Patents Assigned to The Governing Council of the University of Toronto
  • Patent number: 10839825
    Abstract: A system and method for animated lip synchronization. The method includes: capturing speech input; parsing the speech input into phenomes; aligning the phonemes to the corresponding portions of the speech input; mapping the phonemes to visemes; synchronizing the visemes into viseme action units, the viseme action units comprising jaw and lip contributions for each of the phonemes; and outputting the viseme action units.
    Type: Grant
    Filed: March 3, 2017
    Date of Patent: November 17, 2020
    Assignee: THE GOVERNING COUNCIL OF THE UNIVERSITY OF TORONTO
    Inventors: Pif Edwards, Chris Landreth, Eugene Fiume, Karan Singh
  • Publication number: 20200354373
    Abstract: Herein is described the design and synthesis of resorcylate aminopyrazole compounds. These compounds show broad, potent and fungal-selective Hsp90 inhibitory activity. These compounds also find use in treating Hsp90 related diseases.
    Type: Application
    Filed: May 6, 2020
    Publication date: November 12, 2020
    Applicants: TRUSTEES OF BOSTON UNIVERSITY, The Governing Council of the University of Toronto
    Inventors: Lauren Elaine BROWN, David HUANG, Leah E. COWEN, Luke WHITESELL, Paul MARCYK
  • Patent number: 10826005
    Abstract: A PIN type infrared photodiode including a first electrode, a n-type semiconductor, an atomic layer deposition coating of lead sulfide, a p-type semiconductor and a second electrode, wherein the n-type semiconductor comprises nanowires conformally coated with the atomic layer deposition coating of lead sulfide.
    Type: Grant
    Filed: September 24, 2015
    Date of Patent: November 3, 2020
    Assignees: TOYOTA MOTOR EUROPE, THE GOVERNING COUNCIL OF THE UNIVERSITY OF TORONTO
    Inventors: Sachin Kinge, Jixian Xu, Brandon Sutherland, Sjoerd Hoogland, Edward Sargent
  • Patent number: 10816552
    Abstract: A compound of formula (I): as described herein and methods and uses thereof as for mass tagging a biosensor or biologically active material.
    Type: Grant
    Filed: January 11, 2019
    Date of Patent: October 27, 2020
    Assignees: The Governing Council of the University of Toronto, University Health Network
    Inventors: Mark Nitz, Landon J. Edgar, Bradly G. Wouters, David Hedley, Lisa M. Willis, Matthew A. Lumba, Hanuel Park, Ravi N. Vellanki
  • Patent number: 10808017
    Abstract: 53BP1 inhibitors, compositions comprising the inhibitors and methods of using same are provided. The inhibitors can be used in combination with gene editing systems.
    Type: Grant
    Filed: January 31, 2017
    Date of Patent: October 20, 2020
    Assignees: The Governing Council of the University of Toronto, Sinai Health System
    Inventors: Daniel Durocher, Sachdev Sidhu, Wei Zhang, Frank Sicheri, Marella Canny
  • Patent number: 10794932
    Abstract: A substrate for the detection of a biological target by Scanning Electrochemical Microscopy (SECM) is provided. The substrate includes: a conductive surface; a probe area provided on the conductive surface, the probe area comprising receptors responsive to the biological target; and a background area provided on the conductive surface, the background area being disposed around the probe area and comprising electroactive compounds providing imaging contrast between the background area and the probe area.
    Type: Grant
    Filed: August 29, 2017
    Date of Patent: October 6, 2020
    Assignees: Her Majesty the Queen in Right of Canada, as Represented by The Minster of National Defense, The Governing Council of the University of Toronto
    Inventors: Zhe She, Kristin Topping, Heinz-Bernhard Kraatz
  • Patent number: 10784388
    Abstract: Photovoltaic cells are fabricated in which the compositions of the light-absorbing layer and the electron-accepting layer are selected such that at least one side of the junction between these two layers is substantially depleted of charge carriers, i.e., both free electrons and free holes, in the absence of solar illumination. In further aspects of the invention, the light-absorbing layer is comprised of dual-shell passivated quantum dots, each having a quantum dot core with surface anions, an inner shell containing cations to passivate the core surface anions, and an outer shell to passivate the inner shell anions and anions on the core surface.
    Type: Grant
    Filed: June 24, 2016
    Date of Patent: September 22, 2020
    Assignee: THE GOVERNING COUNCIL OF THE UNIVERSITY OF TORONTO
    Inventors: Jiang Tang, Andras Pattantyus-Abraham, Illan Kramer, Aaron Barkhouse, Xihua Wang, Gerasimos Konstantatos, Ratan Debnath, Edward H. Sargent
  • Patent number: 10780164
    Abstract: Disclosed herein are multifunctional nanoparticle compositions. The compositions can be useful for the treatment of cancer by enhancing the anti-tumor effectiveness of radiation directed to a tissue, cell or a tumor and the methods of use thereof. The multifunctional nanoparticle composition comprises a metal oxide nanoparticle core; a functional coating on the surface of the metal oxide nanoparticle core; and a matrix carrier in which the coated nanoparticle is embedded.
    Type: Grant
    Filed: April 7, 2015
    Date of Patent: September 22, 2020
    Assignees: THE GOVERNING COUNCIL OF THE UNIVERSITY OF TORONTO, UNIVERSITY HEALTH NETWORK
    Inventors: Xiaoyu Wu, Claudia Regina Gordijo, Azhar Z. Abbasi, Preethy Prasad, Ralph Dacosta, Azusa Maeda, Mohammad Ali Amini
  • Patent number: 10772928
    Abstract: Methods for treatment and diagnosis of neurological disorders such as autism and autism spectrum disorder are disclosed. Also disclosed are modulators of alternative splicing regulators SRRM4 and/or SRRM3 for treating neurological disorders. Further disclosed are agents that modulate the expression of at least one splice variant for treating neurological disorders. Mouse models of neurological disorders having increased or decreased expression of SRRM4 and/or SRRM3 are also disclosed.
    Type: Grant
    Filed: December 15, 2015
    Date of Patent: September 15, 2020
    Assignees: The Governing Council of the University of Toronto, Sinai Health System
    Inventors: Benjamin J. Blencowe, Mathieu Quesnel-Vallieres, Manuel Irimia, Bushra Raj, Sabine P. Cordes
  • Patent number: 10772992
    Abstract: A soft tissue filler comprising a biodegradable amino-acid derived polycarbonate-urethanes and methods of repairing soft tissue defects are provided. The biodegradable soft tissue filler comprises a porous scaffold that is the reaction product of: a) a divinyl oligomer component that comprises a carbonate-derived divinyl oligomer that is the reaction product of a lysine-derived diisocyanate, a vinyl coupling agent, and a polycarbonate and, optionally, an ether-derived divinyl oligomer, wherein the ether-derived divinyl oligomer is the reaction product of a lysine-derived diisocyanate, a vinyl coupling agent, and an ether; b) at least one anionic monomer; and c) at least one hydrophobic monomer. The molar ratio of (a):(b+c) is between about 1:?21 and about 1:30, the soft tissue filler has a porosity of >75%; and a compressive moduli of between about 1 kPa and about 50 kPa.
    Type: Grant
    Filed: February 16, 2017
    Date of Patent: September 15, 2020
    Assignees: The Governing Council of the University of Toronto, University Health Network
    Inventors: Paul Santerre, Soror Sharifpoor, Wey Liang Leong
  • Patent number: 10770893
    Abstract: A module for interconnecting a pair of DC sources or a pair of DC loads into a DC bus includes: a first port for each source or load; a switching cell for each first port, each cell having a pair of terminals and a switching node; a second port operatively connected to the DC bus and having a pair of terminals, one of the pair of terminals of the second port being connected to one of the terminals of one of the cells and the other of the pair of terminals of the second port being connected to one of the terminals of the other of the cells; and a filter inductor connected between the switching nodes of the cells. Systems including the module and methods utilizing the system are also disclosed.
    Type: Grant
    Filed: October 20, 2017
    Date of Patent: September 8, 2020
    Assignee: THE GOVERNING COUNCIL OF THE UNIVERSITY OF TORONTO
    Inventors: Peter Waldemar Lehn, Mike Kavian Ranjram, Sebastian Rivera Iunnissi, Yuanzheng Han
  • Patent number: 10760087
    Abstract: Described herein are compositions comprising at least one auxin transport inhibitor for pre-treating a plant or seed to increase saccharification, or saccharide release by hydrolysis, the at least one auxin transport inhibitor being in an amount effective to increase sugar release from a plant tissue by hydrolysis. Also described are plant mutations, and methods to screen for such plant mutations, having an improved sugar release phenotype. The described compositions, methods and plant mutations are particularly useful for producing biofuel crops, such as maize, to improve sugar extractability from lignocellulosic biomass and hence, the efficiency of bioethanol production overall.
    Type: Grant
    Filed: November 28, 2017
    Date of Patent: September 1, 2020
    Assignee: THE GOVERNING COUNCIL OF THE UNIVERSITY OF TORONTO
    Inventors: Dario Torquato Bonetta, Peter John McCourt, Danielle Vidaurre, George Stamatiou
  • Patent number: 10759851
    Abstract: Synthetic fragment antigen-binding (Fab) antibodies are disclosed that bind to an N-terminal activation site of BCL-2-associated X-protein (BAX) and inhibit BAX activation. Also disclosed are methods of using the Fabs for measuring inactive monomeric BAX levels, screening for small molecules that bind to an N-terminal activation site of BAX, inhibiting apoptotic cell death, and predicting the ability of a cancer therapy to promote apoptotic cell death.
    Type: Grant
    Filed: January 30, 2019
    Date of Patent: September 1, 2020
    Assignees: ALBERT EINSTEIN COLLEGE OF MEDICINE, THE GOVERNING COUNCIL OF THE UNIVERSITY OF TORONTO
    Inventors: Evripidis Gavathiotis, Jonathan R. Lai, Sachdev Sidhu
  • Patent number: 10746743
    Abstract: There is provided herein a method for identifying and/or recovering at least one genetically encoded affinity reagent specific for a target molecule by screening using molecular display in conjunction with the sequencing of positive and negative selection pools from the screen.
    Type: Grant
    Filed: November 7, 2016
    Date of Patent: August 18, 2020
    Assignee: The Governing Council of the University of Toronto
    Inventors: Sachdev Sidhu, Jason Moffat, Helena Persson, Nish Patel, Saravanan Sundararajan, Amandeep Gakhal, Wei Ye, Jelena Tomic, Megan Elizabeth Mclaughlin
  • Patent number: 10715309
    Abstract: Fully homomorphic encryption integrated circuit (IC) chips, systems and associated methods are disclosed. In one embodiment, a method of operation for a number theoretic transform (NTT) butterfly circuit is disclosed. The (NTT) butterfly circuit includes a high input word path cross-coupled with a low word path. The high input word path includes a first adder/subtractor, and a first multiplier. The low input word path includes a second adder/subtractor, and a second multiplier. The method includes selectively bypassing the second adder/subtractor and the second multiplier, and reconfiguring the low and high input word paths into different logic processing units in response to different mode control signals.
    Type: Grant
    Filed: March 26, 2019
    Date of Patent: July 14, 2020
    Assignee: THE GOVERNING COUNCIL OF THE UNIVERSITY OF TORONTO
    Inventors: Alhassan Khedr, Glenn Gulak
  • Patent number: 10703779
    Abstract: The present invention relates to cyclic amino acid molecules, in particular 1,3,4-oxadiazole containing macrocyclic peptides, and a process to produce the same. The process involves the macrocyclization of amino acids or linear peptides. Specifically, the process comprises reacting an amino acid molecule with an isocyano-iminophosphorane and an aldehyde or a ketone.
    Type: Grant
    Filed: September 16, 2016
    Date of Patent: July 7, 2020
    Assignee: The Governing Council of the University of Toronto
    Inventors: Andrei Yudin, John R. Frost
  • Patent number: 10697963
    Abstract: An antibody and/or binding fragment thereof, wherein the antibody and/or binding fragment thereof specifically binds to an epitope of a ?Klotho polypeptide, optionally a folded ?Klotho or optionally with a dissociation constant (KD) of about 2 nM or less, as measured by competitive ELISA assay, methods of making and using to diagnose kidney diseases.
    Type: Grant
    Filed: January 29, 2019
    Date of Patent: June 30, 2020
    Assignees: The Governing Council of the University of Toronto, Board of Regents, The University of Texas System
    Inventors: Sachdev S. Sidhu, Sarah L. Barker, Orson W. Moe, Makoto Kuro-o
  • Patent number: 10663474
    Abstract: An antibody and/or binding fragment thereof, wherein the antibody and/or binding fragment thereof comprises a light chain variable region and a heavy chain variable region, the light chain variable region comprising complementarity determining region (CDR) CDR-L3 and the heavy chain variable region comprising CDR-H1, CDR-H2 and CDR-H3, with the amino acid sequences of said CDRs comprising one or more of the sequences set forth below: CDR-L3; selected from any one of SEQ ID NOs: 123, 126-130, 142, 148 or 149; CDR-H1: SEQ ID NOs: 121 or 124; CDR-H2; SEQ ID NOs: 122 or 125; and/or CDR-H3: selected from any one of SEQ ID NOs: 196-226.
    Type: Grant
    Filed: February 3, 2017
    Date of Patent: May 26, 2020
    Assignees: The Governing Council of the University of Toronto, Board of Regents, The University of Texas System
    Inventors: Sachdev S. Sidhu, Sarah L. Barker, Orson W. Moe, Makoto Kuro-o, Johanne Pastor
  • Patent number: 10657253
    Abstract: A first set of code, for example source code, and a second code, for example binary code, are compared to find corresponding functions. A comparison of features can be used to find correspondences of functions. The comparison of functions can be iterated and can be refined and can be further used to carry out a further, stricter comparison of functions found to correspond to reduce the chance of falsely finding a function in the second code to be accountable in the first code.
    Type: Grant
    Filed: May 18, 2017
    Date of Patent: May 19, 2020
    Assignee: THE GOVERNING COUNCIL OF THE UNIVERSITY OF TORONTO
    Inventors: David Lie, Dhaval Miyani, Janahan Skandaraniyam, Daniel Thanos
  • Patent number: 10646595
    Abstract: Water soluble porphyrin compounds useful in the field of magnetic resonance imaging (MRI) as contrast agents. Particular compounds include manganese.
    Type: Grant
    Filed: February 12, 2013
    Date of Patent: May 12, 2020
    Assignees: THE GOVERNING COUNCIL OF THE UNIVERSITY OF TORONTO, THE HOSPITAL FOR SICK CHILDREN
    Inventors: Xiao-an Zhang, Wei Ran Cheng, Inga Haedicke, Hai-Ling Cheng