Patents Assigned to The Curators of the University of Missouri
  • Patent number: 10336661
    Abstract: An energetic nanocomposite includes fuel nanoparticles and oxidizer nanoparticles covalently bonded to negatively charged functionalized graphene sheets. A preferred example includes Al fuel nanoparticles and Bi2O3 nanoparticles. A preferred method of formation mixes a solution of positively charged fuel nanoparticles, positively charged oxidizer nanoparticles, and negatively charged functionalized graphene sheets having functional groups to bond with the positively charged fuel nanoparticles and positively charged oxidizer nanoparticles. Self-assembly of the energetic nanocomposite is permitted over a predetermined time via the attraction and aggregation of the positively charged fuel nanoparticles positively charged oxidizer nanoparticles and negatively charged functionalized graphene sheets. Additional methods and nanocomposites include unfunctionalized graphene sheets, which can be commercial grade sheets.
    Type: Grant
    Filed: August 4, 2014
    Date of Patent: July 2, 2019
    Assignee: The Curators of the University of Missouri
    Inventors: Shubhra Gangopadhyay, Stephen W. Chung, Rajagopalan Thiruvengadathan, Clay Stephen Staley, Keshab Gangopadhyay, Kristofer Emile Raymond
  • Patent number: 10329528
    Abstract: The present invention is directed to methods for forming microparticles useful for cell seeding and for conjugating protein to the surface of the microparticles. The method comprises co-injecting an organic solution of PLGA or other polymer with an aqueous solution into a flow focusing tube.
    Type: Grant
    Filed: April 6, 2017
    Date of Patent: June 25, 2019
    Assignee: The Curators of the University of Missouri
    Inventors: Sutapa Barua, Chase Herman
  • Patent number: 10329576
    Abstract: The present invention is directed to a soybean plant with mutations in FAD2-1A and FAD2-1B. Moreover, the present invention is directed to seeds from said plants with altered ratios of monosaturated and polyunsaturated fats. In particular, the present invention is directed to plants where the plants exhibit elevated levels of oleic acid.
    Type: Grant
    Filed: April 14, 2015
    Date of Patent: June 25, 2019
    Assignees: The Curators of the University of Missouri, The United States of America, as Represented by the Secretary of Agriculture
    Inventors: Kristin Bilyeu, Grover Shannon, Jeong-Dong Lee, Anh Tung Pham
  • Patent number: 10330673
    Abstract: The invention is provides for a variety of fluorescence sensing compounds characterized generally as having a coumarin-3-aldehyde scaffold with a pendant aryl moiety at the C4-position of the scaffold. The further provides a method for detecting primary amines in a biological sample using said compounds. Especially, for the selective labeling and imaging of catecholamines in live and fixed secretory cells.
    Type: Grant
    Filed: March 21, 2014
    Date of Patent: June 25, 2019
    Assignee: The Curators of the University of Missouri
    Inventors: Timothy Glass, Kevin Gillis, Kenneth Hettie
  • Publication number: 20190184033
    Abstract: Synthetic nucleic acids encoding mini and microdystrophin genes comprising the membrane binding motifs or domains of the R10-R11-R12 region are provided. Also provided are vectors, host cells, and related methods of using the same to treat a subject suffering from Duchenne muscular dystrophy (DMD), Becker muscular dystrophy (BMD) or X-linked dilated cardiomyopathy (XLDC), or for ameliorating one or more adverse effects of DMD, BMD, or XLDC. Also provided are a fusion protein comprising a nNOS binding domain of dystrophin R16-R17 that is operably linked to a syntrophin PDZ domain and synthetic nucleic acids comprising the same that can be used to treat subjects with diseases characterized by loss of sarcolemmal neuronal nitric oxide synthase (nNOS) activity.
    Type: Application
    Filed: June 21, 2017
    Publication date: June 20, 2019
    Applicant: THE CURATORS OF THE UNIVERSITY OF MISSOURI
    Inventors: Dongsheng Duan, Yi Lai, Junling Zhao, Yongping Yue
  • Patent number: 10317400
    Abstract: A multicomponent nanomaterial AuNP(DTDTPA)(Ga), where DTDTPA is an amino-carboxylate ligand (diethylene triamine pentaacetic acid, DTPA) linked to the surface of the Au nanoparticle (NP) via dithiol (DT) linkage. Another embodiment is a multicomponent nanomaterial AuNP(DTDTPA)(Ga) with a biomolecule attached. In preferred embodiments, the Ga is Ga-67 or Ga-68. Preferred synthesis methods are conducted at room temperature.
    Type: Grant
    Filed: December 23, 2014
    Date of Patent: June 11, 2019
    Assignee: The Curators of the University of Missouri
    Inventors: Raghuraman Kannan, Ajit Zambre, Anandhi Upendran
  • Patent number: 10299887
    Abstract: The provision of dental restorations can be improved by generating a cold atmospheric plasma inside the mouth of the patient and then applying that cold atmospheric plasma onto a dental restoration site. The dental restoration site can be composed of either or both of dentin and enamel. Further, the provision of dental restorations can also be improved by introducing a dental adhesive onto a dental restoration site and treating it with a cold atmospheric plasma.
    Type: Grant
    Filed: April 23, 2010
    Date of Patent: May 28, 2019
    Assignees: Nanova, Inc., Curators of the University of Missouri Office of Intellectual Property Admin.
    Inventors: Qingsong Yu, Hao Li, Meng Chen
  • Patent number: 10301719
    Abstract: A method of forming a low-dielectric-constant amorphous hydrogenated boron carbide film on a substrate includes positioning the substrate within a plasma enhanced chemical vapor deposition (PECVD) chamber, providing a boron carbide precursor and introducing the boron carbide precursor into a carrier gas to form a carrier gas-precursor mixture. The method also includes introducing the carrier gas-precursor mixture into the PECVD chamber. The method also includes applying radio frequency power within the PECVD chamber to the carrier gas-precursor mixture to form one or more plasmas containing one or more species containing at least one of boron, carbon or hydrogen. The method also includes forming the low-dielectric-constant amorphous hydrogenated boron carbide film on the substrate within the PECVD chamber.
    Type: Grant
    Filed: April 6, 2016
    Date of Patent: May 28, 2019
    Assignees: The Curators of the University of Missouri, Intel Corporation
    Inventors: Michelle Paquette, Bradley Nordell, Anthony N. Caruso, Sean King
  • Patent number: 10295487
    Abstract: Devices and methods are provided for measuring temperatures and pHs of a sample in situ using NMR spectroscopy, and for sealing one or more ends of a capillary tube after a reference material has been added to the capillary tube, which is used in an in situ NMR temperature measurement device. A method for measuring a pH of a sample in situ using NMR spectroscopy includes providing an in situ NMR pH measurement device. This device includes a sample housing member configured to house a target sample, at least one pH sensor configured to exhibit an NMR spectral change due to a change in pH value of the target sample, and a pH sensor containment member configured to house the at least one pH sensor. The target sample is added to the sample housing member. NMR spectra are obtained to then determine the pH of the target sample.
    Type: Grant
    Filed: October 15, 2015
    Date of Patent: May 21, 2019
    Assignee: The Curators of the University of Missouri
    Inventors: Ming Huang, Lingyu Chi, Rex E. Gerald, II, Jie Huang, Annalise R. Pfaff, Klaus Woelk
  • Patent number: 10294489
    Abstract: A transgenic soybean plant or parts thereof, resistant to soybean cyst nematodes, transformed to express Glyma18g02570, Glyma18g02580, or Glyma18g02590, or a variant thereof. Also provided is a method of making such a plant. Also provided is an artificial DNA construct encoding Glyma18g02570, Glyma18g02580, or Glyma18g02590, or a variant thereof.
    Type: Grant
    Filed: March 18, 2014
    Date of Patent: May 21, 2019
    Assignees: BOARD OF TRUSTEES OF SOUTHERN ILLINOIS UNIVERSITY, THE CURATORS OF THE UNIVERSITY OF MISSOURI
    Inventors: Khalid Meksem, Shiming Liu, Pramod Kaitheri Kandoth, Melissa G. Mitchum, David Lightfoot
  • Patent number: 10294252
    Abstract: The present disclosure provides a new series of compounds exhibiting high fluorescence quantum yields in the solid state. In one embodiment, the compounds include a series of 2,3,4,5-tetraphenylgermoles with the same or different 1,1-substituents. In another embodiment, substituted germafluorenes, germa-fluoresceins/rhodamines, and germapins are described. These germanium heterocycles possess ideal photophysical and thermostability properties, which makes them excellent candidates for chemical or biological sensors, host materials for electroluminescent devices and solar cells, and emissive and for electron-transport layer components in organic light emitting diode devices.
    Type: Grant
    Filed: June 11, 2013
    Date of Patent: May 21, 2019
    Assignee: The Curators of the University of Missouri
    Inventors: Janet Braddock-Wilking, Teresa Lynn Bandrowsky, James Bryan Carroll, II
  • Publication number: 20190135838
    Abstract: The present invention relates to novel boron cluster compounds and their use as sodium channel blockers. The invention also provides methods for making and using the compounds.
    Type: Application
    Filed: January 3, 2019
    Publication date: May 9, 2019
    Applicant: The Curators of the University of Missouri
    Inventors: George R. Kracke, Yulia Sevryugina, Marion Frederick Hawthorne
  • Publication number: 20190128999
    Abstract: Microwave and millimeter wave imaging. An antenna array in communication with a signal source comprises a plurality of antennas by which a signal generated by the signal source is transmitted incident to an object located remotely from the antenna array and by which a signal reflected from the object is received by the antenna array. The signals transmitted by the antennas collectively have an effective electric field resembling a plane-wave within a target region in front of the antenna array. A plurality of detectors each connected to one of the antennas is configured to simultaneously receive the reflected signal and provide an output signal representative thereof. An image processor configured to execute an imaging algorithm generates a multi-dimensional profile representative of the object based on the output signals from the detectors.
    Type: Application
    Filed: October 25, 2018
    Publication date: May 2, 2019
    Applicant: The Curators of the University of Missouri
    Inventors: Matthew J. Horst, Reza Zoughi, Mohammad Tayeb Ghasr
  • Publication number: 20190132957
    Abstract: A method for producing a metal foil comprising depositing metal onto an oxidizable substrate to form a metal film on the substrate; oxidizing the substrate at an interface between the metal film and the substrate; and removing the metal film from the substrate to yield a metal foil. A method for forming a thin metal film comprising pre-polarizing a single-crystal Si substrate by application of a potential which is negative of a potential at which Si oxidizes, which pre-polarization occurs in the presence of metal ions to form metal growth nucleation sites on the substrate, followed by application of a potential at which both oxidation of Si and electrodeposition of the metal occur to grow the metal film and oxidize the Si to SiOx, which potential is more positive than the potential applied in the pre-polarization step.
    Type: Application
    Filed: November 1, 2018
    Publication date: May 2, 2019
    Applicant: The Curators of the University of Missouri
    Inventor: Jay A. Switzer
  • Publication number: 20190127775
    Abstract: Disclosed are devices and methods for preparing pre-metabolized compound libraries and for screening compound metabolites in a high throughput format. The devices and methods disclosed herein increase the chemical diversity of a chemical library prior to screening, and thereby enhance the number and value of hits identified in such chemical screening efforts.
    Type: Application
    Filed: January 10, 2017
    Publication date: May 2, 2019
    Applicant: CURATORS OF THE UNIVERSITY OF MISSOURI
    Inventor: William G. Gutheil
  • Publication number: 20190130077
    Abstract: Sensors arranged on a chair on which a subject is seated detect a physical characteristic of the subject during administration of a cognitive health assessment. An assessment processor coupled to the sensors executes computer-executable instructions causing the processor to determine a contemporaneous reaction corresponding to each of the questions as a function of the detected physical characteristic. And the subject is assigned a cognitive health assessment score based on the subject's answers and determined reactions.
    Type: Application
    Filed: November 1, 2017
    Publication date: May 2, 2019
    Applicant: The Curators of the University of Missouri
    Inventors: Debraj De, Sajal K. Das, Mignon Makos
  • Publication number: 20190127361
    Abstract: Certain compounds of formula I: I and salts including pharmaceutically acceptable salts thereof are disclosed. Also disclosed are pharmaceutical compositions comprising a compound of formula I, processes for preparing compounds of formula I, intermediates useful for preparing compounds of formula I and therapeutic methods using a compound of formula I.
    Type: Application
    Filed: June 16, 2017
    Publication date: May 2, 2019
    Applicants: Rutgers, The State University of New Jersey, The Curators of the University of Missouri
    Inventors: William J. Welsh, Raymond Birge, Vladyslav Kholodovych, Youyi Peng, Thomas Walter Comollo, Stanley G. Kimani, Kamlendra Singh
  • Patent number: 10273527
    Abstract: The present invention provides a new and improved oligonucleotide detection method based on the nanopore technology with a probe containing a complementary sequence to the target oligonucleotide and a terminal extension at the probe's 3? terminus, 5? terminus, or both termini. The improved nanopore sensor with the probe enables sensitive, selective, and direct detection, differentiation and quantification of target oligonucleotides such as miRNAs. The inventive detection method may also be employed as a non-invasive and cost-effective diagnostic method for cancer detection based on miRNA levels in the patient's blood sample.
    Type: Grant
    Filed: July 13, 2016
    Date of Patent: April 30, 2019
    Assignee: The Curators of the University of Missouri
    Inventors: Li-Qun Gu, Yong Wang, Kai Tian
  • Patent number: 10273522
    Abstract: An improved system and method is provided for detecting viable bacteria in a suspension sample. A sample of a suspension in which bacterial presence is suspected is collected from a source and a portion of the sample transferred to a microfluidic unit. A series of analysis signals at different frequencies are applied to the sample portion. An impedance is measured via a signal analyzer for the sample portion for each of the analysis signals to define an impedance data set. An initial bulk capacitance value is determined for a model circuit based on the impedance dataset. After a predetermined time period, a new bulk capacitance value is determined for on another portion of the sample. The difference between the new bulk capacitance and the initial bulk capacitance value is compared to a threshold value to determine if viable bacterial is present in the sample.
    Type: Grant
    Filed: December 6, 2013
    Date of Patent: April 30, 2019
    Assignees: The Curators of the University of Missouri, University of Notre Dame de Lac
    Inventors: Shramik Sengupta, Sachidevi Puttaswamy, Hsueh-Chia Chang
  • Patent number: 10274492
    Abstract: Disclosed herein are example embodiments of a transformative sensor apparatus that is capable of detecting and quantifying the presence of a substance of interest such as a specified bacteria within a sample via changes in impedance exhibited by a detection electrode array. In an example embodiment, sensitivity is improved by including a focusing electrode array in a rampdown channel to focus a concentration of the substance of interest into a detection region. The focusing electrodes include an opposing pair of electrodes in a rampdown orientation. The focusing electrode may also include tilted thin film finger electrodes extending from the rampdown electrodes. In another example embodiment, trapping electrodes are positioned to trap a concentration of the substance of interest onto the detection electrode array.
    Type: Grant
    Filed: April 8, 2016
    Date of Patent: April 30, 2019
    Assignee: THE CURATORS OF THE UNIVERSITY OF MISSOURI
    Inventors: Mahmoud Almasri, Shibajyoti Ghosh Dastider, Shuping Zhang, Majed El Dweik, Nuh Sadi Yuksek, Ibrahem Jasim, Jiayu Liu