, the method involves co-culturing leaf explants with Agrobacterium in a medium comprising acetosyringone and 2,4-dichlorophenoxyacetic acid in the dark, callus induction and shoot regeneration in a medium comprising 6-benzylaminopurine, 3-indoleacetic acid, a selective agent and an Agrobacterium eradicant in the dark, and root regeneration in a medium comprising 3-indoleacetic acid in a light/dark cycle. The present invention also relates to the overexpression of SrDXS1 and SrKAH in transgenic plants, resulting in the enhancement of steviol glycosides in the transgenic plants. The present invention further relates to the overexpression SrUGT76G1 in transgenic plants, resulting in higher Rebaudioside A (Reb A) to stevioside ratios in the transgenic plants.Type: ApplicationFiled: January 17, 2019Publication date: April 29, 2021Applicant: TEMASEK LIFE SCIENCES LABORATORY LIMITEDInventors: In-Cheol JANG, Jun-shi ZHENG, Mi Jung KIM
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Publication number: 20210108246Abstract: The present invention relates to the field of diagnostics and more particularly to the detection of beta-hemolytic pathogens. More specifically, the present invention relates to the rapid and accurate detection of beta-hemolytic pathogens using sterically-stabilized liposomes.Type: ApplicationFiled: October 22, 2020Publication date: April 15, 2021Applicant: TEMASEK LIFE SCIENCES LABORATORY LIMITEDInventors: Rongji SUM, Muthukaruppan SWAMINATHAN, Ian CHEONG
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Publication number: 20200377898Abstract: The present invention relates to the field of molecular biology and more particularly to promoters useful for metabolic engineering in yeast or fungi for the production of biobased chemicals with broad applications. Intron-containing promoters with strong activity during oil-accumulation stages are particularly useful for genetic engineering in yeast and fungi, particularly Rhodosporidium or Rhodotorula genera. Such promoter are capable of driving strong expression of RNA or proteins in species of the Rhodosporidium or Rhodotorula genera.Type: ApplicationFiled: February 2, 2017Publication date: December 3, 2020Applicant: TEMASEK LIFE SCIENCES LABORATORY LIMITEDInventors: Lianghui JI, Yanbin LIU, Chong Mei John KOH, Sihui Amy YAP
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Publication number: 20200157488Abstract: The present invention relates to the field of fermentation biotechnology, more particularly to methods for the fermentative production of massoia lactone by Aureobasidium species.Type: ApplicationFiled: December 12, 2019Publication date: May 21, 2020Applicant: TEMASEK LIFE SCIENCES LABORATORY LIMITEDInventors: Lianghui JI, Si Te NGOH
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Patent number: 10570402Abstract: The present invention relates to the field of the production of transgenic plants through Agrobacterium-mediated transformation of cells of somatic embryogenic calli or embryogenic suspension cultures and regeneration of the transformed cells into fruit-setting plants. In particular, the present invention relates to the production of transgenic plants in the Euphorbiaceae family. The present invention further relates to media compositions, selection methods and engineered Agrobacterium tumefaciens strains that improve Agrobacterium-mediated transformation efficiency.Type: GrantFiled: November 14, 2018Date of Patent: February 25, 2020Assignee: Temasek Life Sciences Laboratory LimitedInventors: Lin Cai, Longhua Sun, Lin Fu, Lianghui Ji
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Publication number: 20190360003Abstract: The present invention relates to the field of fungal production fatty alcohols. More specifically, the present invention relates to genetically modified host cells, nucleic acid constructs and culture medium for the production of fatty alcohols in Rhodosporidium.Type: ApplicationFiled: January 29, 2018Publication date: November 28, 2019Applicant: TEMASEK LIFE SCIENCES LABORATORY LIMITEDInventors: Lianghui JI, Yanbin LIU, Chong Mei John KOH, Sihui Amy YAP, Si Te NGOH