Abstract: Methods, systems, and devices for ultra or extreme-high vacuum are described. Such systems may comprise a vacuum chamber, a target within the vacuum chamber, two or more overlapping radiation shields arranged within an inner vacuum space of a vacuum chamber, and surrounding at least a portion of the target, a first and a second cooling element unit thermally coupled to a first and second radiation shield of the two or more overlapping radiation shields, wherein the first unit is configured to reduce the first radiation shield's temperature to at least <100K, and the second unit is configured to reduce the second radiation shield's temperature to at least <25K, and a third cooling element unit coupled to the target and isolated from the first and second radiation shield, wherein the third cooling element unit is configured to reduce the target's temperature to at least <4K.
Type:
Grant
Filed:
September 12, 2019
Date of Patent:
April 2, 2024
Assignee:
The Regents of of the University of Colorado, a body corporate
Abstract: The present invention describes peptides, peptides carriers, peptide nanobodies, and peptide-drug covalent conjugates having efficient cell and tissue penetration. The peptides and associated configurations can be used in covalent attachments or as complexes or nanoparticles in conjunction with therapeutic agents to enhance their tissue, cellular, and intracellular delivery. Also, the peptides and associated configurations can enhance binding to negatively charged matrices in the body for improved localization or retention of therapeutic carriers and agents.
Type:
Application
Filed:
July 26, 2023
Publication date:
March 21, 2024
Applicant:
The Regents of the University of Colorado, A Body Corporate
Abstract: Methods of preventing or treating rheumatoid arthritis (RA) in a subject by introducing the DRB1*04:01K71E mutation that is resistant to RA. The resistant allele is introduced into the subject having or at risk of developing RA, using a HLA CRISPR/Cas9 vector that targets codon 71 in the HLA allele DRB1*04:01, introducing a single A to G point mutation in codon 71 by homology directed repair to alter the lysine at position 71 of the expressed protein to glutamic acid. This modified allele is affected in the subject's hematopoietic stem cells, which are then expanded and transplanted back into the patient. This microgene therapy confers RA-resistance via an autologous transplant. The invention includes isolated nucleic acids, vectors, recombinant viruses, cells, and pharmaceutical compositions to modify the HLA DRB1*04:01 allele.
Type:
Grant
Filed:
April 25, 2018
Date of Patent:
March 19, 2024
Assignees:
National Jewish Health, The Regents of the University of Colorado, a Body Corporate
Inventors:
Brian Freed, Kirsten Anderson, Christina Roark, Jennifer Matsuda
Abstract: A two-component biomaterial and method that replicates both the structural complexity and diverse molecular composition necessary to create a tissue's form and function. It is an objective of the current invention to use the unique combination material and methods herein to provide a pharmaceutical composition, a medical device, a tissue regeneration scaffold, as well as a scaffold for 3D organ culture (tissue on a chip, lab grown meat, research stem cell differentiation) comprising a significant amount of acellular tissue particles packed tightly and held together via crosslinking between the acellular particles and a thiolated protein.
Type:
Application
Filed:
December 14, 2021
Publication date:
March 7, 2024
Applicant:
The Regents of the University of Colorado, a body corporate
Abstract: Surface polarity of a ferroelectric nematic can be configured to generate vectorial control of the orientation of its bulk polarization field. The contact between a surface with in-plane polarity and a ferroelectric nematic liquid crystal generates preferred in-plane orientation of the ferroelectric polarization field at that interface, which can lead to the formation of fluid or glassy monodomains of high polarization without electric field poling.
Type:
Application
Filed:
December 30, 2021
Publication date:
March 7, 2024
Applicant:
The Regents of the University of Colorado, a body corporate
Inventors:
Noel A. Clark, Xi Chen, Joseph E. Maclennan, Matthew A. Glaser
Abstract: A wideband amplifier includes a first diplexer receiving broadband input signals and divides them by frequency into a low band input signal and a high band input signal. The amplifier has separate high band and low band amplifiers coupled to amplify the low and high band input signals, and a second diplexer coupled to combine outputs of the low and high band amplifiers to form a wideband output. A method of amplification of an input signal includes separating the input signal into high and low band signals, separately amplifying the high and low band signals, and combining amplified high and low band signals into an output signal.
Type:
Grant
Filed:
May 20, 2021
Date of Patent:
February 27, 2024
Assignees:
The Regents of the University of Colorado, a body corporate, Massachusetts Institute of Technology
Abstract: Provided herein is a class of reversible thermal gel polymers, formulations thereof, methods for using, and methods for making said reversible thermal gel polymers. Reversible thermal gel polymers and formulations are provided having versatile chemical, physical, mechanical and/or optical properties beneficial for a range of applications including medical treatment. In some embodiments, the architecture and composition of the polymer allows for tunable selection of one or more physical properties supporting a particular application.
Type:
Grant
Filed:
March 29, 2018
Date of Patent:
February 27, 2024
Assignee:
The Regents Of The University of Colorado, A Body Corporate
Inventors:
Robin Shandas, Steven Lewis, Daewon Park, Omid Jazaeri, Steven Lammers, James Bardill, Brisa Pena-Castellanos
Abstract: A system and method for nanoparticle synthesis employing an adhesiveless, deconstructable microfluidic mixing chip and an expandable wireless network of syringe pumps fluidly coupled to one or more microfluidic mixing chips. The wireless network of syringe pumps is controlled by a microprocessor with feedback from each of the syringe pumps in the network to allow for both individual, grouped and multiplexed control over the plurality of syringe pumps in the network.
Type:
Application
Filed:
July 26, 2023
Publication date:
February 22, 2024
Applicant:
The Regents of the University of Colorado, A Body Corporate
Abstract: Methods of treating or preventing stress, anxiety, or postoperative cognitive dysfunction. Also provided are methods of improving resilience in a subject by administering a therapeutically effective amount of isolated mycobacterium.
Type:
Grant
Filed:
August 22, 2022
Date of Patent:
February 20, 2024
Assignee:
The Regents of the University of Colorado, a body corporate
Inventors:
Christopher A. Lowry, Matthew G. Frank, Laura Fonken, Steven F. Maier
Abstract: Phenothiazine compounds of Formula (I) are described herein. These compounds are useful as highly reducing organic photoredox catalysts. Suitable substrates for use with the compounds of Formula (I) include acrylates, styrene, acrylamides, acrylonitrile, vinyl chloride, methylacrylonitrile, vinyl acetate, and acrylic acid.
Type:
Grant
Filed:
January 8, 2021
Date of Patent:
February 20, 2024
Assignees:
THE REGENTS OF THE UNIVERSITY OF COLORADO, A BODY CORPORATE, COLORADO STATE UNIVERSITY RESEARCH FOUNDATION
Inventors:
Steven Sartor, Niels Damrauer, Garet Miyake, Cameron Chrisman, Ryan Pearson
Abstract: An ophthalmic implant including an intraocular lens (IOL) and at least one drug delivery device. The IOL including an anterior side, a posterior side, a lens, and at least one haptic extending outwardly from the lens and including a first haptic extending from the lens at a first optic-haptic junction. The at least one drug delivery device including a first drug delivery device including a pad and a fixation portion extending from the pad. The pad including at least one therapeutic agent contained therein, an anterior surface, a posterior surface, and a sidewall extending around the pad and between the anterior surface and the posterior surface. The drug delivery device configured for attachment to the IOL via the fixation portion. In an assembled state of the implant, the first drug delivery device is attached to the IOL and the pad overlays the first optic-haptic junction.
Type:
Grant
Filed:
March 7, 2023
Date of Patent:
February 20, 2024
Assignees:
SpyGlass Pharma, Inc., The Regents of the University of Colorado, a body corporate
Inventors:
James R. Dennewill, Malik Y. Kahook, Glenn R. Sussman, Craig Alan Cable, II
Abstract: An electro-hydraulic actuator includes a deformable shell defining an enclosed internal cavity and containing a liquid dielectric, first and second electrodes on first and second sides, respectively, of the enclosed internal cavity. An electrostatic force between the first and second electrodes upon application of a voltage to one of the electrodes draws the electrodes towards each other to displace the liquid dielectric within the enclosed internal cavity. The shell includes active and inactive areas such that the electrostatic forces between the first and second electrodes displaces the liquid dielectric within the enclosed internal cavity from the active area of the shell to the inactive area of the shell. The first and second electrodes, the deformable shell, and the liquid dielectric cooperate to form a self-healing capacitor, and the liquid dielectric is configured for automatically filling breaches in the liquid dielectric resulting from dielectric breakdown.
Type:
Application
Filed:
October 13, 2023
Publication date:
February 15, 2024
Applicant:
The Regents of the University of Colorado, a body corporate
Inventors:
Christoph Matthias Keplinger, Eric Lucas Acome, Nicholas Alexander Kellaris, Shane Karl Mitchell
Abstract: This disclosure describes single and multi-layer woven meshes designed to enable sucking flow condensation and capillary-driven liquid film boiling, respectively, for instance, in use in heat spreaders. The single-layer woven meshes can include a nanostructure coating and a hydrophobic coating, while the multi-layer meshes can include a microcavity coating and optionally a hydrophilic coating.
Type:
Grant
Filed:
March 8, 2022
Date of Patent:
February 13, 2024
Assignee:
The Regents of the University of Colorado, a body corporate
Inventors:
Ronggui Yang, Rongfu Wen, Shanshan Xu, Yung-Cheng Lee
Abstract: A microsurgical device and methods of its use can be used for treatment of various conditions including eye diseases, such as glaucoma, using minimally invasive surgical techniques. A dual-blade device can be used for cutting the trabecular meshwork (“TM”) in the eye. The device tip provides entry into the Schlemm's canal via its size (i.e., for example, 0.2-0.3 mm width) and configuration where a ramp elevates the TM away from the outer wall of the Schlemm's canal and guides the TM to first and second lateral elements for creating first and second incisions through the TM. The dimensions and configuration of the blade is such that an entire strip of TM is removed without leaving TM leaflets behind and without causing collateral damage to adjacent tissues.
Type:
Grant
Filed:
August 13, 2021
Date of Patent:
February 13, 2024
Assignee:
THE REGENTS OF THE UNIVERSITY OF COLORADO, A BODY CORPORATE
Abstract: A microsurgical device and methods of its use can be used for treatment of various conditions including eye diseases, such as glaucoma, using minimally invasive surgical techniques. A device can be used for cutting the trabecular meshwork (“TM”) in the eye. The device tip provides entry into the Schlemm's canal via its size (i.e., for example, 0.2-0.3 mm width) and configuration where a ramp elevates the TM away from the outer wall of the Schlemm's canal and guides the TM to first and second lateral elements for creating first and second incisions through the TM. The dimensions and configuration of the device is such that an entire strip of TM is removed without leaving TM leaflets behind and without causing collateral damage to adjacent tissues.
Type:
Grant
Filed:
November 28, 2022
Date of Patent:
February 13, 2024
Assignee:
THE REGENTS OF THE UNIVERSITY OF COLORADO, A BODY CORPORATE
Abstract: Disclosed herein are devices, systems, and methods for fabricating alkali vapor cells. The methods disclosed herein comprise depositing a fluid into a reservoir of a device, the device comprising: a reservoir, a set of receptacles, and a set of conduits fluidly connecting each of the receptacles to the reservoir; such that, when a fluid is placed in the reservoir, the fluid flows to each of the receptacles via capillary action. Also disclosed herein are methods comprising flowing a fluid from an inlet to an outlet of a lumen of a main conduit of a device, the device further comprising a set of receptacles, each of the receptacles being in fluid communication with the lumen of the main conduit; such that, when a fluid flows from the inlet to the outlet through the lumen of the main conduit, the fluid further flows into each of the receptacles via capillary action.
Type:
Grant
Filed:
January 7, 2021
Date of Patent:
February 13, 2024
Assignee:
The Regents of the University of Colorado, a body corporate
Abstract: An ophthalmic implant including an IOL with haptics, and drug delivery devices secured to the haptics. The posterior-most extent of the drug delivery device is located anterior to the posterior edge or PCE barrier edge, of the IOL. In other configurations, the drug delivery devices are provided with PCO barrier edges.
Type:
Grant
Filed:
September 16, 2022
Date of Patent:
January 30, 2024
Assignees:
SpyGlass Pharma, Inc., The Regents of the University of Colorado, a body corporate
Inventors:
Craig Alan Cable, II, Glenn R. Sussman, James R. Dennewill, Malik Y. Kahook
Abstract: A polymer brush composed of statistical copolymers of hydrophilic and hydrophobic monomers for enzyme immobilization. The heterogeneous polymer brushes stabilized four different lipases against high temperatures. Notably, the statistical copolymers stabilized the four lipases to a greater extent than a homopolymer brush. Additionally, in the case of Rhizomucor miehei lipase, statistical copolymers stabilized the enzyme to a greater extent than homopolymers of either hydrophilic or hydrophobic monomers. The resulting increase in high-temperature stability enabled significant improvements in catalytic rates by operating reactions at elevated temperatures, which is desirable for enzyme catalysis and sensing applications. Additionally, stabilization against elevated temperatures implies stabilization against non-aqueous solvents, which is of critical importance to numerous applications of biocatalysts.
Type:
Application
Filed:
November 15, 2021
Publication date:
January 25, 2024
Applicant:
The Regents of the University of Colorado, a body corporate
Inventors:
JAMES S. WELTZ, JOEL L. KAAR, DANIEL K. SCHWARTZ, HECTOR SANCHEZ-MORAN