Patents Assigned to The Board of Supervisors of Louisiana State University and Agricultural and Mechanical College
  • Publication number: 20210285938
    Abstract: A method of diagnosing Alzheimer's disease and related dementias (ADRD) in a patient comprising obtaining a plasma sample from the patient; determining a level of a biochemical sulfide in the plasma sample from the subject by trapping volatilized H2S in the plasma sample using alkaline buffer with monobromobiamine, and detecting the level of biochemical sulfide in the plasma sample, the biochemical sulfide being one of acid-labile sulfide, bound sulfide, and total sulfide; and diagnosing the patient with ADRD when the level of the biochemical sulfide is at least an elevated threshold level for the biochemical sulfide.
    Type: Application
    Filed: March 12, 2021
    Publication date: September 16, 2021
    Applicant: Board of Supervisors of Louisiana State University and Agricultural and Mechanical College
    Inventors: Christopher KEVIL, Elizabeth DISBROW, Johnathan Steven ALEXANDER, Karen Y. STOKES
  • Patent number: 11112592
    Abstract: According to some embodiments of the present invention, a fine focus microscope includes an objective lens for collecting light from an object being imaged, and a tube lens for forming a first image from light received from the objective lens. The fine focus microscope further includes a fine focus lens for forming a second image from the first image, and an eyepiece for forming a third image from the second image, wherein the third image is viewable by a user. The fine focus microscope further includes a field lens for directing light from the second image to the eyepiece, and a positioning system mechanically coupled to the fine focus lens, the eyepiece, and the field lens. The positioning system changes a position of the fine focus lens, the eyepiece, and the field lens with respect to the objective lens to provide a change in focus of the object being imaged.
    Type: Grant
    Filed: April 22, 2016
    Date of Patent: September 7, 2021
    Assignee: Board of Supervisors of Louisiana State University and Agricultural and Mechanical College
    Inventor: Martin Feldman
  • Patent number: 11096952
    Abstract: A method of treating an activated fibroblast associated disease or pre-disease condition in a mammal comprising, administering a pharmaceutical composition including a therapeutically effective amount of a first therapeutic, wherein the first therapeutic is one of an intracellular Ca2+ elevator, a YAP/TAZ inhibitor, both a intracellular Ca2+ elevator and a YAP/TAZ inhibitor, or pharmacologically acceptable salts, solvates, esters, amides, clathrates, stereoisomers, enantiomers, prodrugs or analogs thereof, or a combination thereof.
    Type: Grant
    Filed: February 2, 2017
    Date of Patent: August 24, 2021
    Assignee: BOARD OF SUPERVISORS OF LOUISIANA STATE UNIVERSITY AND AGRICULTURAL AND MECHANICAL COLLEGE
    Inventors: James Allen Cardelli, Charles Albert Stephens, Alana Lea Gray, David Thomas Coleman
  • Publication number: 20210252494
    Abstract: The present invention relates in part to a method of fabricating multimetallic nanoparticles, the method comprising the steps of providing a substrate; activating the substrate surface; adsorbing a cationic transition metal complex onto the substrate surface to form a substrate-supported cationic transition metal complex; adsorbing an anionic transition metal complex onto the substrate-supported cationic transition metal complex to form a substrate-supported multimetallic complex salt; and reducing the substrate-supported multimetallic complex salt to provide a plurality of multimetallic nanoparticles. The invention also relates in part to a composition of multimetallic nanoparticles comprising at least two metals Ma and Mb; wherein the ratio of Ma to Mb is between about 2:1 and about 1:2.
    Type: Application
    Filed: August 21, 2019
    Publication date: August 19, 2021
    Applicant: Board of Supervisors of Louisiana State University and Agricultural and Mechanical College
    Inventor: Kunlun Ding
  • Publication number: 20210246409
    Abstract: The presently disclosed invention relates to methods of creating a laminar and shear stress environment for cells and Multidirectional Shear Stress Apparatuses comprising a baseplate, a dish attached to the baseplate, a motor attached to the baseplate, the motor turning a shaft, a cone functionally and rotationally attached to the shaft, a first plurality of wells defined in the baseplate to receive coverslips
    Type: Application
    Filed: March 23, 2021
    Publication date: August 12, 2021
    Applicant: Board of Supervisors of Louisiana State University and Agricultural and Mechanical College
    Inventors: Kevin J. MCCARTHY, Deborah MCCARTHY
  • Patent number: 11083787
    Abstract: The application describes recombinant BoHV-1 triple mutant viruses that express protective antigens of other bovine respiratory viruses associated with Bovine respiratory disease complex (BRDC).
    Type: Grant
    Filed: December 2, 2016
    Date of Patent: August 10, 2021
    Assignee: Board of Supervisors of the Louisiana State University and Agricultural and Mechanical College
    Inventor: Shafiqul I. Chowdhury
  • Patent number: 11085611
    Abstract: Provided are embodiments of a position-adaptive lighting system comprising a pantilt adjustable housing enclosing a digital imaging system and a lens module operably connected to a computer-based digital control unit, a lamp, and a position indicator detectable by the digital camera system and the computer-based digital control unit. The position-adaptive lighting system can adjustably direct a light beam to provide illumination of an object to which the position indicator is attached. The system is advantageous for providing a directed light to a surgical site and accommodate the movement of the position indicator on a surgeons hand or instrument.
    Type: Grant
    Filed: June 13, 2018
    Date of Patent: August 10, 2021
    Assignee: Board of Supervisors of Louisiana State University and Agricultural and Mechanical College
    Inventors: Rohan Walvekar, Jin-Woo Choi
  • Publication number: 20210235648
    Abstract: Provided are the herbicide-tolerant, aromatic (jasmine) rice cultivar designated ‘CLJ01’ and its hybrids and derivatives. The present invention provides a method for controlling weeds in the vicinity of rice, comprising contacting the rice with an herbicide, wherein said rice belongs to any of (a) variety ‘CLJ01’ or (b) a hybrid, derivative, or progeny of ‘CLJOV that expresses the imidazolinone herbicide resistance characteristics of ‘CLJOV. In some embodiments, the rice plants of the present invention include plants that comprise an AHAS mutant polypeptide that confers an increased tolerance to an imidazolinone herbicide when compared to a wild-type rice plant.
    Type: Application
    Filed: April 16, 2019
    Publication date: August 5, 2021
    Applicant: Board of Supervisors of Louisiana State University and Agricultural and Mechanical College
    Inventors: Steven D Linscombe, Adam Famoso, Xueyan Sha
  • Publication number: 20210238623
    Abstract: Aspects of the present disclosure relate to genetically modified plants and/or algae with increased carbon use efficiency as a result of an increased ability for bicarbonate to cross membranes within plant cells. Other aspects of the present disclosure relate to methods of making such plants and/or algae as well as cultivating these genetically modified plants to increase carbon use efficiency and/or growing these genetically modified algae to increase carbon use efficiency.
    Type: Application
    Filed: July 12, 2019
    Publication date: August 5, 2021
    Applicants: Board of Supervisors of Louisiana State University and Agricultural and Mechanical College, University of York
    Inventors: Ananya MUKHERJEE, James V. MORONEY, Chun Sing LAU, Luke C.M. MACKINDER
  • Patent number: 11058662
    Abstract: The present invention relates to methods of treating overweight or obesity, reducing fat, sugar, and food intake, and reducing body weight or body weight gain in a subject using geranium oil or orlistat mouthwash, or a combination of both.
    Type: Grant
    Filed: December 13, 2019
    Date of Patent: July 13, 2021
    Assignee: Board Of Supervisors Of Louisiana State University And Agricultural And Mechanical College
    Inventors: Hans-Rudolf Berthoud, Frank L. Greenway, Stefany Deprato Primeaux
  • Patent number: 11059882
    Abstract: Dual variable domain immunoglobulins (DVD Igs) are provided capable of tetravalent binding to bispecific sites of the human immunodeficiency virus (HIV). The DVD Igs may be asymmetric and may have more variable domains on either the light chain or the heavy chain of the Igs. The DVD Igs may have specificity for gp41 and gp120. Therapies are provided using DVD Igs to neutralize HIV viral loads.
    Type: Grant
    Filed: May 1, 2018
    Date of Patent: July 13, 2021
    Assignee: Board Of Supervisors Of Louisiana State University And Agricultural And Mechanical College
    Inventors: Seth Pincus, Ryan Craig
  • Patent number: 11028307
    Abstract: Bentonite (or other clay) water-based drilling fluids incorporating functionalized cellulose nanocrystals are disclosed. Cellulose nanocrystals are modified with tailored surface charges or tailored levels of salt-tolerant polymer grafting, and combined with bentonite (or other clay) nanoplatelets in an aqueous suspension. Thermal performance of drilling fluids can also be enhanced by surface grafting of thermally functional polymers onto cellulose nanocrystals.
    Type: Grant
    Filed: October 31, 2018
    Date of Patent: June 8, 2021
    Assignee: Board of Supervisors of Louisiana State University and Agricultural and Mechanical College
    Inventors: Qinglin Wu, Meichun Li
  • Publication number: 20210166889
    Abstract: The present invention relates in part to a method of fabricating graphene structures from graphene oxide by reducing the graphene oxide on a patterned substrate. The invention also relates in part to graphene structures produced using said method and electrodes and capacitors comprising said graphene structures.
    Type: Application
    Filed: February 8, 2021
    Publication date: June 3, 2021
    Applicant: Board of Supervisors of Louisiana State University and Agricultural and Mechanical College
    Inventors: Manas Ranjan Gartia, Ardalan Chaichi
  • Publication number: 20210145948
    Abstract: A vaccine is disclosed that promotes CD4+ T cell-independent host defense mechanisms to defend against infection by fungi such as Pneumocystis spp. The vaccine may be used to prevent or to treat fungal infections. The novel vaccine can provide protective immunity, even for immunocompromised individuals such as HIV patients having reduced levels of CD4+ T cells.
    Type: Application
    Filed: May 13, 2020
    Publication date: May 20, 2021
    Applicants: UNIVERSITY OF PITTSBURGH - OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION, Board Of Supervisors Of Louisiana State University And Agricultural And Mechanical College
    Inventors: Jay K. Kolls, Michael Zheng, Karen Norris, Heather Kling
  • Patent number: 11006600
    Abstract: The herbicide-tolerant rice cultivar designated ‘CL272’ and its hybrids and derivatives are disclosed. CL272 is a novel, herbicide-resistant, early maturing, semidwarf, medium-grain rice cultivar with improved yield and improved disease resistance. This invention also pertains to methods for producing a hybrid or new variety by crossing the rice variety ‘CL272’ with another rice line, one or more times. This invention allows for single-gene converted plants of ‘CL272.’ This invention also provides regenerable cells for use in tissue culture of rice plant ‘CL272.’ The present invention provides a method for treating rice.
    Type: Grant
    Filed: May 31, 2017
    Date of Patent: May 18, 2021
    Assignee: Board of Supervisors of Louisiana State University and Agricultural and Mechanical College
    Inventor: Steven D. Linscombe
  • Patent number: 11006595
    Abstract: The herbicide-tolerant rice cultivar designated ‘CL153’ and its hybrids and derivatives are disclosed. CL153 is a novel, herbicide-resistant, high yielding, early maturing, semidwarf, long-grain rice cultivar with excellent grain yield, good grain quality, and produces plans with very good resistance to blast disease. This invention also pertains to methods for producing a hybrid or new variety by crossing the rice variety ‘CL153’ with another rice line, one or more times. This invention allows for single-gene converted plants of ‘CL153.’ This invention also provides regenerable cells for use in tissue culture of rice plant ‘CL153.’ The present invention provides a method for controlling weeds in the vicinity of rice.
    Type: Grant
    Filed: May 31, 2017
    Date of Patent: May 18, 2021
    Assignee: Board of Supervisors of Louisiana State University and Agricultural and Mechanical College
    Inventor: Steven D. Linscombe
  • Patent number: 11007199
    Abstract: This invention is directed to compositions, methods and kits that can be used for the treatment or amelioration of pain and fever.
    Type: Grant
    Filed: January 9, 2020
    Date of Patent: May 18, 2021
    Assignees: The Board of Supervisors of Louisiana State University and Agricultural and Mechanical College, University of Alcala De Hernares, South Rampart Pharma, LLC
    Inventors: Nicolas Bazan, Hernan Bazan, Julio Alvarez-Builla Gomez, Dennis Paul, Carolina Burgos Garcia
  • Publication number: 20210122865
    Abstract: A UV-curable and recyclable thermoset shape memory polymer is provided. The polymer includes a vitrimer-based monomer and a photoinitiator. The vitrimer-based monomer includes a first unit rendering a high chain stiffness upon polymerization of the monomer, and a second photopolymerizable unit for photopolymerization of the monomer under a UV irradiation. The polymer has high strength, high stiffness, high recovery stress, high energy storage, reasonable recycling efficiency, and is printable using SLA with high resolution.
    Type: Application
    Filed: April 30, 2019
    Publication date: April 29, 2021
    Applicant: Board of Supervisors of Louisiana State University and Agricultural and Mechanical College
    Inventors: Ang LI, Guoqiang LI
  • Patent number: 10982226
    Abstract: Provided herein are green alga Cia8 polypeptides and the polynucleotides that encode them. Also provided herein are transformed cells and transgenic plants that include one or more of the polynucleotides and/or polypeptides provided herein.
    Type: Grant
    Filed: June 20, 2017
    Date of Patent: April 20, 2021
    Assignee: Board of Supervisors of Louisiana State University and Agricultural and Mechanical College
    Inventors: James V. Moroney, Marylou C. Machingura, Joanna N. Bajsa-Hirschel
  • Publication number: 20210100268
    Abstract: A method is disclosed for making palatable methionine-restricted foods, to deliver a methionine-restricted diet to human or veterinary patients. A protein or a food product containing protein is partially oxidized, preferably with ozone, to oxidize nearly all of the methionine and cysteine. After oxidation, tryptophan and lysine are optionally added back since they tend to be oxidized also. Optionally, a small amount of methionine is also added back so that the final methionine is within a preferred range of about 0.85 to about 1.8 gram methionine per 100 gram total protein, preferably about 1.2 gram per 100 gram total protein.
    Type: Application
    Filed: December 16, 2020
    Publication date: April 8, 2021
    Applicant: Board of Supervisors of Louisiana State University and Agricultural and Mechanical College
    Inventors: John W. Finley, Thomas Gettys, Frank L. Greenway