Patents Assigned to The Purdue Frederick Company
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Patent number: 4731457Abstract: Analgesic and anti-inflamatory compounds of the formula ##STR1## wherein n=0-1,X=Halo, lower Alkoxy, HO--, Lower Alkyl, andR= ##STR2##Type: GrantFiled: May 27, 1986Date of Patent: March 15, 1988Assignee: The Purdue Frederick CompanyInventors: Bola V. Shetty, Arthur McFadden, Peter Hofer
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Patent number: 4639529Abstract: Analgesic and anti-inflammatory compounds are provided. These compounds possess the following general formula: ##STR1## wherein R=--COOR.sub.5, --CH.sub.2 CO.sub.2 H, ##STR2## wherein A and B=hydrogen, lower alkyl, hydroxy alkyl, lower alkyl amine, substituted lower alkyl amine, aminoalkyl, substituted aminoalkyl;R.sub.5 =lower alkyl;R.sub.1 =aryl, substituted aryl, aralkyl, alkyl, hydrogen, substituted aralkyl and heterocycle;R.sub.2 =aryl, substituted aryl, aralkyl, alkyl, substituted aralkyl, heterocycle, substituted heterocycle, biphenyl, substituted biphenyl, naphthyl, and substituted naphthyl;R.sub.3 =aryl, substituted aryl, hydrogen, aralkyl, substituted aralkyl, alkyl, heterocycle and substituted heterocycle;R.sub.2 and R.sub.3 together form a ring;R.sub.4 =hydrogen, phenyl, substituted phenyl, heterocycle; alkyl, substituted alkyl; or, R.sub.1 and R.sub.4 may form a ring; ##STR3## --CH.sub.2 --; Y=--S--CHR.sub.4 --, --O--OHR.sub.4 --,--CHR.sub.4 --, --CR.sub.6 R.sub.7 --CHR.sub.4, ##STR4## wherein R.Type: GrantFiled: June 18, 1984Date of Patent: January 27, 1987Assignee: The Purdue Frederick CompanyInventors: Bola V. Shetty, Arthur McFadden, Peter Hofer
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Patent number: 4476311Abstract: Analgesic and anti-inflammatory compounds are provided. These compounds possess the following general formula: ##STR1## wherein R=--COOR.sub.5, --CH.sub.2 CO.sub.2 H, ##STR2## wherein A and B=hydrogen, lower alkyl, hydroxy alkyl, lower alkyl amine, substituted lower alkyl amine, aminoalkyl, substituted aminoalkyl;R.sub.5 =lower alkyl;R.sub.1 =aryl, substituted aryl, aralkyl, alkyl, hydrogen, substituted aralkyl and heterocycle;R.sub.2 =aryl, substituted aryl, aralkyl, alkyl, substituted aralkyl, heterocycle, substituted heterocycle, biphenyl, substituted biphenyl, naphthyl, and substituted naphthyl;R.sub.3 =aryl, substituted aryl, hydrogen, aralkyl, substituted aralkyl, alkyl, heterocycle and substituted heterocycle;R.sub.2 and R.sub.3 together form a ring;R.sub.4 =hydrogen, phenyl, substituted phenyl, heterocycle; alkyl, substituted alkyl; or, R.sub.1 and R.sub.4 may form a ring;X=>C.dbd.O, --CH.sub.2 --;Y=--S--CHR.sub.4 --, --O--OHR.sub.4 --, --CHR.sub.4 --, --CR.sub.6 R.sub.7 --CHR.sub.Type: GrantFiled: February 19, 1982Date of Patent: October 9, 1984Assignee: The Purdue Frederick CompanyInventors: Bola V. Shetty, Arthur McFadden, Peter Hofer
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Patent number: 4445626Abstract: A cylindrical container for viscous material has a first open base end of a first diameter and a spaced opposite closed base end with an opening therethrough of a second diameter smaller than the first diameter. A cylindrical plunger of a third diameter slightly smaller than the first diameter is coaxially slidably mounted in the container in a snug manner. The plunger has a closed plunger head perpendicular to its axis. A positioning device selectively positions the plunger and the container relative to each other at a plurality of different axial positions. The plunger, at each of the axial positions, forces a predetermined measured amount of the viscous material out of the opening of the container.Type: GrantFiled: February 10, 1982Date of Patent: May 1, 1984Assignee: The Purdue Frederick CompanyInventors: Cliff Steffen, Nicholas P. Cappelli
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Patent number: 4443616Abstract: Pyrrolidin-2-ones are produced by hydrogenation of 3-pyrrolin-2-ones, which latter compounds could not prior to this invention be easily obtained. These 3-pyrrolin-2-ones with various substituents are produced by ring closure of N-aroylmethyl-acetamides. The ring closure is effected in basic media under nitrogen.Type: GrantFiled: April 21, 1981Date of Patent: April 17, 1984Assignee: The Purdue Frederick CompanyInventor: Peter Hofer
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Patent number: 4420487Abstract: The invention relates to compounds which exhibit diuretic and antihypertensive properties and have the following structures: ##STR1## or pharmaceutically acceptable salts thereof, wherein: X=halogen or trifluoromethylY.sub.1 and Y.sub.2 =independently hydrogen, alkyl, acyl, aryl, substituted aryl or heterocycle,R.sub.1 =hydrogen, lower alkyl, aryl, substituted aryl, benzyl, substituted benzyl, aralkyl, heterocycle or substituted heterocycle,n=O or an integer from 1-4R.sub.2 =amino, substituted amino, guanidino, substituted guanidino, halogen, alkyl, substituted alkyl, aryl, substituted aryl or heterocycle, andR.sub.3 =hydrogen, lower alkyl, aryl, substituted aryl, benzyl, substituted benzyl, aralkyl, heterocycle, substituted heterocycle or acyl.Type: GrantFiled: June 30, 1980Date of Patent: December 13, 1983Assignee: The Purdue Frederick CompanyInventors: Bola V. Shetty, Arthur McFadden
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Patent number: 4395552Abstract: Antimicrobial compounds of the formulae: ##STR1## wherein R and R.sub.1 =H, lower alkyl, halogen, methoxy, hydroxy, nitro, carboxy, aryl (preferably phenyl) substituted aryl (preferably substituted by lower alkyl) and sulfamyl, R.sub.2 =hydrogen, lower alkyl, aryl (preferably phenyl) and substituted aryl (preferably substituted by lower alkyl) and wherein n is an integer from 2-20, are provided. Also provided are the method of producing such compounds.Type: GrantFiled: November 3, 1980Date of Patent: July 26, 1983Assignee: The Purdue Frederick CompanyInventors: Bola V. Shetty, John E. Airey
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Patent number: 4392492Abstract: Apparatus for storing and dispensing a medicated douche solution includes a sealed unitary packette as one of its components and which has a predetermined volume of liquid douche concentrate stored within a sealed interior volume defined thereby. The packette is formed of thin flexible plastic material and includes a container portion in which the douche concentrate is stored and a dispenser portion integral with the container portion and which is constituted by an elongated, small diameter tubular stem which has a constant transverse cross-section throughout its length and a separable terminal tip portion. The packette is openable through separation of the terminal tip portion from the dispenser portion whereupon the dispenser portion is inserted through an opening of a bottle containing a diluent so as to extend to a significant extent into the interior thereof. The concentrate is dispensed into the diluent by squeezing the container portion of the packette.Type: GrantFiled: July 10, 1981Date of Patent: July 12, 1983Assignee: The Purdue Frederick CompanyInventor: Ernest Pick
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Patent number: 4364929Abstract: Germicidal properties are provided for colloidal lubricating gels without destruction of the physical properties of the colloidal gel by the incorporation therein of an iodophor within strict limits as to the quantities and relative quantities of the iodophor-former, the iodine and the gel-forming colloid. These germicidal colloidal lubricating gels remain stable and retain their germicidal effectiveness. As a result, these compositions can be used for the lubrication of catheters and other instruments to facilitate their insertion into a body cavity and because these compositions do not cause pain or irritation their use reduces the risk of infection and tissue-trauma.Type: GrantFiled: April 30, 1980Date of Patent: December 21, 1982Assignee: The Purdue Frederick CompanyInventors: Ernest J. Sasmor, Kenneth G. Rothwell
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Patent number: 4309544Abstract: The invention relates to the production of compounds of the general formula: ##STR1## wherein X is selected from the group consisting of oxygen, CH.sub.2 and CH radicals, and when X designates oxygen, R designates alkyl, isoalkyl, aralkyl, and substituted aralkyl groups and when X designates CH.sub.2 then R designates alkyl, phenyl or substituted phenyl group, and A-B is a single bond, and when X designates CH.sub.2, R designates alkyl, phenyl or substituted phenyl groups and A-B is a double bond; and physiologically acceptable salts of these, and pharmaceutical composition containing the same as active ingredient.Type: GrantFiled: July 20, 1979Date of Patent: January 5, 1982Assignee: The Purdue Frederick CompanyInventors: Sasson Cohen, Abraham Fisher
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Patent number: 4281138Abstract: Antimicrobial compounds of the formulae: ##STR1## wherein R and R.sub.1 =H, lower alkyl, halogen, methoxy, hydroxy, nitro, carboxy, aryl (preferably phenyl) substituted aryl (preferably substituted by lower alkyl) and sulfamyl, and R.sub.2 =hydrogen, lower alkyl, aryl (preferably phenyl) and substituted aryl (preferably substituted by lower alkyl) and wherein n is an integer from 2-20, are provided. Also provided are the method of producing such compounds.Type: GrantFiled: November 8, 1979Date of Patent: July 28, 1981Assignee: The Purdue Frederick CompanyInventors: Bola V. Shetty, John E. Airey
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Patent number: 4226996Abstract: The invention relates to the production of compounds of the general formula: ##STR1## wherein X is selected from the group consisting of oxygen, CH.sub.2 and CH radicals, and when X designates oxygen, R designates alkyl, isoalkyl, aralkyl, and substituted aralkyl groups and when X designates CH.sub.2 then R designates alkyl, phenyl or substituted phenyl group, and A-B is a single bond, and when X designates CH.sub.2, R designates alkyl, phenyl or substituted phenyl groups and A-B is a double bond; and physiologically acceptable salts of these, and pharmaceutical compositions containing the same as active ingredient.Type: GrantFiled: October 23, 1978Date of Patent: October 7, 1980Assignee: The Purdue Frederick CompanyInventors: Sasson Cohen, Abraham Fisher
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Patent number: 4214059Abstract: Iodophor powders are prepared by suspending a particulate iodophor-forming polymer in an iodine solution in which the polymer is insoluble, and adding to the suspension a solution of an iodide in a solvent system miscible with the solvent of the iodine solution, to cause the formation of an iodophor. The iodophor can be separated from the solvent by filtration.Type: GrantFiled: June 12, 1978Date of Patent: July 22, 1980Assignee: The Purdue Frederick CompanyInventor: Peter Hofer
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Patent number: 4183938Abstract: Compounds of the general formula: ##STR1## wherein X is selected from the group consisting of oxygen, CH.sub.2 and CH radicals, and when X designates oxygen, R designates alkyl, isoalkyl, aralkyl, and substituted aralkyl groups and when X designates CH.sub.2 then R designates alkyl, phenyl or substituted phenyl group, and A-B is a single bond, and when X designates CH.sub.2 R designates alkyl, phenyl or substituted phenyl groups and A-B is a double bond; and physiologically acceptable salts of these, and mydriatic pharmaceutical compositions containing the same as active ingredient.Type: GrantFiled: November 17, 1977Date of Patent: January 15, 1980Assignee: The Purdue Frederick CompanyInventors: Sasson Cohen, Abraham Fisher
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Patent number: 4170300Abstract: A kit for aseptic changing of a dressing such as a catheter dressing includes a disposable tray made of a light plastic sheet material and having a cover sheet adhering thereto and closing depressions in the tray. This cover sheet is removable from the tray so as to render the depressions thereof accessible. In these depressions there are a number of items including packettes of antiseptic germicide solution and ointment, cleansing swabs, and the like, as well as a number of swabsticks, gauze pads, and adherent tape. These items also may include a sheet of drape material, a plastic bag for receiving a previously applied dressing which is removed, and plastic gloves. One of the items included in the tray is a suitable cutting tool, such as a disposable scissors.Type: GrantFiled: January 18, 1978Date of Patent: October 9, 1979Assignee: The Purdue Frederick CompanyInventor: Ernest W. Pick
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Patent number: 4167186Abstract: A syringe, particularly a vaginal douche, has a cannula consisting of an elongated hollow tubular body having one open end and an opposed transverse end wall formed with an opening through which a central axis of the cannula body extends. The cannula body has substantially midway between its ends a transverse minimum cross section while tapering only slightly from the transverse end wall toward the minimum cross section. Between its open end and its minimum cross section the cannula body tapers to a substantially greater degree and has the configuration of part of a hollow cone. At its exterior between its minimum cross section and transverse end wall the cannula body is formed with grooves uniformly distributed about the central axis of the cannula body and separated from each other by ribs. Adjacent but inwardly of these ribs the cannula body is formed with additional openings passing therethrough so that a liquid can discharge through the cannula openings.Type: GrantFiled: September 8, 1977Date of Patent: September 11, 1979Assignee: The Purdue Frederick CompanyInventors: Ernest W. Pick, Joseph M. Denaro, Henry R. Goerke
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Patent number: D250546Type: GrantFiled: September 8, 1977Date of Patent: December 12, 1978Assignee: The Purdue Frederick CompanyInventors: Ernest W. Pick, Joseph M. Denaro, Henry R. Goerke
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Patent number: D250600Type: GrantFiled: September 8, 1977Date of Patent: December 19, 1978Assignee: The Purdue Frederick CompanyInventors: Ernest W. Pick, Joseph M. Denaro, Henry R. Goerke
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Patent number: D250601Type: GrantFiled: September 8, 1977Date of Patent: December 19, 1978Assignee: The Purdue Frederick CompanyInventors: Ernest W. Pick, Joseph M. Denaro, Henry R. Goerke
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Patent number: D284088Type: GrantFiled: July 12, 1983Date of Patent: June 3, 1986Assignee: The Purdue Frederick CompanyInventors: Erwig Pinter, Michael Oellerich, Gerhard W. Sybrecht