Abstract: Human lipoxygenases (LOXs) are a family of iron-containing enzymes involved in catalyzing the oxidation of polyunsaturated fatty acids to provide the corresponding bioactive hydroxyeicosatetraenoic acid (HETE) metabolites. These eicosanoid signaling molecules are involved in a number of physiologic responses such as platelet aggregation, inflammation, and cell proliferation. Platelet-type 12-(S)-LOX (12-LOX) is of particular interest because of its demonstrated role in skin diseases, diabetes, platelet hemostasis, thrombosis, and cancer. Disclosed herein is the identification and medicinal chemistry optimization of a 4-((2-hydroxy-3-methoxybenzyl)amino)benzenesulfonamide-based scaffold. The compounds display nM potency against 12-LOX and excellent selectivity over related lipoxygenases and cyclooxygenases. In addition to possessing favorable ADME properties, the compounds also inhibit PAR-4 induced aggregation and calcium mobilization in human platelets, and reduce 12-HETE in mouse/human beta cells.

Abstract: Human lipoxygenases (LOXs) are a family of iron-containing enzymes involved in catalyzing the oxidation of polyunsaturated fatty acids to provide the corresponding bioactive hydroxyeicosatetraenoic acid (HETE) metabolites. These eicosanoid signaling molecules are involved in a number of physiologic responses such as platelet aggregation, inflammation, and cell proliferation. Platelet-type 12-(S)-LOX (12-LOX) is of particular interest because of its demonstrated role in skin diseases, diabetes, platelet hemostasis, thrombosis, and cancer. Disclosed herein is the identification and medicinal chemistry optimization of a 4-((2-hydroxy-3-methoxybenzyl)amino)benzenesulfonamide-based scaffold. The compounds display nM potency against 12-LOX and excellent selectivity over related lipoxygenases and cyclooxygenases. In addition to possessing favorable ADME properties, the compounds also inhibit PAR-4 induced aggregation and calcium mobilization in human platelets, and reduce 12-HETE in mouse/human beta cells.

Abstract: Human lipoxygenases (LOXs) are a family of iron-containing enzymes involved in catalyzing the oxidation of polyunsaturated fatty acids to provide the corresponding bioactive hydroxyeicosatetraenoic acid (HETE) metabolites. These eicosanoid signaling molecules are involved in a number of physiologic responses such as platelet aggregation, inflammation, and cell proliferation. Platelet-type 12-(S)-LOX (12-LOX) is of particular interest because of its demonstrated role in skin diseases, diabetes, platelet hemostasis, thrombosis, and cancer. Disclosed herein is the identification and medicinal chemistry optimization of a 4-((2-hydroxy-3-methoxybenzyl)amino)benzenesulfonamide-based scaffold. The compounds display nM potency against 12-LOX and excellent selectivity over related lipoxygenases and cyclooxygenases. In addition to possessing favorable ADME properties, the compounds also inhibit PAR-4 induced aggregation and calcium mobilization in human platelets, and reduce 12-HETE in mouse/human beta cells.

Abstract: Described herein are assays for identifying piericidins and piericidin compositions.

Abstract: Described herein are assays for identifying piericidins and piericidin compositions.

Abstract: A systematic screening has revealed a family of compounds that exhibit inhibitory effects on 12/15-lipoxygenase. Accordingly, the present invention relates to the use of these compounds for the inhibition of 12/15-lipoxygenase and for the treatment of a condition involving 12/15-lipoxygenase. Exemplary conditions include, but are not limited to, stroke, periventricular leukomalacia, cardiac arrest with resuscitation, atherosclerosis, Parkinson's disease, Alzheimer's disease, and breast cancer.

Abstract: Barcode decoding bypassing binarization is provided which relies on deformable templates to makes use of all the gray level information of each pixel in the barcode image. Parameterization of the deformable templates allow for efficiently performing maximum likelihood estimation independently on each barcode digit and enforcing spatial coherence across the barcode digits.

Abstract: A method of creating a super-resolved color image from multiple lower-resolution color images is provided by combining a data fidelity penalty term, a spatial luminance penalty term, a spatial chrominance penalty term, and an inter-color dependencies penalty term to create an overall cost function. The data fidelity penalty term is an L1 norm penalty term to enforce similarities between raw data and a high-resolution image estimate, the spatial luminance penalty term is to encourage sharp edges in a luminance component to the high-resolution image, the spatial chrominance penalty term is to encourage smoothness in a chrominance component of the high-resolution image, and the inter-color dependencies penalty term is to encourage homogeneity of an edge location and orientation in different color bands. A steepest descent optimization is applied to the overall cost function for minimization by applying a derivative to each color band while the other color bands constant.

Abstract: A method of image processing using kernel regression is provided. An image gradient is estimated from original data that is analyzed for local structures by computing a scaling parameter, a rotation parameter and an elongation parameter using singular value decomposition on local gradients of the estimated gradients locally to provide steering matrices. A steering kernel regression having steering matrices is applied to the original data to provide a reconstructed image and new image gradients. The new gradients are analyzed using singular value decomposition to provide new steering matrices. The steering kernel regression with the new steering matrices is applied to the noisy data to provide a new reconstructed image and further new gradients. The last two steps are repeated up to ten iterations to denoise the original noisy data and improve the local image structure.

Abstract: The temperature distribution associated with a design of an integrated circuit is calculated by convoluting a surface power usage represented by a power matrix with a heat spreading function. The heat spreading function may be calculated from a simulation of a point source on the integrated circuit using a finite element analysis model of the integrated circuit or other techniques. To account for spatial variations on the chip, the heat spreading function may be made dependent on position using a position scaling function. Steady-state or transient temperature distributions may be computed by using a steady-state or transient heat spreading function. A single heat spreading function may be convolved with various alternative power maps to efficiently calculate temperature distributions for different designs. In an inverse problem, one can calculate the power map from an empirically measured temperature distribution and a heat spreading function using various de-convolution techniques.

Abstract: The application concerns prototyped custom Programmable Logic Devices (Pills) for Boolean satisfiability (SAT) problems. This approach is based on the use of clause evaluation circuits (CECs), which indicate whether or not a single variable of the clause is asserted by the clause, and variable evaluation circuits (VECs), which identify the asserted variable of a clause having exactly one variable asserted by the clause. Scaling is provided by the use of partial CEC and VEC circuits.

Abstract: A computer method of creating a super-resolved grayscale image from lower-resolution images using an L1 norm data fidelity penalty term to enforce similarities between low and a high-resolution image estimates is provided. A spatial penalty term encourages sharp edges in the high-resolution image, the data fidelity penalty term is applied to space invariant point spread function, translational, affine, projective and dense motion models including fusing the lower-resolution images, to estimate a blurred higher-resolution image and then a deblurred image. The data fidelity penalty term uses the L1 norm in a likelihood fidelity term for motion estimation errors. The spatial penalty term uses bilateral-TV regularization with an image having horizontal and vertical pixel-shift terms, and a scalar weight between 0 and 1. The penalty terms create an overall cost function having steepest descent optimization applied for minimization. Direct image operator effects replace matrices for speed and efficiency.

Abstract: An integrated method for both super-resolution and multi-frame demosaicing includes an image fusion followed by simultaneous deblurring and interpolation. For the case of color super-resolution, the first step involves application of recursive image fusion separately on the three different color layers. The second step is based on minimizing a maximum a posteriori (MAP) cost function. In one embodiment, the MAP cost function is composed of several terms: a data fidelity penalty term that penalizes dissimilarity between the raw data and the super-resolved estimate, a luminance penalty term that favors sharp edges in the luminance component of the image, a chrominance penalty term that favors low spatial frequency changes in the chrominance component of the image, and an orientation penalty term that favors similar edge orientations across the color channels. The method is also applicable to color super-resolution (without demosaicing), where the low-quality input images are already demosaiced.

Abstract: A method is provided of solving the dynamic super-resolution (SR) problem of reconstructing a high-quality set of monochromatic or color superresolved images from low-quality monochromatic, color, or mosaiced frames. The invention includes a joint method for simultaneous SR, deblurring, and demosaicing, this way taking into account practical color measurements encountered in video sequences. For the case of translational motion and common space-invariant blur, the proposed invention is based on a very fast and memory efficient approximation of the Kalman filter (KF). Experimental results on both simulated and real data are supplied, demonstrating the invention algorithms, and their strength.