Patents Assigned to The Board of Trustees of the Leland Stanford Junior University
  • Patent number: 10338205
    Abstract: A backscatter tag communicate device includes, in part, a receiver configured to receive a WiFi packet conforming to a communication protocol defining a multitude of codewords, a mapper configured to map at least a first subset of the multitude of codewords disposed in the packet to a second multitude of codewords defined by the protocol, and a frequency shifter configured to shift a frequency of the second multitude of codewords such that the frequency shifted codewords are characterized by a single sideband spectrum. The communication protocol may be the 802.11b communication protocol. The mapper may optionally map the first subset of the multitude of codewords by changing phases of the first subset of the multitude of codewords.
    Type: Grant
    Filed: August 14, 2017
    Date of Patent: July 2, 2019
    Assignee: The Board of Trustees of the Leland Stanford Junior University
    Inventors: Pengyu Zhang, Dinesh Bharadia, Kiran Joshi, Sachin Katti
  • Patent number: 10335521
    Abstract: Described generally herein are tissue therapy devices, which may comprise a sealant layer and a suction apparatus. The sealant layer functions so as to create a sealed enclosure between it and the surface of a patient by forming, preferably, an airtight seal around an area of tissue that requires negative pressure therapy. The tissue therapy device may comprise a suction apparatus. The suction apparatus is typically in fluid communication with the sealant layer and functions so as to reduce the amount of pressure present underneath the sealant layer. The reduced pressure is self-created by the suction apparatus. Together the sealant layer and the suction apparatus preferably create a closed reduced pressure therapy system. Preferably, the pressure under the sealant layer is reduced by expanding the volume of the enclosure space and thereby decreasing the density of the air molecules under the sealant layer.
    Type: Grant
    Filed: August 30, 2011
    Date of Patent: July 2, 2019
    Assignee: The Board of Trustees of the Leland Stanford Junior University
    Inventors: Moshe Pinto, Dean Hu, Kenton Fong
  • Patent number: 10336807
    Abstract: The present disclosure provides systems for immune cell regulation and methods of immunotherapy. Systems of the present disclosure for immune cell regulation comprise a chimeric receptor polypeptide, a chimeric adaptor polypeptide, a gene modulating polypeptide (GMP), and a cleavage moiety.
    Type: Grant
    Filed: July 6, 2018
    Date of Patent: July 2, 2019
    Assignee: The Board of Trustees of the Leland Stanford Junior University
    Inventors: Lei S. Qi, Bing C Wang
  • Publication number: 20190198817
    Abstract: A light emitting device including a micro cavity having a phase modulation surface and a display apparatus including the light emitting device are provided. The light emitting device includes a reflective layer including a phase modulation surface; a first electrode disposed on the phase modulation surface of the reflective layer; a light emitting structure disposed on the first electrode; and a second electrode disposed on the light emitting structure. The phase modulation surface may include a plurality of nano scale patterns that are regularly or irregularly arranged. The reflective layer and the second electrode may constitute the micro cavity having a resonance wavelength of the light emitting device.
    Type: Application
    Filed: December 21, 2018
    Publication date: June 27, 2019
    Applicants: SAMSUNG ELECTRONICS CO., LTD., THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY
    Inventors: Wonjae JOO, Mark L. BRONGERSMA, Majid ESFANDYARPOUR
  • Patent number: 10330671
    Abstract: C1q is shown to be expressed in neurons, where it acts as a signal for synapse elimination. Methods are provided for protecting or treating an individual suffering from adverse effects of synapse loss. These findings have broad implications for a variety of clinical conditions, including Alzheimer's disease.
    Type: Grant
    Filed: November 11, 2016
    Date of Patent: June 25, 2019
    Assignee: The Board of Trustees of the Leland Stanford Junior University
    Inventors: Ben A. Barres, Beth A. Stevens
  • Patent number: 10333171
    Abstract: Described here is a solid-state lithium-ion battery, comprising a cathode, an anode, and a solid-state electrolyte disposed between the cathode and the anode, wherein the electrolyte comprises a hexacyanometallate represented by AxPy[R(CN)6-wLw]z, wherein: A is at least one alkali metal cation, P is at least one transition metal cation, at least one post-transition metal cation, and/or at least one alkaline earth metal cation, R is at least one transition metal cation, L is an anion, x, y, and z are related based on electrical neutrality, x>0, y>0, z>0, and 0?w?6.
    Type: Grant
    Filed: September 7, 2016
    Date of Patent: June 25, 2019
    Assignee: The Board of Trustees of the Leland Stanford Junior University
    Inventors: Richard Wang, Yi Cui, Mauro Pasta
  • Patent number: 10329354
    Abstract: Smooth muscle cells (SMC) from subjects carrying at least one 9p21 risk factor, can be resistant to efferocytosis, leading to the retention of such cells in the necrotic core of atherosclerotic plaque. In the methods of the invention, an agent that increases efferocytosis of cellular components of coronary plaque, including efferocytosis of apoptotic smooth muscle cells, is administered to the subject in a dose and for a period of time effective to stabilize, prevent or reduce atherosclerotic plaque in the individual.
    Type: Grant
    Filed: September 15, 2014
    Date of Patent: June 25, 2019
    Assignee: The Board of Trustees of the Leland Stanford Junior University
    Inventors: Nicholas J. Leeper, Irving L. Weissman
  • Patent number: 10329607
    Abstract: The invention provides methods, devices, compositions and kits for diagnosing or predicting transplant status or outcome in a subject who has received a transplant.
    Type: Grant
    Filed: August 23, 2018
    Date of Patent: June 25, 2019
    Assignee: The Board of Trustees of the Leland Stanford Junior University
    Inventors: Stephen R. Quake, Thomas M. Snyder, Hannah Valantine
  • Patent number: 10328262
    Abstract: Described here are stimulation systems and methods for stimulating one or more anatomical targets in a patient for treatment conditions such as dry eye. The stimulation system may include a controller and a microstimulator. The components of the controller and microstimulator may be implemented in a single unit or in separate devices. When implemented separately, the controller and microstimulator may communicate wirelessly or via a wired connection. The microstimulator may generate pulses from a signal received from the controller and apply the signal via one or more electrodes to an anatomical target. In some variations, the microstimulator may include a passive generation circuit configured to generate a pulse based on a signal received from the controller.
    Type: Grant
    Filed: November 2, 2017
    Date of Patent: June 25, 2019
    Assignees: The Board of Trustees of the Leland Stanford Junior University, Oculeve, Inc.
    Inventors: Douglas Michael Ackermann, James Donald Loudin, Janusz Kuzma, Daniel Palanker, Scott Franklin Wetenkamp
  • Publication number: 20190183967
    Abstract: The invention provides methods for treating fibrosis and/or cancer in a subject in need thereof. The methods include providing a composition comprising an inhibitor of IL-4/IL-13 receptor function and administering an effective amount of the composition to the subject to treat fibrosis and/or cancer.
    Type: Application
    Filed: February 13, 2019
    Publication date: June 20, 2019
    Applicants: Cedars-Sinai Medical Center, The Board of Trustees of the Leland Stanford Junior University
    Inventors: Ramachandran Murali, Aida Habtezion, Stephen J. Pandol
  • Publication number: 20190185882
    Abstract: The invention provides delivery methods and compositions for antiviral therapeutics. Methods and compositions are provided for targeted delivery of antiviral therapeutics into cells of interest using, for example, viral vectors such as adenovirus, AAV, and replication incompetent HSV. These and other delivery systems can be used as vehicles to deliver DNA vectors encoding a nuclease or a cell-killing gene. These delivery methods can also be used to deliver naked DNA or RNA, protein products, plasmids containing a promoter that is active only in a latent viral state which drives a cell-killing gene, or other therapeutic agents.
    Type: Application
    Filed: July 26, 2018
    Publication date: June 20, 2019
    Applicant: The Board of Trustees of the Leland Stanford Junior University
    Inventors: Stephen R. Quake, Jianbin Wang
  • Patent number: 10322089
    Abstract: In accordance with the purpose(s) of the present disclosure, as embodied and broadly described herein, embodiments of the present disclosure, in one aspect, relate to nanoparticles, compositions including nanoparticles, methods of making nanoparticles, and the like. In particular, embodiments of the present disclosure include nanoparticles and compositions for the sustained release (e.g., release at a predetermined rate to maintain a certain concentration for a certain period of time) of an agent, such as a small interfering RNA (siRNA) from the nanoparticle.
    Type: Grant
    Filed: March 13, 2013
    Date of Patent: June 18, 2019
    Assignee: The Board of Trustees of the Leland Stanford Junior University
    Inventors: Tatsiana Lobovkina, Gunilla B. Jacobson, Richard N. Zare, Evgenios Neofytou, Ramin E. Beygui, Marie Russo
  • Patent number: 10322289
    Abstract: Implantable devices and/or sensors can be wirelessly powered by controlling and propagating electromagnetic waves in a patient's tissue. Such implantable devices/sensors can be implanted at target locations in a patient, to stimulate areas such as the heart, brain, spinal cord, or muscle tissue, and/or to sense biological, physiological, chemical attributes of the blood, tissue, and other patient parameters. The propagating electromagnetic waves can be generated with sub-wavelength structures configured to manipulate evanescent fields outside of tissue to generate the propagating waves inside the tissue. Methods of use are also described.
    Type: Grant
    Filed: November 17, 2017
    Date of Patent: June 18, 2019
    Assignee: The Board of Trustees of the Leland Stanford Junior University
    Inventors: Ada Shuk Yan Poon, Alexander Yeh, Yuji Tanabe, John Ho, Sanghoek Kim
  • Patent number: 10320232
    Abstract: Described is a locomotive implant for usage within a predetermined magnetic field. In one embodiment magnetohydrodynamics is used to generate thrust with a plurality of electrodes. In another embodiment, asymmetric drag forces are used to generate thrust.
    Type: Grant
    Filed: July 22, 2016
    Date of Patent: June 11, 2019
    Assignee: THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY
    Inventors: Daniel Michael Pivonka, Anatoly Anatolievich Yakovlev, Ada Shuk Yan Poon, Teresa H. Meng
  • Patent number: 10318583
    Abstract: Systems and methods for relationship recommendations systems in accordance with embodiments of the invention are illustrated. In one embodiment, a relationship recommendation server system includes a processor wherein a relationship recommendation program configures the processor to obtain a graph database including a set of nodes including node attribute data and a set of edges including edge attribute data and describing relationships between nodes in the set of nodes, determine a set of motif data, where the motif data describes at least one subgraph including a subset of the nodes and a subset of the edges within the graph database, obtain a search node, generate additional edges between the search node and a subset of the nodes within the graph database, where the additional edges form subgraphs including the search node that are isomorphic to a subset of the motif data, and recommend relationships based on the generated additional edges.
    Type: Grant
    Filed: March 14, 2014
    Date of Patent: June 11, 2019
    Assignee: The Board of Trustees of the Leland Stanford Junior University
    Inventors: Evan Feinberg, Julien Clancy
  • Patent number: 10316872
    Abstract: A magnetic trap droplet controller is provided that includes a solid substrate, a controller operated by an appropriately programmed computer, a two-dimensional distribution of magnetized domains disposed on a surface of the solid substrate, a fluid chamber disposed above the two-dimensional distribution of magnetized domains, and an active magnet, where the active magnet is disposed to provide a dynamic magnetic field in-plane with the solid substrate, where the dynamic magnetic field controls north and south poles of the two-dimensional distribution of magnetized domains according to the controller, where a fluid under test that is disposed in a carrier fluid that is disposed in the fluid chamber propagates according to the controlled north and south poles of the two-dimensional distribution of the magnetized domains.
    Type: Grant
    Filed: August 27, 2013
    Date of Patent: June 11, 2019
    Assignee: The Board of Trustees of the Leland Stanford Junior University
    Inventors: Manu Prakash, Georgios Katsikis
  • Patent number: 10314730
    Abstract: A foot abduction brace is disclosed herein. The foot abduction brace can include a crossbar having a planar bottom end. The foot abduction brace can also include a first end disposed on one side of the crossbar. The foot abduction brace can further include a first locking hub removably coupled to the first end in a first position of a plurality of positions, where the first locking hub is disposed in the first keyhole and includes a first coupling feature disposed at a top end of the first locking hub. The foot abduction brace can also include a first footplate having a first complementary coupling feature that removably couples to the first coupling feature of the first locking hub. The foot abduction brace can further include a first foot restraint mechanically coupled to the first footplate.
    Type: Grant
    Filed: September 17, 2014
    Date of Patent: June 11, 2019
    Assignee: The Board Of Trustees Of The Leland Stanford Junior University, C/O Ms. Katharine Ku, Director Office Of Technology Licensing
    Inventors: Ian Connolly, Jeffrey Yang, Francesca Colloredo-Mansfeld, Brian C. Donnelly, Robert G. Kopp, William J. Phillips, Michael R. Vogler, Richard Byrne, Mark Vasquez, Michael Andrew Ahdoot, Kathryn Ann Jaxheimer
  • Patent number: 10316094
    Abstract: Methods and compositions are provided for inducing phagocytosis of a target cell, treating an individual having cancer, treating an individual having an intracellular pathogen infection (e.g., a chronic infection), and/or reducing the number of inflicted cells (e.g., cancer cells, cells infected with an intracellular pathogen, etc.) in an individual. Methods and compositions are also provided for predicting whether an individual is resistant (or susceptible) to treatment with an anti-CD47/SIRPA agent. In some cases, the subject methods and compositions include an anti-MHC Class I/LILRB1 agent. In some cases, the subject methods and compositions include an anti-MHC Class I/LILRB1 agent and an anti-CD47/SIRPA agent (e.g., co-administration of an anti-MHC Class I/LILRB1 agent and an anti-CD47/SIRPA agent). Kits are also provided for practicing the methods of the disclosure.
    Type: Grant
    Filed: October 23, 2015
    Date of Patent: June 11, 2019
    Assignee: The Board of Trustees of the Leland Stanford Junior University
    Inventors: Roy Louis Maute, Kipp Andrew Weiskopf, Aaron Michael Ring, Irving L. Weissman
  • Patent number: 10316220
    Abstract: A controllable adhesive for non-flat surfaces is provided. The device has a conformable (i.e. flexible) film and directly cast thereto a synthetic dry adhesive film. The synthetic dry adhesive film has elastomeric wedges. The conformable film is capable to deform to a non-flat surface. In one embodiment, the controllable adhesive has a first loading mechanism at one end of the controllable adhesive to apply load to the controllable adhesive. In another embodiment, forming a gripper, the controllable adhesive has a second controllable adhesive with a second loading mechanism, such that the first and second loading mechanism face each other and join a common point of loading.
    Type: Grant
    Filed: January 12, 2016
    Date of Patent: June 11, 2019
    Assignee: The Board of Trustees of the Leland Stanford Junior University
    Inventors: Elliot W. Hawkes, David L. Christensen, Srinivasan Arul Suresh, Mark R Cutkosky
  • Patent number: 10317597
    Abstract: Various aspects of the present disclosure are directed toward optics and imaging. As may be implemented with one or more embodiments, an apparatus includes one or more phase masks that operate with an objective lens and a microlens array to alter a phase characteristic of light travelling in a path from a specimen, through the objective lens and microlens array and to a photosensor array. Using this approach, the specimen can be imaged with spatial resolution characteristics provided via the altered phase characteristic, which can facilitate construction of an image with enhanced resolution.
    Type: Grant
    Filed: August 17, 2015
    Date of Patent: June 11, 2019
    Assignee: The Board of Trustees of the Leland Stanford Junior University
    Inventors: Noy Cohen, Marc S. Levoy, Michael J. Broxton, Logan Grosenick, Samuel Yang, Aaron Andalman, Karl A. Disseroth, Mark A. Horowitz