Patents Assigned to The Governing Council of the University of Toronto
  • Patent number: 10435412
    Abstract: The present invention relates to a family of chromenopyrazole derivatives of formula (I): which have the ability to modulate the receptor of the cannabinoid family GPR55, whereby the invention also relates to the use of these compounds for the manufacture of a medicament for the treatment of diseases in which the GPR55 receptor has a physiological role such as diabetes, Parkinson's disease, multiple sclerosis, neuropathic pain, osteoporosis and cancers such as cholangiocarcinoma, breast cancer, ovarian and prostate cancer, glioblastoma, and cutaneous carcinoma.
    Type: Grant
    Filed: April 27, 2016
    Date of Patent: October 8, 2019
    Assignees: THE GOVERNING COUNCIL OF THE UNIVERSITY OF TORONTO, CONSEJO SUPERIOR DE INVESTIGACIONES CIENTIFICAS (CSIC)
    Inventors: Nadine Jagerovic, Paula Morales Lazaro, Ruth Ross, Lauren Whyte
  • Patent number: 10435461
    Abstract: The present invention addresses a need for improved treatments for filovirus infections. This invention provides an isolated humanized anti-filovirus glycoprotein pre-fusion core antibody comprising a framework region having a sequence of 95% or greater identity to a human antibody framework region. Also provided is a method of treating and/or inhibiting a filovirus infection in a subject comprising administering to the subject an amount of any of the antibodies described herein, or an amount of an antigen-binding fragment thereof. Also provided is composition comprising any of the antibodies described herein, or or an amount of an antigen-binding fragment thereof. In an embodiment, the composition comprises a pharmaceutically acceptably carrier.
    Type: Grant
    Filed: August 6, 2015
    Date of Patent: October 8, 2019
    Assignees: Albert Einstein College of Medicine, The Governing Council of the University of Toronto, The Government of the United States as Represented by the Secretary of the Army
    Inventors: Jonathan R. Lai, Jayne F. Koellhoffer, Julia Frei, Kartik Chandran, Sachdev Sidhu, Gang Chen, John M. Dye, Samantha Zak
  • Patent number: 10416385
    Abstract: In an example, a system includes a grating coupled laser and a photonic integrated circuit. The grating coupled laser includes a first waveguide and a transmit grating coupler optically coupled to the first waveguide. The photonic integrated circuit includes a second waveguide and a receive grating coupler optically coupled to the second waveguide. The second grating coupler may include a negative angle grating coupler.
    Type: Grant
    Filed: May 11, 2018
    Date of Patent: September 17, 2019
    Assignees: FINISAR CORPORATION, THE GOVERNING COUNCIL OF THE UNIVERSITY OF TORONTO
    Inventors: Jared Carl Mikkelsen, Joyce Kai See Poon, Daniel Mahgerefteh
  • Patent number: 10400469
    Abstract: A building structure having at least one storey including at least one column; at least one brace attached at one end to one side of at least one of the columns and at a second end to a fixed foundation surface; the brace attached to the at least one column at an incline; the at least one brace having a first portion and a second portion; wherein the at least one brace has a first in-use configuration in which the first portion is freely moveable with respect to the second portion such that a gap is formed in the brace preventing the transmission of force axially along the brace by preventing tensional forces from travelling axially along the brace, and a second in-use configuration in which the gap is closed by the first portion and the second portion being in contact to permit the transmission of forces axially along the brace; and wherein the second in-use configuration allows compressive forces to be transmitted along the brace such that the brace is activated when sufficient deformation occurs in the col
    Type: Grant
    Filed: May 20, 2018
    Date of Patent: September 3, 2019
    Assignee: The Governing Council of the University of Toronto
    Inventors: Hossein Agha Beigi, Constantin Christopoulos, Timothy John Sullivan
  • Patent number: 10385084
    Abstract: The application describes catalytic materials for hydrogenation or asymmetric hydrogenation. In particular, the application describes iron(II) complexes containing tridentate diphosphine PNP ligands useful for catalytic hydrogenation.
    Type: Grant
    Filed: January 8, 2015
    Date of Patent: August 20, 2019
    Assignee: THE GOVERNING COUNCIL OF THE UNIVERSITY OF TORONTO
    Inventors: Robert H. Morris, Paraskevi Olympia Lagaditis, Jessica Sonnenberg
  • Patent number: 10385099
    Abstract: Macrocyclization of amino acids or linear peptides upon reaction with amphoteric amino aldehydes and isocyanides is provided.
    Type: Grant
    Filed: December 8, 2015
    Date of Patent: August 20, 2019
    Assignee: THE GOVERNING COUNCIL OF THE UNIVERSITY OF TORONTO
    Inventors: Andrei Yudin, Ryan Hili
  • Patent number: 10377780
    Abstract: The present invention relates to novel compounds, compositions containing same and methods for inhibiting STAT3 and/or STAT5 activity or for the treatment of a STAT3 or STAT5-dependent cancer using said compounds; or a pharmaceutically acceptable salt, solvate or prodrug thereof.
    Type: Grant
    Filed: March 30, 2017
    Date of Patent: August 13, 2019
    Assignees: The Governing Council of the University of Toronto, UTI Limited Partnership, Indiana University Research and Technology Corporation
    Inventors: Patrick Thomas Gunning, Sina Haftchenary, Brent David George Page, Samuel Weiss, Hema Artee Luchman, Melissa L. Fishel
  • Patent number: 10377711
    Abstract: The present disclosure relates to indole derivatives of the formula (I) which are cannabinoid type 1 receptor modulators and which are useful in the treatment of diseases in which modulation of the receptor is beneficial; to processes for their preparation; to pharmaceutical compositions comprising them; and to methods of using them.
    Type: Grant
    Filed: August 26, 2015
    Date of Patent: August 13, 2019
    Assignees: The University Court of the University of Aberdeen, The Governing Council of the University of Toronto
    Inventors: Ruth Ross, Iain Greig, Matteo Zanda, Chih-Chung Tseng
  • Patent number: 10345240
    Abstract: The invention combines recent advances in barcode technology with portable wireless communication devices to engineer a simple and low-cost chip-based multiplex wireless detection system. The system can analyze multiple targets of interest simultaneously in minutes and is applicable to detection of pathogens or contaminants in a wide range of fields including medicine, agriculture and the environment.
    Type: Grant
    Filed: December 11, 2013
    Date of Patent: July 9, 2019
    Assignee: THE GOVERNING COUNCIL OF THE UNIVERSITY OF TORONTO
    Inventors: Warren Che Wor Chan, Kevin Ming
  • Patent number: 10346757
    Abstract: Techniques for use in connection with performing optimization using an objective function. The techniques include using at least one computer hardware processor to perform: beginning evaluation of the objective function at a first point; before evaluating the objective function at the first point is completed: identifying, based on likelihoods of potential outcomes of evaluating the objective function at the first point, a second point different from the first point at which to evaluate the objective function; and beginning evaluation of the objective function at the second point.
    Type: Grant
    Filed: May 30, 2014
    Date of Patent: July 9, 2019
    Assignees: President and Fellows of Harvard College, Socpra Sciences ET Genie S.E.C., The Governing Council of the University of Toronto
    Inventors: Ryan P. Adams, Roland Jasper Snoek, Hugo Larochelle
  • Publication number: 20190205875
    Abstract: A system and method of validating and performing operations on homomorphically encrypted data are described herein. The methods include processing a secure financial transaction by receiving a transaction request to complete a financial transaction, with at least a portion of the request encrypted according to a homomorphic encryption scheme, and the transaction request comprising confidential cardholder data including an account number, non-confidential cardholder data, and transaction data, and retrieving one or more sets of encrypted comparison cardholder data encrypted according to a homomorphic encryption scheme. The confidential cardholder data is then compared to each set of the comparison cardholder data using one or more homomorphic operations to determine which set of comparison cardholder data matches the confidential cardholder data and validating the confidential cardholder data.
    Type: Application
    Filed: March 11, 2019
    Publication date: July 4, 2019
    Applicant: THE GOVERNING COUNCIL OF THE UNIVERSITY OF TORONTO
    Inventors: Glenn GULAK, Alhassan KHEDR
  • Publication number: 20190205740
    Abstract: Described is a system, integrated circuit and method for reducing ineffectual computations in the processing of layers in a neural network. One or more tiles perform computations where each tile receives input neurons, offsets and synapses, and where each input neuron has an associated offset. Each tile generates output neurons, and there is also an activation memory for storing neurons in communication with the tiles via a dispatcher and an encoder. The dispatcher reads neurons from the activation memory and communicates the neurons to the tiles and reads synapses from a memory and communicates the synapses to the tiles. The encoder receives the output neurons from the tiles, encodes them and communicates the output neurons to the activation memory. The offsets are processed by the tiles in order to perform computations only on non-zero neurons. Optionally, synapses may be similarly processed to skip ineffectual operations.
    Type: Application
    Filed: June 14, 2017
    Publication date: July 4, 2019
    Applicant: THE GOVERNING COUNCIL OF THE UNIVERSITY OF TORONTO
    Inventors: Patrick Judd, Jorge Albericio, Alberto Delmas Lascorz, Andreas Moshovos, Sayeh Sharify
  • Publication number: 20190192656
    Abstract: Disclosed herein are multifunctional nanoparticle compositions. The compositions can be useful for the treatment of cancer by enhancing the anti-tumor effectiveness of radiation directed to a tissue, cell or a tumor and the methods of use thereof. The multifunctional nanoparticle composition comprises a metal oxide nanoparticle core; a functional coating on the surface of the metal oxide nanoparticle core; and a matrix carrier in which the coated nanoparticle is embedded.
    Type: Application
    Filed: December 18, 2018
    Publication date: June 27, 2019
    Applicant: THE GOVERNING COUNCIL OF THE UNIVERSITY OF TORONTO
    Inventors: Xiaoyu WU, Claudia Regina GORDIJO, Azhar Z. ABBASI, Preethy PRASAD, Mohammad Ali AMINI
  • Publication number: 20190161537
    Abstract: Synthetic fragment antigen-binding (Fab) antibodies are disclosed that bind to an N-terminal activation site of BCL-2-associated X-protein (BAX) and inhibit BAX activation. Also disclosed are methods of using the Fabs for measuring inactive monomeric BAX levels, screening for small molecules that bind to an N-terminal activation site of BAX, inhibiting apoptotic cell death, and predicting the ability of a cancer therapy to promote apoptotic cell death.
    Type: Application
    Filed: January 30, 2019
    Publication date: May 30, 2019
    Applicants: ALBERT EINSTEIN COLLEGE OF MEDICINE, INC., THE GOVERNING COUNCIL OF THE UNIVERSITY OF TORONTO
    Inventors: Evripidis Gavathiotis, Jonathan R. Lai, Sachdev Sidhu
  • Patent number: 10294294
    Abstract: Synthetic fragment antigen-binding (Fab) antibodies are disclosed that bind to an N-terminal activation site of BCL-2-associated X-protein (BAX) and inhibit BAX activation. Also disclosed are methods of using the Fabs for measuring inactive monomeric BAX levels, screening for small molecules that bind to an N-terminal activation site of BAX, inhibiting apoptotic cell death, and predicting the ability of a cancer therapy to promote apoptotic cell death.
    Type: Grant
    Filed: August 25, 2016
    Date of Patent: May 21, 2019
    Assignees: Albert Einstein College of Medicine, The Governing Council of the University of Toronto
    Inventors: Evripidis Gavathiotis, Jonathan R. Lai, Sachdev Sidhu
  • Patent number: 10298385
    Abstract: Fully homomorphic encryption integrated circuit (IC) chips, systems and associated methods are disclosed. In one embodiment, an integrated circuit (IC) homomorphic processor chip is disclosed. The IC homomorphic processor chip includes at least one processor slice. Each processor slice includes local control circuitry, a numeric theoretic transform (NTT) butterfly unit, and on-chip memory. The NTT butterfly unit is responsive to the local control circuitry to operate in multiple modes for performing operations on encrypted data using homomorphic encryption. Each mode is associated with a different configuration of the NTT butterfly unit.
    Type: Grant
    Filed: August 11, 2017
    Date of Patent: May 21, 2019
    Assignee: THE GOVERNING COUNCIL OF THE UNIVERSITY OF TORONTO
    Inventors: Alhassan Khedr, Glenn Gulak
  • Patent number: 10291123
    Abstract: A module for interconnecting a pair of DC sources or a pair of DC loads into a DC bus includes: a first port for each source or load; a switching cell for each first port, each cell having a pair of terminals and a switching node; a second port operatively connected to the DC bus and having a pair of terminals, one of the pair of terminals of the second port being connected to one of the terminals of one of the cells and the other of the pair of terminals of the second port being connected to one of the terminals of the other of the cells; and a filter inductor connected between the switching nodes of the cells. Systems including the module and methods utilizing the system are also disclosed.
    Type: Grant
    Filed: April 30, 2015
    Date of Patent: May 14, 2019
    Assignee: THE GOVERNING COUNCIL OF THE UNIVERSITY OF TORONTO
    Inventors: Peter Waldemar Lehn, Mike Kavian Ranjram, Yuanzheng Han
  • Patent number: 10282858
    Abstract: A method is for estimating a three-dimensional (3D) representation of a set of two-dimensional (2D) curves of a concept drawing, the estimate of the 3D representation corresponding to a 3D object underlying the concept drawing. The method comprises: obtaining a representation of a set of 2D curves a concept drawing that represent a 3D object underlying the concept drawing; determining an energy function based on the set of 2D curves, the energy function comprising one or more terms, each term reflective of a preference for a 3D representation based on a characteristic of the 2D curves which reflects how concept drawings are commonly perceived to represent 3D objects; and performing an optimization which minimizes the energy function to thereby determine the 3D representation.
    Type: Grant
    Filed: April 16, 2015
    Date of Patent: May 7, 2019
    Assignees: The University of British Columbia, The Governing Council of the University of Toronto, Institut National de Recherche en Informatique et en Automatique
    Inventors: Alla Sheffer, Karan Singh, Adrien Bousseau, Will Chang, Baoxuan Xu, James McCrae
  • Patent number: 10274499
    Abstract: The present invention relates to variant SH2 domains for binding a phosphotyrosine (pTyr)-containing peptide. The variant SH2 domains of the present invention include a parent SH2 domain having at least one amino acid substitution in a pre-defined region of 15 amino acid positions of the parent SR2 domain, wherein said at least one amino acid substitution increases the affinity of the variant SH2 domain for the pTyr-containing peptide relative to the parent SH2 domain. The present application relates also to methods of using the variant SH2 domains in the treatment of protein kinase-associated disorders, or the diagnosis or prognosis of protein kinase-associated disorders, for isolating and measuring the concentration of pTyr-containing molecules, and as reagents in research.
    Type: Grant
    Filed: March 27, 2013
    Date of Patent: April 30, 2019
    Assignees: THE UNIVERSITY OF WESTERN ONTARIO, THE GOVERNING COUNCIL OF THE UNIVERSITY OF TORONTO
    Inventors: Shun-Cheng Li, Tomonori Kaneko, Xuan Cao, Sachdev Singh Sidhu, Haiming Huang
  • Patent number: 10274453
    Abstract: Nanostructured microelectrodes and biosensing devices incorporating the same are disclosed herein.
    Type: Grant
    Filed: September 13, 2017
    Date of Patent: April 30, 2019
    Assignee: The Governing Council of the University of Toronto
    Inventors: Leyla Soleymani, Zhichao Fang, Shana Kelley, Edward Sargent, Bradford Taft