Patents Assigned to The Curators of the University of Missouri
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Patent number: 10537089Abstract: A system and method for thermally exchanging heat between waste air being expelled from a poultry barn and fresh outside/outdoor ambient air being introduced into the poultry barn.Type: GrantFiled: November 16, 2016Date of Patent: January 21, 2020Assignees: The Curators of the University of Missouri, Heartland Farm Energy LLCInventors: Tingsheng Xu, Yunsheng Xu
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Publication number: 20200018544Abstract: In general, the present invention is directed to processes for separating a vapor comprising a first component and a second component using high-pressure density-driven separation. The present invention further relates to various processes for the capture of carbon dioxide. In particular, various processes of the present invention relate to the separation of carbon dioxide from flue gas of combustion processes. The invention also applies to upgrading fuel gases containing carbon dioxide. The invention also applies to separation of hydrogen from fuel gas vapor solutions.Type: ApplicationFiled: February 14, 2018Publication date: January 16, 2020Applicant: The Curators of the University of MissouriInventors: William Jacoby, Reza Espanani
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Publication number: 20200008623Abstract: A drinking container system with multiple temperature zones, wherein the container system includes a main body having a sidewall and a bottom that define a phase change material (PCM) module receptacle, and a phase change material (PCM) module having a sidewall that defines a beverage chamber. The PCM module is disposable within the PCM module receptacle such that a beverage egress flow path is defined between the main body sidewall and the PCM module sidewall. The flow path formed in the container can make the beverage achieve the desired drinking temperature. The PCM module sidewall is at least partially filled with a phase change material and is structured and operable to provide a plurality temperature zones within the beverage chamber. Each temperature zone is operable to maintain a temperature of a respective portion of a liquid disposed within the beverage chamber within a respective temperature range.Type: ApplicationFiled: September 20, 2018Publication date: January 9, 2020Applicant: The Curators of the University of MissouriInventors: Hongbin Ma, Michael Merwin, Hao Bai, Robert Riegler, Christopher Vincent, Susan Liu
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Patent number: 10526651Abstract: Disclosed are compositions and methods for modulating expression of genes that function at the step of ER to Golgi trafficking. Compounds that modulate expression of these genes or activity of the encoded proteins can be used to inhibit alpha-synuclein mediated toxicity and used to treat or prevent synucleinopathies such as Parkinson's disease. Also disclosed are methods of identifying inhibitors of alpha-synuclein mediated toxicity.Type: GrantFiled: January 18, 2013Date of Patent: January 7, 2020Assignees: Whitehead Institute for Biomedical Research, The Curators of the University of MissouriInventors: Susan L. Lindquist, Aaron D. Gitler, Anil Cashikar, Antony A. Cooper, Cole M. Haynes
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Patent number: 10512394Abstract: The present invention discloses a new and improved endoscopic-enabled mouth gag for routine ENT procedures, such as adenoidectomy and nasopharyngeal biopsy. The invention modifies the existing mouth gag, provides a stable and adjustable placement for an endoscopic device potentially employed during an ENT procedure, and is to replace the outdated surgical method where the surgical field is visualized indirectly via a handheld mirror (with or without the preexisting mouth gag). The inventive endoscopic-enabled mouth gag not only provides enhanced visualization of the surgical field for a clinician, assistants, and trainees, but also enables a clinician to perform the procedure bimanually (with both hands).Type: GrantFiled: September 26, 2014Date of Patent: December 24, 2019Assignee: The Curators of the University of MissouriInventors: Eliav Gov-Ari, Alexander Madinger
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Patent number: 10516170Abstract: A catalyst obtained by first preparing a cermet material with the general formula ABOx, wherein A is selected from the group consisting of Co, Cu, Ni, Ti, and combinations thereof, wherein B is selected from the group consisting of Mo, W, Ce, and combinations thereof, wherein A and B are different elements, and wherein x is a nonzero number ranging from 3 to 7 and represents the moles of O. Next, the cermet is activated in a reducing atmosphere to yield metal particles dispersed within and/or on the cermet.Type: GrantFiled: April 17, 2017Date of Patent: December 24, 2019Assignee: The Curators of the University of MissouriInventor: Fatih Dogan
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Patent number: 10490679Abstract: Provided are nanograting structures and methods of fabrication thereof that allow for stable, robust gratings and nanostructure embedded gratings that enhance electromagnetic field, fluorescence, and photothermal coupling through surface plasmon or, photonic resonance. The gratings produced exhibit long term stability of the grating structure and improved shelf life without degradation of the properties such as fluorescence enhancement. Embodiments of the invention build nanograting structures layer-by-layer to optimize structural and optical properties and to enhance durability.Type: GrantFiled: October 12, 2018Date of Patent: November 26, 2019Assignee: The Curators of the University of MissouriInventors: Shubhra Gangopadhyay, Sangho Bok, Samiullah Pathan, Cherian Joseph Mathai, Sagnik Basuray, Keshab Gangopadhyay, Biyan Chen, Sheila Grant, Aaron Wood
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Patent number: 10485584Abstract: Media, kits, and methods for cultivation of mammalian embryos from fertilized oocyte stage to blastocyst stage in the presence of N-benzyl-3,5-dicarbethoxy-4-phenyl-1,4-dihydropyridine. The use of this supplement improves the early embryonic development, in particular the quality of zygotes and the blastocyst formation. The supplemented media can be used with pigs, humans, or other mammals N-benzyl-3,5-dicarbethoxy-4-phenyl-1,4-dihydropyridine may be added to known media, and used for with vitro fertilization methods.Type: GrantFiled: June 8, 2017Date of Patent: November 26, 2019Assignees: Lekarska fakulta v Plzni, Univerzita Karlova (Faculty of Medicine in Pilsen, Charles University), The Curators of the University of Missouri, Chonbuk National University, Division of Biotechnology, College of Environmental and Bioresources, Ceska zemedelska univerzita v Praze, Institute of Animal ScienceInventors: Jan Nevoral, Young-Joo Yi, Katerina Zamostna-Adamkova, Jaroslav Petr, Peter Sutovsky, Milena Kralickova
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Patent number: 10472630Abstract: The invention provides methods and compositions for treatment of spinal muscular atrophy (SMA). In one aspect of the invention, a series of compositions comprising an antisense oligonucleotide targeting the Element 1 site on the SMN2 pre-mRNA and a Morpholino backbone is disclosed. In another aspect of the invention, a method of treating SMA patients by modulating the splicing of SMN2 pre-mRNA to increase the amount of full-length SMN is disclosed. Certain embodiments of the inventive method comprise administering an E1-targeting antisense oligonucleotide, such as Morpholino based antisense oligonucleotide, to a SMA subject.Type: GrantFiled: December 29, 2017Date of Patent: November 12, 2019Assignee: The Curators of the University of MissouriInventors: Christian Lorson, Erkan Osman
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Publication number: 20190341836Abstract: An energy harvesting device for generating electrical power from low-frequency oscillations includes a high-frequency cantilever, a plurality of low-frequency cantilevers each configured to contact the high-frequency cantilever in response to environmental vibrations having a frequency within a near-resonance frequency range associated with said low-frequency cantilever, an a generator that produces electrical power in response to contact between at least one of the plurality of low-frequency cantilevers and the high-frequency cantilever. The energy harvesting device may also include an impact mass coupled to a free end of each of the plurality of low-frequency cantilevers. Some aspects may include a common base to which the high-frequency cantilever and the plurality of low-frequency cantilevers are coupled. Other aspects may include the generator comprising one or more of an induction coil and magnet, a variable distance capacitor, or a piezo-electric material.Type: ApplicationFiled: July 16, 2019Publication date: November 7, 2019Applicant: The Curators of the University of MissouriInventors: Nuh Sadi Yuksek, Mahmoud Almasri
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Patent number: 10469076Abstract: Combining the functionality of sleep transistors with logic devices in power-gating circuits by utilizing fully depleted silicon-on-insulator (FDSOI) transistors. In an embodiment, a back gate of a FDSOI transistor controls the threshold voltage to eliminate the need for standalone sleep transistors.Type: GrantFiled: November 17, 2017Date of Patent: November 5, 2019Assignee: The Curators of the University of MissouriInventors: Masud H. Chowdhury, Emesahw Ashenafi
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Patent number: 10465258Abstract: A process for manufacturing an iron-based alloy comprising forming targeted fine oxide and/or carbide dispersoids in a melt, and sequentially precipitating transition-metal nitrides on the dispersoids for heterogeneous nucleation of equiaxed grains. An iron-based cast alloy having a highly equiaxed fine grain structure.Type: GrantFiled: April 18, 2016Date of Patent: November 5, 2019Assignee: The Curators of the University of MissouriInventors: Simon Lekakh, Von Richards, Ronald O'Malley, Jun Ge
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Patent number: 10467400Abstract: Method, system and media for authenticating a subject as a user. Embodiments generate visual stories specific to the user and for which the subject must select the corresponding images from among a plurality of decoy images. Gaze tracking can be used to determine which images the user has selected without allowing an observer to learn which images have been selected. Images for the visual story can be retrieved from the user's social networking profile, and corresponding text storied generated to indicate which images should be selected. Multiple security levels are possible by varying the number of story images and decoy images.Type: GrantFiled: October 16, 2015Date of Patent: November 5, 2019Assignee: The Curators of the University of MissouriInventors: Chi-Ren Shyu, Hongfei Cao, Matthew Klaric, Jeffrey Uhlmann
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Patent number: 10456198Abstract: Systems and methods for the controlled delivery of laser light to target tissue using an improved waveguide. A waveguide controls transmission of wave energy to a target based on direct contact with the target. The waveguide comprises a propagation medium, a cladding causing the electromagnetic wave to be internally reflected in the medium, and an interface formed in the cladding and configured for direct contact with the target. A portion of the laser light penetrates through the cladding at the interface and propagates into the target while a portion internally reflects within the propagation medium.Type: GrantFiled: June 4, 2015Date of Patent: October 29, 2019Assignee: The Curators of the University of MissouriInventors: Paul James Douglas Whiteside, Benjamin Samuel Goldschmidt, John A. Viator, Randy D. Curry, Nicholas J. Golda
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Patent number: 10451479Abstract: Increased sensitivity of spectrometers through reducing noise in independent voltage signals via a differential voltage analyzer utilizing a reference wavelength from a wavelength region in which the optical absorption of the sample is negligible. In an embodiment, a grating permits selection of a reference wavelength. In another embodiment, filters permit selection of a reference wavelength. In yet another embodiment, both a grating and a filter permit selection of a reference wavelength. In an aspect, the differential voltage analyzer reduces noise by minimizing a differential voltage between the independent voltage signals and the reference voltage signal by adjusting the value of a cancellation coefficient.Type: GrantFiled: November 9, 2016Date of Patent: October 22, 2019Assignee: The Curators of the University of MissouriInventor: Zhi Xu
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Patent number: 10441588Abstract: The present disclosure relates to chemical compounds, methods for their discovery, and their therapeutic and research use. In particular, the present disclosure provides compounds as therapeutic agents against bacterial infections (e.g., biofilms). The present disclosure also provides topical formulations for use in methods for treating bacterial infections.Type: GrantFiled: September 21, 2017Date of Patent: October 15, 2019Assignees: Curators of the University of Missouri, Nanova, Inc.Inventors: Hongmin Sun, David W. Anderson, Feng Qi
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Patent number: 10447135Abstract: An energy harvesting device for generating electrical power from low-frequency oscillations includes a high-frequency cantilever, a plurality of low-frequency cantilevers each configured to contact the high-frequency cantilever in response to environmental vibrations having a frequency within a near-resonance frequency range associated with said low-frequency cantilever, an a generator that produces electrical power in response to contact between at least one of the plurality of low-frequency cantilevers and the high-frequency cantilever. The energy harvesting device may also include an impact mass coupled to a free end of each of the plurality of low-frequency cantilevers. Some aspects may include a common base to which the high-frequency cantilever and the plurality of low-frequency cantilevers are coupled. Other aspects may include the generator comprising one or more of an induction coil and magnet, a variable distance capacitor, or a piezo-electric material.Type: GrantFiled: September 28, 2016Date of Patent: October 15, 2019Assignee: The Curators of the University of MissouriInventors: Nuh Sadi Yuksek, Mahmoud Almasri
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Patent number: 10434498Abstract: Embodiments relate to a cerium-containing nano-coating composition, the composition including an amorphous matrix including one or more of cerium oxide, cerium hydroxide, and cerium phosphate; and crystalline regions including one or more of crystalline cerium oxide, crystalline cerium hydroxide, and crystalline cerium phosphate. The diameter of each crystalline region is less than about 50 nanometers.Type: GrantFiled: October 4, 2017Date of Patent: October 8, 2019Assignee: THE CURATORS OF THE UNIVERSITY OF MISSOURIInventors: Matthew J. O'Keefe, Carlos E. Castano Londono, William G. Fahrenholtz
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Patent number: 10434032Abstract: A tool for use in assisting soft tissue mobilization and bodily tissue amelioration, such as stimulation of superficial tissue, deep tissue mobilization, breaking up scar tissue, and soft tissue massaging, are described. The tool comprises a device for application to bodily tissue that includes a body having a substantially teardrop shape in a vertical section. In a longitudinal aspect, the body includes a first and a second portion. The first portion of the device corresponds at least in part to a substantially bulbous handle part of the teardrop shape of the vertical section and is adapted for ease of grasping and manipulation at the first end. The second portion of the device corresponds at least in part to a substantially tapered converging double-beveled linear edge of the teardrop shape of the vertical section and is adapted for facilitated application of the device to bodily tissue at the second end.Type: GrantFiled: December 15, 2015Date of Patent: October 8, 2019Assignee: The Curators of the University of MissouriInventors: Jaya Ghosh, Ellie Koehly, Yaw Sarpong, Roger de la Torre, Jonathon Buehler, Brett Hayes, Teresa Graff, Katherina Chen
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Patent number: 10426842Abstract: Provided are nanoparticle conjugates comprising a drug encapsulated in a gelatin nanoparticle the surface of which is functionalized with an antibody to which a siRNA is linked. Methods with the nanoconjugates for treating diseases are provided as well.Type: GrantFiled: July 14, 2016Date of Patent: October 1, 2019Assignee: The Curators of the University of MissouriInventors: Raghuraman Kannan, Srikar Raman, Anandhi Upendran, Dhananjay Suresh