Patents Assigned to The Royal Institution for the Advancement of Learning (McGill University)
  • Patent number: 10075193
    Abstract: Herein provided are methods and systems for decoding polar codes. A data flow graph relating to a predetermined polar code is converted to a tree graph comprising rate-zero nodes, rate-1 nodes, and rate-R nodes. A rate-R node within the binary tree is replaced with a maximum likelihood node when predetermined conditions are met thereby replacing a sub-tree of the tree graph with a single maximum likelihood node.
    Type: Grant
    Filed: November 3, 2015
    Date of Patent: September 11, 2018
    Assignee: THE ROYAL INSTITUTION FOR THE ADVANCEMENT OF LEARNING/MCGILL UNIVERSITY
    Inventors: Warren Gross, Gabi Sarkis
  • Patent number: 10009668
    Abstract: As photonics evolves closer and closer to the electronic processing elements in order to meet the demands of speed, latency of evolving data communications networks and data centers the inventors, rather than seeking direct monolithically integrated CMOS based processing photonic and electronic elements, have established a different route. Namely replace the computer hubs/electrical bridges interconnecting the multiple core logic chipset elements with a photonic bridge. In this manner high risk chip-to-chip photonic point-to-point links are replaced with photonic SOCs that leverage photonics bandwidth density attribute rather than its bandwidth distance attributes. An SOI based Electronic Embedded Photonic Switching Fabric is presented supporting, for example, N×MGb/s interconnections exploiting N channels of MGb/s wherein each channel of exploits S WDM channels of TGb/s. Embodiments of the invention also support high density optical interconnection via vertical grating couplers and multicore fibers.
    Type: Grant
    Filed: December 1, 2015
    Date of Patent: June 26, 2018
    Assignee: THE ROYAL INSTITUTION FOR THE ADVANCEMENT OF LEARNING / MCGILL UNIVERSITY
    Inventors: Odile Liboiron-Ladouceur, Md. Shafiqul Hai, Monireh Moayedi Pour Fard, Chunshu Zhang, Meer Sakib
  • Patent number: 9991370
    Abstract: High electron mobility leads to better device performance and today is achieved by fabricating “gated devices” within a high-mobility two-dimensional electron gas (2DEG. However, the fabrication techniques used to form these devices lead to rapid degradation of the 2DEG quality which then can limits the mobility of the electronic devices. Accordingly, it would be beneficial to provide a process/technique which circumvents this processing and 2DEG layer damage. By exploiting a flip-chip methodology such damaging processing steps are separated to a second die/wafer which is then coupled to the 2DEG wafer. Extensions of the technique with two or more different semiconductor materials or material systems may be employed in conjunction with one or more electronic circuits to provide 2DEG enabled circuits in 2D and/or 3D stacked configurations. Further semiconductor materials providing EG elements may incorporate one or more of 2DEG, 1DEG, and “zero” DEG structures.
    Type: Grant
    Filed: December 9, 2015
    Date of Patent: June 5, 2018
    Assignee: THE ROYAL INSTITUTION FOR THE ADVANCEMENT OF LEARNING/MCGILL UNIVERSITY
    Inventors: Guillaume Gervais, Keyan Bennaceur
  • Patent number: 9969755
    Abstract: A compound of formula (I) useful as a photosensitizer in photodynamic therapy is provided. There is also provided a photosensitizing composition for use in photodynamic therapy comprising this compound. Finally, there are provided a method of killing cells under oxidative stress conditions and a method for the selective delivery of singlet oxygen (1O2) to cells having an increased reactive oxygen species (ROS) concentration, these methods comprising the steps of contacting such cells with a compound of formula (I), and exposing the cells to light.
    Type: Grant
    Filed: January 12, 2017
    Date of Patent: May 15, 2018
    Assignee: THE ROYAL INSTITUTION FOR THE ADVANCEMENT OF LEARNING/MCGILL UNIVERSITY
    Inventors: Gonzalo Cosa, Andres M. Durantini, Lana E. Greene, Richard Lincoln
  • Publication number: 20180126389
    Abstract: An electrocyclonic particle collector (EPC) for removing particulate matter from a gas includes an EPC gas inlet, an EPC gas outlet, and an EPC gas flow path between the EPC gas inlet and the EPC gas outlet. A first section is downstream of the EPC gas inlet and includes a first cyclonic particle collector in the gas flow path for cyclonically removing particles from the gas. A second section is in series with the first section and includes a rotational flow chamber in the gas flow path, and at least a first electrode in the gas flow path for facilitating electrostatic removal of particles from the gas stream in the rotational flow chamber.
    Type: Application
    Filed: January 12, 2016
    Publication date: May 10, 2018
    Applicant: THE ROYAL INSTITUTION FOR THE ADVANCEMENT OF LEARNING / MCGILL UNIVERSITY
    Inventors: MARK LEFSRUD, YVES ROY, JENNIFER ASHFIELD, LUC ROY
  • Patent number: 9951039
    Abstract: Filamenting temperature-sensitive mutant Z (FtsZ) protein plays a crucial role in the bacterial cell division machinery and is a validated drug target for antibacterial agents. The present invention relates to FtsZ-interacting compounds that possess a 2,4,6-trisubstituted pyrimidine scaffold. Some of these compounds possess potent anti-staphylococcal properties and potent antibacterial activities against clinically isolated MRSA strains. Compounds have been identified to exhibit low spontaneous frequency of resistance, low toxicity as well as the ability to rescue G. mellonella larvae infected with lethal dose of the MRSA ATCC 43300 strain. Characterization by saturation transfer difference NMR, light scattering assay and GTPase hydrolysis assay with purified S. aureus FtsZ protein verified the interaction of 2,4,6-trisubstituted pyrimidine with the FtsZ protein, further confirmed by observations of iconic filamentous cell phenotype and mislocalization of the Z-ring formation.
    Type: Grant
    Filed: September 29, 2016
    Date of Patent: April 24, 2018
    Assignees: THE HONG KONG POLYTECHNIC UNIVERSITY, THE ROYAL INSTITUTION FOR THE ADVANCEMENT OF LEARNING/MCGILL UNIVERSITY
    Inventors: Kwok-yin Wong, Tak-Hang Chan, Kin-Fai Chan
  • Patent number: 9932364
    Abstract: Antisense nucleic acid molecules, such as ribozymes, shRNA and siRNA, targeting the Gag region of HIV-1 open reading frame, and uses thereof for inhibiting HIV-1 replication and infection, are disclosed. The antisense nucleic acid molecules more specifically target a sequence corresponding to about nucleotide 1495 to about nucleotide 1526, or nucleotide 1497 to about nucleotide 1521, of HIV-1 clone pNL4-3.
    Type: Grant
    Filed: August 25, 2014
    Date of Patent: April 3, 2018
    Assignee: The Royal Institution for the Advancement of Learning/McGill University
    Inventors: Anne Gatignol, Robert Scarborough
  • Publication number: 20180086702
    Abstract: This invention relates to novel pharmaceutically-useful compounds, to methods for their preparation, and to pharmaceutical compositions and therapeutic methods for treating certain conditions.
    Type: Application
    Filed: March 29, 2016
    Publication date: March 29, 2018
    Applicants: THE ROYAL INSTITUTION FOR THE ADVANCEMENT OF LEARNING/MCGILL UNIVERSITY, FLORIDA INSTITUTE OF TECHNOLOGY
    Inventors: William S. POWELL, Joshua ROKACH
  • Patent number: 9920084
    Abstract: The invention relates to the chemical synthesis of oligonucleotides, e.g., oligoribonucleotides. In another aspect, the invention relates to compounds of formula (II) processes for making these compounds, and the use thereof in the chemical synthesis of oligonucleotides, e.g., oligoribonucleotides. The invention also relates to methods of synthesis of oligomers, including but not limited to oligopeptides, oligosaccharides and oligonucleotides, particularly oligoribonucleotides and also oligodeoxyribonucleotides, in solution systems, and ionic tag linkers for use in methods provided herein.
    Type: Grant
    Filed: August 23, 2012
    Date of Patent: March 20, 2018
    Assignees: The Royal Institution for the Advancement of Learning/McGill University, Hong Kong Polytechnic University
    Inventors: Masad J. Damha, Matthew Hassler, Tak-Hang Chan, Mallikarjuna Reddy Nandyala, Robert Alexander Donga
  • Patent number: 9917650
    Abstract: Photonic integration has primarily sought to exploit optical parallelism through wavelength division multiplexing whilst in many instances “brute-force” time division multiplexing offers benefits through reduced complexity and cost. However, photoreceivers are primarily the same now for operation at 10 Gb/s, 20 Gb/s, 40 Gb/s and above as 20 or 25 years ago and exploit the same optical detection—amplification—logic processing design. However, high speed low cost electronics ca be leveraged in conjunction with optical time sampling and logic to provide a new design paradigm. An incoming XGbs?1 optical data stream is sampled and processed by N photodetectors each operating at (X/N)Gbs?1 rather than the current direct XGbs?1 front-end of the prior art. Flexibility for the designer in establishing N within optical layer constraints, electronics capabilities etc.
    Type: Grant
    Filed: August 26, 2016
    Date of Patent: March 13, 2018
    Assignees: TRANSFERT PLUS, SOCIÉTÉ EN COMMANDITE, THE ROYAL INSTITUTION FOR THE ADVANCEMENT OF LEARNING/ MCGILL UNIVERSITY
    Inventors: Odile Liboiron-Ladouceur, Md. Shafiqul Hai, Michael Menard
  • Patent number: 9856208
    Abstract: A method for producing an arene with an aromatic C—N bond ortho to an aromatic C—O bond from a hydroxy arene comprising said aromatic C—O bond is provided.
    Type: Grant
    Filed: September 2, 2016
    Date of Patent: January 2, 2018
    Assignee: The Royal Institution for the advancement of Learning/McGill University
    Inventors: Jean-Philip Lumb, Kenneth V. N. Esguerra
  • Patent number: 9854751
    Abstract: A greenhouse having side walls that provide a structural frame and which define an enclosed growing area. The greenhouse also has a roof which extends from the structural frame, and which has multiple roof sections extending inwardly over the growing area. A first roof section covers a first portion of the growing area and terminates in a first remote edge which is spaced inwardly from the structural frame. A second and subsequent roof sections covers the growing area and terminates in a second remote edge which overlaps the first remote edge, thus defining a vertical gap between the adjacent roof sections through which air can circulate. The greenhouse also has a cooling system mounted to a roof section which has nozzles for spraying water vapor into the circulating air, thus cooling the air.
    Type: Grant
    Filed: December 18, 2014
    Date of Patent: January 2, 2018
    Assignee: THE ROYAL INSTITUTION FOR THE ADVANCEMENT OF LEARNING/MCGILL UNIVERSITY
    Inventors: Mark Lefsrud, Polina Fateeva, Lucas McCartney
  • Patent number: 9849153
    Abstract: Nutraceutical or pharmaceutical compositions, functional foods, extracts, dietary supplements and food/feed additives enriched in phytochemicals having antioxidant and/or anti-inflammatory activity may be derived from the skin, pith, or cortex from stem tubers of select potato cultivars, such as Onaway, Russet Burbank, Purple Valley or Bora Valley cultivars. These cultivars and combinations thereof provide a useful antioxidant source enriched in ferulic acid, caffeic acid, chlorogenic acids, ascorbic acid, anthocyanins, and rutin, isomers or derivatives thereof having antioxidant and/or anti-inflammatory activity.
    Type: Grant
    Filed: August 12, 2016
    Date of Patent: December 26, 2017
    Assignee: The Royal Institution For The Advancement Of Learning/McGill University
    Inventors: Stanley Kubow, Danielle Donnelly, Andre Piccolomini, Luis Agellon
  • Patent number: 9828399
    Abstract: The invention encompasses the novel class of compounds represented by the Formula (I) below, which are inhibitors of the TC-PTP enzyme. The invention also encompasses pharmaceutical compositions which include the compounds shown above and methods of treating or preventing TC-PTP mediated diseases, including cancer, via their use in the activation of antigen-presenting cells, like dendritic cells, for applications in the immunotherapeutic treatment of diseases.
    Type: Grant
    Filed: February 27, 2015
    Date of Patent: November 28, 2017
    Assignee: The Royal Institution For The Advancement Of Learning/McGill University
    Inventors: Michel L. Tremblay, Claudia Penafuerte, Matthew Feldhammer, George Zogopoulos, Cameron Black, Brian Kennedy
  • Patent number: 9829629
    Abstract: Photonic integrated circuits required connection to germanium doped silica cored optical fibers or silica cored and fluorine doped silica cladding optical fibers which have low index contrast and large mode field diameters. However, the optical waveguide within a photonic integrated circuit such as formed using silicon-on-insulator or compound semiconductors tends to be high index contrast and small mode field diameter. Accordingly, it is necessary to implement adiabatic waveguide tapers with a high coupling efficiency and small footprint in order to couple into the photonic integrated circuits to/from the optical fiber. Prior art tapers have been generally high loss and absorb valuable die footprint. In contrast the inventors demonstrate a small low loss waveguide taper designed using a methodology they refer to a “constant loss”.
    Type: Grant
    Filed: May 19, 2016
    Date of Patent: November 28, 2017
    Assignee: THE ROYAL INSTITUTION FOR THE ADVANCEMENT OF LEARNING/MCGILL UNIVERSITY
    Inventors: Alexandre Horth, Nathaniel Quitoriano
  • Patent number: 9822890
    Abstract: A major challenge for the general use of “lab-on-a-chip” (LOAC) systems and point-of-care (POC) devices has been the generally complex and need for sophisticated peripheral equipment, such that it is more difficult than anticipated to implement low cost, robust and portable LOAC/POC solutions. It would be beneficial for chemical, medical, healthcare, and environmental applications to provide designs for inexpensive LOAC/POC solutions compatible with miniaturization and mass production, and are potentially portable, using compact possibly hand-held instruments, using reusable or disposable detectors. Embodiments of the invention address improved circuit elements for self-powered self-regulating microfluidic circuits including programmable retention valves, programmable trigger valves, enhanced capillary pumps, and flow resonators.
    Type: Grant
    Filed: August 30, 2012
    Date of Patent: November 21, 2017
    Assignee: THE ROYAL INSTITUTION FOR THE ADVANCEMENT OF LEARNING/MCGILL UNIVERSITY
    Inventors: David Juncker, Hosseinali Safavieh
  • Publication number: 20170291826
    Abstract: The present relates to a method for producing calcium sulfate solid crystals and hydrochloric acid (HCl) from a calcium chloride solution comprising the steps of feeding a continuous stirred-tank reactor with a calcium chloride solution, sulfuric acid and water; mixing the calcium chloride solution, sulfuric acid and water in the reactor; and maintaining the reactor a temperature of less than about 70° C., converting the calcium chloride solution, sulfuric acid and water into HCl and calcium sulfate solid crystals. The method described herein can be incorporated as a means for regenerating HCl from CaCl2 solutions which are generated in the metallurgical industry when processing calcium-bearing ores for recovering metals like rare earth elements.
    Type: Application
    Filed: April 6, 2016
    Publication date: October 12, 2017
    Applicant: THE ROYAL INSTITUTION FOR THE ADVANCEMENT OF LEARNING/MCGILL UNIVERSITY
    Inventors: George DEMOPOULOS, Thomas FELDMANN
  • Patent number: 9764060
    Abstract: There is provided a method for preparing a dense hydrogel comprising providing an at least partially gelled hydrogel, placing the at least partially gelled hydrogel in fluid communication with an end of a capillary, and driving the at least partially gelled hydrogel into the capillary to form a dense hydrogel. There is also provided a system for preparing the dense hydrogel comprising a capillary having a bore; and a driver in communication with an end of the capillary for driving an at least partially gelled hydrogel into the bore of the capillary to form a dense hydrogel.
    Type: Grant
    Filed: August 9, 2013
    Date of Patent: September 19, 2017
    Assignee: THE ROYAL INSTITUTION FOR THE ADVANCEMENT OF LEARNING / MCGILL UNIVERSITY
    Inventors: Showan Nazhat, Benedetto Marelli, Chiara Ghezzi, Neysan Nejat Oliver Kamranpour
  • Patent number: 9750200
    Abstract: A flue gas treatment apparatus has a flue gas inlet, a treated gas outlet downstream of the flue gas inlet, and a gas flow path therebetween. The flue gas treatment apparatus comprises a particulate removal device. A first heater is downstream of the particulate removal device. The first heater heats the flue gas to a first treatment temperature. A first catalytic converter is downstream of the first heater for eliminating at least some CO and SO2 from the flue gas. A second heater is downstream of the first catalytic converter for heating the flue gas to a second treatment temperature. A second catalytic converter is downstream of the second heater for eliminating at least some NOx from the flue gas. At least a first fan forces the flue gas from the flue gas inlet to the treated gas outlet.
    Type: Grant
    Filed: July 11, 2014
    Date of Patent: September 5, 2017
    Assignee: Royal Institution for the Advancement of Learning/McGill University
    Inventors: Mark Lefsrud, Yves Roy, Francis Filion, Julien Bouchard, Quoc Nguyen, Louis-Martin Dion, Antony Glover
  • Patent number: 9746236
    Abstract: The present disclosure relates to a process for reducing particle agglomeration and/or increasing porosity of agglomerated particles, a method for enhancing dispersion of nanoparticles in a polymer matrix, and thermoplastic or thermoset nanocomposites comprising nanoparticles.
    Type: Grant
    Filed: April 14, 2015
    Date of Patent: August 29, 2017
    Assignee: THE ROYAL INSTITUTION FOR THE ADVANCEMENT OF LEARNING/MCGILL UNIVERSITY
    Inventors: Musa Kamal, Vahid Khoshkava