Patents Assigned to The Board of Regents of the University of Oklahoma
  • Patent number: 11634507
    Abstract: A method of producing dendritic gold nanoparticles by combining a gold precursor solution, a reducing agent, and a bifunctional peptide having an amine-rich amino acid sequence into a buffered aqueous solution in a single container, and agitating the mixture causing the formation of the dendritic gold nanoparticles having a surface with a positive charge and a second end portion of the bifunctional peptide exposed on the surface of the dendritic gold nanoparticles. The dendritic gold nanoparticles may be used to deliver therapeutic, diagnostic, and/or immunogenic amino acid sequences as portions of the bifunctional peptide.
    Type: Grant
    Filed: April 2, 2020
    Date of Patent: April 25, 2023
    Assignee: The Board of Regents of the University of Oklahoma
    Inventors: Chuanbin Mao, Lin Wang, Penghe Qiu
  • Patent number: 11624742
    Abstract: A gas sensor comprising: a substrate; a grating array disposed on top of the substrate and comprising grates; and voids defined by the grates and configured to confine gas molecules for absorption of light and analysis. A method of gas sensing comprising: generating first light; converting the first light into second light using grates of a grating array; resonating the second light within the grating array; confining gas molecules in voids defined by the grates; and causing the gas molecules to absorb the second light within the voids.
    Type: Grant
    Filed: October 19, 2020
    Date of Patent: April 11, 2023
    Assignee: The Board of Regents of the University of Oklahoma
    Inventor: Binbin Weng
  • Publication number: 20230080576
    Abstract: Tracking patient compliance with treatment protocols is an important aspect of delivering high quality healthcare. A system for tracking compliance with protocols that include the periodic consumption of oral medication includes a mobile computing device and a pill tracking dispenser. The mobile computing device includes an application program configured to record the periodic consumption of oral medication by the patient. The pill tracking dispenser can be connected to the mobile computing device through a wireless network. The pill tracking dispenser is configured to report to the mobile computing device the number of times the oral medication is consumed by the patient.
    Type: Application
    Filed: February 25, 2021
    Publication date: March 16, 2023
    Applicant: The Board of Regents of the University of Oklahoma
    Inventors: Michael Businelle, Cliff Fitzmorris, BinBin Weng
  • Patent number: 11598540
    Abstract: A double skin façade (DSF) for a building is disclosed. The DSF has a first façade, a second façade, and a gap extending therebetween. Movement of air is driven in an upward direction toward an upper end of the DSF, causing movement of air contaminants from a lower end of the DSF to the upper end of the DSF, and thereby enhancing the air quality of the street canyon by removing air contaminants from a street level adjacent the building. Also disclosed is a building having a DSF, and a method of enhancing air quality in a street canyon by constructing a DSF on a building.
    Type: Grant
    Filed: October 14, 2021
    Date of Patent: March 7, 2023
    Assignee: The Board of Regents of the University of Oklahoma
    Inventor: Lee A. Fithian
  • Patent number: 11591516
    Abstract: High photoluminescence, high stability, inorganic perovskite compounds comprising an alkali metal selected from potassium (K), rubidium (Rb), and cesium (Cs); copper (Cu); and at least one halogen selected from chlorine (Cl), bromine (Br), and iodine (I). The perovskites may be free of lead (Pb). The inorganic perovskite compound may be used in an optoelectronic device. The optoelectronic device optionally contains a phosphor such as a blue-emitting phosphor. The inorganic perovskite compound may be used as an anti-counterfeiting nanotaggant applied on or within an object that susceptible to counterfeiting to enable confirmation of an authentic object.
    Type: Grant
    Filed: October 5, 2020
    Date of Patent: February 28, 2023
    Assignee: The Board of Regents of the University of Oklahoma
    Inventors: Bayram Saparov, Tielyr D. Creason, Rachel M. Roccanova, Aymen Yangui
  • Patent number: 11571978
    Abstract: A charging cable apparatus having a connector, an electrically-conductive cable extending from the connector, the cable configured to be connectable to a charging station for receiving a charging current from the charging station, and having a heat pipe with a phase change section having a wicking structure, the wicking structure having a working fluid therein during operation for receiving heat generated during current flow within the cable. The charging cable apparatus may further have an external condensing surface in fluid communication with the phase change section of the heat pipe for accelerating condensation of evaporated working fluid. The charging cable apparatus may be connected to a charging station for charging an electric battery such as a battery of an electric vehicle.
    Type: Grant
    Filed: January 10, 2020
    Date of Patent: February 7, 2023
    Assignees: The Board of Regents of the University of Oklahoma, The Board of the Trustees of the Leland Stanford Junior University, The University of Connecticut
    Inventors: Hamidreza Shabgard, Amir Faghri, Kenneth Goodson, Mehdi Asheghi
  • Patent number: 11569403
    Abstract: A PV device comprises a first mirror comprising a reflectance of higher than 50%; a second mirror interface; and an optical cavity positioned between the first mirror and the second mirror interface and comprising at least one IC stage. Each of the at least one IC stage comprises a conduction band; a valence band; a hole barrier comprising a first band gap; an absorption region coupled to the hole barrier, comprising a second band gap that is less than the first band gap, and configured to absorb photons; and an electron barrier coupled to the absorption region so that the absorption region is positioned between the hole barrier and the electron barrier. The electron barrier comprises a third band gap that is greater than the second band gap. The PV device is configured to operate at a forward bias voltage with a net photon absorption for generating an electric output.
    Type: Grant
    Filed: June 10, 2021
    Date of Patent: January 31, 2023
    Assignee: The Board of Regents of the University of Oklahoma
    Inventors: Rui Q. Yang, Wenxiang Huang
  • Patent number: 11552590
    Abstract: A mounting system for mounting a solar panel assembly to a base assembly includes a panel support bracket, a base bracket and a clamp configured to exert a compressive force to hold the panel support bracket and the base bracket together. The clamp comprises a V-shaped clamp body that includes a pair of legs that are spring-loaded to oppose an approximation of the legs by an external compressive force. The clamp includes a pair of receiver slots, with each of the pair of receiver slots located on a corresponding one of the pair of legs. The pair of receiver slots collectively provides a clearance to admit the panel support bracket and the base bracket when the legs are compressed together.
    Type: Grant
    Filed: October 8, 2019
    Date of Patent: January 10, 2023
    Assignee: The Board of Regents of the University of Oklahoma
    Inventor: Andres F. Cavieres Pinilla
  • Patent number: 11534397
    Abstract: Microparticulate drug compositions comprising nanocrystals of poorly soluble drugs combined with a carrier are disclosed. Also disclosed are pharmaceutical compositions that include the microparticulate drug compositions. Further disclosed are methods of preparing and using the microparticulate drug compositions/pharmaceutical compositions.
    Type: Grant
    Filed: February 9, 2021
    Date of Patent: December 27, 2022
    Assignee: The Board of Regents of the University of Oklahoma
    Inventors: Lucila Garcia-Contreras, Sevim Manolya Hatipoglu, Doris Manglaracina Benbrook
  • Patent number: 11535999
    Abstract: A pile for use in a ground pile system has a tubular body and one or more sensor modules attached to the tubular body. Each of the one of more sensor modules includes a sensor guard that has a perimeter and a sensor nested within the sensor guard. The sensor is recessed within the perimeter of the sensor guard to protect the sensor during installation of the pile. A data acquisition unit can be used to receive data from the one or more sensor modules. The data acquisition unit includes a solar panel array, a battery charged by the solar panel array, a modem powered by the battery, and a computer powered by the battery. The computer is configured to receive signals from the sensors and transmit the signals to a remote operation center through the modem.
    Type: Grant
    Filed: May 18, 2020
    Date of Patent: December 27, 2022
    Assignee: The Board of Regents of the University of Oklahoma
    Inventor: Amy Cerato
  • Patent number: 11530239
    Abstract: The disclosure is directed in non-limiting embodiments to compounds, compositions, and methods of treating conditions and diseases associated with activation of the gonadotropin GnRH receptor (GnRHR), particularly those involving GnRHR activating autoantibodies (GnRHR AAbs). In one non-limiting embodiment, the disease is Polycystic Ovary Syndrome (PCOS). The therapeutic compounds in at least certain embodiments include peptides which at least partially comprise D-amino acids, such as retro-inverso D-amino acid (RID) peptides, which are able to bind with high affinity to GnRHR AAbs.
    Type: Grant
    Filed: March 4, 2021
    Date of Patent: December 20, 2022
    Assignee: The Board of Regents of the University of Oklahoma
    Inventors: David C. Kem, Xichun Yu, Hongliang Li, LaTasha B. Craig
  • Publication number: 20220371918
    Abstract: A water treatment system is configured to remove salt from a feed brine. The water treatment system includes a primary freezing chamber configured to receive the feed brine and a source of cooled intermediate cold liquid connected to the primary freezing chamber. The cooled intermediate cold liquid and feed brine are mixed within the primary freezing chamber, where ice particles are formed. The water treatment system includes a rotary separator connected to a discharge from the primary freezing chamber. The rotary separator is configured to separate solid ice particles from liquid components in the discharge from the primary freezing chamber. In some embodiments, the rotary separator includes a mesh inner filter tube that is configured for rotation within a solid outer filter tube, where the mesh inner filter tube allows liquid components to drain into the outer filter tube while conveying solid ice particles to an ice recovery tank.
    Type: Application
    Filed: May 20, 2022
    Publication date: November 24, 2022
    Applicant: The Board of Regents of the University of Oklahoma
    Inventors: Hamidreza Shabgard, Ramkumar Parthasarathy, Jie Cai, Reza Kaviani, Aly Elhefny
  • Patent number: 11459552
    Abstract: Bridge helix-modified variant Cas12a and Cas12b proteins having improved DNA cleavage selectivity in comparison to wild type versions of the Cas12a and Cas12b proteins, nucleic acids encoding the variant proteins, host cells containing the nucleic acids, and methods of their use.
    Type: Grant
    Filed: July 1, 2020
    Date of Patent: October 4, 2022
    Assignee: The Board of Regents of the University of Oklahoma
    Inventor: Rakhi Rajan
  • Patent number: 11447452
    Abstract: Benzyl derivative compounds having peroxisome proliferator-activated receptor ? (PPAR?) agonistic activity, compositions containing such compounds, and methods of their use in enhancing PPAR? activity for treating diseases and/or conditions involving inflammation and/or angiogenesis, particularly ocular diseases and/or conditions such as but not limited to retinal inflammation, retinal neovascularization, retinal vascular leakage, retinopathy of prematurity, diabetic retinopathy, age-related macular degeneration, and diabetic macular edema are disclosed.
    Type: Grant
    Filed: March 15, 2019
    Date of Patent: September 20, 2022
    Assignee: The Board of Regents of the University of Oklahoma
    Inventors: Adam Duerfeldt, Jian-xing Ma, Xiaozheng Dou, Dinesh Nath, Young-Hwa Shin
  • Patent number: 11446365
    Abstract: A method, composition, and kit for treating a malarial infection in a subject by using an enzyme conjugate comprising a variant cystathione-gamma-lyase and a targeting ligand which binds to erythrocytes infected with Plasmodium pathogens. The variant cystathione-gamma-lyase has methioninase activity. Also disclosed is a method of treating Plasmodium-infected blood by exposing the infected blood with the enzyme conjugate.
    Type: Grant
    Filed: August 9, 2018
    Date of Patent: September 20, 2022
    Assignee: The Board of Regents of the University of Oklahoma
    Inventors: Roger G. Harrison, Jr., Patrick H. McKernan
  • Publication number: 20220283126
    Abstract: A spray-capillary device is configured to process ultra-low-volume samples. The spray-capillary device includes a capillary tube that includes a lumen, an inner surface, an outer surface, an inlet end for receiving a fluid, and a discharge end having a porous section. A polymer material may be applied to the inner surface to form a polymer coating thereon. A downstream connector provides an interface between the porous section of the capillary tube, a conductive fluid, and a high voltage electrical source. The application of voltage to the downstream connector causes electrospray ionization, which can be used to draw ultra-low-volume samples into the inlet end. A gas injection assembly can be used to increase the pressure on the inlet end of the capillary tube to encourage movement of the sample therethrough. The spray-capillary device may be used to provide the ultra-low-volume samples to a mass spectrometer or other suitable analytic device.
    Type: Application
    Filed: May 20, 2022
    Publication date: September 8, 2022
    Applicant: The Board of Regents of the University of Oklahoma
    Inventors: Si Wu, Lushuang Huang, Zhe Wang
  • Patent number: 11435485
    Abstract: A method comprises: obtaining a GPS measurement; obtaining a first IMU measurement; obtaining a second IMU measurement; applying a first particle filter to the GPS measurement and the first IMU measurement to obtain a first position solution; applying a second particle filter to the GPS measurement and the second IMU measurement to obtain a second position solution; calculating a first sensor weight of the first position solution based on a likelihood function; calculating a second sensor weight of the second position solution based on the likelihood function; resampling the first position solution based on the first sensor weight to obtain a first resampled position solution; resampling the second position solution based on the second sensor weight to obtain a second resampled position solution; and calculating a final position estimate based on the GPS measurement, the first resampled position solution, and the second resampled position solution.
    Type: Grant
    Filed: May 14, 2021
    Date of Patent: September 6, 2022
    Assignee: The Board of Regents of the University of Oklahoma
    Inventors: Jay W. McDaniel, Mark B. Yeary, Hjalti H. Sigmarsson, Brian M. Sun
  • Patent number: 11421146
    Abstract: A viscoelastic emulsion formed by combining at least one extended surfactant, a salt (e.g., brine), an oil, such as crude oil, diesel, kerosene, or a vegetable oil, and water, into a mixture comprising an oil-starved Winsor III microemulsion into which excess oil is dispersed. The viscoelastic emulsion may be combined with a proppant to form a fracking fluid. The viscoelastic emulsion may be used in various reservoir applications, such as hydraulic fracturing, or flooding for enhanced tertiary oil recovery, and in other applications such as, but not limited to, environmental remediation, or formation of consumer products.
    Type: Grant
    Filed: June 6, 2019
    Date of Patent: August 23, 2022
    Assignee: The Board of Regents of the University of Oklahoma
    Inventors: Changlong Chen, Jeffrey H. Harwell, Bor Jier Shiau
  • Patent number: 11414458
    Abstract: The present invention describes novel tumor-specific phosphorylated peptides, nucleic acids encoding those peptides, and antibodies generated against said peptides. The genes, peptides, and antibodies described herein may be used as diagnostic indicators of the presence of breast cancer and/or used in therapeutics to treat breast cancer.
    Type: Grant
    Filed: March 2, 2020
    Date of Patent: August 16, 2022
    Assignees: Agenus Inc., The Board of Regents of the University of Oklahoma
    Inventors: Donald F. Hunt, Andrew Norris, Ann Michelle English, Jeffrey Shabanowitz, William H. Hilderbrand, Oriana E. Hawkins
  • Publication number: 20220249071
    Abstract: An endoscope biopsy device has a hub, an insertion tube connected to the hub, an endoscope module connected to the hub, and a biopsy module connected to the hub. The endoscope module includes a fiber optic line extending through the hub and into the insertion tube. The biopsy module is configured to admit biopsy tools to the patient through the insertion tube from the biopsy module while simultaneously providing a visual examination of the portion of the patient from which the biopsy is taken. In some embodiments, the endoscope biopsy device is configured to perform a biopsy during a ductoscopy on a human patient.
    Type: Application
    Filed: July 17, 2020
    Publication date: August 11, 2022
    Applicant: The Board of Regents of the University of Oklahoma
    Inventors: William Dooley, Apurba Mukherjee