Patents Assigned to The Regents of the University of Colorado, a body corporate
  • Patent number: 11181536
    Abstract: A Disease Severity Index (DSI) is provided for assessment of chronic liver disease in a patient using non-invasive liver function test results. A DSI was derived from non-invasive liver function test results based on hepatic blood flow. The DSI is used in methods for prediction of clinical outcomes, prediction of response to antiviral treatment, and assessment of progression of chronic liver diseases. Non-invasive methods to diagnose three distinct categories of patients with Primary Sclerosing Cholangitis (PSC) are provided. The methods can be used to diagnose PSC patients as Slow Progressors, Moderate Progressors and Rapid Progressors.
    Type: Grant
    Filed: July 2, 2019
    Date of Patent: November 23, 2021
    Assignee: The Regents of the University of Colorado, a Body Corporate
    Inventors: Gregory Thomas Everson, Steve Mark Helmke
  • Patent number: 11180627
    Abstract: Disclosed are cellulose-based flexible gels containing cellulose nanorods, ribbons, fibers, and the like, and cellulose-enabled inorganic or polymeric composites, wherein the gels have tunable optical, heat transfer, and stiffness properties. The disclosed gels are in the form of hydrogels, organogels, liquid-crystal (LC) gels, and aerogels, depending on the solvents in the gels.
    Type: Grant
    Filed: January 11, 2018
    Date of Patent: November 23, 2021
    Assignee: The Regents of the University of Colorado, a body corporate
    Inventors: Andrew J. Hess, Qingkun Liu, Ivan I. Smalyukh
  • Patent number: 11179027
    Abstract: The invention provides devices that can be used for any endoscopy procedure. In certain embodiments, the devices of the invention reduce the occurrence of looping in the most difficult segment of the colon to navigate—the splenic flexure. In other embodiments, the devices of the invention make colonoscopies more comfortable for patients and reduce the risk of damage to the colon. In yet other embodiments, the devices of the invention comprise a supportive, friction-reducing device that can be attached to the tip of existing endoscopes to help the scope advance better through the colon and intestinal tract.
    Type: Grant
    Filed: December 5, 2016
    Date of Patent: November 23, 2021
    Assignee: The Regents of the University of Colorado, a Body Corporate
    Inventors: Mark Rentschler, Levin J. Sliker, Madalyn D. Kern, Joseph Micah Prendergast, William S. Smith, Kyle Galbraith, James Depoy, Karina Rose Laguardia, Andrew Patrick Gloor, Derek Sawyer
  • Patent number: 11171467
    Abstract: A compact diode laser achieves high-power, short duration output pulses by separating the lasing action from the pulse-generating mechanism. A diode seed source is configured for gain-switching via a variable RF source. A time lens element includes an intensity modulation device, a phase modulation device, and a pulse compressor. The intensity modulation device carves shorter pulses from the long gain-switched seed pulses, the phase modulation device adds chirp, and the pulse compressor compensates for the chirp while producing high-power short-duration output pulses.
    Type: Grant
    Filed: May 14, 2019
    Date of Patent: November 9, 2021
    Assignee: The Regents of the University of Colorado, a body corporate
    Inventors: Juliet T Gopinath, Robert D. Niederriter
  • Patent number: 11171511
    Abstract: Capacitive wireless power transfer systems are provided. In one embodiment, for example, the system comprises two pair of coupled conducting plates; a first matching network coupled to the first pair of conducting plates; and a second matching network coupled to the second pair of conducting plates. At least one of the first and second matching networks comprises an inductor having inductance value selected based on at least one parasitic capacitance value of the capacitive wireless power transfer system. In another embodiment, a method of designing a capacitive wireless power transfer system is provided comprising determining a parasitic capacitance value of a capacitive wireless power transfer system and determining an inductance value of an inductor of at least one of the first and second matching network having a value selected based on at least one parasitic capacitance value of the capacitive wireless power transfer system.
    Type: Grant
    Filed: January 3, 2019
    Date of Patent: November 9, 2021
    Assignee: The Regents of the University of Colorado, a body corporate
    Inventors: Khurram K. Afridi, Brandon Regensburger, Sreyam Sinha, Ashish Kumar
  • Patent number: 11169142
    Abstract: In some embodiments, the invention provides a method for identifying a patient suffering from or suspected of suffering in from a disease associated with the cardiovascular system that is having a subnormal response to the treatment for the disease comprising: subjecting a blood sample from a patient being treated for a disease to a viscoelastic analysis in the presence of a known amount of a thrombolytic agent, to obtain a coagulation characteristic value of the patient; and comparing the coagulation characteristic value of the patient to a coagulation characteristic value of a healthy individual, wherein a difference in the coagulation characteristic value of the patient as compared to the coagulation characteristic value of the healthy individual identifies the patient as a patient having a subnormal response to treatment.
    Type: Grant
    Filed: May 11, 2017
    Date of Patent: November 9, 2021
    Assignee: The Regents of the University of Colorado, a body corporate
    Inventor: Michael P. Chapman
  • Patent number: 11160908
    Abstract: The present disclosure provides an implantable device comprising a substrate capable of capturing an intraocular target molecule and to methods of use thereof.
    Type: Grant
    Filed: December 6, 2019
    Date of Patent: November 2, 2021
    Assignee: THE REGENTS OF THE UNIVERSITY OF COLORADO, A BODY CORPORATE
    Inventor: Jeffrey Olson
  • Patent number: 11155821
    Abstract: This invention relates to the field of ribonucleic acid (RNA) regulation of intracellular activity. In particular, the invention relates to compositions and methods of identifying and tracking specific intracellular RNAs. For example, a fluorescently tagged RNA probe may be tracked by in vivo live imaging throughout its intracellular lifetime in order to determine its purpose and identify regulatory targets to modify its effects. Alternatively, an RNA probe may carry a therapeutic payload for treatment of medical condition or disorder.
    Type: Grant
    Filed: July 30, 2019
    Date of Patent: October 26, 2021
    Assignees: The Regents of the University of Colorado, a body corporate, Institute of Organic Chemistry POS
    Inventors: Amy E. Palmer, Esther Braselmann, Robert T. Batey, Dorota Gryko
  • Publication number: 20210322151
    Abstract: Modular IOL systems including a base and a lens, wherein the lens includes tabs for connection to the base. The modular IOL allows for the lens to be adjusted or exchanged while leaving the base in place, either intra-operatively or post-operatively.
    Type: Application
    Filed: June 28, 2021
    Publication date: October 21, 2021
    Applicants: Alcon Inc., The Regents of the University of Colorado, a body corporate
    Inventors: Malik Y. KAHOOK, Glenn SUSSMAN, Rudolph F. ZACHER, Paul J. McLEAN, Harvey UY, Robert CIONNI, Kerry SOLOMON
  • Patent number: 11147946
    Abstract: The present invention contemplates devices and methods to administer nutritional compositions and/or therapeutic drugs directly into a portal venous system. For example, total parenteral nutrition therapy may be administered directly into the hepatic portal venous system thus circumventing known side effects of conventional parenteral administration. Alternatively, hepatic diseases and disorders may be treated using locally administered therapeutic drugs. Devices capable of direct portal venous system administration include, but are not limited to, a direct portal access catheter or a transjugular access catheter.
    Type: Grant
    Filed: October 2, 2015
    Date of Patent: October 19, 2021
    Assignee: THE REGENTS OF THE UNIVERSITY OF COLORADO, A BODY CORPORATE
    Inventor: Thor Johnson
  • Patent number: 11152854
    Abstract: The present disclosure provides methods and circuits of a hybrid converter family that allows using a combination of a switched multiple capacitor network and a number of inductors in order to a power conversion from an input to an output that may require a large conversion ratio, high output current, low output voltage, and/or high input voltage. The disclosed circuits and methods can be applied to today's switching regulators and allow them to provide the same power conversion function with less number of power conversion stages, smaller passive components, and less number of active components, and therefore, reduce the implementation space to save cost as well as improve efficiency. Sample applications include, but are not limited to, point-of-load power converters for data centers, telecommunication systems and other high-performance electronic systems.
    Type: Grant
    Filed: August 12, 2019
    Date of Patent: October 19, 2021
    Assignee: THE REGENTS OF THE UNIVERSITY OF COLORADO, A BODY CORPORATE
    Inventors: Ratul Das, Hanh-Phuc Le, Gabsu Seo
  • Publication number: 20210315706
    Abstract: A spinal implant device comprising a frame and a plurality of mechanical stiffness members extending from the frame, with the plurality of mechanical stiffness members being individually customized to provide a specific axial stiffness. The plurality of mechanical stiffness members may be coupled to the frame, and the plurality of mechanical stiffness members may be a plurality of wave-spring modules. A method of treating spinal disease includes determining actual spatial mechanical properties across a vertebral contact surface of a vertebra of a patient. The method may also include manufacturing a spinal implant device that has conforming spatial mechanical properties that are specific to the patient and that are based on the actual spatial mechanical properties of the vertebral contact surface. The method may include surgically implanting the spinal implant device against the vertebral contact surface such that the actual spatial mechanical properties and the conforming spatial mechanical properties align.
    Type: Application
    Filed: August 8, 2019
    Publication date: October 14, 2021
    Applicant: THE REGENTS OF THE UNIVERSITY OF COLORADO, A BODY CORPORATE
    Inventors: Andriy G. Noshchenko, Evalina Burger-(Van Der Walt), Vikas V. Patel, Christopher J. Kleck, Ji Ma
  • Patent number: 11143721
    Abstract: A probe beam is passed through a first optically pumped magnetometer vapor cell portion that has a first magnetic bias field orientation relative to a pump beam. The probe beam is also passed through a second optically pumped magnetometer vapor cell portion that has a second magnetic bias field orientation relative to the pump beam with the same properties as in the first portion, where the first magnetic bias field orientation is opposite to that of the second magnetic bias field orientation. This configuration reduces or eliminates linearly polarized magnetic signals (e.g., noise) from the output probe beam and passes circularly polarized magnetic signals. Thus, the intensity of the probe beam after passing through the first and second optically pumped magnetometer vapor cell portions is measured to obtain a noise suppressed signal.
    Type: Grant
    Filed: September 16, 2019
    Date of Patent: October 12, 2021
    Assignee: The Regents of the University of Colorado, a body corporate
    Inventor: Vladislav Gerginov
  • Patent number: 11145100
    Abstract: Novel tools and techniques are provided for implementing three-dimensional facial modeling and visual speech synthesis. In various embodiments, a computing system might determine an orientation, size, and location of a face in a received input image; retrieve a three-dimensional model template comprising a face and head; project the input image onto the model template to generate a three-dimensional model; define, on the model, a polygon mesh in a region of facial feature corresponding to feature in the input image; adjust parameters on the model; and display the model. The computing system might parse a text string into allophonic units; encode each allophonic unit into a point(s) in linguistic space corresponding to mouth movements; retrieve, from a codebook, indexed images/morphs corresponding to encoded points in the linguistic space; render the indexed images/morphs into an animation of the three-dimensional model; synchronize, for output, the animation with audio representations of the text string.
    Type: Grant
    Filed: January 12, 2018
    Date of Patent: October 12, 2021
    Assignee: The Regents of the University of Colorado, a body corporate
    Inventors: Sarel van Vuuren, Nattawut Ngampatipatpong, Robert N. Bowen
  • Patent number: 11141546
    Abstract: A system and methods for the delivery of oxygen through a body cavity of a subject using oxygen microbubbles. Through circulation of oxygen microbubbles through the body cavity, oxygen and carbon dioxide exchange may occur. Overall improvement in extending survival rate time during emergency situations caused by pulmonary or similar oxygen-intake restricting injury and/or failure may be achieved through use of the invented system and methods.
    Type: Grant
    Filed: November 2, 2018
    Date of Patent: October 12, 2021
    Assignees: The Regents of the University of Colorado, a Body Corporate, Board of Regents of the University of Nebraska
    Inventors: Mark A. Borden, Benjamin S. Terry
  • Publication number: 20210307589
    Abstract: A medical device includes an elongate body and an inflatable balloon attached to and partially surrounding at least a section of the elongate body. The inflatable balloon is selectively inflatable between a deflated state and an inflated state. Engagement between the balloon and a physiological lumen is provided, in part, by multiple protrusions extending from the inflatable balloon and having various physical and functional characteristics. In certain implementations, the balloon may be configured to exhibit various separation forces by applying different strains to the balloon, such as by varying the degree to which the balloon is inflated or deflated.
    Type: Application
    Filed: June 22, 2021
    Publication date: October 7, 2021
    Applicant: The Regents of the University of Colorado, a Body Corporate
    Inventors: Mark E. Rentschler, Steven A. Edmundowicz, Karl Johannes
  • Patent number: 11137409
    Abstract: In some embodiments, the invention provides methods for detecting an aberrant fibrinolysis condition in a patient. The method includes subjecting a blood sample from the patient to a viscoelastic analysis in the presence of a known amount of a thrombolytic agent, to obtain a coagulation characteristic value of the patient; and comparing the coagulation characteristic value of the patient to a coagulation characteristic value of a healthy individual, the coagulation characteristic value of the healthy individual obtained by subjecting a blood sample from a healthy individual to the viscoelastic analysis in the presence of the known amount of the thrombolytic agent, wherein a difference in the coagulation characteristic value of the patient as compared to the coagulation characteristic value of the healthy individual identifies the patent as having aberrant fibrinolysis.
    Type: Grant
    Filed: November 5, 2015
    Date of Patent: October 5, 2021
    Assignee: The Regents of the University of Colorado, a body corporate
    Inventors: Michael P. Chapman, Hunter B. Moore, Eduardo Gonzalez Barreda, Ernest E. Moore
  • Publication number: 20210301002
    Abstract: This disclosure provides anti-HSPA5 antibodies. Also featured is a method for delivering an agent into the brain, spinal cord, or other component of the central nervous system. In addition, methods of identifying a human subject at risk of relapse of neuromyelitis optica (NMO) or neuropsychiatric systemic lupus erythematosus (NP-SLE) are disclosed, as are methods of determining the severity of an attack of NMO or NP-SLE, and methods of diagnosing NP-SLE.
    Type: Application
    Filed: February 23, 2021
    Publication date: September 30, 2021
    Applicants: Biogen MA Inc., The Regents of the University of Colorado, a body corporate
    Inventors: Jeffrey L. Bennett, Richard M. Ransohoff, Fumitaka Shimizu, Kristin L. Schaller
  • Publication number: 20210299406
    Abstract: A vascular access system and device. The vascular access device includes a frame having a handle, a linear actuation assembly, and a needle retainer, according to various embodiments. The linear actuation assembly is mounted to the frame and has a translating portion configured to translate relative to the frame, according to various embodiments. The needle retainer is coupled to the translating portion and is configured to retainer a needle, according to various embodiments. In various embodiments, the needle retainer is one needle retainer of a plurality of needle retainers, the plurality of needle retainers is configured to retain a respective plurality of needles, and the plurality of needle retainers is configured to operably translate as a unit with the translating portion relative to the frame.
    Type: Application
    Filed: August 6, 2019
    Publication date: September 30, 2021
    Applicant: THE REGENTS OF THE UNIVERSITY OF COLORADO, A BODY CORPORATE
    Inventors: Juan-Pablo Idrovo, Andrew Scallon
  • Patent number: D933819
    Type: Grant
    Filed: October 4, 2019
    Date of Patent: October 19, 2021
    Assignees: Shukla Medical, The Regents of the University of Colorado, a body corporate
    Inventors: Zachary Robert Sweitzer, Jonathan Todd Bravman