Patents Assigned to The Administrators of the Tulane Educational Fund
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Publication number: 20200386742Abstract: The present disclosure generally relates to a cell culturing system, and specifically to a three-dimensional cell culturing system for neuronal cells that promotes both structural and functional characteristics that mimic those of in vivo peripheral fibers, including cell myelination. Using a dual hydrogel construct and spheroids comprising neuronal cells, the present disclosure provides methods, devices, and systems for in vitro spatially-controlled, three-dimensional models that permit intra- and extra-cellular electro-physiological measurements and recordings. The three-dimensional hydrogel constructs allow for flexibility in incorporated cell types, geometric fabrication, and electrical manipulation, providing viable systems for culture, perturbation, and testing of biomimetic neural growth with physiologically-relevant results.Type: ApplicationFiled: December 4, 2018Publication date: December 10, 2020Applicants: The Administrators of the Tulane Educational Fund, AxoSim Technologies LLCInventors: Michael James Moore, Jabe Lowry Curley, Anup D. Sharma, Devon Bowser, Jordan Behn
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Patent number: 10837912Abstract: Manual and automatic methods and devices using a ACOMP system for active control of polymerization reaction processes. An ideal desired trajectory of one or more reaction and polymer characteristics can be established to produce a desired final polymer product with specified characteristics from a polymerization reaction process. A current reaction trajectory of a polymerization reaction process can be driven to an ideal or desired reaction trajectory. In a manual embodiment an operator can use ACOMP data to adjust process variables in order to drive the current reaction trajectory toward the ideal or desired reaction trajectory. In an automated mode a control program can use ACOMP data to make adjustments to process variables to drive the polymerization reaction process toward the desired trajectory as closely as possible either empirically or by solving the governing equations for the polymerization reaction process.Type: GrantFiled: September 30, 2015Date of Patent: November 17, 2020Assignees: ADVANCED POLYMER MONITORING TECHNOLOGIES, INC., THE ADMINISTRATORS OF THE TULANE EDUCATIONAL FUNDInventors: Wayne Frederick Reed, Michael Felix Drenski
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Publication number: 20200306419Abstract: The disclosure provides drug delivery devices and methods of making and using the drug delivery devices. The devices include single and multi-layer polymer films made by a breath figure technique having therapeutic agents associated therewith. For example, the devices may be a dual layer polymer film wherein the first layer includes a therapeutic agent incorporated into it by spin coating the first agent with a polymer solution and the second agent is incorporated into the second layer by loading the agent into pores of the second layer after it is spin coated onto the first layer. In some cases one layer provides a burst release and the second layer provides a slow release drug delivery profile. The devices may take on the form of a surgical mesh with a slow release therapeutic drug.Type: ApplicationFiled: April 14, 2020Publication date: October 1, 2020Applicant: THE ADMINISTRATORS OF THE TULANE EDUCATIONAL FUNDInventors: Diane A. BLAKE, Vijay T. John, Ramesh Ayyala, Thiruselvam Ponnusamy
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Patent number: 10768402Abstract: Systems and methods are provided for evaluating a fresh tissue sample, prepared as to fluoresce under illumination, during a medical procedure. A structured light source is configured to project a spatially patterned light beam onto the fresh tissue sample. An imaging system is configured to produce an image from fluorescence emitted from the illuminated fresh tissue sample. A system control is configured to provide a human-comprehensible clinically useful output associated with the medical procedure.Type: GrantFiled: August 3, 2018Date of Patent: September 8, 2020Assignee: THE ADMINISTRATORS OF THE TULANE EDUCATIONAL FUNDInventor: Jonathon Quincy Brown
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Patent number: 10709811Abstract: The present disclosure relates to surgical grafts for replacing nipples and areolas lost to disease or trauma with surgical grafts of decellularized donor nipples and areolas and to placing and recellularizing such grafts. The disclosure further provides methods for decellularizing epidermis. The decellularized epidermis can be used as a protective cover for skin wounds.Type: GrantFiled: October 31, 2015Date of Patent: July 14, 2020Assignee: The Administrators of the Tulane Educational FundInventors: Nicholas C. Pashos, Bruce A. Bunnell
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Publication number: 20200138934Abstract: The invention provides methods and compositions for preventing or ameliorating pulmonary infections with Pseudomonas aeruginosa.Type: ApplicationFiled: October 2, 2019Publication date: May 7, 2020Applicant: The Administrators of the Tulane Educational FundInventors: Lisa Ann MORICI, Sarah Margaret BAKER
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Patent number: 10620127Abstract: Devices and methods for controlling the properties of chemical species during time-dependent processes. A device includes a reactor for containing one or more chemical species of a time-dependent process, an extraction pump for automatically and continuously extracting an amount of the one or more chemical species from the reactor, one or more detectors for measuring property changes of the one or more extracted chemical species and generating a continuous stream of data related to the one or more property changes to the one or more chemical species during a time interval, and a process controller configured to fit the continuous stream of data to a mathematical function to predict one or more properties of the one or more chemical species at a future time point and make one or more process decisions based on the prediction of one or more properties at the future time point.Type: GrantFiled: January 22, 2019Date of Patent: April 14, 2020Assignees: THE ADMINISTRATORS OF THE TULANE EDUCATIONAL FUND, ADVANCED POLYMER MONITORING TECHNOLOGIES, INC.Inventors: Wayne Frederick Reed, Michael Felix Drenski
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Publication number: 20200106386Abstract: The present invention provides a hybrid, concentrating photovoltaic-solar thermal (CPV/T) system and components thereof, and methods for converting solar energy to electricity at high efficiencies while capturing and storing solar thermal energy for later deployment.Type: ApplicationFiled: February 26, 2018Publication date: April 2, 2020Applicant: The Administrators of the Tulane Educational FundInventors: Daniel Codd, Matthew David Escarra, Brian C. Riggs
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Publication number: 20200040287Abstract: A micellar compositions including oil-soluble surfactants delivered by water-soluble surfactants are disclosed. The micellar compositions demonstrate enhanced crude oil mobilization in porous media. When the porous media was imbued with crude oil, the presence of the surfactant in the oil phase improved the mobilization performance of crude oil. Solutions of SDS were used to solubilize the surfactant, and the formation of SDS/PIBSI micellar composition was confirmed by Cryo-SEM images. High cleaning effectiveness of the micellar compositions on crude oil entrapped in porous media was demonstrated by image binarization.Type: ApplicationFiled: October 6, 2017Publication date: February 6, 2020Applicants: THE ADMINISTRATORS OF THE TULANE EDUCATIONAL FUND, ENI S.p.A.Inventors: Kyriakos PAPADOPOULOS, Riccardo RAUSA
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Patent number: 10538767Abstract: Treatment of tumors, especially breast cancer or glioblastoma tumors, by silencing RAB27A and/or TRAF3IP2, compositions and methods for same.Type: GrantFiled: November 26, 2018Date of Patent: January 21, 2020Assignee: The Administrators of the Tulane Educational FundInventors: Eckhard Alt, Reza Izadpanah
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Patent number: 10537634Abstract: Immunogenic influenza hemagglutinin-derived peptide compositions described herein induce a specific therapeutic antibody response against influenza virus. The immunogenic peptide compositions comprise a segment from the fusion initiation region (FIR) domain of an influenza hemagglutinin protein bound to an immunogenic carrier protein, such as an influenza hemagglutinin (HA) protein (i.e., full length HA), and the like. The immunogenic peptide compositions described herein can be utilized to treat or prevent influenza infection and to prepare influenza-specific therapeutic antibodies that interfere with influenza virus-host cell membrane fusion. The peptide conjugates can be formulated in pharmaceutical compositions useful for broad spectrum treatment or prevention of influenza infections.Type: GrantFiled: October 31, 2018Date of Patent: January 21, 2020Assignees: THE ADMINISTRATORS OF THE TULANE EDUCATIONAL FUND, AUTOIMMUNE TECHNOLOGIES, LLCInventors: Robert Francis Garry, Russell B. Wilson
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Patent number: 10478407Abstract: Disclosed herein are topical compositions comprising a quaternary ammonium salt and optionally ammonium chloride and/or stabilized chlorine dioxide. Also disclosed herein are methods of reducing the severity and/or duration of a dermal and or mucosal infection such as herpes or shingles. Also disclosed herein are methods of preventing the spread of a viral infection such as HIV. Also disclosed herein are methods of treating a viral infection such as keratoconjunctivitis.Type: GrantFiled: February 22, 2019Date of Patent: November 19, 2019Assignee: THE ADMINISTRATORS OF THE TULANE EDUCATIONAL FUNDInventor: Chad Roy
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Patent number: 10472647Abstract: Episomally transfected primary mesenchymal stem cells (MSC) express a polypeptide consisting of an antigenic polypeptide (e.g., one or more polypeptides) relating to a pathogen (e.g., one or more virus, bacterium, or parasite). The antigenic polypeptide can have the amino acid sequence of a natural polypeptide from the pathogen or an amino acid sequence differing from the natural sequence by one or more conservative amino acid substitutions. Uses and method for treating or preventing infections with episomally transfected primary MSC also are described.Type: GrantFiled: November 15, 2013Date of Patent: November 12, 2019Assignee: The Administrators of the Tulane Educational FundInventors: Suzanne L. Tomchuck, Elizabeth B. Norton, Robert F. Garry, Bruce Bunnell, John D. Clements
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Patent number: 10458985Abstract: This invention relates to a cell-surface marker for identifying MSC that are aging. This invention also relates to a method of screening MSCs of low proliferation potential and trilineage potential by removing CD264+ MSCs from the population.Type: GrantFiled: April 10, 2015Date of Patent: October 29, 2019Assignee: The Administrators of the Tulane Educational FundInventor: Kim C. O'Connor
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Publication number: 20190307916Abstract: Otologic materials and methods are provided. For example, a cell-adhesive, biodegradable hydrogel scaffold loaded with time-released drugs for repairing chronic tympanic membrane perforations is disclosed, methods of making same and administering same are provided. This hydrogel may promote vascular in-growth and epithelial cell growth of the tympanic membrane with the purpose of closing the perforation and providing a barrier between the external and middle ear. The hydrogel is initially a liquid polymer that only gels upon exposure to specific conditions, such as exposure to light. This scaffold may simultaneously induce repair of the tympanic membrane while preventing or alleviating middle ear infection, thus filling a void in current tympanic membrane perforation therapies.Type: ApplicationFiled: June 23, 2019Publication date: October 10, 2019Applicant: The Administrators of the Tulane Educational FundInventors: Elaine Horn-Ranney, Parastoo Khoshakhlagh, Michael Moore, Jesse Ranney
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Publication number: 20190282694Abstract: Immunoprotective primary mesenchymal stems cells (IP-MSC) which episomally express immunoreactive polypeptides that specifically target a pathogen (e.g., an infectious species of virus, bacterium, or parasite) or toxin are described herein. The immunoreactive polypeptides can be, e.g., full antibodies, single-chain antibodies (ScFV), Fab or F(ab)2 antibody fragments, diabodies, tribodies, and the like). Optionally IP-MSC are transfected to express one or more other immunomodulating polypeptides, e.g., a cytokine such as an interleukin (e.g., IL-2, IL-4, IL-6, IL-7, IL-9, and IL-12), an interferon (e.g., IFN?, IFN?, or IFN?), and the like, which can enhance the effectiveness of the immunoreactive polypeptides.Type: ApplicationFiled: May 30, 2019Publication date: September 19, 2019Applicants: THE ADMINISTRATORS OF THE TULANE EDUCATIONAL FUND, AUTOIMMUNE TECHNOLOGIES, LLCInventors: Robert Francis Garry, Luis Manuel Branco, Bruce Alan Bunnell, Russell B. Wilson, Samuel E. Hopkins
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Patent number: 10400237Abstract: The present disclosure provides compositions and methods of their use to impair angiogenesis in a patient to treat indications including, but not limited to, tumor growth, age-related macular degeneration, and metastasis. Also provided are compositions and methods for promoting angiogenesis in patients in need thereof.Type: GrantFiled: March 2, 2017Date of Patent: September 3, 2019Assignee: The Administrators of the Tulane Educational FundInventors: Shusheng Wang, Qinbo Zhou
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Patent number: 10399280Abstract: A three dimensional (3D) printing system includes computer-executable instructions for obtaining a volumetric object representation file, parsing the volumetric object representation file into multiple layers, and for each layer, decomposing the layer into a sequence of continuous paths, aggregating non-continuous sets of tool paths with a single outer path and zero or more open or closed inner paths into islands, and generating one or more motion segments according to each island. Once generated, the motion segments may be aggregated to form a toolpath, which is used by the three dimensional printer to print a 3D model. Other embodiments may employ.Type: GrantFiled: April 28, 2017Date of Patent: September 3, 2019Assignee: THE ADMINISTRATORS OF THE TULANE EDUCATIONAL FUNDInventors: Sam Lensgraf, Ramgopal Mettu
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Patent number: 10357562Abstract: Immunoprotective primary mesenchymal stems cells (IP-MSC) which episomally express multiple immunoreactive polypeptides that specifically target a pathogen (e.g., an infectious species of virus, bacterium, or parasite) or toxin are described herein. The IP-MSC express two or more (e.g., 2 to about 100) immunoreactive polypeptides (e.g., full antibodies, single-chain antibodies (ScFV), Fab or F(ab)2 antibody fragments, diabodies, tribodies, and the like), and optionally one or more other immunomodulating polypeptides, e.g., a cytokine such as an interleukin (e.g., IL-2, IL-4, IL-6, IL-7, IL-9, and IL-12), an interferon (e.g., IFN?, IFN?, or IFN?), and the like, which can enhance the effectiveness of the immunoreactive polypeptides.Type: GrantFiled: July 17, 2015Date of Patent: July 23, 2019Assignees: The Administrators of the Tulane Educational Fund, Autoimmune Technologies, LLCInventors: Robert Francis Garry, Luis Manuel Branco, Bruce Alan Bunnell, Russell B. Wilson, Samuel E. Hopkins
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Patent number: 10347476Abstract: Provided are synthetic dendrimer calibrants for mass spectrometry. The calibrants are distinguished by their relative ease and rapidity of synthesis, comparatively low cost, long shelf life, high purity, and amenability to batch synthesis as mixtures. The latter characteristic enables parallel preparation of higher molecular weight compounds displaying useful distributions of discrete molecular weights, thereby providing multi-point mass spectrometry calibration standards. Methods of making, tuning and using said calibrants are provided.Type: GrantFiled: May 21, 2013Date of Patent: July 9, 2019Assignee: The Administrators of the Tulane Educational FundInventor: Scott Grayson