Patents Assigned to The Board of Regents of the University of Oklahoma
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Patent number: 11634507Abstract: A method of producing dendritic gold nanoparticles by combining a gold precursor solution, a reducing agent, and a bifunctional peptide having an amine-rich amino acid sequence into a buffered aqueous solution in a single container, and agitating the mixture causing the formation of the dendritic gold nanoparticles having a surface with a positive charge and a second end portion of the bifunctional peptide exposed on the surface of the dendritic gold nanoparticles. The dendritic gold nanoparticles may be used to deliver therapeutic, diagnostic, and/or immunogenic amino acid sequences as portions of the bifunctional peptide.Type: GrantFiled: April 2, 2020Date of Patent: April 25, 2023Assignee: The Board of Regents of the University of OklahomaInventors: Chuanbin Mao, Lin Wang, Penghe Qiu
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Patent number: 11624742Abstract: A gas sensor comprising: a substrate; a grating array disposed on top of the substrate and comprising grates; and voids defined by the grates and configured to confine gas molecules for absorption of light and analysis. A method of gas sensing comprising: generating first light; converting the first light into second light using grates of a grating array; resonating the second light within the grating array; confining gas molecules in voids defined by the grates; and causing the gas molecules to absorb the second light within the voids.Type: GrantFiled: October 19, 2020Date of Patent: April 11, 2023Assignee: The Board of Regents of the University of OklahomaInventor: Binbin Weng
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Publication number: 20230080576Abstract: Tracking patient compliance with treatment protocols is an important aspect of delivering high quality healthcare. A system for tracking compliance with protocols that include the periodic consumption of oral medication includes a mobile computing device and a pill tracking dispenser. The mobile computing device includes an application program configured to record the periodic consumption of oral medication by the patient. The pill tracking dispenser can be connected to the mobile computing device through a wireless network. The pill tracking dispenser is configured to report to the mobile computing device the number of times the oral medication is consumed by the patient.Type: ApplicationFiled: February 25, 2021Publication date: March 16, 2023Applicant: The Board of Regents of the University of OklahomaInventors: Michael Businelle, Cliff Fitzmorris, BinBin Weng
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Patent number: 11598540Abstract: A double skin façade (DSF) for a building is disclosed. The DSF has a first façade, a second façade, and a gap extending therebetween. Movement of air is driven in an upward direction toward an upper end of the DSF, causing movement of air contaminants from a lower end of the DSF to the upper end of the DSF, and thereby enhancing the air quality of the street canyon by removing air contaminants from a street level adjacent the building. Also disclosed is a building having a DSF, and a method of enhancing air quality in a street canyon by constructing a DSF on a building.Type: GrantFiled: October 14, 2021Date of Patent: March 7, 2023Assignee: The Board of Regents of the University of OklahomaInventor: Lee A. Fithian
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Patent number: 11591516Abstract: High photoluminescence, high stability, inorganic perovskite compounds comprising an alkali metal selected from potassium (K), rubidium (Rb), and cesium (Cs); copper (Cu); and at least one halogen selected from chlorine (Cl), bromine (Br), and iodine (I). The perovskites may be free of lead (Pb). The inorganic perovskite compound may be used in an optoelectronic device. The optoelectronic device optionally contains a phosphor such as a blue-emitting phosphor. The inorganic perovskite compound may be used as an anti-counterfeiting nanotaggant applied on or within an object that susceptible to counterfeiting to enable confirmation of an authentic object.Type: GrantFiled: October 5, 2020Date of Patent: February 28, 2023Assignee: The Board of Regents of the University of OklahomaInventors: Bayram Saparov, Tielyr D. Creason, Rachel M. Roccanova, Aymen Yangui
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Patent number: 11571978Abstract: A charging cable apparatus having a connector, an electrically-conductive cable extending from the connector, the cable configured to be connectable to a charging station for receiving a charging current from the charging station, and having a heat pipe with a phase change section having a wicking structure, the wicking structure having a working fluid therein during operation for receiving heat generated during current flow within the cable. The charging cable apparatus may further have an external condensing surface in fluid communication with the phase change section of the heat pipe for accelerating condensation of evaporated working fluid. The charging cable apparatus may be connected to a charging station for charging an electric battery such as a battery of an electric vehicle.Type: GrantFiled: January 10, 2020Date of Patent: February 7, 2023Assignees: The Board of Regents of the University of Oklahoma, The Board of the Trustees of the Leland Stanford Junior University, The University of ConnecticutInventors: Hamidreza Shabgard, Amir Faghri, Kenneth Goodson, Mehdi Asheghi
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Patent number: 11569403Abstract: A PV device comprises a first mirror comprising a reflectance of higher than 50%; a second mirror interface; and an optical cavity positioned between the first mirror and the second mirror interface and comprising at least one IC stage. Each of the at least one IC stage comprises a conduction band; a valence band; a hole barrier comprising a first band gap; an absorption region coupled to the hole barrier, comprising a second band gap that is less than the first band gap, and configured to absorb photons; and an electron barrier coupled to the absorption region so that the absorption region is positioned between the hole barrier and the electron barrier. The electron barrier comprises a third band gap that is greater than the second band gap. The PV device is configured to operate at a forward bias voltage with a net photon absorption for generating an electric output.Type: GrantFiled: June 10, 2021Date of Patent: January 31, 2023Assignee: The Board of Regents of the University of OklahomaInventors: Rui Q. Yang, Wenxiang Huang
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Patent number: 11552590Abstract: A mounting system for mounting a solar panel assembly to a base assembly includes a panel support bracket, a base bracket and a clamp configured to exert a compressive force to hold the panel support bracket and the base bracket together. The clamp comprises a V-shaped clamp body that includes a pair of legs that are spring-loaded to oppose an approximation of the legs by an external compressive force. The clamp includes a pair of receiver slots, with each of the pair of receiver slots located on a corresponding one of the pair of legs. The pair of receiver slots collectively provides a clearance to admit the panel support bracket and the base bracket when the legs are compressed together.Type: GrantFiled: October 8, 2019Date of Patent: January 10, 2023Assignee: The Board of Regents of the University of OklahomaInventor: Andres F. Cavieres Pinilla
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Patent number: 11534397Abstract: Microparticulate drug compositions comprising nanocrystals of poorly soluble drugs combined with a carrier are disclosed. Also disclosed are pharmaceutical compositions that include the microparticulate drug compositions. Further disclosed are methods of preparing and using the microparticulate drug compositions/pharmaceutical compositions.Type: GrantFiled: February 9, 2021Date of Patent: December 27, 2022Assignee: The Board of Regents of the University of OklahomaInventors: Lucila Garcia-Contreras, Sevim Manolya Hatipoglu, Doris Manglaracina Benbrook
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Patent number: 11535999Abstract: A pile for use in a ground pile system has a tubular body and one or more sensor modules attached to the tubular body. Each of the one of more sensor modules includes a sensor guard that has a perimeter and a sensor nested within the sensor guard. The sensor is recessed within the perimeter of the sensor guard to protect the sensor during installation of the pile. A data acquisition unit can be used to receive data from the one or more sensor modules. The data acquisition unit includes a solar panel array, a battery charged by the solar panel array, a modem powered by the battery, and a computer powered by the battery. The computer is configured to receive signals from the sensors and transmit the signals to a remote operation center through the modem.Type: GrantFiled: May 18, 2020Date of Patent: December 27, 2022Assignee: The Board of Regents of the University of OklahomaInventor: Amy Cerato
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Patent number: 11530239Abstract: The disclosure is directed in non-limiting embodiments to compounds, compositions, and methods of treating conditions and diseases associated with activation of the gonadotropin GnRH receptor (GnRHR), particularly those involving GnRHR activating autoantibodies (GnRHR AAbs). In one non-limiting embodiment, the disease is Polycystic Ovary Syndrome (PCOS). The therapeutic compounds in at least certain embodiments include peptides which at least partially comprise D-amino acids, such as retro-inverso D-amino acid (RID) peptides, which are able to bind with high affinity to GnRHR AAbs.Type: GrantFiled: March 4, 2021Date of Patent: December 20, 2022Assignee: The Board of Regents of the University of OklahomaInventors: David C. Kem, Xichun Yu, Hongliang Li, LaTasha B. Craig
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Publication number: 20220371918Abstract: A water treatment system is configured to remove salt from a feed brine. The water treatment system includes a primary freezing chamber configured to receive the feed brine and a source of cooled intermediate cold liquid connected to the primary freezing chamber. The cooled intermediate cold liquid and feed brine are mixed within the primary freezing chamber, where ice particles are formed. The water treatment system includes a rotary separator connected to a discharge from the primary freezing chamber. The rotary separator is configured to separate solid ice particles from liquid components in the discharge from the primary freezing chamber. In some embodiments, the rotary separator includes a mesh inner filter tube that is configured for rotation within a solid outer filter tube, where the mesh inner filter tube allows liquid components to drain into the outer filter tube while conveying solid ice particles to an ice recovery tank.Type: ApplicationFiled: May 20, 2022Publication date: November 24, 2022Applicant: The Board of Regents of the University of OklahomaInventors: Hamidreza Shabgard, Ramkumar Parthasarathy, Jie Cai, Reza Kaviani, Aly Elhefny
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Patent number: 11459552Abstract: Bridge helix-modified variant Cas12a and Cas12b proteins having improved DNA cleavage selectivity in comparison to wild type versions of the Cas12a and Cas12b proteins, nucleic acids encoding the variant proteins, host cells containing the nucleic acids, and methods of their use.Type: GrantFiled: July 1, 2020Date of Patent: October 4, 2022Assignee: The Board of Regents of the University of OklahomaInventor: Rakhi Rajan
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Patent number: 11447452Abstract: Benzyl derivative compounds having peroxisome proliferator-activated receptor ? (PPAR?) agonistic activity, compositions containing such compounds, and methods of their use in enhancing PPAR? activity for treating diseases and/or conditions involving inflammation and/or angiogenesis, particularly ocular diseases and/or conditions such as but not limited to retinal inflammation, retinal neovascularization, retinal vascular leakage, retinopathy of prematurity, diabetic retinopathy, age-related macular degeneration, and diabetic macular edema are disclosed.Type: GrantFiled: March 15, 2019Date of Patent: September 20, 2022Assignee: The Board of Regents of the University of OklahomaInventors: Adam Duerfeldt, Jian-xing Ma, Xiaozheng Dou, Dinesh Nath, Young-Hwa Shin
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Patent number: 11446365Abstract: A method, composition, and kit for treating a malarial infection in a subject by using an enzyme conjugate comprising a variant cystathione-gamma-lyase and a targeting ligand which binds to erythrocytes infected with Plasmodium pathogens. The variant cystathione-gamma-lyase has methioninase activity. Also disclosed is a method of treating Plasmodium-infected blood by exposing the infected blood with the enzyme conjugate.Type: GrantFiled: August 9, 2018Date of Patent: September 20, 2022Assignee: The Board of Regents of the University of OklahomaInventors: Roger G. Harrison, Jr., Patrick H. McKernan
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Publication number: 20220283126Abstract: A spray-capillary device is configured to process ultra-low-volume samples. The spray-capillary device includes a capillary tube that includes a lumen, an inner surface, an outer surface, an inlet end for receiving a fluid, and a discharge end having a porous section. A polymer material may be applied to the inner surface to form a polymer coating thereon. A downstream connector provides an interface between the porous section of the capillary tube, a conductive fluid, and a high voltage electrical source. The application of voltage to the downstream connector causes electrospray ionization, which can be used to draw ultra-low-volume samples into the inlet end. A gas injection assembly can be used to increase the pressure on the inlet end of the capillary tube to encourage movement of the sample therethrough. The spray-capillary device may be used to provide the ultra-low-volume samples to a mass spectrometer or other suitable analytic device.Type: ApplicationFiled: May 20, 2022Publication date: September 8, 2022Applicant: The Board of Regents of the University of OklahomaInventors: Si Wu, Lushuang Huang, Zhe Wang
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Patent number: 11435485Abstract: A method comprises: obtaining a GPS measurement; obtaining a first IMU measurement; obtaining a second IMU measurement; applying a first particle filter to the GPS measurement and the first IMU measurement to obtain a first position solution; applying a second particle filter to the GPS measurement and the second IMU measurement to obtain a second position solution; calculating a first sensor weight of the first position solution based on a likelihood function; calculating a second sensor weight of the second position solution based on the likelihood function; resampling the first position solution based on the first sensor weight to obtain a first resampled position solution; resampling the second position solution based on the second sensor weight to obtain a second resampled position solution; and calculating a final position estimate based on the GPS measurement, the first resampled position solution, and the second resampled position solution.Type: GrantFiled: May 14, 2021Date of Patent: September 6, 2022Assignee: The Board of Regents of the University of OklahomaInventors: Jay W. McDaniel, Mark B. Yeary, Hjalti H. Sigmarsson, Brian M. Sun
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Patent number: 11421146Abstract: A viscoelastic emulsion formed by combining at least one extended surfactant, a salt (e.g., brine), an oil, such as crude oil, diesel, kerosene, or a vegetable oil, and water, into a mixture comprising an oil-starved Winsor III microemulsion into which excess oil is dispersed. The viscoelastic emulsion may be combined with a proppant to form a fracking fluid. The viscoelastic emulsion may be used in various reservoir applications, such as hydraulic fracturing, or flooding for enhanced tertiary oil recovery, and in other applications such as, but not limited to, environmental remediation, or formation of consumer products.Type: GrantFiled: June 6, 2019Date of Patent: August 23, 2022Assignee: The Board of Regents of the University of OklahomaInventors: Changlong Chen, Jeffrey H. Harwell, Bor Jier Shiau
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Patent number: 11414458Abstract: The present invention describes novel tumor-specific phosphorylated peptides, nucleic acids encoding those peptides, and antibodies generated against said peptides. The genes, peptides, and antibodies described herein may be used as diagnostic indicators of the presence of breast cancer and/or used in therapeutics to treat breast cancer.Type: GrantFiled: March 2, 2020Date of Patent: August 16, 2022Assignees: Agenus Inc., The Board of Regents of the University of OklahomaInventors: Donald F. Hunt, Andrew Norris, Ann Michelle English, Jeffrey Shabanowitz, William H. Hilderbrand, Oriana E. Hawkins
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Publication number: 20220249071Abstract: An endoscope biopsy device has a hub, an insertion tube connected to the hub, an endoscope module connected to the hub, and a biopsy module connected to the hub. The endoscope module includes a fiber optic line extending through the hub and into the insertion tube. The biopsy module is configured to admit biopsy tools to the patient through the insertion tube from the biopsy module while simultaneously providing a visual examination of the portion of the patient from which the biopsy is taken. In some embodiments, the endoscope biopsy device is configured to perform a biopsy during a ductoscopy on a human patient.Type: ApplicationFiled: July 17, 2020Publication date: August 11, 2022Applicant: The Board of Regents of the University of OklahomaInventors: William Dooley, Apurba Mukherjee