Patents Assigned to The California Institute of Technology
  • Publication number: 20220196550
    Abstract: An in-situ sensor system that is configured to be placed inside of an oxygen mask for a pilot. The sensor system is readily placed in a position over the exhalation valve such that it can capture data from the exhaled air of the pilot. The sensor system has an optical sensor element that can capture data real time and feed the data to a control module that can subsequently be use to generate output data for the pilot and/or ground elements.
    Type: Application
    Filed: December 17, 2021
    Publication date: June 23, 2022
    Applicant: California Institute of Technology
    Inventors: Lance E. Christensen, Kamjou Mansour
  • Publication number: 20220195506
    Abstract: This present disclosure provides methods and systems for measuring the concentration of multiple nucleic acid sequences in a sample. The nucleic acid sequences in the sample are simultaneously amplified, for example, using polymerase chain reaction (PCR) in the presence of an array of nucleic acid probes. The amount of amplicon corresponding to the multiple nucleic acid sequences can be measured in real-time during or after each cycle using a real-time microarray. The measured amount of amplicon produced can be used to determine the original amount of the nucleic acid sequences in the sample. Also provided herein are biosensor arrays, systems and methods for affinity based assays that are able to simultaneously obtain high quality measurements of the binding characteristics of multiple analytes, and that are able to determine the amounts of those analytes in solution. The present disclosure also provides a fully integrated bioarray for detecting real-time characteristics of affinity based assays.
    Type: Application
    Filed: July 22, 2021
    Publication date: June 23, 2022
    Applicant: California Institute of Technology
    Inventors: Arjang Hassibi, Babak Hassibi, Haris Vikalo, Jose Luis Riechmann
  • Publication number: 20220197105
    Abstract: A light modulating device for modulating incident light in a given wavelength band is provided. The light modulating device may include: a first semiconductor layer; an active layer provided on the first semiconductor layer and having a multiple quantum well structure and a refractive index that is variable according to an electric field applied thereto, and a second semiconductor layer provided on the active layer and including a grating pattern in which a plurality of gratings extending in a first direction are repeatedly arranged in a second direction perpendicular to the first direction. The light modulating device may have high modulation efficiency owing to guided mode resonance by the grating pattern.
    Type: Application
    Filed: June 23, 2021
    Publication date: June 23, 2022
    Applicants: SAMSUNG ELECTRONICS CO., LTD., CALIFORNIA INSTITUTE OF TECHNOLOGY
    Inventors: Junghyun PARK, Meir GRAJOWER, Harry ATWATER, Ruzan SOHKOYAN, Prachi THUREJA
  • Publication number: 20220194573
    Abstract: A system and method for controlling a multi-rotor aircraft that implements a number of different lifting rotors that are configured to provide lift to the vehicle. Additionally, each of the lifting rotors have a corresponding yaw control rotor that can help provide yaw control as well as additional sideways movement control.
    Type: Application
    Filed: April 21, 2021
    Publication date: June 23, 2022
    Applicant: California Institute of Technology
    Inventor: Reza Nemovi
  • Patent number: 11368196
    Abstract: Communication systems and methods in accordance with various embodiments of the invention utilize modulation on zeros. Carrier frequency offsets (CFO) can result in an unknown rotation of all zeros of a received signal's z-transform. Therefore, a binary MOCZ scheme (BMOCZ) can be utilized in which the modulated binary data is encoded using a cycling register code (e.g. CPC or ACPC), enabling receivers to determine cyclic shifts in the BMOCZ symbol resulting from a CFO. Receivers in accordance with several embodiments of the invention include decoders capable of decoding information bits from received discrete-time baseband signals by: estimating a timing offset for the received signal; determining a plurality of zeros of a z-transform of the received symbol; identifying zeros from the plurality of zeros that encode received bits by correcting fractional rotations resulting from the CFO; and decoding information bits based upon the received bits using a cycling register code.
    Type: Grant
    Filed: March 17, 2021
    Date of Patent: June 21, 2022
    Assignees: California Institute of Technology, The Regents of the University of California, Technische Universität Berlin
    Inventors: Philipp Walk, Babak Hassibi, Peter Jung, Hamid Jafarkhani
  • Patent number: 11365220
    Abstract: The present application provides stable peptide-based antibody capture agents and methods of use as detection and diagnosis agents. The application further provides methods of manufacturing antibody capture agents using iterative on-bead in situ click chemistry.
    Type: Grant
    Filed: March 23, 2020
    Date of Patent: June 21, 2022
    Assignee: CALIFORNIA INSTITUTE OF TECHNOLOGY
    Inventors: Jessica A. Pfeilsticker, Aiko Umeda, James R Heath
  • Patent number: 11365219
    Abstract: Peptides having activity as protein binding agents are disclosed. The peptides have the following structure (I): including stereoisomers, pharmaceutically acceptable salts and prodrugs thereof, wherein R, R1, L1, L2, G, M, Y1Y2 and SEQ are as defined herein. Methods associated with preparation and use of such peptides, as well as pharmaceutical compositions comprising such peptides, are also disclosed.
    Type: Grant
    Filed: June 22, 2020
    Date of Patent: June 21, 2022
    Assignee: CALIFORNIA INSTITUTE OF TECHNOLOGY
    Inventors: James R. Heath, Rosemary Dyane Rohde, Arundhati Nag, Samir Das, Aiko Umeda
  • Publication number: 20220185464
    Abstract: A system and method for controlling a multi-rotor aircraft that implements the unconventional use of an odd number of rotors. The odd or auxiliary rotor is designed to be smaller in diameter than the remaining main rotors and accordingly generates a smaller unbalanced torque and pitch on the aircraft. Additional configurations implement the use of smaller thrust rotors that can be used to generate thrust as well as control yaw and thus counteract any remaining unbalanced torque from the odd auxiliary rotor.
    Type: Application
    Filed: April 21, 2021
    Publication date: June 16, 2022
    Applicants: California Institute of Technology, TooFon, Inc.
    Inventors: Morteza Gharib, Reza Nemovi, Michael V. Ol, Christopher J. Dougherty
  • Publication number: 20220187533
    Abstract: Disclosed herein is a pulse repetition rate multiplier including a photonic integrated circuit (PIC) including cascading Mach-Zehnder interferometers (MZIs). An input may be connected to one end of the PIC and an output may be connected to the other end of the PIC such that a signal from the input runs through the cascading MZIs and out the output. The input may be configured to receive an input pulsed signal and the output may be configured to output a repetition rate multiplied signal. Advantageously, using a PIC as opposed to an optical fiber-based pulse rate multiplier allows for accurate fabrication of a pulse repetition rate multiplier configured to accept higher frequency pulsed signals.
    Type: Application
    Filed: December 13, 2021
    Publication date: June 16, 2022
    Applicant: California Institute of Technology
    Inventors: Stephanie D. Leifer, Wei Zhang, Andrey B. Matsko
  • Patent number: 11362228
    Abstract: A space-based solar power station, a power generating satellite module and/or a method for collecting solar radiation and transmitting power generated using electrical current produced therefrom is provided. Each solar power station includes a plurality of satellite modules. The plurality of satellite modules each include a plurality of modular power generation tiles including a photovoltaic solar radiation collector, a power transmitter and associated control electronics. Numerous embodiments relate to efficient power generation tiles. In one embodiment, an efficient power generation tile includes: at least one photovoltaic material; and at least one concentrator that redirects incident solar radiation towards a photovoltaic material such that the photovoltaic material experiences a greater solar flux relative to the case where the photovoltaic material experiences unaltered solar radiation.
    Type: Grant
    Filed: June 2, 2015
    Date of Patent: June 14, 2022
    Assignee: California Institute of Technology
    Inventors: Harry A. Atwater, Sergio Pellegrino, Seyed Ali Hajimiri, Jeffrey P. Bosco, Dennis Callahan, Emily C. Warmann
  • Patent number: 11362874
    Abstract: Systems and methods for transmitting data using various Modulation on Zeros schemes are described. In many embodiments, a communication system is utilized that includes a transmitter having a modulator that modulates a plurality of information bits to encode the bits in the zeros of the z-transform of a discrete-time baseband signal. In addition, the communication system includes a receiver having a decoder configured to decode a plurality of bits of information from the samples of a received signal by: determining a plurality of zeros of a z-transform of a received discrete-time baseband signal based upon samples from a received continuous-time signal, identifying zeros that encode the plurality of information bits, and outputting a plurality of decoded information bits based upon the identified zeros.
    Type: Grant
    Filed: March 15, 2021
    Date of Patent: June 14, 2022
    Assignee: California Institute of Technology
    Inventors: Philipp Walk, Babak Hassibi, Peter Jung
  • Patent number: 11362229
    Abstract: Photovoltaics configured to be manufactured without epitaxial processes and methods for such manufacture are provided. Methods utilize bulk semiconducting crystal substrates, such as, for example, GaAs and InP such that epitaxy processes are not required. Nanowire etch and exfoliation processes are used allowing the manufacture of large numbers of photovoltaic cells per substrate wafer (e.g., greater than 100). Photovoltaic cells incorporate electron and hole selective contacts such that epitaxial heterojunctions are avoided during manufacture.
    Type: Grant
    Filed: April 2, 2019
    Date of Patent: June 14, 2022
    Assignee: California Institute of Technology
    Inventors: Phillip R. Jahelka, Harry A. Atwater, Wen-Hui Cheng, Rebecca D. Glaudell
  • Publication number: 20220178751
    Abstract: Novel monolithic reflective spatial heterodyne spectrometers (SHS) interferometer systems are presented. Monolithic systems in accordance with the invention have a single supporting structure wherein input optics, output optics, a flat mirror, a roof mirror, and a symmetric grating are affixed. Embodiments of the invention contain only fixed parts, and the optics do not move in relation to the supporting structure. Embodiments of the present invention enables smaller, lighter, and more robust reflective SHS systems as compared to conventional interferometry. Additionally, embodiments of the present invention require less time and skill for construction and maintenance, and is a better economic option. Additional embodiments can include multiple interferometer systems in a single supporting structure.
    Type: Application
    Filed: December 7, 2021
    Publication date: June 9, 2022
    Applicant: California Institute of Technology
    Inventor: Seyedeh Sona Hosseini
  • Patent number: 11353448
    Abstract: Methods and compositions for quantifying the cellular concentration of cyclic adenosine monophosphate (cAMP), cyclic guanine monophosphate (cGMP), glutathione, glucose, and glutamine in a single cell include the use of conjugates and analogs in immunofluorescent assays for on-chip quantification. These metabolite immunofluorescent assays may be incorporated with proteomic assays for simultaneous single cell analysis of metabolites and proteins.
    Type: Grant
    Filed: February 16, 2016
    Date of Patent: June 7, 2022
    Assignee: CALIFORNIA INSTITUTE OF TECHNOLOGY
    Inventors: Min Xue, Wei Wei, James R. Heath
  • Patent number: 11351613
    Abstract: Elements formed from magnetic materials and their methods of manufacture are presented. Magnetic materials include a magnetic alloy material, such as, for example, an Fe—Co alloy material (e.g., the Fe—Co—V alloy Hiperco-50®). The magnetic alloy materials may comprise a powdered material suitable for use in additive manufacturing techniques, such as, for example direct energy deposition or laser powder bed fusion. Manufacturing techniques include the use of variable deposition time and energy to control the magnetic and structural properties of the materials by altering the microstructure and residual stresses within the material. Manufacturing techniques also include post deposition processing, such as, for example, machining and heat treating. Heat treating may include a multi-step process during which the material is heated, held and then cooled in a series of controlled steps such that a specific history of stored internal energy is created within the material.
    Type: Grant
    Filed: June 3, 2019
    Date of Patent: June 7, 2022
    Assignee: California Institute of Technology
    Inventors: Samad A. Firdosy, Robert P. Dillon, Ryan W. Conversano, John Paul C. Borgonia, Andrew A. Shapiro-Scharlotta, Bryan W. McEnerney, Adam Herrmann
  • Patent number: 11350909
    Abstract: Certain embodiments pertain to cross-amplitude modulation (xAM) ultrasound imaging methods and systems configured to excite a first subaperture of transducer elements to transmit a first ultrasound plane wave, excite a second subaperture of transducer elements to transmit a second ultrasound plane wave noncollinear to the first ultrasound plane wave, the second ultrasound plane wave axisymmetric to the first ultrasound plane wave about a bisector, and simultaneously excite both first and second subapertures to transmit first and second ultrasound plane waves to cause an acoustic pressure above a threshold along the bisector.
    Type: Grant
    Filed: April 17, 2019
    Date of Patent: June 7, 2022
    Assignee: CALIFORNIA INSTITUTE OF TECHNOLOGY
    Inventors: David Maresca, Daniel P. Sawyer, Mikhail Shapiro
  • Patent number: 11352705
    Abstract: Processes and systems for oxidation of a hydrocarbon reactant to generate an oxidized hydrocarbon product may include: contacting a water oxidation electrocatalyst with the hydrocarbon reactant and water in the presence of a non-aqueous solvent; wherein an anodic bias is applied to the water oxidation electrocatalyst, thereby generating the oxidized hydrocarbon product; and wherein the water oxidation electrocatalyst comprises one or more transition metals other than Ru. Optionally, the water is provided in the non-aqueous solvent at a concentration less than or equal to 0.5 vol. %. Optionally, the magnitude of the anodic bias is selected to generate the oxidized hydrocarbon product characterized by selected product distribution.
    Type: Grant
    Filed: August 11, 2017
    Date of Patent: June 7, 2022
    Assignee: California Institute of Technology
    Inventors: Bryan M. Hunter, Harry B. Gray
  • Publication number: 20220169707
    Abstract: Embodiments of the present invention are directed to compositions and methods for anti-HIV (anti-CD4 binding site) broadly neutralizing antibodies having improved potency and breadth for neutralizing a range of HIV strains. Combinations of broadly neutralizing antibodies can also improve potency over a single antibody composition.
    Type: Application
    Filed: October 13, 2021
    Publication date: June 2, 2022
    Applicants: The Rockefeller University, California Institute of Technology
    Inventors: Ron Diskin, Anthony P. West, Michel Nussenzweig, Pamela J. Bjorkman
  • Patent number: 11349039
    Abstract: A photoelectrode, methods of making and using, including systems for water-splitting are provided. The photoelectrode can be a semiconducting material having a photocatalyst such as nickel or nickel-molybdenum coated on the material. The photoelectrode includes an elongated axially integrated wire having at least two different wire compositions.
    Type: Grant
    Filed: September 13, 2018
    Date of Patent: May 31, 2022
    Assignee: California Institute of Technology
    Inventors: Nathan S. Lewis, Shu Hu
  • Patent number: 11346718
    Abstract: A freeform imaging system with a spectrometer and telescope components optically connected and optimized to increase the spectral and spatial resolution capabilities. Many embodiments of the system are capable of producing a spectral resolution of approximately 1 nm and a spatial resolution less than 30 m such that the imaging system can be used to accurately capture and measure point source plumes of various atmospheric gases including CH4, CO2, CO, N2O, and H2O.
    Type: Grant
    Filed: October 21, 2019
    Date of Patent: May 31, 2022
    Assignee: California Institute of Technology
    Inventors: Andrew K. Thorpe, Robert O. Green, Pantazis Mouroulis, David R. Thompson, Andrew D. Aubrey, Christian Frankenberg