Patents Assigned to The Curators of the University of Missouri
  • Patent number: 10451479
    Abstract: Increased sensitivity of spectrometers through reducing noise in independent voltage signals via a differential voltage analyzer utilizing a reference wavelength from a wavelength region in which the optical absorption of the sample is negligible. In an embodiment, a grating permits selection of a reference wavelength. In another embodiment, filters permit selection of a reference wavelength. In yet another embodiment, both a grating and a filter permit selection of a reference wavelength. In an aspect, the differential voltage analyzer reduces noise by minimizing a differential voltage between the independent voltage signals and the reference voltage signal by adjusting the value of a cancellation coefficient.
    Type: Grant
    Filed: November 9, 2016
    Date of Patent: October 22, 2019
    Assignee: The Curators of the University of Missouri
    Inventor: Zhi Xu
  • Patent number: 10441588
    Abstract: The present disclosure relates to chemical compounds, methods for their discovery, and their therapeutic and research use. In particular, the present disclosure provides compounds as therapeutic agents against bacterial infections (e.g., biofilms). The present disclosure also provides topical formulations for use in methods for treating bacterial infections.
    Type: Grant
    Filed: September 21, 2017
    Date of Patent: October 15, 2019
    Assignees: Curators of the University of Missouri, Nanova, Inc.
    Inventors: Hongmin Sun, David W. Anderson, Feng Qi
  • Patent number: 10447135
    Abstract: An energy harvesting device for generating electrical power from low-frequency oscillations includes a high-frequency cantilever, a plurality of low-frequency cantilevers each configured to contact the high-frequency cantilever in response to environmental vibrations having a frequency within a near-resonance frequency range associated with said low-frequency cantilever, an a generator that produces electrical power in response to contact between at least one of the plurality of low-frequency cantilevers and the high-frequency cantilever. The energy harvesting device may also include an impact mass coupled to a free end of each of the plurality of low-frequency cantilevers. Some aspects may include a common base to which the high-frequency cantilever and the plurality of low-frequency cantilevers are coupled. Other aspects may include the generator comprising one or more of an induction coil and magnet, a variable distance capacitor, or a piezo-electric material.
    Type: Grant
    Filed: September 28, 2016
    Date of Patent: October 15, 2019
    Assignee: The Curators of the University of Missouri
    Inventors: Nuh Sadi Yuksek, Mahmoud Almasri
  • Patent number: 10434498
    Abstract: Embodiments relate to a cerium-containing nano-coating composition, the composition including an amorphous matrix including one or more of cerium oxide, cerium hydroxide, and cerium phosphate; and crystalline regions including one or more of crystalline cerium oxide, crystalline cerium hydroxide, and crystalline cerium phosphate. The diameter of each crystalline region is less than about 50 nanometers.
    Type: Grant
    Filed: October 4, 2017
    Date of Patent: October 8, 2019
    Assignee: THE CURATORS OF THE UNIVERSITY OF MISSOURI
    Inventors: Matthew J. O'Keefe, Carlos E. Castano Londono, William G. Fahrenholtz
  • Patent number: 10434032
    Abstract: A tool for use in assisting soft tissue mobilization and bodily tissue amelioration, such as stimulation of superficial tissue, deep tissue mobilization, breaking up scar tissue, and soft tissue massaging, are described. The tool comprises a device for application to bodily tissue that includes a body having a substantially teardrop shape in a vertical section. In a longitudinal aspect, the body includes a first and a second portion. The first portion of the device corresponds at least in part to a substantially bulbous handle part of the teardrop shape of the vertical section and is adapted for ease of grasping and manipulation at the first end. The second portion of the device corresponds at least in part to a substantially tapered converging double-beveled linear edge of the teardrop shape of the vertical section and is adapted for facilitated application of the device to bodily tissue at the second end.
    Type: Grant
    Filed: December 15, 2015
    Date of Patent: October 8, 2019
    Assignee: The Curators of the University of Missouri
    Inventors: Jaya Ghosh, Ellie Koehly, Yaw Sarpong, Roger de la Torre, Jonathon Buehler, Brett Hayes, Teresa Graff, Katherina Chen
  • Patent number: 10426842
    Abstract: Provided are nanoparticle conjugates comprising a drug encapsulated in a gelatin nanoparticle the surface of which is functionalized with an antibody to which a siRNA is linked. Methods with the nanoconjugates for treating diseases are provided as well.
    Type: Grant
    Filed: July 14, 2016
    Date of Patent: October 1, 2019
    Assignee: The Curators of the University of Missouri
    Inventors: Raghuraman Kannan, Srikar Raman, Anandhi Upendran, Dhananjay Suresh
  • Patent number: 10421783
    Abstract: Described herein is the discovery of novel PSMA-specific peptides, which were identified through a novel combinatorial biopanning method. One of the novel PSMA-specific peptides discovered, GTIQPYPFSWGY (or GTI) (SEQ ID NO: 2), exhibits high binding affinity and selectivity to PSMA and PSMA-positive prostate cancer cells. It was found that GTI can mediate internalization of the apoptotic KLA peptide (SEQ ID NO: 10) to PSMA-positive LNCaP cells and induce cell death. Moreover, a FAM-labeled GTI peptide shows a high and specific tumor uptake in nude mice bearing human prostate cancer xenografts. It was demonstrated that the GTI peptide can be employed as a PSMA-specific ligand for prostate cancer diagnosis and/or for targeted drug delivery to prostate cancer cells.
    Type: Grant
    Filed: February 20, 2017
    Date of Patent: September 24, 2019
    Assignee: The Curators of the University of Missouri
    Inventors: Kun Cheng, Wei Jin
  • Patent number: 10405526
    Abstract: The present invention generally relates to genetically modified swine wherein at least one allele of a SIGLEC1 gene has been inactivated and/or at least one allele of a CD163 gene has been inactivated. Genetically modified swine having both alleles of the SIGLEC1 gene and/or both alleles CD163 gene inactivated are resistant to porcine reproductive and respiratory syndrome virus (PRRSV). Methods for producing such transgenic swine are also provided.
    Type: Grant
    Filed: August 24, 2018
    Date of Patent: September 10, 2019
    Assignee: The Curators of the University of Missouri
    Inventors: Randall S. Prather, Kevin D. Wells, Kristin M. Whitworth
  • Patent number: 10403810
    Abstract: A magnetic artificial honeycomb lattice comprising a multiplicity of connecting elements separated by hexagonal cylindrical pores, wherein: (a) the hexagonal cylindrical pores: (i) have widths that are substantially uniform and an average width that is in a range of about 15 nm to about 20 nm; and (ii) are substantially equispaced and have an average center-to-center distance that is in a range of about 25 nm to about 35 nm; and (b) the connecting elements comprise a magnetic material layer, and the connecting elements have: (i) lengths that are substantially uniform and an average length that is in a range of about 10 nm to about 15 nm; (ii) widths that are substantially uniform and an average width that is in a range of about 4 nm to about 8 nm; and (iii) a thickness of the magnetic material layer that is substantially uniform and an average thickness that is in a range of about 2 nm to about 8 nm; and (c) the magnetic artificial honeycomb lattice has a surface area, disregarding the presence of th
    Type: Grant
    Filed: May 11, 2018
    Date of Patent: September 3, 2019
    Assignee: The Curators of the University of Missouri
    Inventors: Deepak Kumar Singh, Brock Summers, Ashutosh Dahal
  • Patent number: 10373723
    Abstract: The invention provides methods, devices and systems for excimer fluorescence energy conversion from isotopes. Unprocessed spent nuclear fuel can be used as an isotope, and processed spent nuclear fuel can be used as an isotope. A method includes placing an excimer in the path of radiation decay from the isotope. The excimer is selected according to the isotope to absorb the radiation decay and emit photons in response. Surrounding environment is shielded from the radiation decay. Photons generated from the fluorescence of the excimer are received with photovoltaic material to generate electrical energy. The electrical energy is applied to a load. Systems of the invention can be based upon spent storage casks and handle unprocessed spent nuclear fuel, or can be greatly reduced in size and handle processed fuel, with single isotope isolation allowing consumer battery sized systems.
    Type: Grant
    Filed: September 30, 2015
    Date of Patent: August 6, 2019
    Assignee: The Curators of the University of Missouri
    Inventors: Robert V. Tompson, Jr., Mark A. Prelas
  • Patent number: 10367221
    Abstract: An energy storage system reaction cell configured for distribution throughout a transport system. The length of the reaction cell is substantially greater than its width and is looped throughout the transport system in a serpentine configuration. A membrane within the reaction cell has a length substantially equal to the length of the reaction cell such that surface area of the membrane is maximized relative to volume of the reaction cell to increase electrical power provided to an electrical load of the transport system.
    Type: Grant
    Filed: July 14, 2016
    Date of Patent: July 30, 2019
    Assignee: The Curators of the University of Missouri
    Inventors: Jonghyun Park, Mohammed Al-Yasiri
  • Patent number: 10364195
    Abstract: In some examples, a technique may include positioning a first part comprising a ceramic or ceramic matrix composite and a second part comprising a ceramic or a CMC adjacent to each other to define a joint region at the interface of the first part and the second part. In some examples, the joint region may be heated using at least one of a laser or a plasma arc source to heat the joint region to an elevated temperature. The first and second parts may be pressed together and cooled to join the first and second parts at the joint region. In other examples, a solid braze material including a filler material and a metal or alloy may be delivered to the joint region and locally heated to cause a constituent of the filler material and a constituent of the metal or alloy to react. When reacted, the constituents may form a solid material, which may join the first and second parts.
    Type: Grant
    Filed: May 22, 2015
    Date of Patent: July 30, 2019
    Assignees: Rolls-Royce Corporation, The Curators of the University of Missouri
    Inventors: Sean E. Landwehr, Scott Nelson, Jeremy Lee Watts, Gregory Eugene Hilmas, William Gene Fahrenholtz, Derek Scott King
  • Patent number: 10350330
    Abstract: A solid state method of producing inorganic nanoparticles using glass is disclosed. The nanoparticles may not be formed until the glass is reacted with or degraded by contact with a fluid in vivo or in vitro.
    Type: Grant
    Filed: September 9, 2015
    Date of Patent: July 16, 2019
    Assignee: The Curators of the University of Missouri
    Inventors: Delbert E. Day, Ali Mohammadkah
  • Patent number: 10351611
    Abstract: According to the embodiments described herein, a series of biological materials for treatment/therapy of DMD and/or BMD through the recovery of sarcolemmal nNOS is provided. The biological material comprises the complete dystrophin repeats R16 and R17 or certain domains, sections, or fragments of the dystrophin repeats R16 and R17. In some aspects, such domains, sections, or fragments may be selected from sequence motifs including dystrophin R17 ?1 helix, ?2 and ?3 helices of both R16 and R17, or a combination thereof.
    Type: Grant
    Filed: April 14, 2017
    Date of Patent: July 16, 2019
    Assignee: THE CURATORS OF THE UNIVERSITY OF MISSOURI
    Inventors: Yi Lai, Junling Zhao, Yongping Yue, Dongsheng Duan
  • Publication number: 20190211348
    Abstract: The present invention provides a method and means to change fatty acid and ultimately triacylglycerol production in plants and algae. Methods of the invention comprise the step of altering the activity levels of the committed step for de novo fatty acid biosynthesis, acetyl-CoA carboxylases (ACCase). More specifically, methods of the invention directly enhance the activity of ACCase by overexpression of ?-CT or a catalytic portion thereof.
    Type: Application
    Filed: July 6, 2017
    Publication date: July 11, 2019
    Applicant: The Curators of the University of Missouri
    Inventor: Jay J. Thelen
  • Patent number: 10341795
    Abstract: The present disclosure is generally directed to audio visualization methods for visual pattern recognition of sound. In particular, the present disclosure is directed to plotting amplitude intensity as brightness/saturation and phase-cycles as hue-variations to create visual representations of sound.
    Type: Grant
    Filed: November 28, 2017
    Date of Patent: July 2, 2019
    Assignee: The Curators of the University of Missouri
    Inventors: Philip Fraundorf, Stephen Wedekind, Wayne Garver
  • Patent number: 10336661
    Abstract: An energetic nanocomposite includes fuel nanoparticles and oxidizer nanoparticles covalently bonded to negatively charged functionalized graphene sheets. A preferred example includes Al fuel nanoparticles and Bi2O3 nanoparticles. A preferred method of formation mixes a solution of positively charged fuel nanoparticles, positively charged oxidizer nanoparticles, and negatively charged functionalized graphene sheets having functional groups to bond with the positively charged fuel nanoparticles and positively charged oxidizer nanoparticles. Self-assembly of the energetic nanocomposite is permitted over a predetermined time via the attraction and aggregation of the positively charged fuel nanoparticles positively charged oxidizer nanoparticles and negatively charged functionalized graphene sheets. Additional methods and nanocomposites include unfunctionalized graphene sheets, which can be commercial grade sheets.
    Type: Grant
    Filed: August 4, 2014
    Date of Patent: July 2, 2019
    Assignee: The Curators of the University of Missouri
    Inventors: Shubhra Gangopadhyay, Stephen W. Chung, Rajagopalan Thiruvengadathan, Clay Stephen Staley, Keshab Gangopadhyay, Kristofer Emile Raymond
  • Patent number: 10329528
    Abstract: The present invention is directed to methods for forming microparticles useful for cell seeding and for conjugating protein to the surface of the microparticles. The method comprises co-injecting an organic solution of PLGA or other polymer with an aqueous solution into a flow focusing tube.
    Type: Grant
    Filed: April 6, 2017
    Date of Patent: June 25, 2019
    Assignee: The Curators of the University of Missouri
    Inventors: Sutapa Barua, Chase Herman
  • Patent number: 10329576
    Abstract: The present invention is directed to a soybean plant with mutations in FAD2-1A and FAD2-1B. Moreover, the present invention is directed to seeds from said plants with altered ratios of monosaturated and polyunsaturated fats. In particular, the present invention is directed to plants where the plants exhibit elevated levels of oleic acid.
    Type: Grant
    Filed: April 14, 2015
    Date of Patent: June 25, 2019
    Assignees: The Curators of the University of Missouri, The United States of America, as Represented by the Secretary of Agriculture
    Inventors: Kristin Bilyeu, Grover Shannon, Jeong-Dong Lee, Anh Tung Pham
  • Patent number: 10330673
    Abstract: The invention is provides for a variety of fluorescence sensing compounds characterized generally as having a coumarin-3-aldehyde scaffold with a pendant aryl moiety at the C4-position of the scaffold. The further provides a method for detecting primary amines in a biological sample using said compounds. Especially, for the selective labeling and imaging of catecholamines in live and fixed secretory cells.
    Type: Grant
    Filed: March 21, 2014
    Date of Patent: June 25, 2019
    Assignee: The Curators of the University of Missouri
    Inventors: Timothy Glass, Kevin Gillis, Kenneth Hettie