Patents Assigned to The General Hospital Corporation dba Massachusetts General Hospital
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Patent number: 10238440Abstract: A fastener includes an elongate fastener body defining a longitudinal axis substantially central thereto. The fastener body has a continuous outer fastener shell laterally surrounding the longitudinal axis. The fastener shell longitudinally separates a fastener head end and a fastener tip end. A tool-engaging feature is provided on the fastener head end. A plurality of teeth are located on the fastener shell and extend substantially laterally outward from the longitudinally axis. The fastener shell is comprised of at least one undulate face and at least one substantially flat face. The plurality of teeth are located only on the undulate faces. Each tooth is longitudinally separated from adjacent teeth along an undulate face. A method of installing the fastener into a receiving structure is also described.Type: GrantFiled: January 2, 2014Date of Patent: March 26, 2019Assignees: THE FEINSTEIN INSTITUTE FOR MEDICAL RESEARCH, THE GENERAL HOSPITAL CORPORATION DBA MASSACHUSETTS GENERAL HOSPITALInventors: Stanley E Asnis, Peter D Asnis
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Publication number: 20170100433Abstract: This invention provides ex vivo methods for making modified natural killer cell compositions having overall anti-fugetactic properties for the effective and efficient treatment of tumors or cancers in a patient, and compositions and use thereof.Type: ApplicationFiled: September 16, 2016Publication date: April 13, 2017Applicant: THE GENERAL HOSPITAL CORPORATION DBA MASSACHUSETTS GENERAL HOSPITALInventors: Mark C. POZNANSKY, Fabrizio VIANELLO
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Publication number: 20160193311Abstract: This invention provides methods and compositions for modulating movement of eukaryotic cells with migratory capacity. More specifically, the invention provides anti-fugetactic agents and methods for the use thereof in enhancing an immune response.Type: ApplicationFiled: November 9, 2015Publication date: July 7, 2016Applicant: The General Hospital Corporation dba Massachusetts General HospitalInventors: MARK C. POZNANSKY, JOHN T. POTTS, JR., FABRIZIO VIANELLO, NATALIA PAPETA
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Publication number: 20160193312Abstract: This invention provides methods and compositions for modulating movement of eukaryotic cells with migratory capacity. More specifically, the invention provides anti-fugetactic agents and methods for the use thereof in enhancing an immune response.Type: ApplicationFiled: November 9, 2015Publication date: July 7, 2016Applicant: The General Hospital Corporation dba Massachusetts General HospitalInventors: MARK C. POZNANSKY, JOHN T. POTTS, JR., FABRIZIO VIANELLO, NATALIA PAPETA
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Publication number: 20160184257Abstract: This invention provides methods and compositions for modulating movement of eukaryotic cells with migratory capacity. More specifically, the invention provides anti-fugetactic agents and methods for the use thereof in enhancing an immune response.Type: ApplicationFiled: November 9, 2015Publication date: June 30, 2016Applicant: The General Hospital Corporation dba Massachusetts General HospitalInventors: MARK C. POZNANSKY, JOHN T. POTTS, JR., FABRIZIO VIANELLO, NATALIA PAPETA
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Publication number: 20160166538Abstract: This invention provides methods and compositions for modulating movement of eukaryotic cells with migratory capacity. More specifically, the invention provides anti-fugetactic agents and methods for the use thereof in enhancing an immune response.Type: ApplicationFiled: November 9, 2015Publication date: June 16, 2016Applicant: The General Hospital Corporation dba Massachusetts General HospitalInventors: MARK C. POZNANSKY, JOHN T. POTTS, JR., FABRIZIO VIANELLO, NATALIA PAPETA
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Publication number: 20160166537Abstract: This invention provides methods and compositions for modulating movement of eukaryotic cells with migratory capacity. More specifically, the invention provides antifugetactic agents and methods for the use thereof in enhancing an immune response.Type: ApplicationFiled: November 9, 2015Publication date: June 16, 2016Applicant: The General Hospital Corporation dba Massachusetts General HospitalInventors: MARK C. POZNANSKY, JOHN T. POTTS, Jr., FABRIZIO VIANELLO, NATALIA PAPETA
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Publication number: 20160128976Abstract: This invention provides methods and compositions for modulating movement of eukaryotic cells with migratory capacity. More specifically, the invention provides anti-fugetactic agents and methods for the use thereof in enhancing an immune response.Type: ApplicationFiled: November 9, 2015Publication date: May 12, 2016Applicant: The General Hospital Corporation dba Massachusetts General HospitalInventors: MARK C. POZNANSKY, JOHN T. POTTS, Jr., FABRIZIO VIANELLO, NATALIA PAPETA
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Publication number: 20160128975Abstract: This invention provides methods and compositions for modulating movement of eukaryotic cells with migratory capacity. More specifically, the invention provides anti-fugetactic agents and methods for the use thereof in enhancing an immune response.Type: ApplicationFiled: November 9, 2015Publication date: May 12, 2016Applicant: The General Hospital Corporation dba Massachusetts General HospitalInventors: Mark C. POZNANSKY, John T. POTTS, JR., Fabrizio VIANELLO, Natalia PAPETA
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Publication number: 20140194937Abstract: A fastener includes an elongate fastener body defining a longitudinal axis substantially central thereto. The fastener body has a continuous outer fastener shell laterally surrounding the longitudinal axis. The fastener shell longitudinally separates a fastener head end and a fastener tip end. A tool-engaging feature is provided on the fastener head end. A plurality of teeth are located on the fastener shell and extend substantially laterally outward from the longitudinally axis. The fastener shell is comprised of at least one undulate face and at least one substantially flat face. The plurality of teeth are located only on the undulate faces. Each tooth is longitudinally separated from adjacent teeth along an undulate face. A method of installing the fastener into a receiving structure is also described.Type: ApplicationFiled: January 2, 2014Publication date: July 10, 2014Applicants: The General Hospital Corporation dba Massachusetts General Hospital, THE FEINSTEIN INSTITUTE FOR MEDICAL RESEARCHInventors: Stanley E. Asnis, Peter D. Asnis
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Publication number: 20120215321Abstract: The present invention relates to methods for making oxidation resistant medical devices that comprise polymeric materials, for example, ultra-high molecular weight polyethylene (UHMWPE). The invention also provides methods of making antioxidant-doped medical implants, for example, doping of medical devices containing cross-linked UHMWPE with vitamin E by diffusion and materials used therein.Type: ApplicationFiled: April 23, 2012Publication date: August 23, 2012Applicants: Cambridge Polymer Group, Inc., The General Hospital Corporation dba Massachusetts General HospitalInventors: Orhun K. Muratoglu, Stephen H. Spiegelberg
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Publication number: 20100082101Abstract: The present invention relates to methods for making highly crystalline polymeric material, for example, highly crystalline cross-linked and not cross-linked ultra-high molecular weight polyethylene (UHMWPE). The invention also provides methods of making additive-doped highly crystalline polymeric material using high pressure and high temperature crystallization processes, medical implants made thereof, and materials used therein.Type: ApplicationFiled: August 18, 2006Publication date: April 1, 2010Applicant: The General Hospital Corporation dba Massachusetts General HospitalInventors: Orhun K. Muratoglu, Ebru Oral
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Publication number: 20090210066Abstract: There is disclosed a total knee replacement prosthesis, which can substitute the function of an anterior and/or a posterior cruciate ligament. A femoral component containing two intercondylar surfaces and an intercondylar region, a tibial component having a tibial platform and a bearing component, and a protrusion from the bearing component also are disclosed.Type: ApplicationFiled: January 21, 2005Publication date: August 20, 2009Applicant: The General Hospital Corporation dba Massachusetts General HospitalInventor: Murali Jasty
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Publication number: 20080262120Abstract: The present invention provides partial and complete shielding approaches to alter the cross-linking characteristics of irradiated polymers, such as polyethylene. Irradiated polymers and fabricated articles, such as medical prosteses, comprising irradiated polymers also are provided.Type: ApplicationFiled: April 29, 2008Publication date: October 23, 2008Applicant: The General Hospital Corporation dba Massachusetts General HospitalInventor: Orhun K. MURATOGLU
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Publication number: 20080215142Abstract: The present invention relates to methods for making cross-linked, oxidatively stable, and highly crystalline polymeric materials. The invention also provides methods of treating irradiation-cross-linked antioxidant-containing polymers and materials used therewith.Type: ApplicationFiled: March 3, 2008Publication date: September 4, 2008Applicants: The General Hospital Corporation dba Massachusetts General Hospital, Cambridge Polymer Group, Inc.Inventors: Orhun K. Muratoglu, Stephen H. Spiegelberg
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Publication number: 20080214692Abstract: The present invention relates to methods for making oxidation resistant homogenized polymeric materials and medical implants that comprise polymeric materials, for example, ultra-high molecular weight polyethylene (UHMWPE). The invention also provides methods of making antioxidant-doped medical implants, for example, doping of medical devices containing, cross-linked UHMWPE with vitamin E by diffusion and annealing the antioxidant doped UHMWPE in a super critical fluid, and materials used therein.Type: ApplicationFiled: August 18, 2006Publication date: September 4, 2008Applicant: The General Hospital Corporation dba Massachusetts General HospitalInventors: Orhun K. Muratoglu, Ebru Oral
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Publication number: 20080090934Abstract: The present invention relates to methods for making oxidation resistant medical devices that comprise polymeric materials, for example, ultra-high molecular weight polyethylene (UHMWPE). The invention also provides methods of making antioxidant-doped medical implants, for example, doping of medical devices containing cross-linked UHMWPE with vitamin E by diffusion, post-doping annealing, and materials used therein.Type: ApplicationFiled: November 30, 2007Publication date: April 17, 2008Applicants: The General Hospital Corporation dba Massachusetts General Hospital, Cambridge Polymer Group, Inc.Inventors: Orhun Muratoglu, Stephen Spiegelberg
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Publication number: 20070275030Abstract: The invention relates to cross-link-resistant injectable hydrogel formulations and methods of partially or practically wholly inhibiting injectable hydrogel formulations from cross-linking, for example, during irradiation, using anti-cross-linking agents, which facilitates injectability of the hydrogel formulation. The invention also relates to methods of making the cross-link-resistant, for example, irradiation cross-link resistant, injectable hydrogel formulations, and methods of administering the same in treating a subject in need.Type: ApplicationFiled: May 25, 2007Publication date: November 29, 2007Applicant: The General Hospital Corporation dba Massachusetts General HospitalInventors: Orhun K. MURATOGLU, Ebru Oral, Hatice Bodugoz-Senturk
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Publication number: 20070267030Abstract: The present invention relates to methods for making highly crystalline polymeric material, for example, highly crystalline cross-linked and not cross-linked ultra-high molecular weight polyethylene (UHMWPE). The invention also provides methods of making additive-doped highly crystalline polymeric material using high pressure and high temperature crystallization processes, medical implants made thereof, and materials used therein.Type: ApplicationFiled: April 24, 2007Publication date: November 22, 2007Applicant: The General Hospital Corporation dba Massachusetts General HospitalInventors: Orhun MURATOGLU, Ebru Oral
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Publication number: 20070114702Abstract: The present invention relates to methods for making oxidation resistant medical devices that comprise polymeric materials, for example, ultra-high molecular weight polyethylene (UHMWPE). The invention also provides methods of making antioxidant-doped medical implants, for example, doping of medical devices containing cross-linked UHMWPE with vitamin E by diffusion and materials used therein.Type: ApplicationFiled: November 29, 2006Publication date: May 24, 2007Applicants: The General Hospital Corporation dba Massachusetts General Hospital, Cambridge Polymer Group, Inc.Inventors: Orhun MURATOGLU, Stephen Spiegelberg