Patents Assigned to Terumo BCT, Inc.
  • CENTRIFUGAL FLUID SEPARATION DEVICE
    Publication number: 20180093270
    Abstract: A modular cassette and method for separating a composite fluid into at least two component parts thereof during centrifugation is provided. The modular cassette includes a fluid inlet portion, at least one fluid separation portion, at least one media chamber in fluid communication with the fluid separation portion, a fluid collection portion, at least one fluidic channel configured to form a fluid communication between at least two components of the cassette, at least one wax valve including undulating flow channel portions configured to close at least one of the fluidic channels, and at least one heating element configured to actuate the at least one wax valve.
    Type: Application
    Filed: September 28, 2017
    Publication date: April 5, 2018
    Applicant: Terumo BCT, Inc.
    Inventors: James R. LADTKOW, Dennis J. Hlavinka, Thomas J. Felt, Andrew Gloor, Jesse Janzen, Taylor Polodna, Luke Edwin Ladtkow
  • Lyophilization
    Patent number: 9863699
    Abstract: Embodiments of methods, systems, and apparatuses for lyophilizing, storing, and transfusing materials are described. In embodiments, the materials may include whole blood or a component of whole blood such as plasma.
    Type: Grant
    Filed: June 9, 2015
    Date of Patent: January 9, 2018
    Assignee: Terumo BCT, Inc.
    Inventors: Frank Corbin, III, Dennis J. Hlavinka, Rajesh Pareta, Mark E. Hillam
  • Separating Composite Liquids
    Publication number: 20170369844
    Abstract: Described are embodiments that include methods and devices for separating composite liquids into components. Embodiments involve the use of a flexible membrane for separating a composite liquid into components. The composite liquid may include, in embodiments, a cellular containing liquid, such as whole blood or components of whole blood. In one specific embodiment, the composite liquid is a buffy coat.
    Type: Application
    Filed: September 11, 2017
    Publication date: December 28, 2017
    Applicant: Terumo BCT, Inc.
    Inventors: James R. LADTKOW, Geoffrey M. UHL, Jeremy P. KOLENBRANDER, Briden Ray STANTON
  • Multi-unit blood processor with volume prediction
    Patent number: 9849222
    Abstract: Method and Apparatus for predicting the volume of a component separated from a composite fluid by predicting the volume of the composite fluid from sensed pressure and predicting the volume of other separated components from sensed movement of the other components to collection bags.
    Type: Grant
    Filed: May 11, 2015
    Date of Patent: December 26, 2017
    Assignee: Terumo BCT, Inc.
    Inventors: Victor D. Dolecek, Darryl Hudock
  • Multi-Unit Blood Processor with Temperature Sensing
    Publication number: 20170354775
    Abstract: Method and apparatus for centrifugal blood component separation including temperature sensing in each of a plurality of separation cells. The temperature of unit of bloods over time is recorded. If the temperature of any of the units exceeds a pre-determined maximum, portions of the blood separation device may be cooled. A controller may determine which of the units to process first, generally proceeding from the warmest unit to the coolest. The order of unit processing may be changed during processing. The detected temperature may be used to calibrate a pressure sensor used to predict the volume of a component separated from a composite fluid by predicting the volume of the composite fluid from sensed pressure and predicting the volume of other separated components from sensed movement of the other components to collection bags.
    Type: Application
    Filed: June 26, 2017
    Publication date: December 14, 2017
    Applicant: Terumo BCT, Inc.
    Inventor: Victor D. DOLECEK
  • Coating a Bioreactor
    Publication number: 20170349872
    Abstract: Embodiments for coating a bioreactor with a reagent are described. The embodiments may provide for changing flow rates, direction of flow, and/or bioreactor rotation to enhance the coating of the bioreactor prior to growing cells in the bioreactor.
    Type: Application
    Filed: June 7, 2017
    Publication date: December 7, 2017
    Applicant: Terumo BCT, Inc.
    Inventor: Nathan D. FRANK
  • Coating a Bioreactor
    Publication number: 20170349873
    Abstract: Embodiments described herein generally provide for the expansion of cells in a cell expansion system using an active promotion of a coating agent(s) to a cell growth surface in some embodiments. A coating agent may be applied to a surface, such as the cell growth surface of a hollow fiber in a bioreactor, by controlling the movement of a fluid in which a coating agent is suspended, by changing flow rates, by changing flow directions, by rotation of the bioreactor, and/or combinations thereof.
    Type: Application
    Filed: June 7, 2017
    Publication date: December 7, 2017
    Applicant: Terumo BCT, Inc.
    Inventors: Nathan D. FRANK, Brian J. NANKERVIS, Dennis J. HLAVINKA, Thomas G. DILORENZO
  • Methods and Systems for Coating a Cell Growth Surface
    Publication number: 20170349869
    Abstract: Embodiments described herein generally provide for the expansion of cells in a cell expansion system using an active promotion of a coating agent(s) to a cell growth surface. A coating agent may be applied to a surface, such as the cell growth surface of a hollow fiber, by controlling the movement of a fluid in which a coating agent is suspended. Using ultrafiltration, the fluid may be pushed through the pores of a hollow fiber from a first side, e.g., an intracapillary (IC) side, of the hollow fiber to a second side, e.g., an extracapillary (EC) side, while the coating agent is actively promoted to the surface of the hollow fiber. In so doing, the coating agent may be hydrostatically deposited onto a wall, e.g., inner wall, of the hollow fiber.
    Type: Application
    Filed: June 7, 2017
    Publication date: December 7, 2017
    Applicant: Terumo BCT, Inc.
    Inventors: Nathan D. FRANK, Brian J. NANKERVIS, Dennis J. HLAVINKA, Thomas G. DILORENZO
  • Configurable Methods and Systems of Growing and Harvesting Cells in a Hollow Fiber Bioreactor System
    Publication number: 20170335270
    Abstract: Embodiments described herein generally relate to methods and systems for configuring settings of a cell expansion system including a bioreactor. Through a user interface, a user may configure display settings, system settings, and settings associated with protocols for loading, growing and/or harvesting cells. In configuring settings for protocols and associated processes, a diagram view or window of the cell expansion system is displayed in embodiments. The diagram view displays the process settings as graphical user interface elements. Settings available for configuration are enabled for selection in the diagram view. The diagram view allows the user to visualize the settings available for task configuration and to configure enabled settings. Configured settings are stored and capable of retrieval for subsequent execution or modification of the applicable protocol.
    Type: Application
    Filed: August 7, 2017
    Publication date: November 23, 2017
    Applicant: Terumo BCT, Inc.
    Inventors: Edward Allan STANTON, IV, Glen Delbert ANTWILER, Patrick J. HOWLEY, Michael E. KINZIE, Jon A. DODD, Casey V. MEDINA
  • Pump
    Publication number: 20170333609
    Abstract: Embodiments of pumps are described herein that may be used as peristaltic pumps. The pumps may include features that provide for quiet operation as well as automatically loading of tubing. Embodiments may be implemented in blood separation systems.
    Type: Application
    Filed: May 19, 2017
    Publication date: November 23, 2017
    Applicant: Terumo BCT, Inc.
    Inventors: Peter O'BRIEN, John Goblirsch
  • EXPANDING CELLS IN A BIOREACTOR
    Publication number: 20170275580
    Abstract: Described are embodiments for expanding cells in a bioreactor. In one embodiment, methods are provided that distribute cells throughout the bioreactor and attach cells to specific portions of a bioreactor to improve the expansion of the cells in the bioreactor. Embodiments may be implemented on a cell expansion system configured to load, distribute, attach and expand cells.
    Type: Application
    Filed: April 7, 2017
    Publication date: September 28, 2017
    Applicant: Terumo BCT, Inc.
    Inventors: Nathan D. FRANK, Mark E. JONES
  • Customizable Methods and Systems of Growing and Harvesting Cells in a Hollow Fiber Bioreactor System
    Publication number: 20170267966
    Abstract: Embodiments described herein generally relate to methods and systems for customizing protocols for use with a cell expansion system. Through a user interface, a user may create a custom task for loading, growing and/or harvesting cells. A custom task may comprise one or more steps, in which a user may add or omit steps, as desired. Data may be entered for settings associated with a custom task, in which embodiments provide for such data to be entered each time the custom task is performed. In another embodiment, the settings for a custom task may be configured, in which such settings may be stored and retrieved upon selection of the custom task. Customization and configuration of a custom task may occur using a diagram view of the cell expansion system, in which process settings are associated with graphical user interface elements.
    Type: Application
    Filed: May 31, 2017
    Publication date: September 21, 2017
    Applicant: Terumo BCT, Inc.
    Inventors: Edward Allan STANTON, IV, Glen Delbert ANTWILER, Patrick J. HOWLEY, Michael E. KINZIE, Jon A. DODD, Casey V. MEDINA
  • Separating composite liquids
    Patent number: 9758764
    Abstract: Described are embodiments that include methods and devices for separating composite liquids into components. Embodiments involve the use of a flexible membrane for separating a composite liquid into components. The composite liquid may include, in embodiments, a cellular containing liquid, such as whole blood or components of whole blood. In one specific embodiment, the composite liquid is a buffy coat.
    Type: Grant
    Filed: February 18, 2014
    Date of Patent: September 12, 2017
    Assignee: Terumo BCT, Inc.
    Inventors: James R. Ladtkow, Geoffrey M. Uhl, Jeremy P. Kolenbrander, Briden Ray Stanton
  • System for blood separation with gravity valve for controlling a side-tapped separation chamber
    Patent number: 9737898
    Abstract: A disposable blood separation set and a centrifugal blood processing system comprising a blood processing chamber adapted to be mounted on a rotor of a centrifuge; a frustro-conical cell separation chamber in fluid communication with the processing chamber, the cell separation chamber having an inlet, a primary outlet and a side tap outlet adjacent the inlet. A valve that is responsive to centrifugal force (a “gravity” valve) selects between the outlet and the side tap outlet. The gravity valve is mounted on the rotor. When the rotor spins at high speed, the gravity valve may open the primary outlet and close the side tap outlet. When the rotor spins at a lower speed, the gravity valve may open the side tap outlet and close the primary outlet.
    Type: Grant
    Filed: September 10, 2015
    Date of Patent: August 22, 2017
    Assignee: Terumo BCT, Inc.
    Inventors: Brian M. Holmes, James R. Ladtkow
  • Generating procedures for entering data prior to separating a liquid into components
    Patent number: 9733805
    Abstract: Described are embodiments that are useful for generating procedures for entering data prior to separating liquid into liquid components. The embodiments are applicable to procedures for entering data prior to separating blood into components. Graphical elements are displayed that allow a user to appreciate the workflow of someone who implements the procedures. As a result, the user can create a procedure that is simple, efficient, and is less prone to errors.
    Type: Grant
    Filed: June 26, 2013
    Date of Patent: August 15, 2017
    Assignee: TERUMO BCT, INC.
    Inventors: Luis Diaz, Allan Gallano
  • Configurable methods and systems of growing and harvesting cells in a hollow fiber bioreactor system
    Patent number: 9725689
    Abstract: Embodiments described herein generally relate to methods and systems for configuring settings of a cell expansion system including a bioreactor. Through a user interface, a user may configure display settings, system settings, and settings associated with protocols for loading, growing and/or harvesting cells. In configuring settings for protocols and associated processes, a diagram view or window of the cell expansion system is displayed in embodiments. The diagram view displays the process settings as graphical user interface elements. Settings available for configuration are enabled for selection in the diagram view. The diagram view allows the user to visualize the settings available for task configuration and to configure enabled settings. Configured settings are stored and capable of retrieval for subsequent execution or modification of the applicable protocol.
    Type: Grant
    Filed: October 7, 2011
    Date of Patent: August 8, 2017
    Assignee: Terumo BCT, Inc.
    Inventors: Edward Allan Stanton, IV, Glen Delbert Antwiler, Patrick J. Howley, Michael E. Kinzie, Jon A. Dodd, Casey V. Medina
  • Concentrating components of fluid circulated through a cell growth chamber
    Patent number: 9695393
    Abstract: One or more embodiments are described directed to a method and system for concentrating components of a fluid circulated through a cell growth chamber such as a cell growth chamber. Accordingly, embodiments include methods and systems that utilize a tangential flow filter to concentrate components of a fluid that in embodiments includes expanded cells. In embodiments, a concentrated fluid component and a concentrated cell component are generated by flowing the fluid with expanded cells across a tangential flow filter. The concentrated cell component may be recirculated to the tangential flow filter to reach some desired concentration of cells. The concentrated fluid component may be collected to utilize cellular-produced constituents in the concentrated fluid component.
    Type: Grant
    Filed: August 20, 2013
    Date of Patent: July 4, 2017
    Assignee: Terumo BCT, Inc.
    Inventors: Brian J. Nankervis, Thomas G. DiLorenzo, Michael E. Kinzie, Mark E. Jones
  • Multi-unit blood processor with temperature sensing
    Patent number: 9687598
    Abstract: Method and apparatus for centrifugal blood component separation including temperature sensing in each of a plurality of separation cells. The temperature of unit of bloods over time is recorded. If the temperature of any of the units exceeds a pre-determined maximum, portions of the blood separation device may be cooled. A controller may determine which of the units to process first, generally proceeding from the warmest unit to the coolest. The order of unit processing may be changed during processing. The detected temperature may be used to calibrate a pressure sensor used to predict the volume of a component separated from a composite fluid by predicting the volume of the composite fluid from sensed pressure and predicting the volume of other separated components from sensed movement of the other components to collection bags.
    Type: Grant
    Filed: September 22, 2014
    Date of Patent: June 27, 2017
    Assignee: Terumo BCT, Inc.
    Inventor: Victor D. Dolecek
  • Customizable methods and systems of growing and harvesting cells in a hollow fiber bioreactor system
    Patent number: 9677042
    Abstract: Embodiments described herein generally relate to methods and systems for customizing protocols for use with a cell expansion system. Through a user interface, a user may create a custom task for loading, growing and/or harvesting cells. A custom task may comprise one or more steps, in which a user may add or omit steps, as desired. Data may be entered for settings associated with a custom task, in which embodiments provide for such data to be entered each time the custom task is performed. In another embodiment, the settings for a custom task may be configured, in which such settings may be stored and retrieved upon selection of the custom task. Customization and configuration of a custom task may occur using a diagram view of the cell expansion system, in which process settings are associated with graphical user interface elements.
    Type: Grant
    Filed: October 7, 2011
    Date of Patent: June 13, 2017
    Assignee: Terumo BCT, Inc.
    Inventors: Edward Allan Stanton, IV, Glen Delbert Antwiler, Patrick J. Howley, Michael E. Kinzie, Jon A. Dodd, Casey V. Medina
  • Methods and systems of growing and harvesting cells in a hollow fiber bioreactor system with control conditions
    Patent number: 9670451
    Abstract: Embodiments described herein generally relate to methods and systems for using an air removal chamber as a control for a process in a cell expansion system. The air removal chamber may be mounted on a fluid conveyance assembly for use with the system. Fluid is pumped into a fluid containment chamber of the air removal chamber, in which the level of fluid in the fluid containment chamber may be monitored through the use of one or more sensors. The sensors are capable of detecting air, a lack of fluid, fluid, and/or a gas/fluid interface, e.g., an air/fluid interface, at measuring positions within the air removal chamber. Protocols for use with the system may include one or more stop conditions. In an embodiment, the stopping of a process is automated based on the detection of air, a lack of fluid, and/or a gas/fluid interface in the air removal chamber.
    Type: Grant
    Filed: November 20, 2014
    Date of Patent: June 6, 2017
    Assignee: Terumo BCT, Inc.
    Inventors: Thomas G. Dilorenzo, Edward Allan Stanton, IV, Glen Delbert Antwiler, Michael E. Kinzie, Brian J. Nankervis, Monique Givens, Casey V. Medina, Jon A. Dodd