Patents Assigned to The Children's Medical Center Corporation
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Publication number: 20240060121Abstract: The present disclosure generally relates to systems and methods for multi-focal imaging, for example, for determining nucleic acids in cells or other samples. In some cases, multiple focal planes may simultaneously be determined, e.g., by using a plurality of detectors, such as a plurality of cameras, which image the same sample, but at least some of which are focused on different focal planes within the sample. Thus, the sample may be imaged in 3 dimensions, e.g., without sample refocusing. In certain cases, this may improve the resolution of imaging, in space and/or time. Various embodiments can be used to increase imaging throughput and/or resolution in image-based approaches, e.g., for single-cell molecular profiling such as multiplexed error robust fluorescence in situ hybridization (MERFISH), or for other applications.Type: ApplicationFiled: November 19, 2020Publication date: February 22, 2024Applicants: President and Fellows of Harvard College, Children's Medical Center CorporationInventors: Jeffrey R. Moffitt, Hazen P. Babcock
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Patent number: 11903974Abstract: Therapeutic chondrisome compositions and related methods are described.Type: GrantFiled: November 30, 2016Date of Patent: February 20, 2024Assignees: FLAGSHIP PIONEERING INNOVATIONS V, INC., The Children's Medical Center CorporationInventors: Geoffrey A. von Maltzahn, John Miles Milwid, Michael Travis Mee, Jacob Rosenblum Rubens, David Chess, Kyle Marvin Trudeau, Kiana Mahdaviani, Jacob Feala, James D. McCully, Douglas B. Cowan
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Patent number: 11903975Abstract: Therapeutic chondrisome and mitoplast compositions and related methods are described.Type: GrantFiled: November 30, 2016Date of Patent: February 20, 2024Assignees: FLAGSHIP PIONEERING INNOVATIONS V, INC., The Children's Medical Center CorporationInventors: Geoffrey A. von Maltzahn, John Miles Milwid, Michael Travis Mee, Jacob Rosenblum Rubens, David Chess, Kyle Marvin Trudeau, Kiana Mahdaviani, Jacob Feala, James D. McCully, Douglas B. Cowan
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Publication number: 20240052331Abstract: The disclosure provides fusion proteins comprising a pleckstrin homology (PH) domain and a variant of Botulinum neurotoxin E (BoNT E) protease that cleaves certain non-canonical protein targets (e.g., PTEN). Fusion proteins described in the disclosure are useful for cleaving target proteins found in a cell, that is, in an intracellular environment. Aspects of the disclosure provide methods for inhibiting PTEN amount, activity, or function in a cell or subject, the methods comprising administering to a call or subject a fusion protein described herein.Type: ApplicationFiled: December 17, 2021Publication date: February 15, 2024Applicants: The Board Institute, Inc., President and Fellows of Harvard College, Children's Medical Center CorporationInventors: David R. Liu, Travis R. Blum, Min Dong, Hao Liu
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Patent number: 11896789Abstract: A device and system for flushing a shunt catheter utilizes the available cerebrospinal fluid (CSF) to flush a blocked catheter. The CSF is pressurized to a predetermined amount and then allowed to suddenly, rapidly and forcefully purge any occlusions. The rapid release of CSF produces flow jets from the catheter pores into the ventricle. This impulse, or “cough”, will push and divert choroid plexus and/or other blockages away from the pores. The device and system may then be allowed to refill at a slow rate, thus reducing the possibility of rapid suction of fluid back into the system and the attendant possibility of drawing the choroid plexus back into the pores. The catheter at the proximal end may also include back-up pores that can be opened to restart flow from the ventricle should the primary pores remain blocked after a flushing attempt.Type: GrantFiled: October 16, 2019Date of Patent: February 13, 2024Assignee: Children's Medical Center CorporationInventors: Joseph Madsen, Tomer Anor
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Publication number: 20240042042Abstract: Provided herein, in some aspects, are delivery vehicles comprising a ceramide and an agent to be delivered attached to the ceramide. In some embodiments, the ceramide does not comprise a fatty acid (i.e., is a sphingosine). In some embodiments, the ceramide comprises a fatty acid. In some embodiments, the ceramide is a glycoceramide. In some embodiments, the agent is attached to the ceramide covalently (e.g., via a linker). In some embodiments, the agent to be delivered is a therapeutic agent. The ceramide is able to deliver the agent to a cell or to a cellular compartment, as well as across the musical barrier. In some embodiments, agents delivered using the ceramide described herein exhibit longer half-life, compared to agents delivered alone. Methods of delivering a therapeutic agent to a subject for treating a disease using the ceramide delivery vehicle are also provided.Type: ApplicationFiled: August 11, 2023Publication date: February 8, 2024Applicant: Children's Medical Center CorporationInventors: Wayne I. Lencer, Daniel JF Chinnapen, Richard I. Duclos
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Publication number: 20240041595Abstract: A replacement heart valve device is disclosed. In some embodiments, the device includes a frame coupled to one or more leaflets that are moveable between open and closed configurations. In some embodiments, the frame comprises at least two frame sections that join at a pair of commissural posts. In some embodiments, the device may be geometrically accommodating to adapt to different vasculature shapes and sizes and/or to be able to change size while implanted within a growing patient.Type: ApplicationFiled: July 13, 2023Publication date: February 8, 2024Applicant: The Children's Medical Center CorporationInventors: Sophie-Charlotte Hofferberth, Pedro J. del Nido, Mossab Y. Saeed
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Publication number: 20240025952Abstract: The disclosure provides modified biotin-binding proteins which can be expressed in soluble form in high yield in bacteria. Also provided are fusion proteins comprising the modified biotin-binding protein and an antigen. The disclosure further provides non-hemolytic variants of alpha-hemolysin from S. aureus and fusion protein comprising non-hemolytic variant of alpha-hemolysin and a biotin-binding domains. Immunogenic compositions comprising the proteins are also disclosed and use of such immunogenic compositions for inducing an immune response or for vaccinating a subject are also disclosed.Type: ApplicationFiled: October 13, 2022Publication date: January 25, 2024Applicant: CHILDREN'S MEDICAL CENTER CORPORATIONInventors: Richard Malley, Yingjie Lu, Fan Zhang
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Publication number: 20240024436Abstract: Described herein are methods and compositions for treating cancer. Aspects of the invention relate to administering to a subject having cancer an asparaginase and an agent that inhibits G6PD. Another aspect of the invention relates to administering an asparaginase to a subject having cancer that comprises a G6PD deficiency.Type: ApplicationFiled: June 7, 2023Publication date: January 25, 2024Applicant: CHILDREN'S MEDICAL CENTER CORPORATIONInventors: Yun-Cheol CHAE, Alejandro GUTIERREZ
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Publication number: 20240024368Abstract: As described below, the present invention features compositions and methods for neuroprotection and/or neuroregeneration of damaged or degenerating neurons. In various embodiments, the compositions and methods of the present disclosure are used to treat a neurodegenerative disease and/or nervous system injury. The methods in various embodiments include reducing or eliminating activity or expression of a target gene(s) and/or a polypeptide(s) expressed by a target gene(s) in a neuron.Type: ApplicationFiled: July 14, 2023Publication date: January 25, 2024Applicant: The Children's Medical Center CorporationInventors: Zhigang HE, Shane HEGARTY, Feng TIAN, Joanna STANICKA, Songlin ZHOU
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Publication number: 20240024361Abstract: The disclosed invention provides a method of treating a central nervous system (CNS) disease or disorder comprising administering to a subject diagnosed with the CNS disease or disorder a composition comprising a population of genetically modified, programmed cell death-1 receptor ligand (PD-L1)+-expressing hematopoietic stem cells (HSCs), wherein the CNS disease or disorder involves inflammation of the CNS. In one embodiment, the CNS disease or disorder is Multiple Sclerosis (MS). In certain aspects, the hematopoietic stem cells (HSCs) are obtained from a subject having a CNS disease or disorder prior to modification.Type: ApplicationFiled: June 25, 2021Publication date: January 25, 2024Applicant: THE CHILDREN'S MEDICAL CENTER CORPORATIONInventors: Paolo FIORINA, Alessandra BIFFI
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Publication number: 20240029585Abstract: Surgical simulation devices and their methods of use are described. In some embodiments, a surgical simulation device includes a base, a first surgical model configured to simulate a first cleft lip condition, and a second surgical model configured to simulate a second cleft lip condition. The device includes a model support configured to be releasably engaged with the base. The first surgical model is disposed on a first surface of the model support and the second surgical model is disposed on a second surface of the model support. The base includes an internal volume sized and shaped to receive one of the first surgical model and the second surgical model. The other of the first surgical model and the second surgical model is at least partially exposed when the model support is engaged with the base.Type: ApplicationFiled: July 14, 2023Publication date: January 25, 2024Applicant: The Children's Medical Center CorporationInventors: Carolyn R. Rogers-Vizena, Michael G. Silver, Lindsey Minahan, Stephen F. Wilson
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Publication number: 20240024509Abstract: Provided are methods and compositions for treating cerebrospinal fluid disorders. In embodiments, the methods comprise administering an agent to a subject altering activity, expression, or level of NKCC1 in a cell.Type: ApplicationFiled: July 27, 2023Publication date: January 25, 2024Applicant: The Children's Medical Center CorporationInventors: Maria K. LEHTINEN, Ryann M. FAME, Cameron SADEGH, Huixin XU
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Patent number: 11878063Abstract: Described herein are engineered ligand that binds a cell surface receptor (e.g., GPCR), with improved affinity, potency, and specificity. By conjugating a sub-optimal ligand for a cell surface receptor (e.g., GPCR) to a targeting molecule that binds an epitope (natural or exogenous epitope) in the extracellular portion of the cell surface receptor (e.g., GPCR), the affinity, potency, and/or specificity of the sub-optimal ligand is enhanced.Type: GrantFiled: March 5, 2020Date of Patent: January 23, 2024Assignees: Children's Medical Center Corporation, The General Hospital CorporationInventors: Ross Cheloha, Hidde L. Ploegh, Thomas J. Gardella
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Patent number: 11879137Abstract: Described herein are methods and compositions for producing modified, PD-L1 expressing hematopoietic stem cells, and uses thereof. Aspects of the invention relate to modulating the expression of micro RNA that controls the expression of PD-L1 in the hematopoietic stem cell. Methods for modulating the expression of micro RNA include, e.g., introducing to the cell a nucleic acid encoding a given micro RNA, or an agent that inhibits a given micro RNA.Type: GrantFiled: September 21, 2018Date of Patent: January 23, 2024Assignee: THE CHILDREN'S MEDICAL CENTER CORPORATIONInventors: Paolo Fiorina, Moufida Ben-Nasr
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Publication number: 20240020912Abstract: The invention features a prospective respiratory motion compensation technique for cardiovascular magnetic resonance imaging of the whole-heart of a free-breathing subject.Type: ApplicationFiled: September 26, 2023Publication date: January 18, 2024Applicant: The Children's Medical Center CorporationInventors: Mehdi H. MOGHARI, Andrew J. POWELL, Tal GEVA
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Publication number: 20240018577Abstract: Provided herein are products and methods for detecting analytes using polymers that bind to such analytes and thereby undergo a conformational change or contribute to a newly formed complex.Type: ApplicationFiled: June 26, 2023Publication date: January 18, 2024Applicant: Children's Medical Center CorporationInventors: Wesley Philip Wong, Clinton H. Hansen
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Publication number: 20240000559Abstract: Methods and systems for cardiovascular structure reconstruction are provided. A method of reconstructing a cardiovascular structure may include imaging the cardiovascular structure, producing a three-dimensional model of the cardiovascular structure based on the imaging, and creating a three-dimensional model of a patch corresponding to the three-dimensional model of the cardiovascular structure, where the patch is configured to reconstruct the cardiovascular structure to a normal geometry. A patch for a cardiovascular structure may include at least one layer of anisotropic material including an outermost perimeter and one or more notches extending inward from the outermost perimeter, where each of the one or more notches creates a discontinuity in the outermost perimeter. In some cases, each of the one or more notches includes a first edge and a second opposing edge, and the patch further includes one or more sutures configured to secure the first edge to the second opposing edge.Type: ApplicationFiled: October 7, 2021Publication date: January 4, 2024Applicant: Children's Medical Center CorporationInventors: David Hoganson, Peter E. Hammer, Emily Eickhoff, Noah Schulz
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Publication number: 20240000900Abstract: The invention provides methods for activating a repressed allele within an imprinting control region, thereby treating an imprinting associated disorder.Type: ApplicationFiled: June 26, 2023Publication date: January 4, 2024Applicant: The Children's Medical Center CorporationInventors: Yi ZHANG, Azusa INOUE
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Patent number: 11850266Abstract: Disclosed herein are methods for generating mature cardiomyocytes and compositions including mature cardiomyocytes. Also disclosed herein are methods for enhancing maturation of quiescent cardiomyocytes and compositions including mature quiescent cardiomyocytes.Type: GrantFiled: June 8, 2020Date of Patent: December 26, 2023Assignees: President and Fellows of Harvard College, The Children's Medical Center CorporationInventors: Richard T. Lee, Jessica Garbern, Douglas A. Melton, Aharon Helman