Patents Assigned to The Johns Hopkins University
  • Patent number: 11084833
    Abstract: Antibacterial agents against D,D- and L,D-transpeptidases are disclosed. Pharmaceutical compositions and methods of using the same also are disclosed.
    Type: Grant
    Filed: October 10, 2017
    Date of Patent: August 10, 2021
    Assignee: The Johns Hopkins University
    Inventors: Craig A. Townsend, Evan Lloyd
  • Patent number: 11084879
    Abstract: Death receptor 5 (DR5) agonist compositions and methods for treating pancreatitis have been developed. The compositions include Tumor Necrosis Factor-related apoptosis-inducing ligand (TRAIL), its analogues, and anti-DR5 agonistic antibodies. In certain embodiments, TRAIL analogs and anti-death receptor 5 agonistic antibodies have analgesic and disease modifying effects on the pancreas.
    Type: Grant
    Filed: April 7, 2017
    Date of Patent: August 10, 2021
    Assignee: The Johns Hopkins University
    Inventors: Seulki Lee, Martin G. Pomper, Ogyi Park, Magdalena Scully, Pankaj J. Pasricha
  • Publication number: 20210238233
    Abstract: The disclosure relates, in some aspects, to adeno-associated vims capsid proteins isolated from an in vivo library and recombinant adeno-associated viruses (rAAVs) comprising the same. In some aspects, the disclosure relates to isolated nucleic acids encoding AAV capsid proteins isolated from an in vivo library. In some embodiments, rAAVs and compositions described by the disclosure are useful for delivery of one or more transgenes to the muscle-tissue of a subject.
    Type: Application
    Filed: April 26, 2019
    Publication date: August 5, 2021
    Applicants: University of Massachusetts, The Johns Hopkins University, Kennedy Krieger Institute, Inc.
    Inventors: Miguel Sena Esteves, Sourav Roy Choudhury, Kathryn Rae Wagner, Jennifer Gifford Green, Ana Rita Batista
  • Patent number: 11079380
    Abstract: Disclosed herein are methods of detecting microbial infection in mammalian subjects comprising treatment of a sample and detection of galactofuranose (galF)-containing antigenic components utilizing monoclonal antibodies. The methods disclosed provide for pretreatment of biological samples, such as urine samples, to maximize detection of galF antigens and improvement of sensitivity of galF antigen detection assays. The methods include minimizing intelectin-1 binding to galF antigens and improvement of monoclonal antibody binding. The detection methods are useful for identifying the presence of microbial antigens related to bacterial, fungal, and parasitic pathogens, including Streptococcus pneumoniae, Aspergillus species, Fusarium species, Coccidioides species, Cryptococcus species, Histoplasma species, and Leishmania species.
    Type: Grant
    Filed: January 23, 2020
    Date of Patent: August 3, 2021
    Assignee: The Johns Hopkins University
    Inventor: Kieren Marr
  • Patent number: 11078166
    Abstract: Triazole conjugated urea-based and thiourea-based scaffolds that have high binding affinity to PSMA are disclosed. These scaffolds can be radiolabeled and used to image cells and tumors that express PSMA. Methods of synthesizing radiofluorinated triazole conjugated urea-based and thiourea-based scaffolds also are disclosed.
    Type: Grant
    Filed: August 15, 2016
    Date of Patent: August 3, 2021
    Assignee: The Johns Hopkins University
    Inventors: Martin G. Pomper, Ying Chen, Xing Yang, Ronnie C. Mease, Sangeeta Ray
  • Patent number: 11078461
    Abstract: The invention provides compositions and methods for the preparation of processed adipose tissue. The invention further provides methods of use of the processed adipose tissue.
    Type: Grant
    Filed: October 27, 2017
    Date of Patent: August 3, 2021
    Assignee: THE JOHNS HOPKINS UNIVERSITY
    Inventors: Zayna Nahas, Jennifer H. Elisseeff, Iwen Wu
  • Publication number: 20210231762
    Abstract: An embodiment of a method for recording diagnostic measurement data of a knee of an examination object in knee imaging by a magnetic resonance device, includes performing an overview scan of the knee of the examination object, wherein overview measurement data is acquired in the overview scan, and performing diagnostic scans of the knee of the examination object based on the acquired overview measurement data, wherein two-dimensional diagnostic measurement data is acquired in the diagnostic scans.
    Type: Application
    Filed: November 1, 2018
    Publication date: July 29, 2021
    Applicants: Siemens Healthcare GmbH, The Johns Hopkins University
    Inventors: Jan FRITZ, Dingxin WANG, Esther RAITHEL, Thomas BECK, Flavio CARINCI, Mario ZELLER
  • Patent number: 11072828
    Abstract: The present invention relates to the field of biomarkers. More specifically, the present invention relates to the use of biomarkers to predict post-traumatic stress disorder (PTSD). In one embodiment, a method for predicting PTSD in a subject comprises the steps of (a) measuring the DNA methylation level of a CpG dinucleotide in the 3? untranslated region of SKA2; (b) identifying the genotype at a SNP within the 3? UTR of SKA2, and (c) predicting PTSD in the subject using a prediction algorithm.
    Type: Grant
    Filed: October 6, 2015
    Date of Patent: July 27, 2021
    Assignees: The Johns Hopkins University, UMC UTRECHT HOLDING B.V.
    Inventors: Zachary Kaminsky, Marco Paul Maria Boks
  • Patent number: 11066630
    Abstract: The present invention provides an integrated microphysiological device and fabrication methods thereof, as well as methods of use to perform biological assays.
    Type: Grant
    Filed: July 1, 2016
    Date of Patent: July 20, 2021
    Assignee: The Johns Hopkins University
    Inventors: Onur Kilic, Steven An, Andre Levchenko
  • Patent number: 11066416
    Abstract: The present disclosure provides macrocyclic compounds inspired by the immunophilin ligand family of natural products FK506 and rapamycin. The generation of a Rapafucin library of macrocyles that contain FK506 and rapamycin binding domains should have great potential as new leads for developing drugs to be used for treating diseases.
    Type: Grant
    Filed: October 1, 2019
    Date of Patent: July 20, 2021
    Assignees: The Johns Hopkins University, Rapafusyn Pharmaceuticals, Inc.
    Inventors: Jun Liu, Sam Hong, Brett R. Ullman, Joseph E. Semple, Kana Yamamoto, Puneet Kumar, Magesh Sadagopan, Jennifer C. Schmitt
  • Patent number: 11067635
    Abstract: An example battery cell diagnostic apparatus is provided that may include control circuitry, a current source, measurement circuitry, and a first and a second multiplexer. The control circuitry may be configured to control the first multiplexer to electrically connect the measurement circuitry to a battery cell and control the second multiplexer to electrically connect the current source to the battery cell to apply a current, output from the current source, at each of a set of frequencies to the battery cell. The control circuitry may also be configured to receive measurements from the measurement circuitry at each of the frequencies, which may include respective frequencies that correlate to an electrolytic resistance of the battery cell, an anode impedance of the battery cell, and a cathode impedance of the battery cell. Similar measurements may also be taken for each cell in a battery.
    Type: Grant
    Filed: December 5, 2018
    Date of Patent: July 20, 2021
    Assignee: The Johns Hopkins University
    Inventors: Rengaswamy Srinivasan, Bliss G. Carkhuff
  • Patent number: 11067449
    Abstract: A multispectral imager includes processing circuitry, an illumination assembly, a detector assembly, and a focusing assembly. The illumination assembly includes an array of illumination elements controlled by the processing circuitry to illuminate a scene. The detector assembly includes a detector array controlled by the processing circuitry to capture images from the scene at different wavelengths. The focusing assembly includes a lens and is controlled by the processing circuitry to adjust a focal point for the detector array. The processing circuitry generates and processes the images from the scene, taken at different wavelengths and focal points, combines the images to form a multispectral image cube for the scene, and determines a composition of an object within the scene based on a spectral profile of the multispectral image cube.
    Type: Grant
    Filed: September 5, 2020
    Date of Patent: July 20, 2021
    Assignee: The Johns Hopkins University
    Inventors: Jorge I. Nunez Sanchez, Rachel L. Klima, Scott L. Murchie, Seppo J. Lehtonen, John D. Boldt, Jacob M. Greenberg, Bryan J. Maas, Kyle L. Anderson, Trevor W. Palmer, Heidi E. Warriner
  • Patent number: 11066455
    Abstract: The present invention features compositions of Tmem100 peptides and variants thereof, and their use in treating or preventing diseases or conditions.
    Type: Grant
    Filed: February 20, 2015
    Date of Patent: July 20, 2021
    Assignee: The Johns Hopkins University
    Inventors: Xinzhong Dong, Hao-Jui Weng
  • Patent number: 11059775
    Abstract: Prodrugs of hydroxamate-based GCPII inhibitors and methods of their use for treating a disease or condition are disclosed.
    Type: Grant
    Filed: November 20, 2017
    Date of Patent: July 13, 2021
    Assignees: The Johns Hopkins University, INSTITUTE OF ORGANIC CHEMISTRY & BIOCHEMISTRY
    Inventors: Barbara Slusher, Rana Rais, Jan Vavra, Tomas Tichy, Pavel Majer, Andrej Jancarik, Lukas Tenora
  • Patent number: 11060064
    Abstract: The present invention relates to the area of in vitro cell populations useful for generating vascular networks in vitro and are suitable for use in vivo for regeneration of vascular tissue. In some embodiments, the bipotent cell population of the present invention comprise endothelial cells and pericytes that express vascular endothelial cadherin and are 95% or more positive for CD105 and CD146, and which work syergistically to recreate vascular tissues in vitro.
    Type: Grant
    Filed: June 5, 2018
    Date of Patent: July 13, 2021
    Assignee: The Johns Hopkins University
    Inventors: Sharon Gerecht, Sravanti Kusuma
  • Patent number: 11059855
    Abstract: The present invention provides a new methodology combining MD simulations and database-guided high-throughput screening to rationally design pore forming membrane-active peptides. The present inventive methodology is able to allow tuning of a range of structural and functional properties such as pore size and selectively targeting membranes with specific lipid compositions. The present inventive methods will ultimately allow de novo design of membrane-active peptides for a wide range of biomedical applications, including for example, antimicrobial agents.
    Type: Grant
    Filed: March 12, 2018
    Date of Patent: July 13, 2021
    Assignee: THE JOHNS HOPKINS UNIVERSITY
    Inventors: Charles H. Chen, Martin B. Ulmschneider
  • Patent number: 11058541
    Abstract: Provided is a functional, low-profile intercranial device (LID). The LID includes a base portion; at least one cavity associated with the base portion and configured to accept at least one functional component; and at least one conduit having a first end in communication with the at least one cavity. The at least one functional component includes a medicinal, electronic, or optic therapeutic. The at least one conduit is configured to accept the medicinal therapeutic and a second end configured to dispense the therapeutic.
    Type: Grant
    Filed: May 2, 2016
    Date of Patent: July 13, 2021
    Assignee: THE JOHNS HOPKINS UNIVERSITY
    Inventor: Chad Gordon
  • Patent number: 11059043
    Abstract: A microfluidic system includes a microfluidic chip including a channel layer and a fluid control layer operatively connected to the channel layer, the channel layer having one or more fluid channels. The one or more channels are configured to contain a plurality of droplets. A valve control system is provided to control flow of fluid through the one or more fluid channels in the channel layer. The microfluidic system also includes a droplet impedance detection and feedback control system operatively connected to the valve control system. The droplet impedance detection and feedback control system is configured to detect at least a position of at least one droplet in a fluid channel and to send a signal to the valve control system to operate a particular valve at a particular time based on the detected position of the at least one droplet.
    Type: Grant
    Filed: April 19, 2017
    Date of Patent: July 13, 2021
    Assignees: The Johns Hopkins University, Pioneer Hi-Bred International, Inc.
    Inventors: Tza-Huei Wang, Brant Axt, Yi-Fan Hsieh, Helena C. Zec, Aniruddha Kaushik, Kuangwen Hsieh, Yue Yun
  • Patent number: 11061032
    Abstract: The presently disclosed fluidic sensor system and method comprise multifunctional nanoprobe-enabled capture for early detection of chemical and/or biological pathogens in a liquid sample. This sensor system and method can be used for food and environmental monitoring.
    Type: Grant
    Filed: June 4, 2019
    Date of Patent: July 13, 2021
    Assignee: THE JOHNS HOPKINS UNIVERSITY
    Inventors: Chao Wang, Kellogg Schwab, Charles Young
  • Publication number: 20210205032
    Abstract: The present disclosure provides a system and method for controlling an articulating member including a tool. The method includes determining a first confidence indicator based on a manual control mode for the articulating member, determining a second confidence indicator based on an autonomous control mode for the articulating member, generating an allocation function based on the first confidence indicator and the second confidence indicator, and generating a control command for the articulating member based on the allocation function.
    Type: Application
    Filed: May 16, 2019
    Publication date: July 8, 2021
    Applicants: University of Maryland, College Park, The Johns Hopkins University, Children's National Medical Center
    Inventors: Hamed Saeidi, Axel Krieger, Simon Leonard, Justin Opfermann