Patents Assigned to The Governors of the University of Alberta
  • Publication number: 20230172221
    Abstract: A method for preparing a kefir product involves providing bacterial strains selected from Acetobacter, Leuconostoc, Lactococcus, or Lactobacillus; providing yeast strains selected from Pichia, Saccharomyces, Kazachstania, or Kluyveromyces; adding the bacterial and yeast strains to milk to form a mixture; and allowing the mixture to ferment to yield the kefir product.
    Type: Application
    Filed: March 3, 2020
    Publication date: June 8, 2023
    Applicants: The Governors of the University of Alberta, Teagasc, The Agriculture and Food Development Authority
    Inventors: Benjamin WILLING, Benjamin BOURRIE, Paul COTTER
  • Patent number: 11633735
    Abstract: A sensor and method for use in measuring a physical characteristic of a fluid in a microfluidic system is provided. A microfluidic chip has a thin deformable membrane that separates a microfluidic channel from a microwave resonator sensor. The membrane is deformable in response to loading from interaction of the membrane with the fluid. Loading may be fluid pressure in the channel, or shear stress or surface stress resulting from interaction of the membrane with the fluid. The deformation of the membrane changes the permittivity in the region proximate the sensor. A change in permittivity causes a change in the electrical parameters of the sensor, thereby allowing for a characteristic of the fluid, such as flow rate, or a biological or chemical characteristic, to be measured. Also, a microwave sensor with improved sensitivity for characterizing a fluid in a microfluidic channel is provided.
    Type: Grant
    Filed: August 24, 2018
    Date of Patent: April 25, 2023
    Assignees: UTI Limited Partnership, The Governors of the University of Alberta
    Inventors: Hamid Sadabadi, Mohammad Hossein Zarifi, Mojgan Daneshmand, Amir Sanati-Nezhad
  • Publication number: 20230093537
    Abstract: An atomic orbital based memory storage is provided that includes a plurality of surface atoms forming dangling bonds (DBs) and a subset of the plurality of surface atoms passivated with spatial control to form covalent bonds with hydrogen, deuterium, or a combination thereof. The atomic orbital based data storage that can be rewritten and corrected as needed. The resulting data storage is also archival and capable of high data densities than any known storage as the data is retained in a binary storage or a given orbital being passivated or a dangling bond (DB). A method of forming and reading the atomic orbital data storage is also provided. The method including selectively removing covalent bonds to form dangling bonds (DBs) extending from a surface atom by hydrogen lithography and imaging the covalent bonds spatially to read the atomic orbital data storage.
    Type: Application
    Filed: November 28, 2022
    Publication date: March 23, 2023
    Applicants: National Research Council of Canada, Quantum Silicon Inc., The Governors of the University of Alberta
    Inventors: Roshan Achal, Robert A. Wolkow, Jason Pitters, Martin Cloutier, Mohammad Rashidi, Marco Taucer, Taleana Huff
  • Patent number: 11591570
    Abstract: Provided herein are recombinant cardiomyocytes and cardiomyocyte cell lines expressing human Ether-a-go-go Related Gene (hERG) potassium ion channel, including, for example, stable cell lines, that comprise a transfected or transduced nucleic acid sequence encoding hERG. Also provided herein are methods of using the recombinant cardiomyocytes and cardiomyocyte cell lines expressing hERG for screening compounds for cardiotoxicity, including methods for determining the activity of compounds to inhibit hERG.
    Type: Grant
    Filed: September 13, 2017
    Date of Patent: February 28, 2023
    Assignee: The Governors of the University of Alberta
    Inventors: Rakesh Bhat, Michael Houghton
  • Patent number: 11585777
    Abstract: The present disclosure provides a biosensor for detecting the presence of and/or the amount of at least one fungal plant pathogen in a sample, comprising: a support structure; at least two interdigitated electrodes coupled to the support structure, wherein at least one of the interdigitated electrodes is functionalized with a linker coupled to at least one biological component that recognizes the at least one fungal plant pathogen; and an impedance measurement circuit coupled to the at least two interdigitated electrodes. The present disclosure also provides methods of detecting the presence of and/or the amount of at least one fungal plant pathogen in a sample, methods of making the biosensor described herein, as well as methods and uses of using the herein described biosensor for detecting the presence of and/or amount of at least one fungal plant pathogen.
    Type: Grant
    Filed: April 25, 2019
    Date of Patent: February 21, 2023
    Assignees: InnoTech Alberta Inc., The Governors of the University of Alberta
    Inventors: Xiujie Li, Jie Chen, Jian Yang, Scott Mackay, Lian C. T. Shoute
  • Patent number: 11576967
    Abstract: The present disclosure provides heterodimeric polypeptides comprising: 1) a variant hepatitis C virus (HCV) E2 polypeptide and an HCV E1 polypeptide; 2) a variant HCV E1 polypeptide and an HCV E2 polypeptide; or 3) a variant HCV E1 polypeptide and a variant HCV E2 polypeptide, where the variant HCV E2 polypeptide and/or the HCV E1 polypeptide comprises one or more T cell epitopes, present in an HCV polypeptide other than an HCV E1 polypeptide or an HCV E2 polypeptide. The present disclosure provides nucleic acids encoding a polyprotein that includes E1 and variant E2, E2 and variant E1, or variant E2 and variant E1. The present disclosure provides a method of producing an E1/E2 heterodimer of the present disclosure. The present disclosure provides a method of inducing an immune response in an individual. The present disclosure provides variant E2 polypeptides and variant E1 polypeptides; and nucleic acids encoding same.
    Type: Grant
    Filed: December 15, 2020
    Date of Patent: February 14, 2023
    Assignee: The Governors of the University of Alberta
    Inventors: Michael Houghton, John L. Law, Michael Logan, Darren Hockman, Abdolamir Landi
  • Patent number: 11576968
    Abstract: The present disclosure provides immunogenic compositions comprising: a) hepatitis C virus (HCV) E1E2 heterodimers, HCV E2, or HCV E1; and b) an adjuvant, where the adjuvant is a cyclic dinucleotide or an archaeosome. The present disclosure provides methods of inducing an immune response in an individual to HCV, the methods comprising administering to an individual an effective amount of an immunogenic composition of the present disclosure.
    Type: Grant
    Filed: December 15, 2020
    Date of Patent: February 14, 2023
    Assignee: The Governors of the University of Alberta
    Inventors: Michael Houghton, Abdolamir Landi, Carlos A. Guzman, Thomas Ebensen, Darren Hockman, John L. Law, Michael Logan
  • Patent number: 11566018
    Abstract: The present disclosure relates to 2-(3-indoyl)indolin-3-one derivatives of the natural product isatisine A, synthesized from dual catalytic synthesis on metallocarbene-azide cascade chemistry, useful for treating a subject having or suspected of having an infectious disease, wherein the infection disease is caused by a virus, wherein the virus is from the family flaviviridae or paramyxoviridae.
    Type: Grant
    Filed: March 27, 2019
    Date of Patent: January 31, 2023
    Assignee: The Governors of the University of Alberta
    Inventors: Frederick Glenn West, David J. Marchant, Bren Jordan P. Atienza, Lionel D. Jensen
  • Patent number: 11557337
    Abstract: An atomic orbital based memory storage is provided that includes a plurality of surface atoms forming dangling bonds (DBs) and a subset of the plurality of surface atoms passivated with spatial control to form covalent bonds with hydrogen, deuterium, or a combination thereof. The atomic orbital based data storage that can be rewritten and corrected as needed. The resulting data storage is also archival and capable of high data densities than any known storage as the data is retained in a binary storage or a given orbital being passivated or a dangling bond (DB). A method of forming and reading the atomic orbital data storage is also provided. The method including selectively removing covalent bonds to form dangling bonds (DBs) extending from a surface atom by hydrogen lithography and imaging the covalent bonds spatially to read the atomic orbital data storage.
    Type: Grant
    Filed: June 19, 2019
    Date of Patent: January 17, 2023
    Assignees: National Research Council of Canada, Quantum Silicon Inc., The Governors of the University of Alberta
    Inventors: Roshan Achal, Robert A. Wolkow, Jason Pitters, Martin Cloutier, Mohammad Rashidi, Marco Taucer, Taleana Huff
  • Publication number: 20220396509
    Abstract: A system and method for treatment of wastewater, in which the system includes a blackwater reactor configured to receive a stream of blackwater influent, to contain the blackwater therein during treatment of the blackwater, to facilitate recovery of methane and nutrient precipitates therefrom, and to output partially treated blackwater, and a greywater reactor configured to receive a stream of greywater influent and the partially treated blackwater output from the blackwater reactor, to contain the greywater and the partially treated blackwater therein during greywater treatment, and to output greywater treatment discharge.
    Type: Application
    Filed: June 10, 2022
    Publication date: December 15, 2022
    Applicant: The Governors of the University of Alberta
    Inventors: Yang Liu, Lei Zhang
  • Patent number: 11518995
    Abstract: The disclosure relates to compositions comprising a nucleotide sequence having two domains: a locked nucleic acid (LNA) domain and a DNA gap domain, wherein nucleotide sequence binds to an endogenous DUX4 mRNA sequence disrupts DUX4 expression.
    Type: Grant
    Filed: September 19, 2018
    Date of Patent: December 6, 2022
    Assignees: Children's National Medical Center, The Governors of the University of Alberta
    Inventors: Yi-wen Chen, Toshifumi Yokota, Rika Yokota-Maruyama, Yusuke Echigoya
  • Patent number: 11512848
    Abstract: A system and method for estimating steam quality for a steam generator is provided which involves obtaining raw measurement values for process variables of the steam generator from sensors coupled to the steam generator; receiving the raw measurement values and slow-rate steam quality samples in order to determine a steam quality estimate, using a measurement module to receive the raw measurement values and determine model input values and a robustness index; using an estimator module to determines a raw steam quality estimate using the model input values and a model that is selected from several models depending on reliability of some of the raw measurements; and using a corrector module to determine the steam quality estimate using the raw steam quality estimate, robustness index, and slow-rate steam quality samples. An output receives the steam quality estimate and can provide the steam quality estimate to another device.
    Type: Grant
    Filed: March 5, 2019
    Date of Patent: November 29, 2022
    Assignee: The Governors of the University of Alberta
    Inventors: Biao Huang, Yanjun Ma, Seraphina Kwak
  • Publication number: 20220372212
    Abstract: The invention provides methods for the formation of thermo-reversible hydrogels from triblock copolymers of poly(ethylene glycol) and poly(?-benzyl carboxylate-?-caprolactone) (PBCL-PEG-PBCL) prepared by bulk and solution polymerization. PBCL-PEG-PBCLs prepared at fixed PBCL to PEG ratios but different polymerization times were characterized for their average molecular weights, molar-mass disparity and intrinsic viscosity using 1H NMR and gel permeation chromatography (GPC). The results indicated a copolymer of high molecular weight population with elevated intrinsic viscosity. The size and proportion of this population grew as a function of polymerization time. The formation of this high molecular weight PBCL-PEG-PBCL population can be attributed to non-linear architecture caused by partial cross-linking of the PBCL segment during the polymerization reaction.
    Type: Application
    Filed: April 29, 2022
    Publication date: November 24, 2022
    Applicant: The Governors of the University of Alberta
    Inventors: Nasim GHASEMI, Mohammad Reza VAKILI, Afsaneh LAVASANIFAR
  • Publication number: 20220347114
    Abstract: Amphiphilic copolymers and compositions including amphiphilic copolymers. The amphiphilic copolymers include modified maleimide subunits, for example, as illustrated by the structures of Formula IA and Formula IB. The compositions form water-soluble complexes upon association with biological material wherein such biological material can include lipids or membrane proteins. Methods for producing, purifying, analyzing, and using the compositions and complexes are provided.
    Type: Application
    Filed: October 23, 2020
    Publication date: November 3, 2022
    Applicant: The Governors of the University of Alberta
    Inventors: Michael OVERDUIN, Mansoore ESMAILI
  • Patent number: 11479477
    Abstract: The present application relates to copper-doped double perovskites, for example, copper-doped double perovskites of the formula (I) and to uses thereof, for example as low-bandgap materials such as a semiconducting material in a device. The present application also relates to methods of tuning the bandgap of a Cs2SbAgZ6 double perovskite (for example, wherein Z is Cl) comprising doping the double perovskite with copper.
    Type: Grant
    Filed: June 23, 2020
    Date of Patent: October 25, 2022
    Assignee: The Governors of the University of Alberta
    Inventors: Vladimir Michaelis, Abhoy Karmakar
  • Publication number: 20220299544
    Abstract: A nano-positioning system for fine and coarse nano-positioning including at least one actuator, wherein the at least one actuator includes a high Curie temperature material and wherein the nano-positioning system is configured to apply a voltage to the at least one actuator to generate fine and/or coarse motion by the at least one actuator. The nano-positioning system being a stand-alone system, a scanning probe microscope, or an attachment to an existing microscope configured to perform a method of creepless nano-positioning that includes positioning a probe relative to a first area of a substrate using coarse stepping and interacting with the first area of the substrate using fine motion after less than 60 seconds of the positioning the probe. The movement of the scanning probe microscope is actuated by a high Curie temperature piezoelectric material that limits and/or eliminates creep, hysteresis and aging.
    Type: Application
    Filed: August 31, 2020
    Publication date: September 22, 2022
    Applicants: National Research Council of Canada, The Governors of the University of Alberta
    Inventors: Robert A. Wolkow, Jason Pitters, Mark Salomons
  • Patent number: 11385230
    Abstract: Methods for the diagnosis of CRC, colorectal polyps in general and adenomatous polyps in particular by measurement of metabolites in urine are described. In some embodiments, certain metabolites are identified as being elevated or reduced in concentration or quantity in subjects with CRC and/or colorectal polyps as compared with subjects without CRC or colorectal polyps. The measurement of these metabolites in urine can indicate the presence of CRC or colorectal polyps in general or adanomatous polyps in particular in a subject.
    Type: Grant
    Filed: March 6, 2019
    Date of Patent: July 12, 2022
    Assignee: The Governors of the University of Alberta
    Inventors: Richard Neil Fedorak, Haili Wang
  • Patent number: 11370822
    Abstract: The present disclosure relates to bioactive self-assembling peptides, nanofibers and hydrogels for activating human mast cells. The peptides, nanofibers and hydrogels comprise a self-assembling peptide that mediates self-assembly linked to a MrgX2 agonist peptide; for example, (RADA)4 linked to proadrenomedullin-12 (PAMP-12).
    Type: Grant
    Filed: May 25, 2018
    Date of Patent: June 28, 2022
    Assignees: The Governors of the University of Alberta, National Research Council of Canada
    Inventors: Larry D. Unsworth, Lei Lu, Marianna Kulka
  • Publication number: 20220183828
    Abstract: A device for replacing a mitral valve includes a substantially cylindrically-shaped body having a top portion, a bottom portion, and a waist portion disposed therebetween and having ferromagnetic elements arranged circumferentially, and the top portion, waist portion, and bottom portion defining an aperture extending therethrough for allowing blood flow; and a clamping ring formed of a ferromagnetic material and supporting a plurality of ferromagnetic spheres thereon.
    Type: Application
    Filed: March 10, 2020
    Publication date: June 16, 2022
    Applicant: The Governors of the University of Alberta
    Inventor: Keysun ALIZADEHRANJBAR
  • Patent number: 11353764
    Abstract: An electrochromic (EC) device comprises a first electrode and a second electrode separated by an electrolyte. The first electrode comprises an electrochromic (EC) layer comprising a compound having the formula AiBjOk, where A comprises one or more elements selected from a group consisting of W, Mn, Mo, Co, Ni, Cs, and Zn, where B is different than A and comprises one or more elements selected from a group consisting of Mo, Ti, Nb, and V, where i and j have values that are greater than 0, and where k is a stoichiometric value that balances the formula. A is selected such that the EC layer has an improved optical contrast relative to BjOk and B is selected such that the EC layer has an improved specific charge capacity relative to AiOk.
    Type: Grant
    Filed: February 24, 2020
    Date of Patent: June 7, 2022
    Assignee: The Governors of the University of Alberta
    Inventors: Abdulhakem Elezzabi, Hai Zeng Li