Patents Assigned to The Cleveland Clinic Foundation
  • Patent number: 10895906
    Abstract: Holographic image-guidance can be used to track an interventional device during a non-vascular percutaneous procedure. The holographic image guidance can be provided by a head-mounted device by transforming tracking data and body image data to a common coordinate system and creating a holographic display relative to a patient's body to track the interventional device during the non-vascular percutaneous procedure. The holographic display can also include graphics to provide guidance for the physical interventional device as it travels through the patient's anatomy.
    Type: Grant
    Filed: April 20, 2018
    Date of Patent: January 19, 2021
    Assignee: THE CLEVELAND CLINIC FOUNDATION
    Inventors: Karl West, Jeffrey H. Yanof
  • Patent number: 10888455
    Abstract: Systems and methods are provided for image-guided delivery of therapeutics to an eye. An optical coherence tomography (OCT) imager is configured to produce at least one OCT image of the eye. A therapeutic delivery system is configured to deliver a therapeutic to the eye through a distal end of a delivery mechanism. A system control is configured to determine a position of the distal end of the delivery mechanism and control the therapeutic delivery system according to at least the determined position.
    Type: Grant
    Filed: April 11, 2019
    Date of Patent: January 12, 2021
    Assignee: THE CLEVELAND CLINIC FOUNDATION
    Inventors: Sunil K. Srivastava, Justis P. Ehlers, Yuankai K. Tao
  • Patent number: 10890639
    Abstract: Systems and methods are provided for correlating functional magnetic resonance imaging (fMRI) with gene expression. Brains of first and second sets of patients are imaged at first and second times to provide first and second sets of fMRI images. Blood is drawn from each of the first and second sets of patients at the first and second times to provide first and second sets of gene expression transcripts. A therapeutic is administered to the first set of patients between the first and second times. A change in the connectivity of the brain for each patient is determined from the first and second sets of fMRI images. A set of changes in the peripheral lymphocyte gene expression that are correlated with changes in the connectivity of the brain are determined from the change in the connectivity of the brain for each patient and the collected imaging and gene expression data.
    Type: Grant
    Filed: May 16, 2019
    Date of Patent: January 12, 2021
    Assignee: THE CLEVELAND CLINIC FOUNDATION
    Inventor: Amit Anand
  • Patent number: 10869727
    Abstract: An interventional procedure can be performed less invasively with live 3D holographic guidance and navigation. Advantageously, the 3D holographic guidance and navigation overcomes the limitations of conventional displays of medical images on standard 2D flat panel screens. The live 3D holographic guidance can utilize a 3D holographic visualization that is derived from complementary imaging modalities (e.g., ultrasound and computed tomography) to provide a complete holographic view of a portion of the patient's body to enable navigation of a tracked interventional instrument/device.
    Type: Grant
    Filed: May 7, 2019
    Date of Patent: December 22, 2020
    Assignee: THE CLEVELAND CLINIC FOUNDATION
    Inventors: Jeffrey H. Yanof, Karl West, Sara Al-Nimer
  • Patent number: 10849866
    Abstract: A method of inhibiting the conversion of choline to trimethylamine (TMA) and lowering TMAO in an individual by providing a composition comprising a compound set forth in Formula (I):
    Type: Grant
    Filed: October 2, 2018
    Date of Patent: December 1, 2020
    Assignees: The Procter & Gamble Company, The Cleveland Clinic Foundation
    Inventors: Jose Carlos Garcia-Garcia, George Franklin Gerberick, Stanley Leon Hazen, Xiaodong Gu
  • Patent number: 10849708
    Abstract: Device and methods for treating conditions caused by or associated with a sacroiliac joint abnormality using radiofrequency ablation. A surgical jig is provided that facilitates safe, easy, and quick placement of electrodes in a patient's spinal region for radiofrequency ablation of a set of spinal nerves and/or sacroiliac ligaments.
    Type: Grant
    Filed: December 9, 2014
    Date of Patent: December 1, 2020
    Assignee: THE CLEVELAND CLINIC FOUNDATION
    Inventor: Jianguo Cheng
  • Patent number: 10850079
    Abstract: A system is provided for healing a wound. The system includes a flexible body, a therapeutic agent delivery mechanism, a suction mechanism, and a power source. The flexible body includes a cover film having oppositely disposed first and second surfaces that define a compartment. The compartment includes a first porous material, a second porous material, and at least one electrode disposed therein. The second porous material is disposed between the first porous material and the at least one electrode. The therapeutic agent delivery mechanism and the suction mechanism are fluidly connected to the compartment. The power source is in electrical communication with the at least one electrode.
    Type: Grant
    Filed: June 7, 2018
    Date of Patent: December 1, 2020
    Assignee: THE CLEVELAND CLINIC FOUNDATION
    Inventors: Francis A. Papay, Ji-Feng Chen, Shengqiang Gao
  • Patent number: 10842631
    Abstract: Systems and methods for de-airing a cardiac chamber during cardiac surgery are provided. A catheter-based inflatable device is inserted adjacent a target area of the heart, and the frequency of inflation and deflation of the inflatable device is controlled via a remote controller to change the shape of the cardiac chamber to dislodge air bubbles from their deposition site in the cardiac chamber.
    Type: Grant
    Filed: February 23, 2018
    Date of Patent: November 24, 2020
    Assignee: THE CLEVELAND CLINIC FOUNDATION
    Inventors: Jamshid Karimov, Marc Gillinov, Kiyotaka Fukamachi
  • Patent number: 10835521
    Abstract: A method of treating or preventing a neuroinflammatory and/or neurodegenerative disease in a subject by administering a pharmaceutically effective amount of a CB2 receptor agonist is described. The CB2 receptor agonist can be a compound according to formula I (structurally represented) or a pharmaceutically acceptable salt thereof, with R1 and R2 functional groups as defined herein. Administration of the CB2 receptor agonist activates CB2 receptors in the microglia, and can restore synaptic plasticity, cognition, and memory in subjects having elevated levels of amyloid-13 peptide in the brain.
    Type: Grant
    Filed: July 12, 2013
    Date of Patent: November 17, 2020
    Assignee: THE CLEVELAND CLINIC FOUNDATION
    Inventors: Mohamed Naguib Attala, David L. Brown
  • Publication number: 20200352703
    Abstract: A branched and fenestrated prosthesis may include a main tubular graft body including a proximal end opening, a distal end opening, a lumen, and a sidewall. A branch may extend from the sidewall and may include a first end opening, a second end opening, and a lumen. A fenestration may be disposed in the sidewall and positioned distal of the second end opening of the branch. The branched and fenestrated prosthesis may include a plurality of branches and a plurality of fenestrations.
    Type: Application
    Filed: July 24, 2020
    Publication date: November 12, 2020
    Applicants: Cook Medical Technologies LLC, The Cleveland Clinic Foundation
    Inventors: Roy K. Greenberg, Karl J. West, Timothy A. Resch, Blayne A. Roeder
  • Patent number: 10820948
    Abstract: Holographic image-guidance can be used to track an interventional device during an endovascular percutaneous procedure. The holographic image guidance can be provided by a head-mounted device by transforming tracking data and vasculature image data to a common coordinate system and creating a holographic display relative to a patient's vasculature to track the interventional device during the endovascular percutaneous procedure. The holographic display can also include graphics to provide guidance for the physical interventional device as it travels through the patient's anatomy (e.g., the vasculature).
    Type: Grant
    Filed: October 4, 2019
    Date of Patent: November 3, 2020
    Assignee: THE CLEVELAND CLINIC FOUNDATION
    Inventors: Karl West, Jeffrey H. Yanof
  • Patent number: 10799360
    Abstract: A system for treating regurgitation of blood through a diseased heart valve having at least two leaflets can include an implantable, lollipop-shaped device and an adjustment mechanism. The device can have a proximal end portion, a distal end portion, and an intermediate portion extending therebetween. The intermediate portion can include an expandable occluding member having a selectively adjustable diameter and a biocompatible layer attached to at least a portion thereof. The distal end portion can include an anchoring member. The adjustment member can include a distal connecting end that is operatively connected to the proximal end portion of the device. Operation of the adjustment member, after implantation of the device, can cause the diameter of the occluding member to change so that at least one of the heart leaflet coapts with a portion of the occluding member to mitigate or prevent regurgitation of blood through the diseased heart valve.
    Type: Grant
    Filed: May 1, 2018
    Date of Patent: October 13, 2020
    Assignee: THE CLEVELAND CLINIC FOUNDATION
    Inventor: Samir Kapadia
  • Patent number: 10799145
    Abstract: System and methods are disclosed to facilitate intra-operative procedures and planning. A method can include storing tracking data in memory, the tracking data being generated by a tracking system to represent a location of an object in a tracking coordinate system of the tracking system. The method can also include storing a patient-specific implicit model in memory, the patient-specific implicit model being generated based on image data acquired for the patient to define geometry of an anatomical structure of the patient. The method can also include registering the tracking data and the patient-specific implicit model in a common three-dimensional coordinate system. The method can also include generating an output visualization representing a location of the object relative to the geometry of the anatomical structure of the patient in the common coordinate system.
    Type: Grant
    Filed: March 13, 2014
    Date of Patent: October 13, 2020
    Assignee: THE CLEVELAND CLINIC FOUNDATION
    Inventors: Karl West, Vikash Goel, James Foster
  • Patent number: 10792393
    Abstract: A biocompatible tissue graft is provided. The tissue graft includes an extracellular matrix patch and a means for reinforcing the patch.
    Type: Grant
    Filed: October 5, 2017
    Date of Patent: October 6, 2020
    Assignee: THE CLEVELAND CLINIC FOUNDATION
    Inventors: Kathleen A. Derwin, Amit Aurora, Joseph P. Iannotti, Jesse A. McCarron
  • Patent number: 10786640
    Abstract: One aspect of the present disclosure relates to a reversible airway device. The reversible airway device (10) can include: a supra-glottic airway support (12) comprising a multi-lumen tubular guide (14) and an optional sealing member (16); an endotracheal tube (26); and at least one seal (42). The multi-lumen tubular guide has a distal end portion (18), a proximal end portion (22), a first passageway (20) extending between the distal and proximal end portions, and a second passageway (24) that is non-concentric with the first passageway and also extends between the distal and proximal end portions. The at least one seal is disposed within the first passageway, the second passageway, or both, so as to occlude the flow of a gas through the first passageway and/or the second passageway. The endotracheal tube can be inserted into the first or second passageway and can traverse the seal.
    Type: Grant
    Filed: May 16, 2016
    Date of Patent: September 29, 2020
    Assignees: PARKER-HANNIFIN CORPORATION, THE CLEVELAND CLINIC FOUNDATION
    Inventors: Rafi Avitsian, Andrew Zura, Gino Banco, Sean Lee
  • Patent number: 10786479
    Abstract: The invention provides a method of inhibiting the conversion of carnitine to trimethylamine (TMA) and lowering TMAO in an individual comprising administering to the individual one or more compositions comprising a compound set forth in Formula (I): Wherein the compound is administered in an amount effective to inhibit conversion of carnitine to TMA in the individual.
    Type: Grant
    Filed: December 1, 2016
    Date of Patent: September 29, 2020
    Assignees: The Procter & Gamble Company, The Cleveland Clinic Foundation
    Inventors: Stanley Leon Hazen, Jose Carlos Garcia-Garcia, George Franklin Gerberick, John August Wos, David Thomas Stanton, Thomas Alfred Inglin, Michael Reilly, Angela Jane Deutsch, Jodie Michele Reed, David Blair Cody
  • Patent number: 10779731
    Abstract: A patient management system includes a patient unit that obtains results data from a patient device and provides for two-way communication between the patient unit and a remote database. The patient unit can communicate with the remote database to obtain encounter instruction data for a given encounter as well as to send response data for the given encounter. A back office system can also access the database to retrieve the patient data for one or more patient users. The back office system can further add or modify encounter instruction data for use during a next encounter at the patient unit. The back office system can also set a dosage for the patient that can be stored in the remote database and retrieved by the patient unit as part of the given encounter. The back office system may also employ a rules engine that can be programmed according to an established protocol and can automatically generate encounter instructions and dosage information for one or more patient.
    Type: Grant
    Filed: August 16, 2010
    Date of Patent: September 22, 2020
    Assignees: THE CLEVELAND CLINIC FOUNDATION, ZTECH, INC.
    Inventors: Alan Chmiel, Heather Gornik, John R. Bartholomew, Carlos Grodsinsky, Jonathan Schaffer
  • Patent number: 10779930
    Abstract: An endoluminal prosthesis may include a tubular main graft body including a sidewall and proximal and distal ends. A first stent may be positioned near the proximal end of the main graft body. A second stent may be positioned adjacent to and distal of the first stent. An opening in the sidewall may be positioned longitudinally between a peak of the first stent and a valley of the second stent. A tubular branch may be disposed in the opening. The branch may include first and second end openings. The branch may be flexibly orientable between a retrograde configuration in which the first end opening is oriented toward the distal end and the second end opening is oriented toward the proximal end and an antegrade configuration in which the first end opening is oriented toward the proximal end and the second end opening is oriented toward the distal end.
    Type: Grant
    Filed: May 24, 2017
    Date of Patent: September 22, 2020
    Assignees: The Cleveland Clinic Foundation, Cook Medical Technologies LLC
    Inventors: Blayne A. Roeder, Roy K. Greenberg, Jarin Kratzberg, Matthew S. Huser
  • Patent number: 10780072
    Abstract: The invention provides one or more methods of inhibiting the conversion of choline to trimethylamine (TMA) and lowering TMAO in an individual comprising administering to the individual one or more compositions comprising a compound set forth in Formula (I): wherein the compound is administered in an amount effective to inhibit formation of trimethylamine (TMA) from choline in the individual.
    Type: Grant
    Filed: December 1, 2016
    Date of Patent: September 22, 2020
    Assignees: The Procter & Gamble Company, The Cleveland Clinic Foundation
    Inventors: Stanley Leon Hazen, Jose Carlos Garcia-Garcia, George Franklin Gerberick, John August Wos, David Thomas Stanton, Thomas Alfred Inglin, Michael Reilly, Angela Jane Deutsch, Jodie Michele Reed, David Blair Cody
  • Patent number: D903982
    Type: Grant
    Filed: November 30, 2017
    Date of Patent: December 8, 2020
    Assignee: THE CLEVELAND CLINIC FOUNDATION
    Inventor: Jill Elizabeth Byrne