Abstract: A prosthesis including a socket configured to receive a residual limb, a pylon attached to the socket, the pylon comprising at least one fin, and an artificial foot attached to an end portion of the pylon.
Type:
Grant
Filed:
May 2, 2018
Date of Patent:
June 2, 2020
Assignee:
THE FEINSTEIN INSTITUTES FOR MEDICAL RESEARCH
Abstract: Methods and systems are described for detecting the likelihood of patent ductus arteriosus (PDA) in an infant using electrocardiogram and photoplethysmographic pulse signals obtained from the upper body and foot of the infant.
Type:
Grant
Filed:
August 27, 2015
Date of Patent:
May 19, 2020
Assignees:
The Feinstein Institutes for Medical Research, Jerusalem College of Technology
Abstract: Methods of diagnosis and methods of treatment and prevention for autism spectrum disorder are provided using decoy antigens to maternal brain-reactive antibodies.
Type:
Grant
Filed:
September 30, 2016
Date of Patent:
May 19, 2020
Assignee:
The Feinstein Institutes for Medical Research
Inventors:
Betty A. Diamond, Simone Mader, Lior Brimberg, Peter Gregersen
Abstract: Methods are disclosed for treating a subject having a disease or disorder comprising stimulating a nerve of the subject with a corrective stimulus pattern derived from a disease-specific, condition-specific, endogenous mediator-specific or pharmacologic agent-specific neurogram in an amount and manner effective to treat the disease or disorder.
Type:
Application
Filed:
November 26, 2019
Publication date:
April 2, 2020
Applicant:
THE FEINSTEIN INSTITUTES FOR MEDICAL RESEARCH
Abstract: A method of inhibiting the release of a proinflammatory cytokine in a cell is disclosed. The method comprises treating the cell with a cholinergic agonist. The method is useful in patients at risk for, or suffering from, a condition mediated by an inflammatory cytokine cascade, for example endotoxic shock. The cholinergic agonist treatment can be effected by stimulation of an efferent vagus nerve fiber, or the entire vagus nerve.
Type:
Grant
Filed:
December 23, 2018
Date of Patent:
February 18, 2020
Assignee:
The Feinstein Institutes for Medical Research
Abstract: The subject matter of the present disclosure generally relates to techniques for neuromodulation of tissue that include applying energy (e.g., electromagnetic energy) into the target tissue to cause altered activity of a neuron in the tissue. In certain embodiments, the altered activity causes a change in one or molecules in the tissue or blood.
Type:
Application
Filed:
October 31, 2017
Publication date:
February 13, 2020
Applicant:
THE FEINSTEIN INSTITUTE FOR MEDICAL RESEARCH
Inventors:
Kevin J. Tracey, Sangeeta S. Chavan, Chad E. Bouton
Abstract: Methods of treating sepsis or endotoxemia in a subject comprising administering to the subject an amount of an antagonist of a Panx1 hemichannel protein or an amount of an antagonist of a Cx43 hemichannel protein.
Type:
Grant
Filed:
August 3, 2016
Date of Patent:
February 4, 2020
Assignee:
The Feinstein Institutes for Medical Research
Inventors:
Haichao Wang, Wei Li, Kevin J. Tracey, Ping Wang
Abstract: Methods are disclosed for treating a subject having a disease or disorder comprising stimulating a nerve of the subject with a corrective stimulus pattern derived from a disease-specific, condition-specific, endogenous mediator-specific or pharmacologic agent-specific neurogram in an amount and manner effective to treat the disease or disorder.
Type:
Grant
Filed:
August 15, 2017
Date of Patent:
December 17, 2019
Assignee:
The Feinstein Institutes for Medical Research
Abstract: Methods are disclosed for treating inflammation and sepsis and for promoting thermoregulation by activating neurons expressing TRPA1 in the vagus nerve.
Type:
Application
Filed:
February 13, 2019
Publication date:
August 22, 2019
Applicant:
THE FEINSTEIN INSTITUTE FOR MEDICAL RESEARCH
Inventors:
Kevin J. Tracey, Sangeeta S. Chavan, Harold A. Silverman
Abstract: Methods and systems are described for detecting the likelihood of an aortic coarctation in an infant using photoplethysmographic pulse signals obtained from the hand and foot of the infant.
Type:
Grant
Filed:
March 12, 2015
Date of Patent:
August 13, 2019
Assignees:
The Feinstein Institute for Medical Research, Jerusalem College of Technology
Abstract: Systems, devices and methods are disclosed for collecting laboratory specimens from laboratory specimen boxes once a specimen has been placed inside a box.
Type:
Application
Filed:
October 15, 2018
Publication date:
April 18, 2019
Applicant:
THE FEINSTEIN INSTITUTE FOR MEDICAL RESEARCH
Inventors:
Mike Eller, Ross Schneidman, Chris Zavala, Brian Torpey
Abstract: A fastener includes an elongate fastener body defining a longitudinal axis substantially central thereto. The fastener body has a continuous outer fastener shell laterally surrounding the longitudinal axis. The fastener shell longitudinally separates a fastener head end and a fastener tip end. A tool-engaging feature is provided on the fastener head end. A plurality of teeth are located on the fastener shell and extend substantially laterally outward from the longitudinally axis. The fastener shell is comprised of at least one undulate face and at least one substantially flat face. The plurality of teeth are located only on the undulate faces. Each tooth is longitudinally separated from adjacent teeth along an undulate face. A method of installing the fastener into a receiving structure is also described.
Type:
Grant
Filed:
January 2, 2014
Date of Patent:
March 26, 2019
Assignees:
THE FEINSTEIN INSTITUTE FOR MEDICAL RESEARCH, THE GENERAL HOSPITAL CORPORATION DBA MASSACHUSETTS GENERAL HOSPITAL
Abstract: Methods of diagnosis and methods of treatment and prevention for autism spectrum disorder are provided using decoy antigens to maternal brain-reactive antibodies.
Type:
Application
Filed:
September 30, 2016
Publication date:
February 7, 2019
Applicant:
THE FEINSTEIN INSTITUTE FOR MEDICAL RESEARCH
Inventors:
Betty A. Diamond, Simone Mader, Lior Brimberg
Abstract: Methods are disclosed for preventing systemic infection or controlling metastases or providing a vaccine adjuvant in a subject, the methods comprising stimulating one or more peripheral nerves innervating one or more lymph nodes of the subject.
Type:
Application
Filed:
February 8, 2017
Publication date:
February 7, 2019
Applicant:
THE FEINSTEIN INSTITUTE FOR MEDICAL RESEARCH
Inventors:
Sangeeta S. Chavan, William M. Hanes, Kevin J. Tracey
Abstract: A method of treating a sterile inflammatory condition in a subject using an isolated dermcidin peptide or an active fragment thereof of or an active analog thereof is provided. Also provided is a method of inhibiting organ transplantation-associated is chemia/reperfusion and/or organ transplantation-associated inflammation.
Type:
Application
Filed:
October 21, 2016
Publication date:
January 31, 2019
Applicant:
THE FEINSTEIN INSTITUTE FOR MEDICAL RESEARCH