Patents Assigned to The Alfred E. Mann Foundation for Scientific Research
  • Publication number: 20210205614
    Abstract: An electrode lead comprises an elongated lead body, at least one lead connector terminal affixed to the proximal end of the lead body, and an electrically insulative cuff body affixed to the distal end of the lead body. The cuff body is configured for being circumferentially disposed around a nerve. The cuff body comprises cutouts, slits, a wrinkled portion, a thin stretchable portion, and/or a serpentine strap, which increases that increase the expandability of the cuff body when disposed around the nerve. The electrode lead further comprises at least one electrode contact affixed to the cuff body, and at least one electrical conductor extending through the lead body between the at least one lead connector terminal and the electrode contact(s). If the cuff body comprises cutouts or slits, the electrode lead can further comprise a thin stretchable film affixed to the cuff body over cutouts or slits.
    Type: Application
    Filed: March 18, 2021
    Publication date: July 8, 2021
    Applicant: THE ALFRED E. MANN FOUNDATION FOR SCIENTIFIC RESEARCH
    Inventors: Boon Khai Ng, William Alexander Dai
  • Publication number: 20210187288
    Abstract: An electrode lead comprises a lead body, connector contacts affixed to the proximal end of the lead body, and a cuff body affixed to the distal end of the lead body. The cuff body is pre-shaped to transition from an unfurled state to a furled state, wherein the cuff body, when in the furled state has an inner surface for contacting a nerve and an overlapping inner cuff region and an outer cuff region. The electrode lead further comprise electrode contacts circumferentially disposed along the cuff body when in the furled state, such that at least one of the electrode contacts is located on the inner surface of the cuff body, and at least another of the electrode contacts is located between the overlapping inner and outer cuff regions. The electrode lead further comprises electrical conductors extending through the lead body respectively between the connector contacts and the electrode contacts.
    Type: Application
    Filed: March 3, 2021
    Publication date: June 24, 2021
    Applicant: THE ALFRED E. MANN FOUNDATION FOR SCIENTIFIC RESEARCH
    Inventors: Boon Khai Ng, Joseph L. Calderon
  • Publication number: 20210121624
    Abstract: Implantable infusion devices and methods that provide closed loop control.
    Type: Application
    Filed: October 23, 2020
    Publication date: April 29, 2021
    Applicant: The Alfred E. Mann Foundation for Scientific Research
    Inventors: Robert J. GREENBERG, Harshit R. Suri, Thomas J. Lobl, Brian M. Shelton, Sam W. Bowman
  • Patent number: 10981000
    Abstract: An electrode lead comprises an elongated lead body, at least one lead connector terminal affixed to the proximal end of the lead body, and an electrically insulative cuff body affixed to the distal end of the lead body. The cuff body is configured for being circumferentially disposed around a nerve. The cuff body comprises cutouts, slits, a wrinkled portion, a thin stretchable portion, and/or a serpentine strap, which increases that increase the expandability of the cuff body when disposed around the nerve. The electrode lead further comprises at least one electrode contact affixed to the cuff body, and at least one electrical conductor extending through the lead body between the at least one lead connector terminal and the electrode contact(s). If the cuff body comprises cutouts or slits, the electrode lead can further comprise a thin stretchable film affixed to the cuff body over cutouts or slits.
    Type: Grant
    Filed: April 30, 2018
    Date of Patent: April 20, 2021
    Assignee: THE ALFRED E. MANN FOUNDATION FOR SCIENTIFIC RESEARCH
    Inventors: Boon Khai Ng, William Dai
  • Patent number: 10967178
    Abstract: An electrode lead comprises a lead body, connector contacts affixed to the proximal end of the lead body, and a cuff body affixed to the distal end of the lead body. The cuff body is pre-shaped to transition from an unfurled state to a furled state, wherein the cuff body, when in the furled state has an inner surface for contacting a nerve and an overlapping inner cuff region and an outer cuff region. The electrode lead further comprise electrode contacts circumferentially disposed along the cuff body when in the furled state, such that at least one of the electrode contacts is located on the inner surface of the cuff body, and at least another of the electrode contacts is located between the overlapping inner and outer cuff regions. The electrode lead further comprises electrical conductors extending through the lead body respectively between the connector contacts and the electrode contacts.
    Type: Grant
    Filed: August 30, 2018
    Date of Patent: April 6, 2021
    Assignee: THE ALFRED E. MANN FOUNDATION FOR SCIENTIFIC RESEARCH
    Inventors: Boon Khai Ng, Joseph L. Calderon
  • Patent number: 10971950
    Abstract: A charger including a class E power driver, a frequency-shift keying (“FSK”) module, and a processor. The processor can receive data relating to the operation of the class E power driver and can control the class E power driver based on the received data relating to the operation of the class E power driver. The processor can additionally control the FSK module to modulate the natural frequency of the class E power transformer to thereby allow the simultaneous recharging of an implantable device and the transmission of data to the implantable device. The processor can additionally compensate for propagation delays by adjusting switching times.
    Type: Grant
    Filed: September 6, 2019
    Date of Patent: April 6, 2021
    Assignee: THE ALFRED E. MANN FOUNDATION FOR SCIENTIFIC RESEARCH
    Inventors: Brian R. Dearden, James H. Wolfe, Manish Khemani
  • Patent number: 10940303
    Abstract: The various implementations described herein include a percutaneous port for promoting tissue in-growth around the percutaneous port. In one aspect, the percutaneous port includes a tubular structure having an outer surface, and a coil having an outer surface and comprised of a plurality of loops. Furthermore, at least a portion of the outer surface of the coil is joined to the outer surface of the tubular structure.
    Type: Grant
    Filed: March 11, 2019
    Date of Patent: March 9, 2021
    Assignee: ALFRED E. MANN FOUNDATION FOR SCIENTIFIC RESEARCH
    Inventors: Guangqiang Jiang, Tom He
  • Publication number: 20210052893
    Abstract: An electrode lead comprises an electrically insulative cuff body and at least three axially aligned electrode contacts circumferentially disposed along the inner surface of the cuff body when in the furled state. The electrode contacts may be circumferentially disposed around a nerve, and an electrical pulse train may be delivered to the electrode contacts thereby stimulating the nerve to treat obstructive sleep apnea. The electrical pulse train may be one that pre-conditions peripherally located nerve fascicles to not be stimulated, while stimulating centrally located nerve fascicles. A feedback mechanism can be used to titrate electrode contacts and electrical pulse train to the patient. A sensor that is affixed to the case of a neurostimulator can be used to measure physiological artifacts of respiration, and a motion detector can be used to sense tapping of the neurostimulator to toggle the neurostimulator between an ON position and an OFF position.
    Type: Application
    Filed: November 6, 2020
    Publication date: February 25, 2021
    Applicant: THE ALFRED E. MANN FOUNDATION FOR SCIENTIFIC RESEARCH
    Inventors: Harshit Suri, Joseph L. Cakleron, Gregory Frederick Moinar, George S. Goding, JR., Alanie Atyabi, Siegmar Schmidt, William Dai, Brian Dearden, Desmond B. Keenan
  • Patent number: 10925489
    Abstract: A medical system and method of communicating between a telemetry controller and medical devices is provided. Coupling coefficients between a primary coil of the telemetry controller and secondary coils of the medical devices differ from each other. A primary carrier signal is applied to the primary coil, thereby respectively inducing secondary carrier signals on the secondary coils. An amplitude of the secondary carrier signal is measured on each of the secondary coils. The envelope of each secondary carrier signal is modulated in accordance with data, thereby inducing modulation of the envelope of the primary carrier signal for the implanted medical devices. The secondary carrier signal envelopes are modulated based on the measured amplitudes of the respective secondary carrier signals.
    Type: Grant
    Filed: September 24, 2019
    Date of Patent: February 23, 2021
    Assignee: THE ALFRED E. MANN FOUNDATION FOR SCIENTIFIC RESEARCH
    Inventors: Edward K. F. Lee, Harshit R. Suri
  • Publication number: 20210038889
    Abstract: An electrode lead comprises an electrically insulative cuff body and at least three axially aligned electrode contacts circumferentially disposed along the inner surface of the cuff body when in the furled state. The electrode contacts may be circumferentially disposed around a nerve, and an electrical pulse train may be delivered to the electrode contacts thereby stimulating the nerve to treat obstructive sleep apnea. The electrical pulse train may be one that pre-conditions peripherally located nerve fascicles to not be stimulated, while stimulating centrally located nerve fascicles. A feedback mechanism can be used to titrate electrode contacts and electrical pulse train to the patient. A sensor that is affixed to the case of a neurostimulator can be used to measure physiological artifacts of respiration, and a motion detector can be used to sense tapping of the neurostimulator to toggle the neurostimulator between an ON position and an OFF position.
    Type: Application
    Filed: October 29, 2020
    Publication date: February 11, 2021
    Applicant: THE ALFRED E. MANN FOUNDATION FOR SCIENTIFIC RESEARCH
    Inventors: Harshit Suri, Joseph L. Calderon, Gregory Frederick Molnar, George S. Goding, JR., Alanie Atyabi, Siegmar Schmidt, William Dai, Brian Dearden, Desmond B. Keenan
  • Publication number: 20200368526
    Abstract: An electrode lead comprises an electrically insulative cuff body and at least three axially aligned electrode contacts circumferentially disposed along the inner surface of the cuff body when in the furled state. The electrode contacts may be circumferentially disposed around a nerve, and an electrical pulse train may be delivered to the electrode contacts thereby stimulating the nerve to treat obstructive sleep apnea. The electrical pulse train may be one that pre-conditions peripherally located nerve fascicles to not be stimulated, while stimulating centrally located nerve fascicles. A feedback mechanism can be used to titrate electrode contacts and electrical pulse train to the patient. A sensor that is affixed to the case of a neurostimulator can be used to measure physiological artifacts of respiration, and a motion detector can be used to sense tapping of the neurostimulator to toggle the neurostimulator between an ON position and an OFF position.
    Type: Application
    Filed: August 13, 2020
    Publication date: November 26, 2020
    Applicant: THE ALFRED E. MANN FOUNDATION FOR SCIENTIFIC RESEARCH
    Inventors: Harshit Suri, Joseph L. Calderon, Gregory Frederick Molnar, George S. Goding, JR., Alanie Atyabi, Siegmar Schmidt, William Dai, Brian Dearden, Desmond B. Keenan
  • Publication number: 20200269054
    Abstract: In accordance with the present invention, various embodiments of neurostimulators and stimulation systems are disclosed that provide different shapes and patterns of stimulus pulses and trains of pulses with fixed and no fixed frequencies. The neurostimulator can be configured to provide high frequency stimulation and also be implantable in the head or neck regions in order to stimulate nerves and nerve ganglions in the head and neck regions and also stimulate the brain.
    Type: Application
    Filed: May 4, 2020
    Publication date: August 27, 2020
    Applicant: THE ALFRED E. MANN FOUNDATION FOR SCIENTIFIC RESEARCH
    Inventors: Brian R. Dearden, Harshit Suri, Edward K. F. Lee
  • Publication number: 20200267550
    Abstract: A medical device of a medical system is configured for communicating with an external programmer over a wireless communications link. The medical device comprises a wireless communications module configured for receiving a first unencrypted version of a random number and a first encrypted version of the random number from the external programmer over the wireless communications link. The medical device further comprises control circuitry configured for performing an authentication procedure on the external programmer based on the first unencrypted version of the random number and the first encrypted version of the random number, and preventing the external programmer from commanding the medical device to perform an action unless the authentication procedure is successful.
    Type: Application
    Filed: May 8, 2020
    Publication date: August 20, 2020
    Applicant: THE ALFRED E. MANN FOUNDATION FOR SCIENTIFIC RESEARCH
    Inventors: Saul Rodriguez, Dianna (Dan) Han, Emile lstoc
  • Patent number: 10739218
    Abstract: Pressure sensors having ring-tensioned membranes are disclosed. A tensioning ring is bonded to a membrane in a manner that results in the tensioning ring applying a tensile force to the membrane, flattening the membrane and reducing or eliminating defects that may have occurred during production. The membrane is bonded to the sensor housing at a point outside the tensioning ring, preventing the process of bonding the membrane to the housing from introducing defects into the tensioned portion of the membrane. A dielectric may be introduced into the gap between the membrane and the counter electrode in a capacitive pressure sensor, resulting in an improved dynamic range.
    Type: Grant
    Filed: April 11, 2017
    Date of Patent: August 11, 2020
    Assignee: THE ALFRED E. MANN FOUNDATION FOR SCIENTIFIC RESEARCH
    Inventors: Siegmar Schmidt, William A. Dai, Boon Khai Ng
  • Publication number: 20200206501
    Abstract: An electrode lead comprises an electrically insulative cuff body and at least three axially aligned electrode contacts circumferentially disposed along the inner surface of the cuff body when in the furled state. The electrode contacts may be circumferentially disposed around a nerve, and an electrical pulse train may be delivered to the electrode contacts thereby stimulating the nerve to treat obstructive sleep apnea. The electrical pulse train may be one that pre-conditions peripherally located nerve fascicles to not be stimulated, while stimulating centrally located nerve fascicles. A feedback mechanism can be used to titrate electrode contacts and electrical pulse train to the patient. A sensor that is affixed to the case of a neurostimulator can be used to measure physiological artifacts of respiration, and a motion detector can be used to sense tapping of the neurostimulator to toggle the neurostimulator between an ON position and an OFF position.
    Type: Application
    Filed: March 9, 2020
    Publication date: July 2, 2020
    Applicant: THE ALFRED E. MANN FOUNDATION FOR SCIENTIFIC RESEARCH
    Inventors: Harshit Suri, Joseph L Calderon, Gregory Frederick Molnar, George S. Goding, JR., Alanie Atyabi, Siegmar Schmidt, William Dai, Brian Dearden, Desmond B. Keenan
  • Patent number: 10687719
    Abstract: A hermetically sealed biocompatible pressure sensor module configured for implant at a desired site at which a pressure is to be measured. Anodic bonding of the pressure module package components which have similar thermal coefficients of expansion provides low stress bonding and maintains long term reliability, dependability and accuracy. The pressure sensor module includes a pressure sensitive membrane which is in direct contact with the environment at which a pressure is to be measured. The pressure sensor module forms a part of a pressure measuring system which uses a telemetry link between the pressure sensor module and an external controller for data transmission and transfer. Operating power for the pressure sensor module is provided by the external controller and an internal rechargeable energy storage component. Accordingly, the pressure measuring system provides a dual stage power and data transfer capability for use with an implantable system.
    Type: Grant
    Filed: July 3, 2017
    Date of Patent: June 23, 2020
    Assignee: The Alfred E. Mann Foundation for Scientific Research
    Inventors: Siegmar Schmidt, Charles L. Byers, Guangqiang Jiang, Brian R. Dearden, John C. Gord, Daniel Rodriguez
  • Publication number: 20200179702
    Abstract: A multiple output current stimulator circuit with fast turn on time is described. At least one pair of input side and output side transistors is arranged in a current mirror connected to a supply transistor by cascode coupling. The output side transistor supplies stimulation current to an electrode in contact with tissue. An operational amplifier connected to a reference voltage and to the output side transistor drives the supply transistor to maintain the voltage at the output side transistor equal to the reference voltage. The at least one pair of transistors includes multiple pairs of transistors whose output side transistors drive respective electrodes with stimulation currents. The stimulator determines the initiation and duration of stimulation current pulses supplied to each electrode. At circuit activation, large currents are generated which discharge capacitances in the output side transistors causing rapid output side transistor turn on.
    Type: Application
    Filed: February 14, 2020
    Publication date: June 11, 2020
    Applicant: ALFRED E. MANN FOUNDATION FOR SCIENTIFIC RESEARCH
    Inventor: EDWARD K.F. LEE
  • Patent number: 10652740
    Abstract: A medical device of a medical system is configured for communicating with an external programmer over a wireless communications link. The medical device comprises a wireless communications module configured for receiving a first unencrypted version of a random number and a first encrypted version of the random number from the external programmer over the wireless communications link. The medical device further comprises control circuitry configured for performing an authentication procedure on the external programmer based on the first unencrypted version of the random number and the first encrypted version of the random number, and preventing the external programmer from commanding the medical device to perform an action unless the authentication procedure is successful.
    Type: Grant
    Filed: March 7, 2017
    Date of Patent: May 12, 2020
    Assignee: THE ALFRED E. MANN FOUNDATION FOR SCIENTIFIC RESEARCH
    Inventors: Saul Rodriguez, Dianna (Dan) Han, Emil Istoc
  • Patent number: 10639480
    Abstract: In accordance with the present invention, various embodiments of neurostimulators and stimulation systems are disclosed that provide different shapes and patterns of stimulus pulses and trains of pulses with fixed and no fixed frequencies. The neurostimulator can be configured to provide high frequency stimulation and also be implantable in the head or neck regions in order to stimulate nerves and nerve ganglions in the head and neck regions and also stimulate the brain.
    Type: Grant
    Filed: December 21, 2017
    Date of Patent: May 5, 2020
    Assignee: THE ALFRED E. MANN FOUNDATION FOR SCIENTIFIC RESEARCH
    Inventors: Brian R. Dearden, Harshit Suri, Edward K. F. Lee
  • Patent number: 10603495
    Abstract: A multiple output current stimulator circuit with fast turn on time is described. At least one pair of input side and output side transistors is arranged in a current mirror connected to a supply transistor by cascode coupling. The output side transistor supplies stimulation current to an electrode in contact with tissue. An operational amplifier connected to a reference voltage and to the output side transistor drives the supply transistor to maintain the voltage at the output side transistor equal to the reference voltage. The at least one pair of transistors includes multiple pairs of transistors whose output side transistors drive respective electrodes with stimulation currents. The stimulator determines the initiation and duration of stimulation current pulses supplied to each electrode. At circuit activation, large currents are generated which discharge capacitances in the output side transistors causing rapid output side transistor turn on.
    Type: Grant
    Filed: May 15, 2018
    Date of Patent: March 31, 2020
    Assignee: THE ALFRED E. MANN FOUNDATION FOR SCIENTIFIC RESEARCH
    Inventor: Edward K.F. Lee