Abstract: The current disclosure provides methods for detecting and analyzing K17 expression in a bladder sample obtained from a subject. The current disclosure also pertains to methods and kits for identifying a mammalian subject with bladder cancer by detecting the expression of K17 in a sample. The present methods include both cell-based and cell-free methods for determining the level of keratin 17 in a sample obtained from the bladder of a subject.

Abstract: Provided are a computer mouse and a method for operating the computer mouse, with the computer mouse including a palm-rest on a first side thereof, a baseplate on a second side substantially opposite the first side, hinges positioned along an edge of the palm-rest, and finger-rests, with each finger-rest fixedly attached to one end of a respective hinge.

Abstract: Described herein are peptides that can be used to treat pain or increase pain sensitivity in subject in need of treatment. Additionally, peptides of the present disclosure can be administered with an analgesic agent and/or anesthetic agent. Peptides of the present disclosure are suitable for use when a subject in need of treatment has an injury, a chronic disease, a chronic inflammation, Morton's neuroma, operative/post-operative pain, or a combination thereof.

Abstract: Structures operable to detect radiation are described. The structure may two screens with a phosphor layer, respective. The structure may further include a photosensor array disposed between the first screen and the second screen such that the photosensor array directly contacts the first screen or is directly attached to the first screen using an optical adhesive and directly contacts the second screen or is directly attached to the second screen using an optical adhesive.

Abstract: Preparation, characterization, and an electrochemical study of Mg0.1V2O5 prepared by a novel sol-gel method with no high-temperature post-processing are disclosed. Cyclic voltammetry showed the material to be quasi-reversible, with improved kinetics in an acetonitrile-, relative to a carbonate-, based electrolyte. Galvanostatic test data under a C/10 discharge showed a delivered capacity >250 mAh/g over several cycles. Based on these results, a magnesium anode battery, as disclosed, would yield an average operating voltage ˜3.2 Volts with an energy density ˜800 mWh/g for the cathode material, making the newly synthesized material a viable cathode material for secondary magnesium batteries.

Abstract: The present invention provides a compound having the structure: and use of the compound for inhibiting the growth of or killing

Abstract: A metal sequestering material can be contacted with a reaction mixture of a metal-catalyzed reaction to remove transition metals or transition metal complexes. The reaction mixture contains transition metals and a reaction product in solution. These transition metals may be, for example, Pd, Ir, Ru, Rh, Pt, Au, or Hg. The concentration of transition metals in the reaction mixture is reduced to less than 100 ppm or even less than 10 ppm.

Abstract: A cluster of nodes, comprising: a plurality of nodes, each having a security policy, and being associated task processing resources; a registration agent configured to register a node and issue a node certificate to the respective node; a communication network configured to communicate certificates to authorize access to computing resources, in accordance with the respective security policy; and a processor configured to automatically dynamically partition the plurality of nodes into subnets, based on at least a distance function of at least one node characteristic, each subnet designating a communication node for communicating control information and task data with other communication nodes, and to communicate control information between each node within the subnet and the communication node of the other subnets.

Abstract: There is set forth herein an optoelectrical device, comprising: a substrate; an interposer dielectric stack formed on the substrate, the interposer dielectric stack including a base interposer dielectric stack, a photonics device dielectric stack, and a bond layer that integrally bonds the photonics device dielectric stack to the base interposer dielectric stack. There is set forth herein a method comprising building an interposer base structure on a first wafer having a first substrate, including fabricating a plurality of through vias in the first substrate and fabricating within an interposer base dielectric stack formed on the first substrate one or more metallization layers; and building a photonics structure on a second wafer having a second substrate, including fabricating one or more photonics devices within a photonics device dielectric stack formed on the second substrate.

Abstract: A method for treating damaged peripheral nerves of a subject includes irradiating at least a portion of the damaged PNs with an array of x-ray microbeams having an in-beam dose sufficient to at least initiate demyelination, each of the microbeams being no greater than 0.7 mm in thickness, and separated for tissue sparing, e.g., by at least 0.05 mm, and optionally administering schwann cell progenitors (SCPs) to the irradiated portion to remyelination before or after irradiating. In-beam dose may be between about 30 to 200 Gy. The method may include irradiating using an x-ray tube of a CT scanner having a multi-aperture collimator mounted thereto and on/near the subject. The SCPs may be adult rat olfactory sphere cells or neural stem cells.

Abstract: A system associated with predicting authentication of a device user based on a joint features representation related to an echo-signature associated with a device is disclosed. The system performs operations that include emitting acoustic signals in response to a request for processing of a profile associated with the device. The system receives a set of echo acoustic signals that are tailored based on reflection of the acoustic signals from unique contours of one or more depth portions associated with the user relative to a discrete epoch. One or one or more region segments associated with the echo acoustic signals are extracted in order to train a classification model. A classification model is generated based on the one or more region segments as extracted. A joint features representation based on the classification model is generated. A vector-based classification model is used in the prediction of the joint features representation.

Abstract: A hybrid radiation imaging sensor includes a low x-ray attenuating substrate, a photoconductor disposed over the substrate, and a scintillator disposed over the photoconductor. By combining direct x-ray conversion to electron-hole pairs in the photo-conductor with indirect conversion of x-rays downstream of the photoconductor within the scintillator, improved x-ray imaging can be attained through an electronic readout located upstream of both the photoconductor and the scintillator without the need for excessive x-ray dosing.

Abstract: Provided is a field shaping multi-well detector and method of fabrication thereof. The detector is configured by depositing a pixel electrode on a substrate, depositing a first dielectric layer, depositing a first conductive grid electrode layer on the first dielectric layer, depositing a second dielectric layer on the first conductive grid electrode layer, depositing a second conductive grid electrode layer on the second dielectric layer, depositing a third dielectric layer on the second conductive grid electrode layer, depositing an etch mask on the third dielectric layer. Two pillars are formed by etching the third dielectric layer, the second conductive grid electrode layer, the second dielectric layer, the first conductive grid electrode layer, and the first dielectric layer. A well between the two pillars is formed by etching to the pixel electrode, without etching the pixel electrode, and the well is filled with a-Se.

Abstract: The disclosure provides an electricity generating insert for a piece of footwear, the insert can be removably placed in the heel portion, e.g. under the insole. The insert comprises a multilayer piezoelectric stack that alternatively flexes under the compression-decompression that occurs during locomotion, which flexing causes friction in the stack to generate electricity capable of charging electronic devices and the like, e.g. via a port on the footwear.

Abstract: A composition of an omega-3 polyunsaturated fatty acid (PUFA)-taxoid conjugate formulated in an oil-in-water nanoemulsion (NE) drug delivery system in combination with an immune-oncology (IO) agent to enhance therapeutic efficacy in refractory cancers, such as PDAC. A method of treating cancer, by administering an effective amount of a pharmaceutical composition including an omega03 PUFA-taxoid conjugate in combination with an IO agent encapsulated in an NE drug delivery system to a subject in need of treatment, and treating cancer.

Abstract: A system and method for monitoring and analyzing activities of a user operating an electric tooth brush having an electric motor. The magnetic field induced by motions of the electric motor can be detected by a sensor array to generate signals. The signals are processed to determine a position of the brush head and a roll angle of the brush head. Based on the position and roll angle of the brush head, the surface of the teeth of the user, which is being brushed by the brush head, can be determined. This operation can be repeated to determine whether all the surfaces of the teeth have been brushed.

Abstract: There is set forth herein a photonics device. The photonics device can comprise a substrate, a conductive material formation, a dielectric stack, and a barrier layer. The photonics device can transmit a light signal.

Abstract: A microphone, comprising at least two electrodes, spaced apart, configured to have a magnetic field within a space between the at least two electrodes; a conductive fiber, suspended between the at least two electrodes; in an air or fluid space subject to waves; wherein the conductive fiber has a radius and length such that a movement of at least a central portion of the conductive fiber approximates an oscillating movement of air or fluid surrounding the conductive fiber along an axis normal to the conductive fiber. An electrical signal is produced between two of the at least two electrodes, due to a movement of the conductive fiber within a magnetic field, due to viscous drag of the moving air or fluid surrounding the conductive fiber. The microphone may have a noise floor of less than 69 dBA using an amplifier having an input noise of 10 nV/?Hz.

Abstract: Disclosed herein are methods of treatment for an intraocular pressure (IOP)-associated condition in a subject, that include administering to the subject an effective amount of a tissue plasminogen activator (tPA) therapeutic agent. In one embodiment, the IOP-associated condition is glaucoma. The administration of a tPA therapeutic agent can be an extended administration intended to cause a reduction in IOP in the subject for a period of at least one day to a year or more, relative to IOP levels in the subject prior to administration of the tPA therapeutic agent. The tPA therapeutic agent can be, for example, tPA, a tPA derivative, a small molecule direct or indirect tPA agonist, or a gene therapy vector.

Abstract: Disclosed are fiber optic devices and related methods that allow for measurement of blood flow and oxygenation in real time. These devices have particular application to the spinal cord. Such devices have applicability in, for example, the care of military members sustaining combatant and noncombatant spinal injuries, as well as to civilians. The devices also have utility in the acute and subacute management of spine trauma, enhancing the efficacy of interventions aimed at the prevention of secondary ischemic injury, and ultimately improving neurologic outcome.