Patents Assigned to The Catholic University of America
  • Patent number: 8257410
    Abstract: Enhancing the effectiveness of therapeutic ionizing radiation and other treatments of disease in which cells are to be destroyed or modified, by subjecting cells in need thereof to low-dose radiation to increase the sensitivity of the cells to subsequent subjection with a lethal dose of high dose radiation (HDR), a chemotherapeutic agent, or other type of therapeutic treatment.
    Type: Grant
    Filed: February 3, 2006
    Date of Patent: September 4, 2012
    Assignee: The Catholic University of America
    Inventors: Theodore A Litovitz, Patrick Mehl, Andrea L Cohen
  • Patent number: 8148130
    Abstract: T4 bacteriophages are bound to substrates such as liposomes using a binder.
    Type: Grant
    Filed: February 29, 2008
    Date of Patent: April 3, 2012
    Assignee: The Catholic University of America
    Inventors: Carl R. Alving, Venigalla Rao
  • Publication number: 20110261321
    Abstract: The multi-aperture system of the present invention provides a retinal oximetry apparatus for determining the level of oxygen saturation in retinal vessels using a lenslet array comprising at least seven lenses for the simultaneous measurement of reflected light with at least three wavelengths and at least four polarization states. The multi-aperture system of the present invention further provides an apparatus for determining the level of oxygen saturation in retinal vessels using a lenslet array comprising at least ten lenses for the simultaneous measurement of reflected light with at least three wavelengths for oxygen measurement, at least three wavelengths for melanin content, and at least four polarization states. Methods of operating the same are also provided.
    Type: Application
    Filed: July 7, 2011
    Publication date: October 27, 2011
    Applicant: The Catholic University of America
    Inventors: Jessica C. RAMELLA-ROMAN, Mark Mirotznik, Scott A. Mathews
  • Publication number: 20110250263
    Abstract: Complex viruses are assembled from simple protein subunits by sequential and irreversible assembly. During genome packaging in bacteriophages, a powerful molecular motor assembles at the special portal vertex of an empty prohead to initiate packaging. An aspect of the invention relates to the phage T4 packaging machine being highly promiscuous, translocating DNA into finished phage heads as well as into proheads. Single motors can force exogenous DNA into phage heads at the same rate as into proheads and phage heads undergo repeated initiations, packaging multiple DNA molecules into the same head. This shows that the phage DNA packaging machine has unusual conformational plasticity, powering DNA into an apparently passive capsid receptacle, including the highly stable virus shell, until it is full. These features allow for the design of a novel class of nanocapsid delivery vehicles.
    Type: Application
    Filed: April 8, 2011
    Publication date: October 13, 2011
    Applicant: The Catholic University of America
    Inventor: Venigalla B. RAO
  • Patent number: 8014846
    Abstract: The present invention provides a method and apparatus for delivering an electric field to a body by delivering a first magnetic field from a first coil in a first orientation to a body and directed at a desired target within the body, and delivering a second magnetic field from a second coil in a second orientation directed at the desired target within the body to induce an electric field across the desired target, wherein only one magnetic field is delivered to the body at any one time.
    Type: Grant
    Filed: August 3, 2009
    Date of Patent: September 6, 2011
    Assignee: The Catholic University of America
    Inventor: Theodore A. Litovitz
  • Patent number: 7997732
    Abstract: The multi-aperture system of the present invention provides a retinal oximetry apparatus for determining the level of oxygen saturation in retinal vessels using a lenslet array comprising at least seven lenses for the simultaneous measurement of reflected light with at least three wavelengths and at least four polarization states. The multi-aperture system of the present invention further provides an apparatus for determining the level of oxygen saturation in retinal vessels using a lenslet array comprising at least ten lenses for the simultaneous measurement of reflected light with at least three wavelengths for oxygen measurement, at least three wavelengths for melanin content, and at least four polarization states. Methods of operating the same are also provided.
    Type: Grant
    Filed: October 31, 2008
    Date of Patent: August 16, 2011
    Assignee: The Catholic University of America
    Inventors: Jessica C. Ramella-Roman, Mark Mirotznik, Scott A. Mathews
  • Patent number: 7879076
    Abstract: Enhancing the effectiveness of therapeutic ionizing radiation and other treatments of disease in which cells are to be destroyed or modified, by subjecting cells in need thereof to low-dose radiation to increase the sensitivity of the cells to subsequent subjection with a lethal dose of high dose radiation (HDR), a chemotherapeutic agent, or other type of therapeutic treatment.
    Type: Grant
    Filed: August 28, 2006
    Date of Patent: February 1, 2011
    Assignee: The Catholic University of America
    Inventors: Theodore Aaron Litovitz, Andrea Lynn Cohen, Patrick Mehl
  • Publication number: 20100085537
    Abstract: The multi-aperture system of the present invention provides a retinal oximetry apparatus for determining the level of oxygen saturation in retinal vessels using a lenslet array comprising at least seven lenses for the simultaneous measurement of reflected light with at least three wavelengths and at least four polarization states. The multi-aperture system of the present invention further provides an apparatus for determining the level of oxygen saturation in retinal vessels using a lenslet array comprising at least ten lenses for the simultaneous measurement of reflected light with at least three wavelengths for oxygen measurement, at least three wavelengths for melanin content, and at least four polarization states. Methods of operating the same are also provided.
    Type: Application
    Filed: October 31, 2008
    Publication date: April 8, 2010
    Applicant: THE CATHOLIC UNIVERSITY OF AMERICA
    Inventors: Jessica C. RAMELLA-ROMAN, Mark MIROTZNIK, Scott A. Mathews
  • Publication number: 20100049284
    Abstract: A method wherein, following a therapeutic radiation treatment, a heat dose is administered to the treated cells to decrease the damage caused by radiation exposure or a therapeutic agent.
    Type: Application
    Filed: December 23, 2008
    Publication date: February 25, 2010
    Applicant: The Catholic University of America
    Inventors: PATRICK M. MEHL, James K. Keeven
  • Publication number: 20090292159
    Abstract: The present invention provides a method and apparatus for delivering an electric field to a body by delivering a first magnetic field from a first coil in a first orientation to a body and directed at a desired target within the body, and delivering a second magnetic field from a second coil in a second orientation directed at the desired target within the body to induce an electric field across the desired target, wherein only one magnetic field is delivered to the body at any one time.
    Type: Application
    Filed: August 3, 2009
    Publication date: November 26, 2009
    Applicant: The Catholic University of America
    Inventor: Theodore A. LITOVITZ
  • Publication number: 20090292158
    Abstract: The present invention provides a method and apparatus for delivering an electric field to a body by delivering a first magnetic field from a first coil in a first orientation to a body and directed at a desired target within the body, and delivering a second magnetic field from a second coil in a second orientation directed at the desired target within the body to induce an electric field across the desired target, wherein only one magnetic field is delivered to the body at any one time.
    Type: Application
    Filed: August 3, 2009
    Publication date: November 26, 2009
    Applicant: The Catholic University of America
    Inventor: Theodore A. LITOVITZ
  • Patent number: 7587230
    Abstract: The present invention provides a method and apparatus for delivering an electric field to a body by delivering a first magnetic field from a first coil in a first orientation to a body and directed at a desired target within the body, and delivering a second magnetic field from a second coil in a second orientation directed at the desired target within the body to induce an electric field across the desired target, wherein only one magnetic field is delivered to the body at any one time.
    Type: Grant
    Filed: February 14, 2005
    Date of Patent: September 8, 2009
    Assignee: The Catholic University of America
    Inventor: Theodore A. Litovitz
  • Publication number: 20080274533
    Abstract: T4 bacteriophages are bound to substrates such as liposomes using a binder.
    Type: Application
    Filed: February 29, 2008
    Publication date: November 6, 2008
    Applicant: THE CATHOLIC UNIVERSITY OF AMERICA
    Inventors: Carl R. Alving, Venigalla Rao
  • Patent number: 7367988
    Abstract: Methods and apparatus are described for the treatment of diseases by exposures to electromagnetic fields. Also, apparatus is described for focusing the biological effectiveness of such fields on specific cells, tissues or organs of a human or animal body.
    Type: Grant
    Filed: December 22, 2004
    Date of Patent: May 6, 2008
    Assignee: The Catholic University of America
    Inventor: Theodore A. Litovitz
  • Publication number: 20070184056
    Abstract: Enhancing the effectiveness of therapeutic ionizing radiation and other treatments of disease in which cells are to be destroyed or modified, by subjecting cells in need thereof to low-dose radiation to increase the sensitivity of the cells to subsequent subjection with a lethal dose of high dose radiation (HDR), a chemotherapeutic agent, or other type of therapeutic treatment.
    Type: Application
    Filed: February 3, 2006
    Publication date: August 9, 2007
    Applicant: The Catholic University of America
    Inventors: Theodore Litovitz, Andrea Cohen, Patrick Mehl
  • Patent number: 6856839
    Abstract: Methods and apparatus are described for the treatment of diseases by exposures to electromagnetic fields. Also, apparatus is described for focusing the biological effectiveness of such fields on specific cells, tissues or organs of a human or animal body.
    Type: Grant
    Filed: May 1, 2003
    Date of Patent: February 15, 2005
    Assignee: Catholic University of America
    Inventor: Theodore A. Litovitz
  • Patent number: 6853864
    Abstract: Methods and apparatus are described for the treatment of diseases by exposures to electromagnetic fields. Also, apparatus is described for focusing the biological effectiveness of such fields on specific cells, tissues or organs of a human or animal body.
    Type: Grant
    Filed: December 18, 2000
    Date of Patent: February 8, 2005
    Assignee: Catholic University of America, The
    Inventor: Theodore A. Litovitz
  • Patent number: RE40912
    Abstract: A method of isolating, purifying and recrystallizing substantially pure lutein, preferably from saponified marigold oleoresin in its pure free form, apart from chemical impurities and other carotenoids. Lutein may be used as an analytical standard or in cancer prevention trials and as a safe and effective color additive for human food.
    Type: Grant
    Filed: June 10, 2005
    Date of Patent: September 8, 2009
    Assignee: The Catholic University of America
    Inventor: Frederick Khachik
  • Patent number: RE40931
    Abstract: A method of isolating, purifying and recrystallizing substantially pure lutein, preferably from saponified marigold oleoresin in its pure free form, apart from chemical impurities and other carotenoids. Lutein may be used as an analytical standard or in cancer prevention trials and as a safe and effective color additive for human food.
    Type: Grant
    Filed: January 10, 2006
    Date of Patent: October 6, 2009
    Assignee: The Catholic University of America
    Inventor: Frederick Khachik
  • Patent number: RE40938
    Abstract: A method of isolating, purifying and recrystallizing substantially pure lutein, preferably from saponified marigold oleoresin in its pure free form, apart from chemical impurities and other carotenoids. Lutein may be used as an analytical standard or in cancer prevention trials and as a safe and effective color additive for human food.
    Type: Grant
    Filed: February 5, 2007
    Date of Patent: October 13, 2009
    Assignee: The Catholic University of America
    Inventor: Frederick Khachik