Patents Assigned to The Regents of the University of Colorado, a body corporate
  • Publication number: 20200370203
    Abstract: Provided herein, in some embodiments, are methods and compositions for gene editing using a trackable gene library, for example, a barcoded and gene edited library.
    Type: Application
    Filed: February 4, 2019
    Publication date: November 26, 2020
    Applicant: The Regents of the University of Colorado, a Body Corporate
    Inventors: Kenneth Felsenstein, Dan Theodorescu, Ryan T. Gill
  • Publication number: 20200352424
    Abstract: A self-propelled semi- or fully-autonomous robotic endoscope device is provided that include multi-degrees of freedom movement and may be sensor-enabled for colonoscopy procedures. The device may include two independently controlled motors configured to drive micro-pillared treads above and below the device, allowing for 2-degrees of freedom (DOF) skid-steering even in a collapsed lumen. The robotic device contains similar functionality of a traditional endoscope, such as a camera, adjustable LEDs, channels for insufflation and irrigation, and a tool port for common endoscopy instruments (e.g., forceps, snares, etc.).
    Type: Application
    Filed: May 6, 2020
    Publication date: November 12, 2020
    Applicant: The Regents of the University of Colorado, a body corporate
    Inventors: Mark E. Rentschler, Gregory Formosa, Joseph M. Prendergast
  • Publication number: 20200352539
    Abstract: Various systems and methods for generating images are provided. In some embodiments, the techniques can include acquiring a medical image and an associated motion characterization. The motion characterization can then be used to generate a plurality of gated image data sets, sorted by phase in the motion cycle. A new amplitude-based motion characterization curve is derived from the association of phases with amplitude-based characteristics in the phase gated images. This newly derived amplitude-based motion characterization curve can then be used to re-sort data according to amplitude-based gating techniques known in the field or with data driven optimization techniques.
    Type: Application
    Filed: April 6, 2020
    Publication date: November 12, 2020
    Applicant: The Regents of the University of Colorado, a body corporate
    Inventor: Adam Kesner
  • Patent number: 10830262
    Abstract: A phononic material and a method of using a phononic material for use in interacting with a fluid or solid flow are provided. The phononic material includes an interface surface and a subsurface feature. The interface surface is adapted to move in response to a pressure, and/or velocity gradients, associated with complex motion of a turbulent flow exhibiting a polarity of frequencies exerted on the interface surface. The subsurface feature extends from the interface surface. The subsurface feature comprises a phononic crystal or locally resonant metamaterial adapted to receive the pressure, and/or velocity gradients, from the turbulent flow via the interface surface and alter the phase and amplitude of a polarity of frequency components of the turbulent flow in order to reduce or increase the kinetic energy of the turbulent flow.
    Type: Grant
    Filed: June 29, 2017
    Date of Patent: November 10, 2020
    Assignee: The Regents of the University of Colorado, a body corporate
    Inventors: Mahmoud Hussein, Sedat Biringen
  • Patent number: 10829834
    Abstract: Systems and methods for recovering material from a gas phase are provided. Exemplary systems include a moving bed of particles onto which material can be deposited. The systems can operate in a continuous or semi-continuous mode.
    Type: Grant
    Filed: March 4, 2016
    Date of Patent: November 10, 2020
    Assignee: THE REGENTS OF THE UNIVERSITY OF COLORADO A Body Corporate
    Inventors: Alan W. Weimer, Aaron W. Palumbo, Illias Hischier, Arto J. Groehn, Boris A. Chubukov, Scott C. Rowe, Richard Fisher
  • Patent number: 10829420
    Abstract: The invention provides filamentous organism-derived carbonaceous materials doped with organic and/or inorganic compounds, and methods of making the same. In certain embodiments, these carbonaceous materials are used as electrodes in solid state batteries and/or lithium-ion batteries. In another aspect, these carbonaceous materials are used as a catalyst, catalyst support, adsorbent, filter and/or other carbon-based material or adsorbent. In yet another aspect, the invention provides battery devices incorporating the carbonaceous electrode materials.
    Type: Grant
    Filed: July 21, 2017
    Date of Patent: November 10, 2020
    Assignees: The Regents of the University of Colorado, a body corporate, The Government of the United States of America, as represented by the Secretary of the Navy
    Inventors: Zhiyong Ren, Mitchell Tyler Huggins, Justin C. Biffinger, Corey T. Love, Se-Hee Lee, Justin M. Whiteley
  • Patent number: 10807864
    Abstract: The invention includes a method of promoting interfacial mechanical bonding of two or more components through the use of suspended and/or freestanding structures fabricated using an atom-scale assembly process on at least a portion of the surfaces of such components.
    Type: Grant
    Filed: January 29, 2018
    Date of Patent: October 20, 2020
    Assignee: The Regents of the University of Colorado, a body corporate
    Inventors: Joseph J. Brown, Victor M. Bright
  • Publication number: 20200323658
    Abstract: Systems and methods for postural control of a multi-function prosthesis are provided. Various embodiments provide for a postural controller that use EMG signals to drive a point in a posture space and outputs continuously varying joint angles for a powered prosthetic hand. The postural controller can include an EMG signal processing unit to receive signals from electrodes for processing (e.g., band pass filtering, rectification, root mean square averaging, dynamic tuning, etc.). The processed EMG signals can then be combined or converted to produce a point in the postural control domain. The PC domain map defines the posture that corresponds to each PC cursor coordinate. This map can have limitless possible postures and limitless possible positions of the postures. The Joint Angle Transform converts the PC cursor coordinate into the joint angle array which is sent to the prosthetic hand thereby creating more natural movements.
    Type: Application
    Filed: April 27, 2020
    Publication date: October 15, 2020
    Applicant: The Regents of the University of Colorado, a body corporate
    Inventors: Jacob Segil, Richard Weir
  • Patent number: 10799511
    Abstract: The present invention includes compounds, compositions and methods for reducing or ameliorating mortality and/or morbidity due to chlorine inhalation.
    Type: Grant
    Filed: August 17, 2018
    Date of Patent: October 13, 2020
    Assignee: The Regents of the University of Colorado, a body corporate
    Inventor: Livia A. Veress
  • Publication number: 20200316645
    Abstract: The present invention relates to the unexpected discovery of novel methods of preparing nanodevices and/or microdevices with predetermined patterns. In one aspect, the methods of the invention allow for engineering structures and films with continuous thickness equal to or less than 50 nm.
    Type: Application
    Filed: May 25, 2017
    Publication date: October 8, 2020
    Applicants: The Regents of the University of Colorado, a Body Corporate, DRS Network & Imaging Systems, LLC
    Inventors: Steven M. GEORGE, Victor M. BRIGHT, Joseph J. BROWN, Jonas GERTSCH, Nathan Thomas EIGENFELD, George SKIDMORE
  • Patent number: 10791731
    Abstract: Systems for controlled freezing, storing and thawing a biological material in a bag and supporting apparatus. The systems are adapted to receive the biological material therein for freezing, storing, transporting and rapid thawing immediately prior to administration to a patient in need of the biological material.
    Type: Grant
    Filed: June 8, 2016
    Date of Patent: October 6, 2020
    Assignee: The Regents of the University of Colorado, a body corporate
    Inventors: Michael P. Chapman, Ernest Moore
  • Patent number: 10793851
    Abstract: Compositions and methods for tracking combinations of mutations in populations by coupling DNA assembly and paired-end sequencing technology with high-throughput sequencing. This allows for an unlimited number of mutation sites in a population of microorganisms to be identified, and allows sites to be sequenced across several replicates. Unique identifiers (DNA barcodes) can be used to measure fitness data by sequencing of the barcodes multiplexed with the mutation sites with high-throughput short sequencing read technology, allowing selections to be rapidly performed on populations of known combinatorial genotypes.
    Type: Grant
    Filed: August 4, 2016
    Date of Patent: October 6, 2020
    Assignee: The Regents of the University of Colorado, a body corporate
    Inventors: Ryan T. Gill, Ramsey Zeitoun
  • Patent number: 10794453
    Abstract: A miniturized laminar gear box possessing high torque densities and methods of manufacturing the same. The high torque density is possible by directing the output shaft of the planetary stages through the sun gear and behind the input shaft. This allows the input shafts of the planetary stages to face towards the interior of the gearbox and provides a rotary shaft for the spur stages housed in between the planetary stages.
    Type: Grant
    Filed: March 27, 2019
    Date of Patent: October 6, 2020
    Assignees: THE REGENTS OF THE UNIVERSITY OF COLORADO, A BODY CORPORATE, COLORADO SCHOOL OF MINES
    Inventors: Richard Weir, Stephen Huddle, Barathwaj Murali, Ozkan Celik
  • Patent number: 10796403
    Abstract: An imaging system is provided. The imaging system includes a 3D image capture device, which is configured to capture a depth image of an object, and a thermal image capture device, which is configured to capture a thermal image of the object. The imaging system also includes a processing system, which is coupled with the 3D image capture device and the thermal image capture device. The processing system is configured to process the depth image and the thermal image to produce a thermal-depth fusion image by aligning the thermal image with the depth image, and assigning a thermal value derived from the thermal image to a plurality of points of the depth image.
    Type: Grant
    Filed: September 14, 2018
    Date of Patent: October 6, 2020
    Assignee: The Regents of the University of Colorado, a body corporate
    Inventors: Min-Hyung Choi, Shane Transue
  • Patent number: 10786391
    Abstract: A microsurgical device and methods of its use can be used for treatment of various conditions including eye diseases, such as glaucoma, using minimally invasive surgical techniques. A dual-blade device can be used for cutting the trabecular meshwork (“TM”) in the eye. The device tip provides entry into the Schlemm's canal via its size (i.e., for example, 0.2-0.3 mm width) and configuration where a ramp elevates the TM away from the outer wall of the Schlemm's canal and guides the TM to first and second lateral elements for creating first and second incisions through the TM. The dimensions and configuration of the blade is such that an entire strip of TM is removed without leaving TM leaflets behind and without causing collateral damage to adjacent tissues.
    Type: Grant
    Filed: November 8, 2019
    Date of Patent: September 29, 2020
    Assignee: THE REGENTS OF THE UNIVERSITY OF COLORADO, A BODY CORPORATE
    Inventor: Malik Y. Kahook
  • Patent number: 10787744
    Abstract: The invention includes a method of promoting atomic layer etching (ALE) of a surface. In certain embodiments, the method comprises sequential reactions with a metal precursor and a halogen-containing gas. In other embodiments, the etching rate is increased by removing residual species bound to and/or adsorbed onto the surface.
    Type: Grant
    Filed: July 30, 2018
    Date of Patent: September 29, 2020
    Assignee: The Regents of the University of Colorado, a body corporate
    Inventors: Steven McClellan George, Nicholas Ray Johnson, Jaime Willadean Dumont, Amy Elizabeth Marquardt, Younghee Lee, David Richard Zywotko, Aziz Abdulagatov
  • Patent number: 10786289
    Abstract: A plate including elements for receiving threads of a fastener element such that the fastener element may be positioned close, if not flush, to a surface of the plate allowing placement of the assembly much closer to a joint than previous known methods and without interfering with the function of a joint.
    Type: Grant
    Filed: July 16, 2015
    Date of Patent: September 29, 2020
    Assignee: The Regents of the University of Colorado a Body Corporate
    Inventors: Vikas Patel, Jay Nanninga
  • Publication number: 20200283683
    Abstract: Liquid crystal polymers (LCPs) are described herein that include novel arrangements of bio-mimicking properties for use in surgery, therapy, and treatment of medical or comfort issues. Through the particular arrangements medical devices and portions of them may be adapted to have properties that dampen and dissipate vibrations such as shocks to body tissues during surgical recovery and/or during subsequent use. This dampening is attained by novel arrangements of LCP and processes for forming them that vary from prior attempts at synthesizing activated LCP elements. These novel arrangements include using LCP bodies that include thicknesses and properties that have not been demonstrated or achieved for medical or other purposes and that are achieved using distinct processes. These novel LCP arrangements and methods of creating them can produce medical devices that bio-mimic natural tissue or operation to provide better results for patients.
    Type: Application
    Filed: October 21, 2019
    Publication date: September 10, 2020
    Applicant: The Regents of the University of Colorado, a body corporate
    Inventor: Christopher M. Yakacki
  • Patent number: 10765509
    Abstract: A device according to the present disclosure comprises an intraocular prosthetic. In some embodiments, the device comprises a lens portion and a plurality of arms that radiate outward from the lens portion. The lens portion can comprise a central ring used to hold an intraocular lens. Each arm can comprise a foot plate which allows the device to push out distally against a ciliary body. Among other things, an intraocular device according to the present disclosure can be useful in correction of aphakia, restoration of accommodation, and treatment of glaucoma.
    Type: Grant
    Filed: October 20, 2016
    Date of Patent: September 8, 2020
    Assignee: THE REGENTS OF THE UNIVERSITY OF COLORADO, A BODY CORPORATE
    Inventors: Jeffrey Olson, Michael Erlanger
  • Publication number: 20200276203
    Abstract: Provided are methods for treating a disease or condition associated with reduced autophagy in a patient, which includes administering to the patient, either simultaneously or sequentially, a therapeutically effective amount of a synergistic combination of compounds from at least two and preferably three of the classes of compounds selected from a saccharide, a vitamin, a ketone body, a polyphenol, and a methylxanthine. The compounds may be present in a subtherapeutic effective amount relative to the compound's dosing when given as a single agent. Also provided are pharmaceutically acceptable compositions and kits including at least two and preferably three of the named classes of compounds.
    Type: Application
    Filed: May 15, 2020
    Publication date: September 3, 2020
    Applicant: The Regents Of The University Of Colorado, a body corporate
    Inventors: Thomas LAROCCA, Douglas SEALS