Patents Assigned to The Regents of the University of Colorado, a body corporate
  • Publication number: 20220371953
    Abstract: Methods of forming cement pastes, methods of forming concrete, and methods of forming other compositions using mineral particles formed from the one or more of biomineralizing microorganisms and biomineralizing microorganisms. Desired features, such as size and morphology, can be controlled by controlling growth parameters of the biomineralizing microorganisms and biomineralizing microorganisms.
    Type: Application
    Filed: October 30, 2020
    Publication date: November 24, 2022
    Applicant: The Regents of the University of Colorado, a body corporate
    Inventors: Wilfred V. Srubar, III, Sarah Lynn Williams, Jeffrey Cameron, Mija Hubler, Sherri Cook, Aparna Nagarajan, Chelsea Heveran
  • Publication number: 20220370195
    Abstract: Modular IOL removal systems and methods that cut an optic portion of an intraocular in a single motion such to facilitate removal of the optic portion from an eye through an incision, for example a corneal incision, without increasing the size of the corneal incision. Various cutting tools having one or more blades may be utilized. The cut intraocular lens may have one continuous cut or be cut into multiple smaller pieces. The single cutting step may apply balanced forces and torque to avoid damaging the surrounding eye anatomy, reducing the risk of trauma.
    Type: Application
    Filed: August 3, 2022
    Publication date: November 24, 2022
    Applicants: Alcon Inc., The Regents of the University of Colorado, a body corporate
    Inventors: Malik Y. KAHOOK, Glenn SUSSMAN, Paul McLEAN, Andrew Thomas SCHIEBER
  • Patent number: 11508951
    Abstract: An aspect of the present disclosure is a system that includes a first deposition system that includes a first cylinder having a first outer surface configured to hold a first substrate, a first spray nozzle configured to receive at least a first fluid, and a first fiber nozzle configured to receive at least a second fluid, where the first spray nozzle is configured to operate at a first voltage, the first fiber nozzle is configured to operate at a second voltage, the first cylinder is configured to be electrically connected to ground, the first spray nozzle is configured to apply onto the substrate a first plurality of at least one of particles or droplets from the first fluid, the first fiber nozzle is configured to apply onto the substrate a first fiber from the second fluid, and the first plurality of particles or droplets and the first fiber combine to form a first composite layer on the substrate.
    Type: Grant
    Filed: November 13, 2019
    Date of Patent: November 22, 2022
    Assignees: Alliance for Sustainable Energy, LLC, The Regents of the University of Colorado, a Body Corporate
    Inventors: Chunmei Ban, Simon Elnicki Hafner, Se-Hee Lee
  • Publication number: 20220357116
    Abstract: Polymer-based selective radiative cooling structures are provided which include a selectively emissive layer of a polymer or a polymer matrix composite material. Exemplary selective radiative cooling structures are in the form of a sheet, film or coating. Also provided are methods for removing heat from a body by selective thermal radiation using polymer-based selective radiative cooling structures.
    Type: Application
    Filed: June 24, 2022
    Publication date: November 10, 2022
    Applicants: The Regents of the University of Colorado, A Body Corporate, University of Wyoming
    Inventors: Ronggui YANG, Xiaobo YIN, Gang TAN, Dongliang ZHAO, Yaoguang MA, Yao ZHAI
  • Patent number: 11496045
    Abstract: The present disclosure provides methods and circuits of multi-output hybrid voltage regulators that generate multiple lower level DC voltages lower than the magnitude of an input voltage provided to an input node of the regulator. The disclosed methods and circuits can be applied to today's Large conversion ratio DC-DC converters that allow them to support same power conversion functionality for multiple output voltages with one core switched capacitor network sharing passive components and switches with less voltage ratings, and therefore, reduce the implementation space to save cost as well as improve efficiency. Sample applications include, but are not limited to, PoL converters for data centers and telecommunication systems with better efficiency and compactness for higher conversion ratio.
    Type: Grant
    Filed: August 12, 2019
    Date of Patent: November 8, 2022
    Assignee: THE REGENTS OF THE UNIVERSITY OF COLORADO, A BODY CORPORATE
    Inventors: Ratul Das, Hanh-Phuc Le
  • Patent number: 11493749
    Abstract: A tunable optical electrowetting element having a liquid-liquid interface shape controlled by an applied voltage. Circuitry for applying a voltage to the electrowetting element is configured to apply a shaped voltage signal comprising a first fast-rising signal combined with a second fast-rising signal. The second signal is selected to damp oscillations in the liquid-liquid interface caused by the first signal.
    Type: Grant
    Filed: February 28, 2019
    Date of Patent: November 8, 2022
    Assignee: Regents of the University of Colorado, a body corporate
    Inventors: Juliet T. Gopinath, Victor M. Bright, Mo Zohrabi, Omkar D. Supekar, Robert H. Cormack, Wei Yang Lim
  • Patent number: 11491111
    Abstract: The present invention relates generally to the field of immunogenic compositions containing volatile salts. In certain embodiments, compositions and methods disclosed herein relate to producing and using novel combinations to create frozen immunogenic agents bound to adjuvant having improved formulations and improved consistency of distribution of adjuvant for storage and subsequent delivery to a subject in need thereof.
    Type: Grant
    Filed: June 21, 2019
    Date of Patent: November 8, 2022
    Assignee: The Regents of the University of Colorado, a body corporate
    Inventors: Kimberly Hassett, Pradyot Nandi, John Carpenter, Theodore Randolph
  • Publication number: 20220346943
    Abstract: A modular IOL system including intraocular primary and secondary components, which, when combined, form an intraocular optical correction device, wherein the secondary component is placed on the primary component within the perimeter of the capsulorhexis, thus avoiding the need to touch or otherwise manipulate the capsular bag. The secondary component may be manipulated, removed, and/or exchanged for a different secondary component for correction or modification of the optical result, on an intra-operative or post-operative basis, without the need to remove the primary component and without the need to manipulate the capsular bag. The primary component may have haptics extending therefrom for centration in the capsular bag, and the secondary component may exclude haptics, relying instead on attachment to the primary component for stability. Such attachment may include actuatable interlocking members.
    Type: Application
    Filed: July 1, 2022
    Publication date: November 3, 2022
    Applicants: Alcon Inc., The Regents of the University of Colorado, a body corporate
    Inventors: Malik Y. KAHOOK, Naresh MANDAVA, Glenn SUSSMAN, Paul MCLEAN, Robert E. ATKINSON
  • Patent number: 11486421
    Abstract: Hydraulically-amplified, self-healing, electrostatic transducers that harness electrostatic and hydraulic forces to achieve various actuation modes. Electrostatic forces between electrode pairs of the transducers generated upon application of a voltage to the electrode pairs draws the electrodes in each pair towards each other to displace a liquid dielectric contained within an enclosed internal cavity of the transducers to drive actuation in various manners. The electrodes and the liquid dielectric form a self-healing capacitor whereby the liquid dielectric automatically fills breaches in the liquid dielectric resulting from dielectric breakdown. Due to the resting shape of the cavity, a zipping-mechanism allows for selectively actuating the electrodes to a desired extent by controlling the voltage supplied.
    Type: Grant
    Filed: March 4, 2019
    Date of Patent: November 1, 2022
    Assignee: The Regents of the University of Colorado, a body corporate
    Inventors: Christoph Matthias Keplinger, Eric Lucas Acome, Nicholas Alexander Kellaris, Shane Karl Mitchell, Timothy G. Morrissey
  • Patent number: 11480560
    Abstract: A system comprising a respirator, a biochip, and an atomizer for studying respiratory pathogens. The respirator of the system is configured to create breathe-mimicking air movement, the biochip comprises an airway lumen in fluid communication with the respirator, and the atomizer is in fluid communication with the airway lumen of the biochip, according to various embodiments. The atomizer may be configured to generate droplets of a respiratory pathogen (e.g., from liquid inoculum). In various embodiments, the breath-mimicking air movement comprises air volume as a function of time, wherein the respirator is configured to generate breathing cycles.
    Type: Grant
    Filed: June 11, 2019
    Date of Patent: October 25, 2022
    Assignee: The Regents of the University of Colorado, A Body Corporate
    Inventors: Kambez Hajipouran Benam, Brian Frazier Niemeyer, Alexander Joseph Kaiser
  • Patent number: 11480736
    Abstract: A fiber-to-chip coupler includes a substrate, a waveguide on a top surface of the substrate, an optical fiber axially aligned to the waveguide, and a cap. The waveguide has a uniform region with uniform width and a tapered-waveguide region having a width that adiabatically increases from a minimum width to the uniform width. The optical fiber has a tapered fiber tip having a minimum core diameter, a cylindrical section having a maximum core diameter, and a tapered-fiber section therebetween. The optical fiber is located at least in part above the tapered-waveguide region, and has a core diameter that adiabatically decreases within a taper length of the tapered-fiber section. The cap extends from the tapered fiber tip toward the cylindrical section, is formed of a second material having a cap refractive index that exceeds a refractive index of the optical fiber, and includes a cap-region disposed on the tapered-waveguide region.
    Type: Grant
    Filed: January 8, 2021
    Date of Patent: October 25, 2022
    Assignees: The Regents of the University of Colorado, a body corporate, Government of the United States of America, as represented by the Sec. of Commerce
    Inventors: Saeed Khan, Jeffrey Shainline
  • Patent number: 11478367
    Abstract: Systems and methods for postural control of a multi-function prosthesis are provided. Various embodiments provide for a postural controller that use EMG signals to drive a point in a posture space and outputs continuously varying joint angles for a powered prosthetic hand. The postural controller can include an EMG signal processing unit to receive signals from electrodes for processing (e.g., band pass filtering, rectification, root mean square averaging, dynamic tuning, etc.). The processed EMG signals can then be combined or converted to produce a point in the postural control domain. The PC domain map defines the posture that corresponds to each PC cursor coordinate. This map can have limitless possible postures and limitless possible positions of the postures. The Joint Angle Transform converts the PC cursor coordinate into the joint angle array which is sent to the prosthetic hand thereby creating more natural movements.
    Type: Grant
    Filed: April 27, 2020
    Date of Patent: October 25, 2022
    Assignee: The Regents of the University of Colorado, a body corporate
    Inventors: Jacob Segil, Richard Weir
  • Patent number: 11481979
    Abstract: Systems and methods are described for mobile and augmented reality-based depth and thermal fusion scan imaging. Some embodiments of the present technology use sophisticated techniques to fuse information from both thermal and depth imaging channels together to achieve synergistic effects for object recognition and personal identification. Hence, the techniques used in various embodiments provide a much better solution for, say, first responders, disaster relief agents, search and rescue, and law enforcement officials to gather more detailed forensic data. Some embodiments provide a series of unique features including small size, wearable devices, and ability to feed fused depth and thermal streams into AR glasses. In addition, some embodiments use a two-layer architecture for performing device local fusion and cloud-based platform for integration of data from multiple devices and cross-scene analysis and reconstruction.
    Type: Grant
    Filed: April 23, 2019
    Date of Patent: October 25, 2022
    Assignee: The Regents of the University of Colorado, a body corporate
    Inventors: Min-Hyung Choi, Shane Transue
  • Publication number: 20220331094
    Abstract: Modular IOL systems including a base and a lens, wherein the lens includes fixed and actuatable tabs for connection to the base. The modular IOL allows for the lens to be adjusted or exchanged while leaving the base in place, either intra-operatively or post-operatively. Drug delivery capabilities and/or sensing capabilities may be incorporated into the base. Injector devices may be used to facilitate placement of the base and the lens sequentially or simultaneously into the eye.
    Type: Application
    Filed: June 30, 2022
    Publication date: October 20, 2022
    Applicants: Alcon Inc., The Regents of the University of Colorado, a body corporate
    Inventors: Malik Y. KAHOOK, Glenn SUSSMAN, Paul McLEAN, Andrew SCHIEBER
  • Patent number: 11473135
    Abstract: Disclosed herein is a multiplexed design with three-dimensional plasmonic nanofocusing and confinement of light, demonstration of reproducible and robust single-molecule optical fingerprints using two complementary vibrational spectroscopy techniques (infrared and Raman spectroscopy), identification of respective vibrational modes which uniquely fingerprint the biomolecular species, and facile differentiation of respective fingerprints in DNA mixtures, as well as epigenetic modifications. While the nanometer scale mode volumes still prevent single letter identification of DNA sequence, we show an alternative method for identifying A, T, G, C DNA nucleotides in “k-mers” using sequences of these blocks as a unique and high-throughput alternative to single letter sequences (similar to binary and hexadecimal systems). Furthermore, additivity shown in single-molecule DNA mixtures and robust optical signatures can also be used in a raster-type step scan to identify single letter sequences.
    Type: Grant
    Filed: December 6, 2018
    Date of Patent: October 18, 2022
    Assignee: THE REGENTS OF THE UNIVERSITY OF COLORADO, A BODY CORPORATE
    Inventors: Prashant Nagpal, Manjunatha Sagar Dodderi
  • Patent number: 11472812
    Abstract: Methods of inhibiting the growth or metastasis of a cancer in a subject by inhibiting a Ral GTPase in the subject, and small molecule inhibitors of Ral GTPases useful in the methods of the invention. Pharmaceutical compositions containing the compounds of the invention, and methods of using the same.
    Type: Grant
    Filed: April 30, 2020
    Date of Patent: October 18, 2022
    Assignee: THE REGENTS OF THE UNIVERSITY OF COLORADO, A BODY CORPORATE
    Inventors: Dan Theodorescu, Michael Fitzpatrick Wempe, David Ross, Chao Yan, Phillip Reigan
  • Patent number: 11473096
    Abstract: Compositions and methods for providing desired cannabinoid content in cannabis plants. More particularly, the invention relates to compositions and methods for using cannabinoid synthase paralogs as guidance for breeding cannabis plants with a desired cannabinoid content, including but not limited to cultivars, varieties, lines and methods of breeding the same for commercial use.
    Type: Grant
    Filed: October 3, 2018
    Date of Patent: October 18, 2022
    Assignees: The Regents of the University of Colorado, A Body Corporate, Steve DeAngelo & Associates, LLC
    Inventors: Christopher Pauli, Kayia Clancy, Daniela Vergara, Nolan Coburn Kane, Reginald Gaudino, Robert Givens, Anthony C. Torres, Christian Cizek
  • Patent number: 11466010
    Abstract: Toll-like receptor 8 (TLR8)-specific inhibitors and methods of using the same in individuals having an autoimmune disease or an inflammatory disorder.
    Type: Grant
    Filed: October 30, 2018
    Date of Patent: October 11, 2022
    Assignee: THE REGENTS OF THE UNIVERSITY OF COLORADO, A BODY CORPORATE
    Inventors: Hang Hubert Yin, Shuting Zhang, Zhenyi Hu
  • Publication number: 20220316466
    Abstract: A pumping system includes a conduit with an inlet region and an outlet region and a first pump coupled with the conduit between the inlet region and the outlet region. The first pump includes a first actuator chamber configured to house at least a first actuator, a first pump chamber aligned along a longitudinal axis of the conduit, wherein the first pump chamber is in fluid communication with the inlet region and the outlet region, and a first flexible diaphragm separating the first actuator chamber from the first pump chamber. Methods for operating the pumping system are also disclosed.
    Type: Application
    Filed: August 14, 2020
    Publication date: October 6, 2022
    Applicant: The Regents of the University of Colorado, a body corporate
    Inventors: Shane Karl Mitchell, Eric Lucas Acome, Christoph Matthias Keplinger
  • Publication number: 20220313785
    Abstract: This invention provides compositions and methods for preventing inflammatory diseases of the joints, including rheumatoid and osteoarthritis, tendonitis, bursitis, inflammation of the ligament, synovitis, gout, and systemic lupus erythematosus, wherein the methods include injecting into the inflamed joint a therapeutic anti-inflammatory composition comprising a bacterial or viral IL-10 expression construct, wherein the IL-10 expression construct comprises a bacterial or viral backbone and a nucleic acid sequence encoding interleukin-10.
    Type: Application
    Filed: June 21, 2022
    Publication date: October 6, 2022
    Applicants: Xalud Therapeutics, Inc., The Regents of the University of Colorado, a Body Corporate
    Inventors: Raymond A. Chavez, Linda May Rothblum Watkins, Robert Landry