Abstract: Systems and methods for treatment of neurological conditions using aTBS in accordance with embodiments of the invention are illustrated. One embodiment includes a method for treating neurological conditions, including generating a personalized accelerated theta burst stimulation (aTBS) target representing a location in a patient's brain related to a neurological condition, placing a TMS device relative to the patient's brain such that the focus of the magnetic field is over the aTBS target, applying TMS to the aTBS target according to an aTBS protocol to the brain using the TMS device to alleviate the neurological condition.

Abstract: Certain examples are directed to optical elements or devices that pass or process the light based on a set of connectable metasurface elements having been topology optimized. The connectable metasurface elements are independently optimized or designed to have each section having its own metasurface phase profile corresponding to a desired phase profile. In this way, such devices need not be designed or manufactured by importing a large number of results into simulation efforts, thereby realizing significant saving in terms of optimization time and computational power.

Abstract: An apparatus including direct-current (DC)-alternating-current (AC) inverter circuitry, first and second circuits, and output circuitry. The DC-AC inverter circuitry inverts a DC input signal corresponding to an input voltage to an AC signal. The first circuit and second circuits respectively include inductive isolation circuits driven in response to power from the at least one AC signal, and rectifier circuits that responds to the inductive isolation circuits by outputting first and second rectified signals, where at least one of the first and second rectifier circuits characterized as being limited by a voltage breakdown rating. The output circuitry provides a DC output voltage signal and to cascade a plurality of signals, including the first and second rectified signals, to provide a voltage source that is dependent on the first and second rectified signals and greater than voltage breakdown rating.

Abstract: Activity-based probe compounds for use in labeling a cysteine protease are provided. The compounds are targeted to the protease through a specific targeting element. The compounds additionally include a detectable element, such as a fluorescent label, a radiolabel, or a chelator. In some cases, the compounds additionally include a quenching element that is released upon reaction with the protease. Also provided are compositions comprising the compounds and methods for using the compounds, for example in labeling a protease in an animal and in visualizing a tumor in an animal.

Abstract: A method is provided for treating a subject suffering from a chronic infection that involves the brain. The chronic infection may range from those causing only mild cognitive impairment, to those present in individuals who have been diagnosed with Alzheimer's Disease. The method includes forming a composition containing (a) an anti-infective peptoid, and (b) a blood-brain barrier (BBB) manipulator that enhances the ability of the anti-infective peptoid to cross the BBB; and administering a therapeutic amount of the composition to a subject in need thereof.

Abstract: Systems and methods for determining a treatment regimen for a neoplasm or a cancer are provided. A treatment regimen can be based on the mutational burden of the neoplasm or the cancer. When the mutational burden is high, the treatment regimen can include a drug that targets the cellular processes that protect the neoplasm or cancer in response to mutational burden.

Abstract: Disclosed herein are methods for providing a molecular efficacy of a ligand, especially when utilizing single-molecule fluorescence resonance energy transfer (“smFRET”) imaging, as well as compounds useful in such methods.

Abstract: Provided herein are compounds, pharmaceutical compositions comprising the compounds, methods of preparing the compounds, and methods of using the compounds and compositions in treating conditions associated with voltage-gated sodium channel function where the compounds are 11,13-modified saxitoxins according to Formula (I): where R4, R4a, R7, R7a, and X2 are as described herein.

Abstract: A method includes: 1) performing an atomic layer deposition cycle including (a) introducing precursors into a deposition chamber housing a substrate to deposit a material on the substrate; and (b) introducing a passivation gas into the deposition chamber to passivate a surface of the material; and 2) repeating 1) a plurality of times to form a film of the material.

Abstract: Instrument free “plasticware” is provided that enables multi-step molecular reactions in a diagnostics context. A hollow plunger that is movable within a surrounding tube defines a reaction chamber inside the plunger. By moving the plunger to different positions in the tube, a sample can be collected, then the sample can be washed, and finally the reaction chamber can be sealed to perform diagnostic reactions on the sample. The juxtaposition of large sample collection/washing volume with small reaction volume allows one to conduct a wide range of diagnostic assays including a LAMP (Loop mediated isothermal amplification) based saliva test in a small, portable self-contained device. Applications include Molecular diagnostics for health applications (including COVID19 test), Environmental Monitoring, Disease surveillance, and Veterinary health.

Abstract: The invention provides compositions and methods for high-efficiency genome editing. In some aspects, the invention provides retron-guide RNA cassettes and vectors comprising the cassettes. Also provided are host cells that have been transformed with the vectors. In other aspects, the invention provides retron donor DNA-guide molecules. In some other aspects, methods for genome editing and the screening of genetic loci are provided. In further aspects, methods and compositions are provided for the prevention or treatment of genetic diseases. Kits for genome editing and screening are also provided.

Abstract: Systems and methods for global positioning satellite (GPS)/global navigation satellite system (GNSS) based real time global asset tracking are described. In an embodiment provides a system for real time, fast, global asset tracking, the system includes: a server with a processor, a memory, and a network interface, wherein the memory includes a tracking application, where the tracking application directs the processor to: receive a message including specific data from a tag; determine a time search window based on the message received from the tag; perform an initial position search; perform calculations for position and time, utilizing the time search window, the initial position search and satellite ephemeris information; and display a position information of the tag.

Abstract: The present disclosure provides methods related to determining the level of afucosylated Fc glycans in IgG antibodies in a biological sample from a subject. This level can be used in methods aimed at monitoring and/or treating subject suffering from an acute flavivirus infection and/or who are at risk for progression to clinically significant infection or disease. This level can also be used in a vaccination method to ensure that those who receive a flavivirus vaccine have a reduced risk of reacting to the vaccine be developing clinically significant infection or disease. The disclosure also provides treatment methods based on inhibiting Fc?RIIA or Fc?RIIIA receptor signaling. Also provided are novel cell lines that are useful in measuring afucosylated Fc glycans.

Abstract: According to certain aspects, an electric-propulsion thruster is used as part of a base or platform which also includes a power converter, having a plurality of inductors and other electrical components, and a printed circuit board (PCB). The PCB includes a layer at which the other electrical components and printed circuit inductor traces, for the plurality of inductors, are secured. The electric-propulsion thruster includes a housing (e.g., as part of the base or platform) providing a cavity and having at least one structurally-rigid side wall along the cavity, where the PCB is integrated with the electric-propulsion thruster for a compact arrangement which can be used to propel the apparatus. Such a compact design might be used as an important part of thruster spacecraft architecture such as micro-satellites (e.g., CubeSats).

Abstract: Systems and methods for generating and evaluating driving scenarios with varying difficulty levels is provided. The disclosed systems and methods may be used to develop a suite of regression tests that track the progress of an autonomous driving stack. A robustness trace of a temporal logic formula may be computed from an always-eventually fragment using a computation graph. The robustness trace may be approximated by a smoothly differentiable computation graph, which can be implemented in existing machine learning programming frameworks. The systems and methods provided herein may be useful in automatic test case generation for autonomous or semi-autonomous vehicles.

Abstract: Methods, systems, compositions and strategies for the delivery of WW domain-containing fusion proteins into cells in vivo, ex vivo, or in vitro via ARMMs are provided. Methods, systems, compositions and strategies for the delivery of Cas9 proteins and/or Cas9 variants into cells in vivo, ex vivo, or in vitro via fusion to ARMM associated proteins (e.g., ARRDC1 or TSG101) are also provided.

Abstract: We provide a wide-field time-resolved imaging apparatus using resonant drive. We also identify ideal configurations of electro-optic (EO) modulator crystals for wide-field imaging. These techniques enable compact and low-cost LIDAR imaging devices. Resonant drive affords modulation of various EO modulators at high voltage by means of resonant voltage enhancement. Further, it enables operation of imaging modulators at high frequencies which would otherwise not be possible with conventional pulsed drivers—this leads to improved LIDAR accuracy and dynamic range. Resonant drive uniquely enables Pockels cell LIDAR beyond normal flash mode by allowing for multiple pulses or multiple cycles of amplitude modulated illumination to be present simultaneously in a scene. This corresponds to illumination and modulation waveforms having a defined phase relationship where time-of-flight is encoded in the phase of the returning light waveform.

Abstract: A metallic glass coating material is composed of an alloy of Fe, B, and one of the metals Nb, Mo, Zr, or W. The ratios of Fe, B, and the metal are predetermined using machine learning predictions and high-throughput experiments. In one example, the material is an alloy of Fe, Nb, Mo and B, of the form Fex(Nb, Mo)yBz, where x is in the range 18-28, y is in the range 35-45, and z is in the range 32-42. In another example, the material may be the alloy Fe23(Nb, Mo)40B37. The alloy may be doped with Zr and/or W, where the Zr and/or W comprises at most 10% of the alloy.

Abstract: Many embodiments describe a scalable scheme for performing quantum computation in a synthetic time dimension which uses a single coherently controlled atom. Quantum operations applied to the atomic qubit can be teleported onto the photonic qubits via projective measurement, and arbitrary quantum circuits can be compiled into a sequence of these teleported gates. The synthetic time dimension can negate the need for many identical quantum emitters to be integrated into a photonic circuit, and the single atom may provide effective all-to-all connectivity between photonic qubits.

Abstract: Disclosed herein are apparatus for a cooler device includes a manifold constructed at least partially of silicon oxide. The manifold includes an array of inlet channels and an array of outlet channels. Each inlet channel has a first depth. The array of outlet channels are interlaced with the array of inlet channels, Each outlet channel has a second depth that is larger than the first depth. Each of the array of outlet channels has a pair of sidewalls separating each outlet channel from adjacent inlet channels of the array of inlet channels.