Patents Assigned to The Brigham & Women's Hospital, Inc.
  • Publication number: 20200352467
    Abstract: A system for cardiac monitoring and therapy includes a mother device configured to receive signals indicative of cardiac electrical activity in a patient's heart. The mother device includes a mother wireless communications module configured to transmit and receive information to and from the mother device. The system also includes a satellite device configured to receive the signals indicative of the cardiac electrical activity in the patient's heart from a remote location relative to the mother device and includes a satellite wireless communications module configured to transmit from and receive communications sent to the satellite device to at least communicate with the mother wireless communications module. The system also includes a processor configured to receive the signals indicative of the cardiac electrical activity in the heart received by the mother device and the satellite device and, based thereon, control delivery of electrical therapy to the patient's heart.
    Type: Application
    Filed: July 29, 2020
    Publication date: November 12, 2020
    Applicant: The Brigham and Women's Hospital, Inc.
    Inventor: Michael O. Sweeney
  • Publication number: 20200352870
    Abstract: Compositions, articles, and methods for targeted drug delivery, such as thermoresponsive hydrogel polymers, are generally provided. In one aspect, the compositions and articles comprise a thermoresponsive hydrogel polymer comprising a releasable therapeutic agent. In some cases, the compositions described herein have advantageous combinations of properties including mechanical strength, biocompatibility, tunable charge densities, thermal responsiveness, drug loading, and/or configurations for targeted drug delivery. In one embodiment, the composition comprises a solution comprising a thermoresponsive polymer including one or more ligands attached to the polymer, wherein the solution is configured to undergo a sol-to-gel transition under physiological conditions. In another embodiment, the composition comprises a plurality of nanoparticles e.g., associated with the thermoresponsive polymer. In yet another embodiment, the composition comprises a therapeutic agent e.g.
    Type: Application
    Filed: December 8, 2017
    Publication date: November 12, 2020
    Applicants: Massachusetts Institute of Technology, The Brigham and Women's Hospital Inc.
    Inventors: Carlo Giovanni Traverso, Ashok Kakkar, Joshua Korzenik, Robert S. Langer, Sufeng Zhang
  • Publication number: 20200345775
    Abstract: This technology describes novel cell based combined therapeutic modalities that induces mechanism based tumor cell killing in a broad spectrum of sensitive and resistant tumors. These new agents are tumor specific and target a broad spectrum of solid tumors.
    Type: Application
    Filed: November 20, 2018
    Publication date: November 5, 2020
    Applicant: THE BRIGHAM AND WOMEN'S HOSPITAL, INC.
    Inventor: Khalid SHAH
  • Patent number: 10814032
    Abstract: The present invention provides an improved tissue adhesive to repair defects in soft tissue. Following ASTM standard tests, crosslinked methacryloyl-substituted gelatin hydrogels of the present invention (GelSEAL) were shown to exhibit adhesive properties, i.e. wound closure strength, shear resistance and burst pressure, that were superior to clinically used fibrin- and poly(ethylene glycol)-based glues. Chronic in vivo experiments in rats proved GelSEAL to effectively seal large lung leakages without additional sutures or staples, presenting improved performance as compared to fibrin and poly(ethylene glycol) glues. Furthermore, subcutaneous implantation in rats revealed high biocompatibility of GelSEAL as evidenced by low inflammatory host response.
    Type: Grant
    Filed: August 6, 2015
    Date of Patent: October 27, 2020
    Assignee: The Brigham and Women's Hospital, Inc.
    Inventors: Ali Khademhosseini, Nasim Annabi, Alexander Assmann
  • Patent number: 10815460
    Abstract: Human pluripotent stem cells (hPSCs) have dual value as microphysiological laboratory models and regenerative therapeutics. hPSCs are epithelial cells, but the extent to which hPSCs and descendant epithelia can reconstitute lineage-specific functions remains poorly understood. Here the Inventors show that hPSCs in three-dimensional cultures and their differentiated descendants can functionally recapitulate tissue-specific epithelial morphogenesis, physiology, and disease.
    Type: Grant
    Filed: September 2, 2016
    Date of Patent: October 27, 2020
    Assignee: THE BRIGHAM AND WOMEN'S HOSPITAL, INC.
    Inventors: Benjamin S. Freedman, Joseph V. Bonventre
  • Patent number: 10813931
    Abstract: The compositions and methods described herein relate to the treatment of cancer, e.g. by reducing the regression of cancer cells from regressing into cancer stem cell-like phenotypes and/or reducing the development of drug-resistant cancer cells. In some embodiments, the compositions and methods relate to inhibitors of PI3K pathway kinases and Src family kinases.
    Type: Grant
    Filed: February 12, 2014
    Date of Patent: October 27, 2020
    Assignee: THE BRIGHAM AND WOMEN'S HOSPITAL, INC.
    Inventors: Aaron Goldman, Ashish Kulkarni, Shiladitya Sengupta
  • Publication number: 20200330553
    Abstract: Sortilin is a sorting receptor that directs target proteins to the secretary or endocytic compartments of cells that is found in both extracellular vesicles and cells. Provided herein are methods and compositions for decreasing or inhibiting trafficking of sortilin to an extracellular vesicle, for example by inhibiting the formation of intermolecular sortilin dimers.
    Type: Application
    Filed: October 23, 2018
    Publication date: October 22, 2020
    Applicant: THE BRIGHAM AND WOMEN'S HOSPITAL, INC.
    Inventors: Shinsuke ITO, Elena AIKAWA, Masanori AIKAWA
  • Publication number: 20200333356
    Abstract: Provided herein are methods of detecting an antibody directed against a pathogen and uses thereof.
    Type: Application
    Filed: July 8, 2020
    Publication date: October 22, 2020
    Applicant: THE BRIGHAM AND WOMEN'S HOSPITAL, INC.
    Inventors: Stephen J. Elledge, Harry B. Larman, Tomasz Kula, George Xu
  • Patent number: 10806761
    Abstract: Malignant tumors that are resistant to conventional therapies represent significant therapeutic challenges. An embodiment of the present invention provides a second generation oncolytic virus rQNestin34.5v2 with less toxicity that is more effective at selective killing target cells, such as tumor cells. In various embodiments presented herein, the oncolytic virus described herein is suitable for treatment of glioblastoma, as well as other cancers.
    Type: Grant
    Filed: May 4, 2016
    Date of Patent: October 20, 2020
    Assignee: The Brigham and Women's Hospital, Inc.
    Inventors: Hiroshi Nakashima, Ennio Antonio Chiocca
  • Publication number: 20200325482
    Abstract: The invention relates to compositions and methods for inhibiting macrophage activation via modulating PARP9 and/or PARP14 expression or activity, such as small molecules, RNAi and antibodies.
    Type: Application
    Filed: May 14, 2020
    Publication date: October 15, 2020
    Applicant: THE BRIGHAM AND WOMEN'S HOSPITAL, INC.
    Inventors: Hiroshi IWATA, Masanori AIKAWA, Takuya HARA, Sasha SINGH, Piero RICCHIUTO, Hideo YOSHIDA, Iwao YAMADA
  • Publication number: 20200324095
    Abstract: Components with relatively high loading of active pharmaceutical ingredients are generally provided. In some embodiments, the component (e.g., a tissue interfacing component) comprises a solid therapeutic agent and a supporting material such that the solid therapeutic agent is present in the component in an amount of greater than or equal to 10 wt % versus the total weight of the tissue interfacing component. Such tissue-interfacing components may be useful for delivery of API doses e.g., to a subject. Advantageously, in some embodiments, the reduction of volume required to deliver the required API dose as compared to a liquid formulation permits the creation of solid needle delivery systems for a wide variety of drugs in a variety of places/tissues (e.g., tongue, GI mucosal tissue, skin) and/or reduces and/or eliminates the application of an external force in order to inject a drug solution through the small opening in the needle.
    Type: Application
    Filed: May 17, 2018
    Publication date: October 15, 2020
    Applicants: Massachusetts Institute of Technology, The Brigham and Women's Hospital, Inc.
    Inventors: Carlo Giovanni Traverso, Alex G. Abramson, Ester Caffarel Salvador, Niclas Roxhed, Minsoo Khang, Taylor Bensel, Robert S. Langer
  • Publication number: 20200323955
    Abstract: In some aspects, the invention teaches pharmaceutical compositions that include a TGF-? ligand trap, and methods of using a TGF-? ligand trap to treat, prevent, or reduce the progression rate of pulmonary hypertension (PH). The invention also provides methods of using a TGF-? ligand trap to treat, prevent, or reduce the progression rate of a variety of conditions including, but not limited to, pulmonary vascular remodeling, pulmonary fibrosis, right ventricular hypertrophy, diseases associated with excessive TGF-? signaling, diseases associated with excessive GDF15 signaling, and diseases associated with excessive PAI-1 signaling. The invention further provides methods of using a TGF-? ligand trap to reduce right ventricular systolic pressure in a subject.
    Type: Application
    Filed: April 17, 2020
    Publication date: October 15, 2020
    Applicants: THE BRIGHAM AND WOMEN'S HOSPITAL, INC., ACCELERON PHARMA INC.
    Inventors: Paul B. YU, Asya GRINBERG, Dianne S. SAKO, Roselyne CASTONGUAY, Rita STEEVES, Ravindra KUMAR
  • Patent number: 10799233
    Abstract: A suturing device includes an elongated body having an outer wall defining an interior space of the body, a shaft located in the interior space, and a needle mounted on a distal end of the shaft. The needle has a distal section transverse to a longitudinal axis of the shaft. The distal section of the needle terminates in a first jaw and a second jaw forming a forceps defining a piercing tip. The first jaw and second jaw have a grasping position wherein the first jaw and second jaw grasp a suturing material, and a release position wherein the first jaw and second jaw release the suturing material. After grasping the suturing material with the needle, the shaft rotates the needle to advance the needle and suturing material through tissue and mesh placed on the tissue. Spaced apart portions of the suturing material are then fused to create a suture.
    Type: Grant
    Filed: May 23, 2018
    Date of Patent: October 13, 2020
    Assignee: Brigham and Women's Hospital, Inc.
    Inventor: Jon Einarsson
  • Publication number: 20200317767
    Abstract: The methods and uses described herein relate to the treatment of age-related conditions, e.g. by administering an agent that inhibits the interaction of GDF11 and follistatin. In some embodiments, the agent can bind to an epitope of GDF11 as described herein.
    Type: Application
    Filed: May 26, 2020
    Publication date: October 8, 2020
    Applicant: THE BRIGHAM AND WOMEN'S HOSPITAL, INC.
    Inventor: Richard Theodore LEE
  • Patent number: 10793601
    Abstract: Isolated peptides and pharmaceutical compositions comprising isolated peptides that bind to retinoblastoma binding protein 4 (RBBp4) and block the Spalt-Like Transcription Factor 4 (SALL4)-RBBp4 interaction are described. Methods of inhibiting binding of SALL4 to RBBp4 and methods of treating a subject having a disorder mediated by a dysregulation of SALL4 are also described.
    Type: Grant
    Filed: April 28, 2017
    Date of Patent: October 6, 2020
    Assignees: National University of Singapore, The Brigham and Women's Hospital, Inc., Agency for Science, Technology and Research
    Inventors: Bee Hui Liu, Daniel Geoffrey Tenen, Li Chai, Cheng San Brian Chia, Anders Poulsen
  • Patent number: 10791933
    Abstract: A hand held spectrometer is used to illuminate the object and measure the one or more spectra. The spectral data of the object can be used to determine one or more attributes of the object. In many embodiments, the spectrometer is coupled to a database of spectral information that can be used to determine the attributes of the object. The spectrometer system may comprise a hand held communication device coupled to a spectrometer, in which the user can input and receive data related to the measured object with the hand held communication device. The embodiments disclosed herein allow many users to share object data with many people, in order to provide many people with actionable intelligence in response to spectral data.
    Type: Grant
    Filed: July 26, 2017
    Date of Patent: October 6, 2020
    Assignees: VERIFOOD, LTD., THE BRIGHAM AND WOMEN'S HOSPITAL, INC.
    Inventors: Damian Goldring, Menahem Kaplan, William B. Gormley
  • Publication number: 20200306515
    Abstract: Self-righting articles, such as self-righting capsules for administration to a subject, are generally provided. In some embodiments, the self-righting article may be configured such that the article may orient itself relative to a surface (e.g., a surface of a tissue of a subject). The self-righting articles described herein may comprise one or more tissue engaging surfaces configured to engage (e.g., interface with, inject into, anchor) with a surface (e.g., a surface of a tissue of a subject). In some embodiments, the self-righting article may have a particular shape and/or distribution of density (or mass) which, for example, enables the self-righting behavior of the article. In some embodiments, the self-righting article may comprise a tissue interfacing component and/or a pharmaceutical agent (e.g., for delivery of the active pharmaceutical agent to a location internal of the subject).
    Type: Application
    Filed: May 17, 2018
    Publication date: October 1, 2020
    Applicants: Massachusetts Institute of Technology, The Brigham and Women's Hospital, Inc
    Inventors: Carlo Giovanni Traverso, Alex G. Abramson, Ester Caffarel Salvador, Niclas Roxhed, Minsoo Khang, Taylor Bensel, David Dellal, Robert S. Langer
  • Patent number: 10788500
    Abstract: This invention pertains to methods and compositions for the diagnosis and treatment of cardiovascular conditions. More specifically, the invention relates to isolated molecules that can be used to diagnose and/or treat cardiovascular conditions including cardiac hypertrophy, myocardial infarction, stroke, arteriosclerosis, and heart failure.
    Type: Grant
    Filed: December 20, 2017
    Date of Patent: September 29, 2020
    Assignee: Brigham & Women's Hospital, Inc.
    Inventor: Richard T. Lee
  • Patent number: 10787433
    Abstract: Pyradizine derivatives that activity the excitatory amino acid transporter 2 (EAAT2) of the formula: and methods of use thereof for treating or preventing diseases, disorders, and conditions with glutamate toxicity.
    Type: Grant
    Filed: January 13, 2017
    Date of Patent: September 29, 2020
    Assignees: THE BRIGHAM AND WOMEN'S HOSPITAL, INC., OHIO STATE UNIVERSITY
    Inventors: Kevin Hodgetts, Chien-Liang Glenn Lin
  • Publication number: 20200288980
    Abstract: An automated system and method is provided for biotype extraction and biomarker discovery from task-based fMRI imaging data. The system and method may include automatically mapping a localizome, such as a task-condition/contrast/population-specific brain functional localizome, based on fMRI data and automatically selecting and sorting brain regions or brain nodes to produce a subset of functional brain regions or brain nodes. A report may then be generated indicating that the subject has a particular brain circuit pattern of activity and connectivity associated with one or more symptoms of the given mental disorder, treatments, or associated with normal brain functions, based upon the extracted biosignatures by searching for the optimal multivariate classifier with least dimensionality in the brain functional localizome.
    Type: Application
    Filed: October 3, 2018
    Publication date: September 17, 2020
    Applicant: THE BRIGHAM AND WOMEN'S HOSPITAL, INC.
    Inventors: Emily Stern, David Silbersweig, Hong Pan