Patents Assigned to The Board of Governors of Wayne State University
  • Patent number: 4959182
    Abstract: A method and compositions including a 1,2-dioxetane and a fluorescent compound is described. In particular, enzymatic triggering of a triggerable 1,2-dioxetane admixed with a surfactant and the fluorescent compound attached to a hydrocarbon to provide a co-surfactant in a micelle or other structure providing close association of these molecules is described. The method and compositions are useful in immunoassays and in DNA probes used for various purposes.
    Type: Grant
    Filed: March 1, 1989
    Date of Patent: September 25, 1990
    Assignee: Board of Governors of Wayne State University
    Inventor: Arthur P. Schaap
  • Patent number: 4950680
    Abstract: Compositions and a method for inhibiting tumor cell induced platelet aggregation are described. Platelet aggregation by tumor cells is part of the metastatic cascade which is interrupted according to the present invention. The compounds include a mixture of at least two members of the group including a calcium channel blocker, a prostacyclin, a thromboxane synthase inhibitor and a phosphodiesterase inhibitor. All of the compounds utilized have an affect on calcium ion which controls platelet aggregation.
    Type: Grant
    Filed: October 17, 1984
    Date of Patent: August 21, 1990
    Assignee: Board of Governors of Wayne State University
    Inventors: John D. Taylor, Kenneth V. Honn
  • Patent number: 4950590
    Abstract: A micro-enzyme described immunosorbent assay (microELISA) method is described for detecting small amounts of thymosin alpha.sub.1 in a solution such as serum. The method uses a known amount of an antibody to the thymosin alpha.sub.1 which is reacted with the thymosin alpha.sub.1 in solution to form a first complex. The solution with the first complex and unreacted antibody is then contacted with thymosin alpha.sub.1 bound to a solid phase which quantitatively forms a second complex with the unreacted antibody. The amount of the second complex is determined and correlated with the amount of thymosin alpha.sub.1 of the solution. Thymosin alpha.sub.1 is an important hormone the presence or absence of which is significant clinically.
    Type: Grant
    Filed: January 13, 1986
    Date of Patent: August 21, 1990
    Assignee: Board of Governors of Wayne State University
    Inventors: Milton G. Mutchnick, Frederick E. Weller
  • Patent number: 4944196
    Abstract: A conjugate gear system including a pair of meshingly engageable toothed gears, at least one member of the gear pair having at least one three-component tooth. Each three-component tooth is comprised of a central core, at least one face disposed thereon, and a means for displaceably attaching the face section to the core such that the face section is displaceable with respect to the core in the direction of the sliding component of motion created by meshing engagement of the gear pair. By separating out the sliding component in this fashion, relatively pure rolling contact is maintained between the engaged surfaces of the gear pair at all times, thus reducing sliding friction, thermal expansion, and noise levels created by the engagement of the gears.
    Type: Grant
    Filed: March 10, 1989
    Date of Patent: July 31, 1990
    Assignee: The Board of Governors of Wayne State University
    Inventor: Eugeny I. Rivin
  • Patent number: 4906646
    Abstract: A method for the treatment of malignant tumors by co-administering a platinum coordination compound and a dihydropyridine class calcium channel blocker compound is described. The compounds are administered over a period of several days in at least two separate dosages of each compound so as to produce regression of the tumor in vitro and in vivo and inhibition of metastasis of the tumor in vivo.
    Type: Grant
    Filed: October 10, 1985
    Date of Patent: March 6, 1990
    Assignee: Board of Governors of Wayne State University
    Inventors: Kenneth V. Honn, John D. Taylor, James M. Onoda
  • Patent number: 4880053
    Abstract: A two-phase cooling device includes a sealed enclosure defined by at least first and second, spaced thermally conductive walls interconnected by side walls. One of the thermally conductive walls is adapted for interconnection in a thermally conductive relationship with the item desired to be cooled. A wick structure is disposed within the generally hollow interior of the sealed enclosure, and includes a first wick portion extending along at least a portion of the thermally conductive wall adjacent the item to be cooled and at least one second wick portion protruding transversely from the first wick portion. The second wick portion is at least partially submerged within a thermally conductive liquid disposed within the hollow interior of the sealed enclosure. The thermally conductive liquid is capable of being transported through the wick portions, with the liquid being evaporated by the transfer of heat from the item to be cooled into the first wick portion.
    Type: Grant
    Filed: April 24, 1989
    Date of Patent: November 14, 1989
    Assignee: The Board of Governors of Wayne State University
    Inventor: Sheyman: Vladimir
  • Patent number: 4873360
    Abstract: Cyclopentanoids (I) of the formula: ##STR1## including stereoisomers are described along with a process for the preparation of I. In particular the preparation of prostanoids of the formula: ##STR2## wherein R.sub.1 is a alkyl group containing 1 to 8 carbon atoms and R.sub.2 CO.sub.2 R.sub.3 is an alkenyl ester group, R.sub.2 contains 2 to 6 carbon atoms and R.sub.3 is a lower alkyl group containing 1 to 6 carbon atoms is described. A particular prostaglandin prepared by the process is PGE.sub.2. The prostanoids have been demonstrated to have pharmacological activity in animals and humans. Novel intermediates of (I) are also described.
    Type: Grant
    Filed: January 21, 1988
    Date of Patent: October 10, 1989
    Assignee: Board of Governors of Wayne State University
    Inventors: Carl R. Johnson, Thomas D. Penning
  • Patent number: 4857652
    Abstract: Novel light producing 1,2-dioxetanes are described of the formula ##STR1## wherein ArOX is an aryl ring substituted with an X oxy group and A are passive organic groups which allow the 1,2-dioxetane to produce light when triggered by removing X. X is a chemically labile group which is removed by an activating agent. The 1,2-dioxetane compounds can be triggered to produce light at room temperatures.
    Type: Grant
    Filed: August 23, 1988
    Date of Patent: August 15, 1989
    Assignee: Board of Governors of Wayne State University
    Inventor: Arthur P. Schaap
  • Patent number: 4830961
    Abstract: A method and test kit for selectively staining histamine or histamine blocker sites on mammalian cells is described. Novel fluorescently labeled histamines or histamine blocker compounds are described. The method allows the visualization of sites on individual cells which are receptors for the histamines or histamine blockers.
    Type: Grant
    Filed: June 5, 1986
    Date of Patent: May 16, 1989
    Assignee: Board of Governors of Wayne State University
    Inventor: Howard R. Petty
  • Patent number: 4784945
    Abstract: A method for determining lipids using thin layer chromatography and multiple enzymatic staining is described. The method uses a hydrolase enzyme, an oxidase enzyme and a peroxidase enzyme in the presence of a chromogen precursor to form an oxidized chromogen stain. The method is particularly useful in determining phospholipids from animal and human tissue and/or fluids.
    Type: Grant
    Filed: October 30, 1986
    Date of Patent: November 15, 1988
    Assignee: Board of Governors of Wayne State University
    Inventors: Joseph D. Artiss, Dennis Bozimowski, Robert J. McEnroe, Bennie Zak
  • Patent number: 4773862
    Abstract: A method and map (10) for charting historical events by ventures A and B in a joint venture is described. The method and map enable a visual understanding of the operation of joint venture in the past and possibly more effective development of the joint venture in the future.
    Type: Grant
    Filed: August 10, 1987
    Date of Patent: September 27, 1988
    Assignee: Board of Governors of Wayne State University
    Inventor: Marietta L. Baba
  • Patent number: 4708808
    Abstract: Synergistic anti-microbial compositions containing a mixture of a metal complex of a polyfunctional organic ligand and a biocidal composition which contains or releases a lower aldehyde containing 1 to 5 carbon atoms are described. The compositions are particularly useful as metal working fluids at alkaline pH and have a broad spectrum of activity against fungi and bacteria.
    Type: Grant
    Filed: March 20, 1987
    Date of Patent: November 24, 1987
    Assignee: The Board of Governors of Wayne State University
    Inventor: Harold W. Rossmoore
  • Patent number: 4707282
    Abstract: Synergistic anti-microbial compositions containing a mixture of a metal complex of a polyfunctional organic ligand and a biocidal composition which contains or releases a lower aldehyde containing 1 to 5 carbon atoms are described. The compositions are particularly useful as metal working fluids at alkaline pH and have a broad spectrum of activity against fungi and bacteria.
    Type: Grant
    Filed: March 20, 1987
    Date of Patent: November 17, 1987
    Assignee: The Board of Governors of Wayne State University
    Inventor: Harold W. Rossmoore
  • Patent number: 4608183
    Abstract: Antimicrobial mixtures of isothiazolones and a metal complex with a polyfunctional ligand which are synergistic are described. The mixtures particularly include mixtures of a monocopper disodium citrate as the ligand and a 5-x-2-lower alkyl 4-isothiazolin-3-one wherein x is a halo or hydrogen group as the isothiazolone. The compositions are particularly useful for metal cutting fluids wherein long duration antimicrobial activity is desired.
    Type: Grant
    Filed: January 14, 1985
    Date of Patent: August 26, 1986
    Assignee: Board of Governors of Wayne State University
    Inventor: Harold W. Rossmoore