Patents Assigned to The Board of Trustees of Leland Stanford University
  • Publication number: 20120255046
    Abstract: Recombinant adeno-associated viral (AAV) capsid proteins are provided. Methods for generating a library of recombinant adeno-associated viral capsid proteins are also provided.
    Type: Application
    Filed: May 15, 2012
    Publication date: October 4, 2012
    Applicant: The Board of Trustees of The Leland Stanford University
    Inventors: MARK KAY, Dirk Grimm
  • Patent number: 7544800
    Abstract: A method is provided for carrying out depolymerization of a polymer containing electrophilic linkages in the presence of a catalyst and a nucleophilic reagent, wherein production of undesirable byproducts resulting from polymer degradation is minimized. The reaction can be carried out at a temperature of 80° C. or less, and generally involves the use of an organic, nonmetallic catalyst, thereby ensuring that the depolymerization product(s) are substantially free of metal contaminants. In an exemplary depolymerization method, the catalyst is a carbene compound such as an N-heterocyclic carbene, or is a precursor to a carbene compound. The method provides an important alternative to current recycling techniques such as those used in the degradation of polyesters, polyamides, and the like.
    Type: Grant
    Filed: August 18, 2005
    Date of Patent: June 9, 2009
    Assignees: International Business Machines Corporation, The Board of Trustees of the Leland Stanford University
    Inventors: James Lupton Hedrick, Gregory Walker Nyce, Robert M. Waymouth
  • Publication number: 20080234220
    Abstract: Methods and compositions for reducing viral genome amounts in a target cell are provided. In the subject methods, the activity of a miRNA is inhibited in a manner sufficient to reduce the amount of viral genome in the target cell, e.g., by introducing a miRNA inhibitory agent in the target cell. Also provided are pharmaceutical compositions, kits and systems for use in practicing the subject methods. The subject invention finds use in a variety of applications, including the treatment of subjects suffering from a viral mediated disease condition, e.g., an HCV mediated disease condition.
    Type: Application
    Filed: December 10, 2007
    Publication date: September 25, 2008
    Applicant: The Board of Trustees of The Leland Stanford University
    Inventors: Peter Sarnow, Catherine L. Jopling, Alissa M. Lancaster
  • Patent number: 7312048
    Abstract: Novel polyketides and novel methods of efficiently producing both new and known polyketides, using recombinant technology, are disclosed. In particular, a novel host-vector system is described which is used to produce polyketide synthases which in turn catalyze the production of a variety of polyketides.
    Type: Grant
    Filed: September 15, 2005
    Date of Patent: December 25, 2007
    Assignees: The Board of Trustees of the Leland Stanford University, The John Innes Institute
    Inventors: Chaitan Khosla, David A. Hopwood, Susanne Ebert-Khosla, Robert McDaniel, Hong Fu, Camilla M. Kao
  • Patent number: 7307067
    Abstract: Methods and compositions for reducing viral genome amounts in a target cell are provided. In the subject methods, the activity of a miRNA is inhibited in a manner sufficient to reduce the amount of viral genome in the target cell, e.g., by introducing a miRNA inhibitory agent in the target cell. Also provided are pharmaceutical compositions, kits and systems for use in practicing the subject methods. The subject invention finds use in a variety of applications, including the treatment of subjects suffering from a viral mediated disease condition, e.g., an HCV mediated disease condition.
    Type: Grant
    Filed: May 3, 2005
    Date of Patent: December 11, 2007
    Assignee: The Board of Trustees of the Leland Stanford University
    Inventors: Peter Sarnow, Catherine L. Jopling, Alissa M. Lancaster
  • Patent number: 7147865
    Abstract: Devices and methods are provided for administering a fluid to a neuronal site. The device comprises a reservoir, an aperture in fluid connection to the reservoir, and electrical means for moving to the fluid to or through the aperture. The electrical means may take the form of electroosmotic force, piezoelectric movement of a diaphragm or electrolysis of a solution. The electrical means may be external to the host, implanted in the host or may be photodiodes activated by light, particularly where the neuronal site is associated with the retina.
    Type: Grant
    Filed: November 13, 2003
    Date of Patent: December 12, 2006
    Assignee: The Board of Trustees of the Leland Stanford University
    Inventors: Harvey A. Fishman, David Bloom, Stacey F. Bent, Mark C. Peterman, Jaan Noolandi, Neville Mehenti
  • Patent number: 7113594
    Abstract: A method and system for encrypting a first piece of information M to be sent by a sender [100] to a receiver [110] allows both sender and receiver to compute a secret message key using identity-based information and a bilinear map. In a one embodiment, the sender [100] computes an identity-based encryption key from an identifier ID associated with the receiver [110]. The identifier ID may include various types of information such as the receiver's e-mail address, a receiver credential, a message identifier, or a date. The sender uses a bilinear map and the encryption key to compute a secret message key gIDr, which is then used to encrypt a message M, producing ciphertext V to be sent from the sender [100] to the receiver [110] together with an element rP. An identity-based decryption key dID is computed by a private key generator [120] based on the ID associated with the receiver and a secret master key s.
    Type: Grant
    Filed: August 13, 2002
    Date of Patent: September 26, 2006
    Assignees: The Board of Trustees of the Leland Stanford University, University of California Davis
    Inventors: Dan Boneh, Matthew Franklin
  • Patent number: 7049102
    Abstract: This invention relates to the use of promoters for ribonucleic acid amplification and other genetic manipulations. Processes are provided wherein complementary deoxyribonucleic acid (cDNA) is synthesized from a ribonucleic acid (RNA) sequence using a complementary primer linked to an RNA polymerase promoter region complement and then anti-sense RNA (aRNA) is transcribed from the cDNA by introducing an RNA polymerase capable of binding to the promoter region. Additional processes using the resulting aRNA are also described.
    Type: Grant
    Filed: November 15, 2000
    Date of Patent: May 23, 2006
    Assignee: Board of Trustees of Leland Stanford University
    Inventors: Russell N. Van Gelder, Mark E. Von Zastrow, Jack D. Barchas, James H. Eberwine
  • Patent number: 6994986
    Abstract: Compositions and methods are provided for the enhanced in vitro synthesis of polypeptides. In order to improve the performance of in vitro protein synthesis reactions, metabolic inhibitors, or manipulation of a source organism, is used to diminish or avoid the action of enzymes responsible for undesirable amino acids production or depletion. A homeostatic system may be used for production of ATP, where the required high energy phosphate bonds are generated in situ, e.g. through coupling with an oxidation reaction. The homeostatic energy source will typically lack high energy phosphate bonds itself, and will therefore utilize free phosphate in the reaction mix during generation of ATP. The homeostatic energy source is provided in combination with an enzyme that catalyzes the creation of high energy phosphate bonds and with an enzyme that can use that high energy phosphate bond to regenerate ATP.
    Type: Grant
    Filed: September 7, 2001
    Date of Patent: February 7, 2006
    Assignee: The Board of Trustees of the Leland Stanford University
    Inventors: James Robert Swartz, Dong-Myung Kim
  • Patent number: 6974664
    Abstract: Screening methods and methods of treatment taking advantage of the mode of action of apoptolidin and its analogs are described.
    Type: Grant
    Filed: July 25, 2001
    Date of Patent: December 13, 2005
    Assignee: The Board of Trustees of the Leland Stanford University
    Inventors: Chaitan Khosla, Art Salomon
  • Patent number: 6969611
    Abstract: Novel polyketides and novel methods of efficiently producing both new and known polyketides, using recombinant technology, are disclosed. In particular, a novel host-vector system is described which is used to produce polyketide synthases which in turn catalyze the production of a variety of polyketides.
    Type: Grant
    Filed: August 8, 2001
    Date of Patent: November 29, 2005
    Assignees: The Board of Trustees of the Leland Stanford University, The John Innes Institute
    Inventors: Chaitan Khosla, David A. Hopwood, Suzanne Ebert-Khosla, Robert McDaniel, Hong Fu, Camilla Kao
  • Publication number: 20050261215
    Abstract: This invention relates to methods and compositions for treating or preventing disease comprising the administration of immune modulatory nucleic acids having one or more immune modulatory sequences (IMSs). The invention further relates to the means and methods for the identification of the IMSs for preventing or treating disease, more particularly the treatment and prevention of autoimmune or inflammatory diseases. The invention also relates to the treatment or prevention of disease comprising the administration of the immune modulatory nucleic acids alone or in combination with a polynucleotide encoding self-protein(s), -polypeptide(s) or -peptide(s). The present invention also relates to methods and compositions for treating diseases in a subject associated with one or more self-protein(s), -polypeptide(s) or -peptide(s) that are present in the subject and involved in a non-physiological state.
    Type: Application
    Filed: November 21, 2003
    Publication date: November 24, 2005
    Applicants: Bayhill Therapeutics, Inc., The Board of Trustees of the Leland Stanford University
    Inventors: Hideki Garren, Peggy Ho, Lawrence Steinman
  • Patent number: 6923951
    Abstract: Methods and compositions for detecting and localizing light originating from a mammal are disclosed. Also disclosed are methods for targeting light emission to selected regions, as well as for tracking entities within the mammal. In addition, animal models for disease states are disclosed, as are methods for localizing and tracking the progression of disease or a pathogen within the animal, and for screening putative therapeutic compounds effective to inhibit the disease or pathogen.
    Type: Grant
    Filed: December 16, 2002
    Date of Patent: August 2, 2005
    Assignee: Board of Trustees of the Leland Stanford University
    Inventors: Pamela R. Contag, Christopher H. Contag, David A. Benaron
  • Patent number: 6856393
    Abstract: A method measures a nolinearity profile of a sample with at least one sample surface and having a sample nonlinearity profile along a sample line through a predetermined point on the sample surface. The sample line is oriented perpendicularly to the sample surface. The method includes measuring a Fourier transform of the sample nonlinearity profile and obtaining a reference nonlinearity profile from a reference material. The method includes forming a first composite sample having a first composite nonlinearity profile and forming a second composite sample having a second composite nonlinearity profile inequivalent to the first composite nonlinearity profile. The method further includes measuring a Fourier transform of the first composite nonlinearity profile and measuring a Fourier transform of the second composite nonlinearity profile.
    Type: Grant
    Filed: March 3, 2003
    Date of Patent: February 15, 2005
    Assignee: The Board of Trustees of the Leland Stanford University
    Inventors: Aydogan Ozcan, Michel J.F. Digonnet, Gordon S. Kino
  • Patent number: 6642371
    Abstract: Haemophilus adhesion and penetration proteins, nucleic acids, vaccines and monoclonal antibodies are provided.
    Type: Grant
    Filed: April 20, 2001
    Date of Patent: November 4, 2003
    Assignees: The Board of Trustees of the Leland Stanford University, Washington University
    Inventors: Joseph W. St. Geme, III, Stanley Falkow
  • Patent number: 6531130
    Abstract: Compositions and methods are provided for the treatment of demyelinating autoimmune disease. Therapeutic doses are administered of an ordered peptide comprising a repeated motif {SEQ ID NO: 1} [1E2Y3Y4K]n, where n is from 2 to 6. Some specific peptides of interest include those having the sequence {SEQ ID NO: 4} EYYKEYYKEYYK. The peptide may consist only of the ordered repeats, or may be extended at either termini by the addition of other amino acid residues. For therapy, the peptides may be administered topically or parenterally, e.g. by injection at a particular site, including subcutaneously, intraperitoneally, intravascularly, or the like or transdermally, as by electrotransport. In a preferred embodiment, subcutaneous injection is used to deliver the peptide. The subject methods are used for prophylactic or therapeutic purposes. The compositions of the invention may also contain other therapeutically active agents, e.g. immunosuppressants, &bgr;-interferon, steroids, etc.
    Type: Grant
    Filed: June 28, 2000
    Date of Patent: March 11, 2003
    Assignee: The Board of Trustees of the Leland Stanford University
    Inventors: Lawrence Steinman, Pedro José Ruiz
  • Patent number: 6329148
    Abstract: A synergistic combination of ligands that interact with death domain receptors, and diterpenoid triepoxides is used to increase tumor cell killing by induction of apoptosis. Ligands useful in the invention include TRAIL, TNF-&agr;, analogs thereof, stabilized multimers thereof, mimetics, etc. Of particular interest are combined therapy with the diterpenoid triepoxides triptolide and derivatives and analogs thereof.
    Type: Grant
    Filed: February 15, 2000
    Date of Patent: December 11, 2001
    Assignee: The Board of Trustees of the Leland Stanford University
    Inventors: Glenn D. Rosen, Peter Kao
  • Patent number: 6291170
    Abstract: This invention relates to the use of promoters for ribonucleic acid amplification and other genetic manipulations. Processes are provided wherein complementary deoxyribonucleic acid (cDNA) is synthesized from a ribonucleic acid (RNA) sequence using a complementary primer linked to an RNA polymerase promoter region complement and then anti-sense RNA (aRNA) is transcribed from the cDNA by introducing an RNA polymerase capable of binding to the promoter region. Additional processes using the resulting aRNA are also described.
    Type: Grant
    Filed: April 5, 1999
    Date of Patent: September 18, 2001
    Assignee: Board of Trustees of Leland Stanford University
    Inventors: Russell N. Van Gelder, Mark E. Von Zastrow, Jack D. Barchas, James D. Eberwine
  • Patent number: 6245531
    Abstract: Polynucleotide sequences which encode ecdysone receptors have been isolated and expressed in host cells.
    Type: Grant
    Filed: June 5, 1995
    Date of Patent: June 12, 2001
    Assignee: Board of Trustees of Leland Stanford University
    Inventors: David S. Hogness, Michael R. Koelle, William A. Seagraves
  • Patent number: 6008045
    Abstract: The human DNA polymerase .alpha. catalytic polypeptide has been functionally over-expressed by a recombinant baculovirus in insect cells at >1000 fold higher levels than that found in cultured normal human cells.
    Type: Grant
    Filed: November 15, 1991
    Date of Patent: December 28, 1999
    Assignee: Board of Trustees of the Leland Stanford University
    Inventors: William C. Copeland, Teresa S.-F. Wang