Abstract: This invention is directed to compositions and methods for detecting proteinopathies.

Abstract: Provided are compositions that include a platelet-activating factor antagonist, pharmaceutical compositions including the platelet-activating factor antagonist, methods of treating a modulating the proliferation of a glioma or a pathological condition resulting from patient having a glioma.

Abstract: The present disclosure provides compositions comprising a lyn kinase activator and TRPM8 agonist, and to methods of: reducing blood glucose levels, weight gain, or fat depot levels; treating metabolic syndrome, Syndrome X, obesity, prediabetes, type II diabetes, type I diabetes; treating hypercholesterolemia, hypertension, coronary heart disease, diabetic neuropathy, lipodystrophy, diabetic retinopathy, erectile dysfunction, kidney disease, dyslipidemia, dyslipoproteinemia, a peroxisome proliferator activated receptor-associated disorder, septicemia, a thrombotic disorder, or pancreatitis; inducing the beiging of adipocytes; and preventing pancreatic beta cell degeneration.

Abstract: A system and method are disclosed for overheight vehicle impact avoidance and incident detection. A detection subsystem of the system determines whether an incoming vehicle is clear to pass, depending at least on its height. The detection subsystem relies on distance sensors located along the freeway to detect the highest point of the vehicle and outputs an indication of whether the vehicle can pass. A warning subsystem receives the indication that a vehicle is overheight and provides a warning indication to the driver about the vehicle's inability to pass an upcoming structure. The warning subsystem may also perform a variety of other tasks, such as, for example, logging a variety of information about the vehicle and the incident, sending data about the incident locally to a central command, and generating reports.

Abstract: Therapeutics and methods treating Alzheimer's disease or a pre-Alzheimer's disease condition in a patient comprising administering a pharmaceutical composition containing a therapeutically effective dose therapeutic, wherein the therapeutic contains a PRMT4 inhibitor, or a pharmaceutically acceptable salt, solvate, ester, amide, clathrate, stereoisomer, enantiomer, prodrug or analog thereof. According to a further embodiment, the PRMT4 inhibitor is one of TP-064 and SCFFBXO9.

Abstract: A device and method are disclosed for intravenous cannulation. The device employs a spring to precisely and accurately control the force and velocity imparted to a piercing needle, with mechanical constraints built into the device to precisely and accurately control the distance through which the piercing needle travels. A sheathed-needle configuration is used with an outer, echogenic needle that can be seen via ultrasound; and an inner needle used to pierce the vein. The operator releases the piercing needle with a controlled velocity, controlled force, and controlled travel distance. The device reduces the human error and complications that have previously been associated with manually piercing a vein for cannulation.

Abstract: In one aspect, the disclosure relates to compositions, methods, and devices pertaining to polymeric nanoparticle compositions (pNP), pNP compositions comprising a therapeutic agent, devices comprising a drug-coated balloon comprising a disclosed pNP comprising a therapeutic agent, and methods for treating peripheral artery disease using the disclosed compositions and devices. In further aspects, the pNP comprises a poly (lactic-co-glycolic) acid possessing a positive charge for firm attachment to the balloon matrix, followed by adhesion to the negatively charged bilayer of the vascular wall. In still further aspects, the therapeutic agent comprises a resveratrol or derivative thereof, a quercetin or derivative thereof, or combinations thereof. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present disclosure.

Abstract: Male-sterile EGMS rice lines, both conventional and herbicide-tolerant, and their Fi hybrids are disclosed. The EGMS lines can produce Fi hybrids with high yield, desirable agronomic traits, and good milling characteristics.

Abstract: A method of treating prostate cancer in a patient comprising administering to the patient a pharmaceutical composition including a first therapeutic including a TLK1B inhibitor, or a pharmaceutically acceptable salt, solvate, ester, amide, clathrate, stereoisomer, enantiomer, prodrug or analog thereof, and a second therapeutic including an antiandrogen or a pharmaceutically acceptable salt, solvate, ester, amide, clathrate, stereoisomer, enantiomer, prodrug or analog thereof.

Abstract: A composition and method for killing feral hogs: a bait that is attractive to hogs is mixed with a lethal amount of sodium nitrite, along with sufficient base to inhibit decomposition of the sodium nitrite. At sufficiently high pH, encapsulation of the sodium nitrite is not required to inhibit decomposition. In the absence of substantial decomposition, the sodium nitrite itself is not aversive to the pigs, and may even enhance acceptance of the baits by the pigs. Optionally, an anti-emetic compound is added to the mixture to reduce the likelihood the bait will be vomited. Optionally, an additional toxicant such as luteolin is added to the mixture.

Abstract: This invention is directed to neuroprotective compositions and methods of using the same to treat neurodegenerative diseases.

Abstract: A concentric tube steerable device includes a plurality of tubes having a nested, concentric configuration. The tubes include an outer tube and an inner tube that extends coaxially within the outer tube. The inner tube terminates at a tip, and a pose of the tip is effectuated through individual or collective rotation or translation of the tubes about a tube axis. The concentric tube steerable device includes an actuator for rotating at least one tube about a respective tube axis, and a translator for translating at least one tube along a respective tube axis. Each tube includes a precurved portion and a corresponding axis of precurvature. For at least one tube, a flexural rigidity of the tube along its axis of precurvature is less than a flexural rigidity of the tube along a second axis that is perpendicular to the axis of precurvature, thereby improving stability of the tube.

Abstract: Oral formulations comprising one or more proteasome inhibitors for use as a treatment of coronavirus infection in a subject. Also disclosed are the use of such for the treatment or prevention of SARS-CoV-2 infection in humans.

Abstract: This invention comprises compositions and methods to determine the prognosis of necrotizing enterocolitis.

Abstract: The present disclosure provides for sampling instruments and methods of collecting sample particles. The sampling instrument can include a high-pressure pulsed valve coupled to a gas flow system to displace a sample from a surface. Also included can be a voltage supply coupled to a voltage switch, a suction device, a sample collector, and a collection filter. To collect a sample, extractive particles can be deposited onto a sample present on a substrate. At least a portion of the sample becomes coupled to a portion of the extractive particles to form sample particles. High-pressure gas can be discharged at the sample, thereby aerosolizing a portion of the sample particles to disperse aerosolized sample particles. A portion of the aerosolized sample particles can be collected onto a collection filter to form a collected sample.

Abstract: The present invention relates in part to a method of fabricating multimetallic nanoparticles, the method comprising the steps of providing a substrate; activating the substrate surface; adsorbing a cationic transition metal complex onto the substrate surface to form a substrate-supported cationic transition metal complex; adsorbing an anionic transition metal complex onto the substrate-supported cationic transition metal complex to form a substrate-supported multimetallic complex salt; and reducing the substrate-supported multimetallic complex salt to provide a plurality of multimetallic nanoparticles. The invention also relates in part to a composition of multimetallic nanoparticles comprising at least two metals Ma and Mb; wherein the ratio of Ma to Mb is between about 2:1 and about 1:2.

Abstract: A method of preventing or reducing the occurrence and/or development of a hernia within a subject at risk of developing a hernia includes implanting a graft material in contact with an opening in an abdominal wall. The graft material promotes healing of the abdominal wall and includes placental or placental derived tissue.

Abstract: The invention relates to a Quadruple Gene Deleted Mutant Bovine Herpesvirus Type 1 (BHV-1 QMV) engineered to express protective antigens derived from viruses associated with infection in livestock. The recombinant vector includes a deletion of a cytoplasmic tail of envelope glycoprotein gE (gE-CT), a truncation of glycoprotein gG, a deletion of envelope protein UL49.5 amino acid residues 30-32, and a deletion of UL49.5 cytoplasmic tail amino acid residues 80-96. The truncation of glycoprotein gG comprises a deletion of amino-terminal amino acid residues 1-67. The recombinant vector can include at least two heterologous antigens inserted therein.

Abstract: According to some embodiments of the invention, a near-infrared fluorescence endoscopic dental imaging system includes an endoscope forming a plurality of lumens therein; a spectrometer optically coupled to a first lumen of the endoscope; a near-infrared camera optically coupled to a second lumen of the endoscope; a data processor in communication with the spectrometer and the near-infrared camera; and a display system in communication with the data processor. The near-infrared camera is configured to capture a near-infrared two-dimensional dental image of a specimen and transmit the near-infrared two-dimensional dental image to the data processor. The spectrometer is configured to capture fluorescent light from the specimen and provide a spectroscopic signal to the data processor. The display system is configured to communicate with the data processor to receive the near-infrared two-dimensional dental image and the spectroscopic signal and to display a two-dimensional dental image of the specimen.

Abstract: Therapeutics and methods of diagnosing non-alcoholic fatty liver disease (NAFLD) and non-alcoholic steatohepatitis (NASH) in a patient comprising obtaining a sample from the patient, determining a level of a signaling lymphocytic activation molecule 1 (SLAMF1) in the sample from the patient, and diagnosing the patient with NAFLD when the level of the SLAMF1 is at least an elevated threshold level for the SLAMF1. Therapeutics and methods of treating non-alcoholic fatty liver disease (NAFLD) and non-alcoholic steatohepatitis (NASH) in a patient in need of treatment comprising administering a pharmaceutically effective dose of a therapeutic, wherein the therapeutic includes a signaling lymphocytic activation molecule 1 (SLAMF1) antagonist.