Patents Assigned to The Cleveland Clinic Foundation
  • Patent number: 10445378
    Abstract: A computer-implemented method can include acquiring data from at least one data source, the acquired data including health data for a patient. The acquired data can be transformed into episode model data according to a context-specific data model and the episode model data can be stored in a database. The method also includes generating at least one inverted index document for at least a portion of an episode for the patient based on the episode model data.
    Type: Grant
    Filed: June 14, 2016
    Date of Patent: October 15, 2019
    Assignee: THE CLEVELAND CLINIC FOUNDATION
    Inventor: Madhu Sasidhar
  • Publication number: 20190290895
    Abstract: A fluid distribution system for delivering fluid internally of a body comprises a hollow needle and an implantable access port. The needle has a tip with a predetermined shape. The access port includes (a) a housing that includes at least two fluid outlets, (b) a septum received in the housing, and (c) a valve member rotatable in the housing. The valve member includes valve fluid inlet and outlet openings and a valve inlet passage extending from the inlet opening to the outlet opening. The valve inlet passage has a shape complementary to the shape of the needle tip. The valve member is rotatable into (i) a first position in which the valve fluid outlet opening communicates with a first housing fluid outlet and (ii) a second position in which the valve fluid outlet opening communicates with a second housing fluid outlet.
    Type: Application
    Filed: May 5, 2017
    Publication date: September 26, 2019
    Applicant: The Cleveland Clinic Foundation
    Inventor: Michael A. VOGELBAUM
  • Publication number: 20190290185
    Abstract: A method of identifying an epileptogenic zone of a subjects brain includes: receiving a plurality N of physiological brain signals that extend over a duration, each of the plurality N of physiological brain signals acquired from the subjects brain; calculating within a time window a state transition matrix based on at least a portion of each of the plurality N of physiological brain signals, wherein the state transition matrix is a linear time invariant model of a network of N nodes corresponding to the plurality N of physiological brain signals; calculating a minimum norm of a perturbation on the state transition matrix that causes the network to transition from a stable state to an unstable state; and assigning a fragility metric to each of the plurality N of physiological brain signals based on the minimum norm of the perturbation for that physiological brain signal.
    Type: Application
    Filed: November 10, 2017
    Publication date: September 26, 2019
    Applicants: The Johns Hopkins University, The Cleveland Clinic Foundation
    Inventors: Sridevi SARMA, Adam LI, Jorge GONZALEZ-MARTINEZ
  • Patent number: 10420497
    Abstract: This disclosure relates to a device to mechanically and electrically connect with a touch screen computing device, such as a tablet computer. The device can include a platform that can be moved into and out of physical contact with a surface of a touch screen. During engagement with the surface, the moveable platform electrically interacts with the touch screen (e.g., via capacitive coupling) to enable detection by the touch screen of contact members (e.g., pegs) even in the absence of user contact with the pegs.
    Type: Grant
    Filed: April 18, 2016
    Date of Patent: September 24, 2019
    Assignees: THE CLEVELAND CLINIC FOUNDATION, BIOGEN MA, INC.
    Inventors: Jay L. Alberts, David D. Schindler, Jane Rhodes, Wendy Gabel, Jim Best
  • Patent number: 10420939
    Abstract: Temporary or sub-threshold electrical stimulation to promote recovery of a damaged or injured nerve. Methods include promoting neuroregeneration of a nerve iatrogenically injured during a medical procedure performed on a target site of a patient's body. Methods include placing an electrical lead in electrical communication with the injured or damaged nerve. Methods further include temporarily stimulating the nerve and/or applying sub-threshold stimulation to the nerve to promote neuroregeneration of the nerve. The nerve can be a peripheral nerve.
    Type: Grant
    Filed: March 9, 2017
    Date of Patent: September 24, 2019
    Assignee: THE CLEVELAND CLINIC FOUNDATION
    Inventors: Bradley C. Gill, Yaw A. Nyame, Eric A. Klein
  • Patent number: 10413435
    Abstract: A pre-loaded stent graft delivery device and stent graft, the stent graft delivery device. The stent graft has at least one fenestration or side arm and the fenestration is preloaded with an indwelling guide wire. The indwelling guide wire are configured to receive the access sheaths. A handle assembly at a distal end of the guide wire catheter. The handle includes a multiport manifold with access ports to the auxiliary lumens in the pusher catheter. Upon deployment of the stent graft into the vasculature of a patient, the indwelling guide wire can be used to facilitate catheterization of a side branch or target vessel through the fenestration or be used to stabilize the access sheath during catheterization, advancement of the access sheath into the target vessel and deployment of a covered or uncovered stent therein through the access sheath.
    Type: Grant
    Filed: August 21, 2018
    Date of Patent: September 17, 2019
    Assignees: The Cleveland Clinic Foundation, Cook Medical Technologies LLC
    Inventors: Roy K. Greenberg, Krasnodar Ivancev, David Ernest Hartley, Werner D. Ducke, Erik E. Rasmussen
  • Patent number: 10406206
    Abstract: The use and screening of modulators of apoptosis is disclosed. The modulators may be, for example, modulator of NF-?B activity. The modulators may be used, for example, in the treatment of NF-?B-mediated diseases, conditions, and injuries.
    Type: Grant
    Filed: January 24, 2017
    Date of Patent: September 10, 2019
    Assignee: The Cleveland Clinic Foundation
    Inventor: Andrei V. Gudkov
  • Patent number: 10398763
    Abstract: Methods are provided for treating astigmatism in an eye of a patient. An axis of greater curvature of the eye is determined. A stiffening process is applied to a cornea of the eye in a pattern defined from the axis of greater curvature of the eye.
    Type: Grant
    Filed: January 28, 2014
    Date of Patent: September 3, 2019
    Assignee: THE CLEVELAND CLINIC FOUNDATION
    Inventors: William J. Dupps, Ibrahim Seven
  • Patent number: 10398461
    Abstract: An endoscopic endocap for excising a target portion of a native tissue from a remaining portion of the native tissue during a surgical procedure includes an annular main body. The main body has a proximal end and an oppositely disposed distal end. The distal end includes an extension that protrudes longitudinally beyond a remaining portion of the distal end. An outer surface of the distal end, and an inner surface of the main body, extend longitudinally between the proximal and distal ends. The inner surface defines at least one lumen with an opening terminating at the terminal portion of the distal end. At least one excisor is disposed on the extension with the excisor laterally spaced from the outer surface of the annular main body. The excisor remains stationary with respect to the lumen during use of the excisor to excize the target portion of the native tissue.
    Type: Grant
    Filed: November 7, 2014
    Date of Patent: September 3, 2019
    Assignee: THE CLEVELAND CLINIC FOUNDATION
    Inventors: Amit Bhatt, Yutaka Saito
  • Patent number: 10391173
    Abstract: Provided herein are compositions, systems, kits, and methods for treating cancer in a subject with androgen receptor positive cancer cells by sensitizing such cancer cells with anti-androgen receptor therapy (e.g., Enzalutamide or anti-androgen antibody), and then treating with radiation therapy.
    Type: Grant
    Filed: April 21, 2017
    Date of Patent: August 27, 2019
    Assignee: THE CLEVELAND CLINIC FOUNDATION
    Inventor: Mohamed Abazeed
  • Patent number: 10391285
    Abstract: Systems, devices and methods for minimizing or preventing catheter or other medical device occlusion. Mechanical motion is applied to the inner and outer walls of the catheter to minimize blood clots or other biological substances from obstructing the catheter and to help maintain catheter patency.
    Type: Grant
    Filed: June 11, 2014
    Date of Patent: August 27, 2019
    Assignee: THE CLEVELAND CLINIC FOUNDATION
    Inventors: Jamshid Karimov, Kiyotaka Fukamachi, Ray Dessoffy
  • Patent number: 10385034
    Abstract: The present invention describes compounds according to formula I: and compounds according to formula II: and additional related flavonoid compounds, as well as the use of the compounds in methods for the prevention or treatment of IL-17A-mediated disease in a subject.
    Type: Grant
    Filed: September 8, 2015
    Date of Patent: August 20, 2019
    Assignee: THE CLEVELAND CLINIC FOUNDATION
    Inventors: Xiaoxia Li, Caini Liu, Jun Qin, Liang Zhu, Koichi Fukuda
  • Patent number: 10383657
    Abstract: One aspect of the present disclosure relates to a cannula for passing a tissue graft through soft tissue. The cannula can comprise an elongated body including oppositely disposed first and second ends and an axis that extends between the first and second ends. The elongated body can further include a passage extending between the first and second ends. The second end can include a curved portion that terminates at a sharpened, pointed tip configured to pierce and/or cut soft tissue at the surgical repair site. The tip can be axially offset from the axis of the elongated body at an angle that is less than 180°.
    Type: Grant
    Filed: December 1, 2015
    Date of Patent: August 20, 2019
    Assignee: THE CLEVELAND CLINIC FOUNDATION
    Inventors: Kathleen A. Derwin, Joseph P. Iannotti, Ryan A. Milks
  • Publication number: 20190239999
    Abstract: A stent graft (2) for placement in the thoracic arch of a patient has a first tubular body portion (6) with a first lumen therein for placement in the ascending aorta of a patient and a second tubular body portion (8) to extend along the thoracic arch and down the descending aorta. The second tubular body portion is of a lesser diameter than the first tubular body portion. There is a step portion (10) between the first body portion and the second body portion. The step portion is joined to and continuous with the first portion and the second portion. A first side of each of the first body portion, the step portion and the second body portion are substantially aligned so that there is a step (18) defined on a second side opposite to the first side of the body portion. There is an aperture (30) in the step portion and an internal tube (32) extending from the aperture towards the first body portion.
    Type: Application
    Filed: April 1, 2019
    Publication date: August 8, 2019
    Applicants: COOK MEDICAL TECHNOLOGIES LLC, THE CLEVELAND CLINIC FOUNDATION
    Inventors: David E. Hartley, Roy K. Greenberg, Krasnodar Ivancev, Michael Lawrence-Brown
  • Patent number: 10370373
    Abstract: Imidazopyridine derivatives according to formula I are described wherein X is selected from CH, N, S, and O, Y is selected from S, CO, and O, R1 and optional R2 are independently selected from H, OH, substituted or unsubstituted C1-C6 alkyl, and substituted or unsubstituted C4-C6 cycloalkyl or cycloheteroalkyl, R3 is selected from H, OH, substituted or unsubstituted C1-C6 alkyl, and optional Z is selected from OH, NH2, NH(CO)R4, NH(SO2)R4, guanidine, alkylguanidine, and fluoroguanidine, R4 is polyethylene glycol or substituted or unsubstituted C1-C6 alkyl, and pharmaceutically acceptable salt thereof. The imidazopyridine derivatives can be used for treatment of cancer in a subject.
    Type: Grant
    Filed: March 8, 2018
    Date of Patent: August 6, 2019
    Assignee: THE CLEVELAND CLINIC FOUNDATION
    Inventors: Yogenthiran Saunthararajah, Kwok Peng Ng, James G. Phillips, Babal Kant Jha, Anand Dev Tiwari
  • Patent number: 10368987
    Abstract: One aspect of the present disclosure includes a system comprising prosthetic chordae, at least one attachment member including a channel, a female securing member, and a papillary penetration member configured to pass through the channel, the chordae, and the securing member when implanted in a patient's heart. The penetration member includes an axis.
    Type: Grant
    Filed: June 9, 2016
    Date of Patent: August 6, 2019
    Assignee: THE CLEVELAND CLINIC FOUNDATION
    Inventors: A. Marc Gillinov, Michael K. Banbury, Jeremy Hemingway, Craig B. Berky, Jonathan Bauer
  • Patent number: 10369260
    Abstract: A blood pump (20) includes a stator assembly comprising a motor stator (52), a fluid inlet (24), and a fluid outlet (26). A rotor assembly includes a motor rotor (54) and an impeller (40) rotatable about an axis (44) to move fluid from the inlet (24) to the outlet (26). An outflow sheath (300) directs the flow along the outside of the pump (20).
    Type: Grant
    Filed: March 6, 2015
    Date of Patent: August 6, 2019
    Assignee: The Cleveland Clinic Foundation
    Inventors: William A. Smith, Markus Lorenz, David Dudzinski, Hsiang Ming Chen, Peter A. Chapman, Jr., Charles J. Prisco, Nicholas G. Vitale, Stephan Weber
  • Patent number: 10357068
    Abstract: A temperature-regulating garment is provided for assisting a user with regulating body temperature. A garment body has first and second major garment body edges. The garment body has a neckline formed by a least a portion of the first major garment body edge. The garment body has a front right panel, a front left panel, and a back panel. At least one armhole is located laterally between the back panel and a selected one of the right front panel and the left front panel. First and second neck pockets are each configured to accept a temperature-regulating pack. The first neck pocket is disposed upon at least one of the right front panel and the back panel, spanning the first major garment body edge. The second neck pocket is disposed upon at least one of the left front panel and the back panel, spanning the first major garment body edge.
    Type: Grant
    Filed: July 5, 2016
    Date of Patent: July 23, 2019
    Assignee: THE CLEVELAND CLINIC FOUNDATION
    Inventor: Jill Elizabeth Byrne
  • Patent number: 10360511
    Abstract: A computer-implemented method for determining the volume of activation of neural tissue. In one embodiment, the method uses one or more parametric equations that define a volume of activation, wherein the parameters for the one or more parametric equations are given as a function of an input vector that includes stimulation parameters. After receiving input data that includes values for the stimulation parameters and defining the input vector using the input data, the input vector is applied to the function to obtain the parameters for the one or more parametric equations. The parametric equation is solved to obtain a calculated volume of activation.
    Type: Grant
    Filed: March 15, 2013
    Date of Patent: July 23, 2019
    Assignee: THE CLEVELAND CLINIC FOUNDATION
    Inventors: J. Luis Lujan, Ashutosh Chaturvedi, Cameron McIntyre
  • Patent number: 10342552
    Abstract: A tissue collection and processing system for collecting bone fragments and tissue therein. The tissue collection and processing system includes a collection vessel, a collection vessel cap and a filter container. The collection vessel has an opening formed therein. The collection vessel cap is capable of engaging the collection vessel to substantially seal the opening. The collection vessel cap or the collection vessel includes a first port and a second port. The filter container is mounted with respect to the first port.
    Type: Grant
    Filed: May 9, 2016
    Date of Patent: July 9, 2019
    Assignees: Fortus Medical, Inc., The Cleveland Clinic Foundation
    Inventors: Robert Assell, Andy Freeman, George Muschler