Patents Assigned to The Board of Regents of the University of Nebraska
  • Patent number: 10414725
    Abstract: Provided herein are pyrrolomycin derivatives, which can be used to modulate Mcl-1, inhibit proliferation of bacteria and pathogens, as well as to treat infectious diseases and cancers.
    Type: Grant
    Filed: July 15, 2016
    Date of Patent: September 17, 2019
    Assignee: BOARD OF REGENTS OF THE UNIVERSITY OF NEBRASKA
    Inventors: Kenneth Bayles, Rongshi Li, Yan Liu
  • Patent number: 10398811
    Abstract: Medical wound irrigation systems are described that may be used in environments such as hospitals and first aid stations, and for military applications, e.g., for medics and along transport routes for the wounded. The irrigation systems can provide continuous variable pressure for irrigating a wound. For example, in some embodiments, a medical irrigation system can be used to provide a steady pressure level while irrigating about one liter of solution in less than about one minute, e.g., to assist during wound irrigation and debridement. The medical irrigation system may include an air-powered irrigation device, which pressurizes an irrigation solution, such as a cleansing fluid, to create an ejection force. In some embodiments, the medical irrigation system can include a replaceable bottle cap with an inlet for connecting to a source of pressurized fluid (e.g., pressurized gas, such as pressurized air) and an outlet for the irrigation solution/cleansing fluid.
    Type: Grant
    Filed: July 28, 2017
    Date of Patent: September 3, 2019
    Assignee: Board of Regents of the University of Nebraska
    Inventors: Thang Nguyen, Michael Wadman, Richard Morris, Vincent Morris
  • Publication number: 20190247354
    Abstract: The present invention provides a creatine ester anti-inflammatory compound which may be received by animals and then metabolized into a biologically active form of creatine. The biologically active creatine inhibits the production of chemical mediators, released during an inflammatory response, which are important components in the inflammatory response and the inflammation and pain resulting from physical or chemical trauma to cells and tissue.
    Type: Application
    Filed: February 19, 2019
    Publication date: August 15, 2019
    Applicant: Board of Regents of the University of Nebraska
    Inventors: Donald W. Miller, Samuel C. Augustine, Jon C. Wagner, Thomas L. McDonald, Dennis H. Robinson
  • Patent number: 10376322
    Abstract: The embodiments disclosed herein relate to various robotic and/or in vivo medical devices having compact joint configurations. Other embodiments relate to various medical device components, including forearms having grasper or cautery end effectors, that can be incorporated into certain robotic and/or in vivo medical devices.
    Type: Grant
    Filed: November 11, 2015
    Date of Patent: August 13, 2019
    Assignee: Board of Regents of the University of Nebraska
    Inventors: Tom Frederick, Eric Markvicka, Shane Farritor, Dmitry Oleynikov
  • Patent number: 10376323
    Abstract: The various embodiments disclosed herein relate to modular medical devices, including various devices with detachable modular components and various devices with pivotally attached modular components. Additional embodiments relate to procedures in which various of the devices are used cooperatively. Certain embodiments of the medical devices are robotic in vivo devices.
    Type: Grant
    Filed: February 5, 2018
    Date of Patent: August 13, 2019
    Assignee: Board of Regents of the University of Nebraska
    Inventors: Shane Farritor, Amy Lehman, Mark Rentschler, Nathan Wood, Jason Dumpert, Dmitry Oleynikov
  • Publication number: 20190240541
    Abstract: Disclosed herein are examples of user-paced exercise equipment, as well as related circuitry, methods, and computer-readable media. For example, disclosed herein is a user-paced treadmill, including a belt, a motor coupled to the belt, and control circuitry communicatively coupled to the motor. The control circuitry may be configured to change a velocity of the belt based at least in part on a body velocity and a leg swing velocity of a user of the user-paced treadmill.
    Type: Application
    Filed: October 17, 2017
    Publication date: August 8, 2019
    Applicant: Board of Regents of the University Of Nebraska
    Inventors: William Denton, Molly Schieber, Casey Wiens
  • Patent number: 10363282
    Abstract: Materials and methods for treating an infection or disease, activating an immune cell at a site of infection or disease, and for directly killing microorganisms, using response-selective carboxy-terminal C5a analogs, are provided.
    Type: Grant
    Filed: January 12, 2018
    Date of Patent: July 30, 2019
    Assignees: Board of Regents of The University of Nebraska, San Diego State University Research Foundation
    Inventors: Sam D. Sanderson, Joy Arlene Phillips, Edward Leroy Morgan, Marilyn Louise Thoman, Tamsin Sheen, Kelly S. Doran, Elizabeth Louise Virts, Tammy Kielian, Mark Hanke
  • Patent number: 10357601
    Abstract: A hemodialysis catheter is disclosed for deploying in an artery or vein, comprising various means for disrupting, mechanically and/or chemo-mechanically, a fibrous sheath forming naturally outside of the catheter; optionally the disrupted fibrin sheath and/or thrombus is captured.
    Type: Grant
    Filed: September 6, 2016
    Date of Patent: July 23, 2019
    Assignees: CHRYSALIS MEDICAL, INC., BOARD OF REGENTS OF THE UNIVERSITY OF NEBRASKA
    Inventors: Maurino G. Flora, David L. Black, Celso J. Bagaoisan, Suresh Subraya Pai, Marius C. Florescu
  • Publication number: 20190216552
    Abstract: Disclosed herein are various robotic surgical devices and systems that include first and second elongate bodies, first and second driveshafts disposed through the second elongate body, and an in-line shoulder joint with a robotic arm coupled thereto. In certain implementations, the in-line shoulder joint has a differential yoke and a dual shaft disposed within the yoke lumen.
    Type: Application
    Filed: January 7, 2019
    Publication date: July 18, 2019
    Applicant: Board of Regents of the University of Nebraska
    Inventors: Joseph Palmowski, Shane Farritor
  • Patent number: 10350000
    Abstract: The embodiments disclosed herein relate to various medical device components, including components that can be incorporated into robotic and/or in vivo medical devices, and more specifically including end effectors that can be incorporated into such devices. Certain end effector embodiments include various vessel cautery devices that have rotational movement as well as cautery and cutting functions while maintaining a relatively compact structure. Other end effector embodiments include various end effector devices that have more than one end effector.
    Type: Grant
    Filed: September 11, 2017
    Date of Patent: July 16, 2019
    Assignee: Board of Regents of the University of Nebraska
    Inventors: Shane Farritor, Tom Frederick, Joe Bartels
  • Patent number: 10342561
    Abstract: The various embodiments disclosed herein relate to arms or forearms of medical devices that are configured to couple with quick-release end effectors, quick-release end effectors for use with such medical devices, and arms or forearms coupled to such quick-release end effectors. Certain forearms and end effectors have magnetic couplings, while others have mechanical couplings, and further implementations have both magnetic and mechanical couplings.
    Type: Grant
    Filed: September 14, 2015
    Date of Patent: July 9, 2019
    Assignee: Board of Regents of the University of Nebraska
    Inventors: Shane Farritor, Jeff Shasho, Alan Bachman, Kenneth Blier
  • Patent number: 10342771
    Abstract: The present invention is directed to an oral supplement including creatine hydrochloride, which has an aqueous solubility that is at least 15 times greater than creatine monohydrate, where the oral supplement drives significant improvements in muscle development and recovery due to its enhanced bio-availability, while causing fewer negative side effects compared to previous forms of creatine.
    Type: Grant
    Filed: May 2, 2018
    Date of Patent: July 9, 2019
    Assignees: Vireo Systems, Inc., Board of Regents of the University of Nebraska
    Inventors: Donald W. Miller, Jonathan L. Vennerstrom, Mark C. Faulkner
  • Patent number: 10335024
    Abstract: The various embodiments disclosed herein relate to procedural space maintenance devices, medical device positioning devices, and devices that provide both procedural space maintenance and device positioning. Further embodiments relate to medical device insertion and/or retraction devices.
    Type: Grant
    Filed: February 8, 2016
    Date of Patent: July 2, 2019
    Assignee: Board of Regents of the University of Nebraska
    Inventors: Mark Rentschler, Shane Farritor
  • Patent number: 10333439
    Abstract: At least one example embodiment discloses a method of estimating a position of a rotor in a motor. The method includes obtaining a current regulation quality index based on a current command and a measured current, determining an estimated position of the rotor based on the current regulation quality index and position estimation data and controlling the motor based on the estimated position of the rotor.
    Type: Grant
    Filed: January 10, 2017
    Date of Patent: June 25, 2019
    Assignees: THE BOARD OF REGENTS OF THE UNIVERSITY OF NEBRASKA, DEERE & COMPANY
    Inventors: Long Wu, Yue Zhao, Wei Qiao
  • Patent number: 10307199
    Abstract: The present invention relates to robotic surgical devices. More specifically, the present invention relates to robotic surgical devices that can be inserted into a patient's body and can be positioned within the patient's body.
    Type: Grant
    Filed: February 9, 2015
    Date of Patent: June 4, 2019
    Assignee: Board of Regents of the University of Nebraska
    Inventors: Shane Farritor, Amy Lehman, Nathan A. Wood, Mark Rentschler, Jason Dumpert, Dmitry Oleynikov
  • Publication number: 20190153539
    Abstract: The present invention provides methods of determining a survival predictor score of a subject having mantle cell lymphoma (MCL). The present invention also provides methods of predicting the survival outcome of a subject having MCL and provides methods of selecting a treatment for a subject having MCL.
    Type: Application
    Filed: April 20, 2017
    Publication date: May 23, 2019
    Applicants: The United States of America, as represented by the secretary, Dep. of Health and Human Service, British Columbia Cancer Agency Branch, Julius-Maximilians - University of W├╝rzburg, Oregon Health and Science University, Hospital Clinic de Barcelona, Universitat de Barcelona, Oslo University Hospital HF, Board of Regents of the University of Nebraska, The Cleveland Clinic Foundation, Mayo Foundation for Medical Education and Research
    Inventors: Louis M. Staudt, David William Scott, George W. Wright, Andreas Rosenwald, Pau Abrisqueta, Rita Braziel, Elias Campo Guerri, Wing C. Chan, Joseph M. Connors, Jan Delabie, Diego Villa, Kai Fu, Randy D. Gascoyne, Timothy Greiner, Elaine S. Jaffe, Pedro Jares, Anja Mottok, German Ott, Lisa M. Rimsza, Graham Slack, Dennis Weisenburger, Erlend B. Smeland, James Robert Cook
  • Patent number: 10220002
    Abstract: Controlled-release formulations of carboxy-terminal C5a analogs (such as sustained-release formulations of the analogs), and their use in methods for treating and preventing an infection or a disease such as cancer, for directly killing microorganisms, for vaccine preparation, for inducing an immune response and for targeting antigen-presenting cells and other cells bearing a C5a receptor, are provided.
    Type: Grant
    Filed: November 30, 2012
    Date of Patent: March 5, 2019
    Assignee: BOARD OF REGENTS OF THE UNIVERSITY OF NEBRASKA
    Inventors: Joseph A. Vetro, Sam D. Sanderson
  • Patent number: 10219811
    Abstract: A number of improvements are provided relating to computer aided surgery utilizing an on tool tracking system. The various improvements relate generally to both the methods used during computer aided surgery and the devices used during such procedures. Other improvements relate to the structure of the tools used during a procedure and how the tools can be controlled using the OTT device. Still other improvements relate to methods of providing feedback during a procedure to improve either the efficiency or quality, or both, for a procedure including the rate of and type of data processed depending upon a CAS mode.
    Type: Grant
    Filed: June 27, 2012
    Date of Patent: March 5, 2019
    Assignee: Board of Regents of the University of Nebraska
    Inventors: Hani Haider, Ibrahim Al-Shawi, Osvaldo Andres Barrera
  • Patent number: 10219870
    Abstract: Disclosed herein are various medical device components, including components that can be incorporated into robotic and/or in vivo medical devices. Also disclosed are various medical devices for in vivo medical procedures. Included herein, for example, is a surgical robotic device having an elongate device body, a right robotic arm coupled to a right shoulder assembly, and a left robotic arm coupled to a left shoulder assembly.
    Type: Grant
    Filed: November 21, 2016
    Date of Patent: March 5, 2019
    Assignee: Board of Regents of the University of Nebraska
    Inventors: Jack Mondry, Shane Farritor, Eric Markvicka, Thomas Frederick, Joe Bartels
  • Patent number: 10206897
    Abstract: The present invention provides a creatine ester anti-inflammatory compound which may be received by animals and then metabolized into a biologically active form of creatine. The biologically active creatine inhibits the production of chemical mediators, released during an inflammatory response, which are important components in the inflammatory response and the inflammation and pain resulting from physical or chemical trauma to cells and tissue.
    Type: Grant
    Filed: December 4, 2017
    Date of Patent: February 19, 2019
    Assignee: Board of Regents of the University of Nebraska
    Inventors: Donald W. Miller, Samuel C. Augustine, Jon C. Wagner, Thomas L. McDonald, Dennis H. Robinson