Patents Assigned to The Royal Institution for the Advancement of Learning (McGill University)
  • Patent number: 8809382
    Abstract: The present invention relates to novel pharmaceutically-useful compounds which are antagonists of the 5-oxo-ETE receptors, such as the OXE receptor. These compounds have use as therapeutic and/or prophylactic agents for diseases characterized by tissue eosinophilia, such as inflammatory conditions including respiratory diseases. The invention also relates to pharmaceutical compositions, to the use of such compounds and compositions as medicaments, and to therapeutic methods.
    Type: Grant
    Filed: May 4, 2010
    Date of Patent: August 19, 2014
    Assignees: The Royal Institution for the Advancement of Learning/McGill University, Florida Institute of Technology
    Inventors: William S. Powell, Joshua Rokach
  • Publication number: 20140219279
    Abstract: Internet routers are a key component in today's Internet. Each router forwards received packets toward their final destinations based upon a Longest Prefix Matching (LPM) algorithm select an entry from a routing table that determines the closest location to the final packet destination among several candidates. Prior art solutions to LPM lookup offer different tradeoffs and that it would be beneficial for a design methodology that provides for low power large scale IP lookup engines addressing the limitations within the prior art. According to embodiments of the invention a low-power large-scale IP lookup engine may be implemented exploiting clustered neural networks (CNNs). In addition to reduced power consumption embodiments of the invention provide reduced transistor count providing for reduced semiconductor die footprints and hence reduced die cost.
    Type: Application
    Filed: February 7, 2014
    Publication date: August 7, 2014
    Applicant: THE ROYAL INSTITUTION FOR THE ADVANCEMENT OF LEARNING / MCGILL UNIVERSITY
    Inventors: Warren Gross, Naoya Onizawa
  • Publication number: 20140186263
    Abstract: A maleimide-functionalized gold nanoparticle is described herein. More specifically, a maleimide-functionalized gold nanoparticle of formula (I): is described, wherein “n” and “m” are integers independently ranging from 1 to 100.
    Type: Application
    Filed: May 31, 2012
    Publication date: July 3, 2014
    Applicant: THE ROYAL INSTITUTION FOR THE ADVANCEMENT OF LEARNING/MCGILL UNIVERSITY
    Inventors: Ralf Schirrmacher, Jun Zhu, R. Bruce Lennox
  • Publication number: 20140155487
    Abstract: The present invention relates to methods for the treatment of a disease or condition associated with lipid imbalance using fenretinide. The invention also relates to diagnostic and screening methods based on the determination of lipid levels.
    Type: Application
    Filed: February 5, 2014
    Publication date: June 5, 2014
    Applicant: THE ROYAL INSTITUTION FOR THE ADVANCEMENT OF LEARNING/MCGILL UNIVERSITY
    Inventors: Danuta RADZIOCH, Claudine GUILBAULT, Juan Bautista DE SANCTIS
  • Patent number: 8722332
    Abstract: The invention relates to a method for determining the responsiveness of a Dirofilaria spp. nematode to a macrocyclic lactone, by determining the genotype of the nematode at a position in a P-glycoprotein gene of the nematode corresponding to position 11, and optionally to position 618, in SEQ ID NO: 1, wherein the genotype GG at a position corresponding to position 11, or at positions corresponding to positions 11 and 618, in SEQ ID NO: 1 indicates that the nematode is likely resistant to the macrocyclic lactone. The invention also relates to methods for selecting a treatment to treat an animal infected with macrocyclic lactone resistant Dirofilaria spp nematode, and treating the animal; or for selecting a prophylactic to prevent an animal from becoming infected with a macrocyclic lactone resistant Dirofilaria spp nematode, and providing the prophylactic to the animal. The invention further relates to an isolated nucleic acid having at least 80% sequence identity to SEQ ID NO: 1.
    Type: Grant
    Filed: March 30, 2011
    Date of Patent: May 13, 2014
    Assignees: The Royal Institution for the Advancement of Learning/McGill University, Novartis AG
    Inventors: Roger Prichard, Catherine Bourguinat, Timothy Geary, Rudolf Schenker
  • Publication number: 20140120149
    Abstract: A composite comprising monetite and calcium sulphate is provided.
    Type: Application
    Filed: October 30, 2013
    Publication date: May 1, 2014
    Applicant: THE ROYAL INSTITUTION FOR THE ADVANCEMENT OF LEARNING/MCGILL UNIVERSITY
    Inventors: ANDREW FLYNN, J. DENNIS BOBYN, MICHAEL TANZER, JAKE E. BARRALET
  • Publication number: 20140114430
    Abstract: A method for generating a lattice cell shape for a stent comprising generating a unit cell model representing a stent cell to be made of a given material, the unit cell model comprising elements each comprising points defining a G2-continuous curve, setting a weighting factor to a same value for each one of the points, the weighting factor representing a contribution of a corresponding one of the points to a curvature of an optimal curve, determining a curvature of the G2-continuous curve as a function of the weighting factors having the same value, and structurally optimizing the unit cell model by iteratively determining a variable value for the weighting factor value using stress-strain characteristics for the given material, determining a new curvature of the G2-continuous curve as a function of the variable value, and minimizing the new curvature, thereby obtaining an optimized curve corresponding to an optimized lattice cell shape.
    Type: Application
    Filed: October 24, 2012
    Publication date: April 24, 2014
    Applicant: THE ROYAL INSTITUTION FOR THE ADVANCEMENT OF LEARNING / MCGILL UNIVERSITY
    Inventors: Damiano PASINI, Ehsan Masoumi Khalil ABAD
  • Publication number: 20140113973
    Abstract: Compounds, methods, uses, compositions, kits and packages for the prevention and/or treatment of neural injury or a neurodegenerative disease, based on the use of a retinoic acid derivative, such as fenretinide, and/or analogs, derivatives, prodrugs, precursors thereof, and/or salts thereof, are described.
    Type: Application
    Filed: December 23, 2013
    Publication date: April 24, 2014
    Applicant: Royal Institution for the Advancement of Learning/McGill University
    Inventors: Danuta Radzioch, Samuel David, Ruben Lopez-Vales, Thomas Skinner
  • Patent number: 8697545
    Abstract: A method for manufacturing microelectromechanical structures (MEMS) is disclosed. A low temperature MEMS device is designed. The low temperature MEM device is based upon a semiconductor manufacturing process comprising at least one semiconductor process for providing at least a heater therein. Each semiconductor process used in implementing the design is limited to a maximum temperature of the in-process low temperature MEMs device or a substrate onto which the low temperature MEMS device is being manufactured to below 300° C.
    Type: Grant
    Filed: December 29, 2008
    Date of Patent: April 15, 2014
    Assignee: The Royal Institution for the Advancement of Learning/McGill University
    Inventors: Frederic Nabki, Mourad El-Gamal, Tomas A. Dusatko
  • Publication number: 20140092469
    Abstract: Optical microscopy of biological specimens, particularly live cells, is difficult as they generally lack sufficient contrast to be studied successfully as typically the internal structures of the cell are colourless and transparent. Commonly, contrast is increased by staining the different structures with selective dyes, but this involves killing and fixing the sample. Staining may also introduce artifacts, apparent structural details caused by the processing of the specimen and are thus not a legitimate feature of the specimen. Further, microscopy of different elements of these biological specimens typically requires multiple microscopy techniques on multiple specimens. According to embodiments of the invention simultaneous imaging techniques are applied to a biological specimen such as fluorescent imaging and dark field imaging by designing an experimental evaluation system and associated illumination system addressing the conflicting demands of these approaches.
    Type: Application
    Filed: October 1, 2012
    Publication date: April 3, 2014
    Applicant: The Royal Institution for the Advancement of Learning / McGill University
    Inventors: Dilson Rassier, Albert Kalganov, Aleksander Labuda
  • Publication number: 20140094924
    Abstract: A method for making an orthopaedic implant, the method comprising: characterizing at least a portion of a bone corresponding to the bone to be replaced, said corresponding bone being on the contralateral side of the patient; providing a model of the orthopaedic implant based on a mirror image of the contralateral bone; and forming the orthopaedic implant based on the model.
    Type: Application
    Filed: December 5, 2013
    Publication date: April 3, 2014
    Applicant: THE ROYAL INSTITUTION FOR THE ADVANCEMENT OF LEARNING / MCGILL UNIVERSITY
    Inventors: Adam S. Hacking, Edward J. HARVEY, Corey RICHARDS
  • Patent number: 8680153
    Abstract: The present invention relates to methods for the treatment of a disease or condition associated with lipid imbalance, comprising (a) decreasing arachidonic acid (AA) levels, (b) increasing docosahexaenoic acid (DHA) levels, (c) increasing DHA/AA ratio or (d) any combination of (a)-(c) in a subject using fenretinide. The invention also relates to diagnostic and screening methods based on the determination of lipid levels.
    Type: Grant
    Filed: December 13, 2006
    Date of Patent: March 25, 2014
    Assignee: The Royal Institution for the Advancement of Learning/McGill University
    Inventors: Danuta Radzioch, Claudine Guilbault, Juan Bautista De Sanctis
  • Publication number: 20140080225
    Abstract: Fluorescence based sensing systems and methods that exploit xerogels are provided. Embodiments of the invention encompass a sensing system that includes: an optical excitation source emitting over a first predetermined wavelength range and capable of analog modulation over a predetermined frequency range; a sensor including a gel substrate incorporating within its matrix a receptor for molecular recognition of an analyte and a luminophore for signaling a recognition event relating to the analyte, the luminophore emitting an optical signal over a second predetermined wavelength range; a detection circuit including an optical detector for receiving the optical signal emitted by the luminophore and generating a photocurrent in dependence thereof; an excitation circuit that generates an analog signal for modulating the optical excitation source in dependence upon a digital control; and a read circuit for receiving the photocurrent and generating a digital output.
    Type: Application
    Filed: September 18, 2013
    Publication date: March 20, 2014
    Applicant: The Royal Institution for the Advancement of Learning / McGill University
    Inventors: Vamsy Chodavarapu, Daisy Daivasagay
  • Patent number: 8677227
    Abstract: Low-Density Parity-Check (LDPC) codes offer error correction at rates approaching the link channel capacity and reliable and efficient information transfer over bandwidth or return-channel constrained links with data-corrupting noise present. They also offer performance approaching channel capacity exponentially fast in terms of the code length, linear processing complexity, and parallelism that scales with code length. They also offer challenges relating to decoding complexity and error floors limiting achievable bit-error rates.
    Type: Grant
    Filed: August 24, 2011
    Date of Patent: March 18, 2014
    Assignee: Royal Institution for the Advancement of Learning / McGill University
    Inventors: Warren Gross, Saied Hemati, Shie Mannor, Ali Naderi, Francois Leduc-Primeau
  • Patent number: 8669544
    Abstract: Amongst the candidates for very high efficiency solid state light sources and full solar spectrum solar cells are devices based upon InGaN nanowires. Additionally these nanowires typically require heterostructures, quantum dots, etc which all place requirements for these structures to be grown with relatively few defects and in a controllable reproducible manner. Additionally flexibility according to the device design requires that the nanowire at the substrate may be either InN or GaN. According to the invention a method of growing relatively defect free nanowires and associated structures for group IIIA-nitrides is presented without the requirement for foreign metal catalysts and overcoming the non-uniform growth of prior art non-catalyst growth techniques. According to other embodiments of the invention self-organizing dot-within-a-dot nanowire and dot-within-a-dot-within-a-well nanowire structures are presented.
    Type: Grant
    Filed: February 10, 2012
    Date of Patent: March 11, 2014
    Assignee: The Royal Institution for the Advancement of Learning/McGill University
    Inventors: Zetian Mi, Kai Cui, Hieu Pham Trung Nguyen
  • Publication number: 20140065724
    Abstract: A method for diagnosing the presence of hereditary spastic paraplegia (HSP) or predicting the risk of developing HSP in a human subject, comprising detecting the presence or absence of a defect in a gene encoding a polypeptide comprising the sequence of FIG. 9 (SEQ ID NO: 19), in a nucleic acid sample of the subject, whereby the detection of the defect is indicative that the subject has or is at risk of developing HSP.
    Type: Application
    Filed: August 2, 2013
    Publication date: March 6, 2014
    Applicants: Universite Montreal, Val-Chum L.P., The Royal Institution for the Advancement of Learning/McGill University
    Inventors: Guy A. Rouleau, Paul Valdmanis, Inge Meijer, Pierre Drapeau, Patrick Dion
  • Patent number: 8667611
    Abstract: Atomic Force Microscopes (AFMs) allow forces within systems under observation to be probed from the piconewton forces of a single covalent bond to the forces exerted by cells in the micronewton range. The pendulum geometry prevents the snap-to-contact problem afflicting soft cantilevers in AFMs which enable attonewton force sensitivity. However, the microscopic length scale studies of cellular/subcellular forces parallel to the imaging plane of an optical microscope requires high sensitivity force measurements at high sampling frequencies despite the difficulties of implementing the pendulum geometry from constraints imposed by the focused incoming/outgoing light interfering with the sample surface. Additionally measurement systems for biological tissue samples in vitro must satisfy complex physical constraints to provide access to the vertical cantilever.
    Type: Grant
    Filed: April 29, 2011
    Date of Patent: March 4, 2014
    Assignee: The Royal Institution for the Advancement of Learning/McGill University
    Inventors: Dilson Rassier, Aleksander Labuda
  • Patent number: 8658452
    Abstract: A method of providing microelectromechanical structures (MEMS) that are compatible with silicon CMOS electronics is provided. The method providing for processes and manufacturing sequences limiting the maximum exposure of an integrated circuit upon which the MEMS is manufactured to below 350° C., and potentially to below 250° C., thereby allowing direct manufacturing of the MEMS devices onto electronics, such as Si CMOS circuits. The method further providing for the provisioning of MEMS devices with multiple non-conductive structural layers such as silicon carbide separated with small lateral gaps. Such silicon carbide structures offering enhanced material properties, increased environmental and chemical resilience whilst also allowing novel designs to be implemented taking advantage of the non-conductive material of the structural layer.
    Type: Grant
    Filed: July 8, 2009
    Date of Patent: February 25, 2014
    Assignee: The Royal Institution for the Advancement of Learning / McGill University
    Inventors: Mourad El-Gamal, Frederic Nabki, Paul-Vahe Cicek
  • Publication number: 20140051760
    Abstract: Hybrid molecules comprising a retinoic acid receptor agonist moiety and a histone deacetylase inhibitor (HDAC) moiety are disclosed. Hybrid molecule 3 (6-(5,5,8,8-tetramethyl-6,7-dihydronaphthalen-2-yl)naphthalene-2-hydroxamic acid) was proven to posses HDAC activity while maintaining RAR agonist activity. Hybrid molecule 3 and pharmaceutical compositions thereof can be used in the treatment of breast cancer, leukemia, non-small cell lung cancer, colon cancer, melanoma, ovarian cancer, renal cancer, prostate cancer and cancer of the CNS.
    Type: Application
    Filed: October 21, 2013
    Publication date: February 20, 2014
    Applicants: Universite de Montreal, The Royal Institution for the Advancement of Learning/McGill University
    Inventors: Wilson H. Miller, James Gleason, Sylvie Mader
  • Patent number: D704046
    Type: Grant
    Filed: May 10, 2012
    Date of Patent: May 6, 2014
    Assignee: The Royal Institution for the Advancement of Learning/McGill University
    Inventors: Colin Rogers, Thomas Morrison